Click here to switch to the map view.

The map label for this gene is tolC [C]

Identifier: 85858989

GI number: 85858989

Start: 1168107

End: 1169537

Strand: Direct

Name: tolC [C]

Synonym: SYN_01010

Alternate gene names: 85858989

Gene position: 1168107-1169537 (Clockwise)

Preceding gene: 85858981

Following gene: 85858990

Centisome position: 36.74

GC content: 51.5

Gene sequence:

>1431_bases
TTGCATTCATTTATGAACCATCGTTCATCATCATTATCAGATCCCCTATCGGGAGGGCAGGCTATGAAAAGGAGGAGACC
GCTAAAAAAGATTCTGGGGAGCCTGTTTCTCGGACTGTTGCTGGCCTGGGCGGCATGCCCCACCATGGTTTCCGGAGAAA
ATCCGTCGACCATCACTTTGAAGGAAAGCATCGAAGAGGCCTTGAAGAAAAGTGCAACCCTACATTCCACAAAAGAAGGA
GTTCTGATCGCAGAAGCGCAGCGCAGAGAGGCTTTTTCCGCTTTTCTTCCTTCATTCAGCACATCTTACAGCTACAAACA
CTTGAATGAAGCCCCGGAATTTACTTTGCCGATTGTTGTTGAACTGGGTCTGACGCCCTTGGCGACACAAGCGGGTACAA
AGGACAACTATAACTGGACTGTTGAAGTCCGGCAGCCTCTCTTTGCCGGAGGGGGCATCCTGTCTAATTATCAGGCCAAT
AGAATCGGTCTGGATGCGGCACGCCAGGAAGAGCAGACCGTCGTTCAGGAACTGGTCCTGGAAGTTCAGACGGCATATCT
GAATATCATCAAGGCGGAAAAACTTCGAGAAGTGGCCCTGCAGTCATTGGAGCGCCTGACCGCCCATCGGGACATGACCC
GTCACTTTTACGAAGTGGGAATGGTTCCACGGAACGACCTCCTTTTTGCTGAGGTTGAGCTGGCTAATGGCCGGCAGGAA
CTGCTCCGGGCGGAAAACGGGATTGCCATGGCGAAAGCGAAGTTCAACACGCTTCTCAGAAGATCGATGGATAAACCAGT
GGTCGTGGAGGATATCCTGGCCTACAAGCCCTACGATAAGGACTTTAATGACTGTCTGAAAACGGCGCTGGAGAGGAGAA
CGGAGATCAAGACATATTCTCTGAAGTTGGAACAGGCCGGCAAGGCTGTTCAGGTGGCCCGAAGCGAGTATTATCCTTCC
GTCAATTTCGTGGGCAATTATTCCCGATATGGCGACAAACCCCGGTTGGGTGGTACTTCTTATCAGGACTCGGAAAGCTG
GTATGTGATGACTGTGGCAACCTGGAATTTCTGGGAATGGGGAAGGACGAAAAACAGAGTGGAAGCCAGTCTCAGCAGGG
AACGCCAGGTGAATGACGCTCTGGAGAATATTCGGGATCAGATCGCCCTGGAATTGAAAAATGCCTGGTTGCTTCTGAAG
GAAGCGGAGGAACAGATTTCGGTTACCCGGCAGGCTGTGGTTCAGGCTGAAGAAAATTATCGGATCAGTTCGGAGAGATA
CCGGGAACAGGTTGCCACCGCCACGGATGTGATTGATGCCCAGACGCTGCTCACAAGAGCCAACTCTGATGCTACCCTGG
CCTTGAGCAATTATCAGACTCAACTGGCCCGTTTGAAACGGGCCATGGGGTTGAACTACGATGAGGAGTAA

Upstream 100 bases:

>100_bases
TTAAATATGTAAGCATTGCCATTAATCATAGTGCCGGAATATTGTCAAGATTAAAATCCCTGAGGGGGGCATGCTGATTT
TCTGTTGACAAGCTCAAGCA

Downstream 100 bases:

>100_bases
GGAAAAATAATGCAATGGCATCATAAGGATGTAGACCGTATCTTTTCGGAGCTAAAGACTTCACCCCGAGGGCTCTCTTC
TGATGAAGCCGCTGCACGTT

Product: type I secretion outer membrane protein

Products: NA

Alternate protein names: Outer Membrane Protein; Outer Membrane Protein lC; Type I Secretion Outer Membrane Protein; Outer Membrane Macrolide Efflux Protein; Acriflavin Resistance Protein; RND Family Efflux Pump Outer Membrane Protein; Outer Membrane Efflux Family Protein; LipD Protein; Outer Membrane Efflux Protein Domain-Containing Protein; RND Efflux System Outer Membrane Lipoprotein; Efflux System Outer Membrane Protein; Outer Membrane Protein-Like; Type I Secretion Outer Membrane Protein lC; RND Family Efflux Pump Inner Membrane Protein; Outer Membrane Protein CyaE

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MHSFMNHRSSSLSDPLSGGQAMKRRRPLKKILGSLFLGLLLAWAACPTMVSGENPSTITLKESIEEALKKSATLHSTKEG
VLIAEAQRREAFSAFLPSFSTSYSYKHLNEAPEFTLPIVVELGLTPLATQAGTKDNYNWTVEVRQPLFAGGGILSNYQAN
RIGLDAARQEEQTVVQELVLEVQTAYLNIIKAEKLREVALQSLERLTAHRDMTRHFYEVGMVPRNDLLFAEVELANGRQE
LLRAENGIAMAKAKFNTLLRRSMDKPVVVEDILAYKPYDKDFNDCLKTALERRTEIKTYSLKLEQAGKAVQVARSEYYPS
VNFVGNYSRYGDKPRLGGTSYQDSESWYVMTVATWNFWEWGRTKNRVEASLSRERQVNDALENIRDQIALELKNAWLLLK
EAEEQISVTRQAVVQAEENYRISSERYREQVATATDVIDAQTLLTRANSDATLALSNYQTQLARLKRAMGLNYDEE

Sequences:

>Translated_476_residues
MHSFMNHRSSSLSDPLSGGQAMKRRRPLKKILGSLFLGLLLAWAACPTMVSGENPSTITLKESIEEALKKSATLHSTKEG
VLIAEAQRREAFSAFLPSFSTSYSYKHLNEAPEFTLPIVVELGLTPLATQAGTKDNYNWTVEVRQPLFAGGGILSNYQAN
RIGLDAARQEEQTVVQELVLEVQTAYLNIIKAEKLREVALQSLERLTAHRDMTRHFYEVGMVPRNDLLFAEVELANGRQE
LLRAENGIAMAKAKFNTLLRRSMDKPVVVEDILAYKPYDKDFNDCLKTALERRTEIKTYSLKLEQAGKAVQVARSEYYPS
VNFVGNYSRYGDKPRLGGTSYQDSESWYVMTVATWNFWEWGRTKNRVEASLSRERQVNDALENIRDQIALELKNAWLLLK
EAEEQISVTRQAVVQAEENYRISSERYREQVATATDVIDAQTLLTRANSDATLALSNYQTQLARLKRAMGLNYDEE
>Mature_476_residues
MHSFMNHRSSSLSDPLSGGQAMKRRRPLKKILGSLFLGLLLAWAACPTMVSGENPSTITLKESIEEALKKSATLHSTKEG
VLIAEAQRREAFSAFLPSFSTSYSYKHLNEAPEFTLPIVVELGLTPLATQAGTKDNYNWTVEVRQPLFAGGGILSNYQAN
RIGLDAARQEEQTVVQELVLEVQTAYLNIIKAEKLREVALQSLERLTAHRDMTRHFYEVGMVPRNDLLFAEVELANGRQE
LLRAENGIAMAKAKFNTLLRRSMDKPVVVEDILAYKPYDKDFNDCLKTALERRTEIKTYSLKLEQAGKAVQVARSEYYPS
VNFVGNYSRYGDKPRLGGTSYQDSESWYVMTVATWNFWEWGRTKNRVEASLSRERQVNDALENIRDQIALELKNAWLLLK
EAEEQISVTRQAVVQAEENYRISSERYREQVATATDVIDAQTLLTRANSDATLALSNYQTQLARLKRAMGLNYDEE

Specific function: Required For Proper Expression Of Outer Membrane Protein Genes Such As Ompf, Nmpc, Protein 2, Hemolysin, Colicin V, Or Colicin E1. May Be Specialized For Signal Sequence Independent, Extracellular Secretion In Gram-Negative Bacteria. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Outer Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 53912; Mature: 53912

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSFMNHRSSSLSDPLSGGQAMKRRRPLKKILGSLFLGLLLAWAACPTMVSGENPSTITL
CCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEH
KESIEEALKKSATLHSTKEGVLIAEAQRREAFSAFLPSFSTSYSYKHLNEAPEFTLPIVV
HHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEE
ELGLTPLATQAGTKDNYNWTVEVRQPLFAGGGILSNYQANRIGLDAARQEEQTVVQELVL
ECCCCCHHHCCCCCCCCEEEEEECCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EVQTAYLNIIKAEKLREVALQSLERLTAHRDMTRHFYEVGMVPRNDLLFAEVELANGRQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHH
LLRAENGIAMAKAKFNTLLRRSMDKPVVVEDILAYKPYDKDFNDCLKTALERRTEIKTYS
HHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEE
LKLEQAGKAVQVARSEYYPSVNFVGNYSRYGDKPRLGGTSYQDSESWYVMTVATWNFWEW
EEHHHCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCHHH
GRTKNRVEASLSRERQVNDALENIRDQIALELKNAWLLLKEAEEQISVTRQAVVQAEENY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RISSERYREQVATATDVIDAQTLLTRANSDATLALSNYQTQLARLKRAMGLNYDEE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHSFMNHRSSSLSDPLSGGQAMKRRRPLKKILGSLFLGLLLAWAACPTMVSGENPSTITL
CCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEH
KESIEEALKKSATLHSTKEGVLIAEAQRREAFSAFLPSFSTSYSYKHLNEAPEFTLPIVV
HHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCEEE
ELGLTPLATQAGTKDNYNWTVEVRQPLFAGGGILSNYQANRIGLDAARQEEQTVVQELVL
ECCCCCHHHCCCCCCCCEEEEEECCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
EVQTAYLNIIKAEKLREVALQSLERLTAHRDMTRHFYEVGMVPRNDLLFAEVELANGRQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHH
LLRAENGIAMAKAKFNTLLRRSMDKPVVVEDILAYKPYDKDFNDCLKTALERRTEIKTYS
HHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEE
LKLEQAGKAVQVARSEYYPSVNFVGNYSRYGDKPRLGGTSYQDSESWYVMTVATWNFWEW
EEHHHCCHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCHHH
GRTKNRVEASLSRERQVNDALENIRDQIALELKNAWLLLKEAEEQISVTRQAVVQAEENY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RISSERYREQVATATDVIDAQTLLTRANSDATLALSNYQTQLARLKRAMGLNYDEE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA