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The map label for this gene is thrC [H]

Identifier: 85858909

GI number: 85858909

Start: 1088775

End: 1090226

Strand: Direct

Name: thrC [H]

Synonym: SYN_02122

Alternate gene names: 85858909

Gene position: 1088775-1090226 (Clockwise)

Preceding gene: 85858908

Following gene: 85858910

Centisome position: 34.25

GC content: 55.1

Gene sequence:

>1452_bases
TTGAAGGTGGAATTCAGCGTTCCACGCCGTCGGGAAAAGTTGCACCGTATGGGGGAATTCATGAGAGAGAGAATCCTGTA
TTACAGCACGAATTGTTACCTCGATAATGTTGAAGGAATGGAGCCGTTCAAGGATCGAGTTTCCTTCCGGGAAGCCCTGC
TTCTGGGGCAGGCTCCGGATGAAGGACTGTTCATGCCCGAGAGCATTCCCCAACTGTCCCTCGACGAGATCCTGAATCTG
AAAGGCAGGCCCTATACGGCGGCCGCTCTGCTGGTGGCGGAGGCTTATCTCGGGGCGGATCTGCCTCTGGAAACTCTGAA
GGCGGTGATTGAATCTTCCTATAATTATGAAGTTCCCCTGGAACGCGTTGTGGACCGTCGGTATGTTCTCCGACTCGACC
GGGGACCGACGGCTTCCTTCAAGGATTTCGCGGCCCGGATGATGGCCCGCCTGATGAGTCATTTTCGCGATCCGGGAAAG
CGCCTCAATGTCCTGGTGGCCACTTCGGGGGATACAGGCAGTGCCGTGGGGGAAGCCTTTAAGGGCGTTGCCGGAATTGA
CGTCTATATCCTGTATCCCCGGGAAGAGGTGAGTGGCCGGCAGAAAAAGCAGTTGGACACCATCGGCGGCAATGTCCGGA
CCCTGTCCGTGGAAGGAAAGTTCGATGACTGCCAGGATCTCGTCAAACAGGCCTTTGCCGATCCCGCCCTGGCGGGATTG
AATCTGACCTCCGCCAATTCCATCAATTTCGGCCGGATTCTACCCCAGATGATTTATTATGTTTATGCCTATGCCCAGCT
TGCCGAAAGGGGGGAAGAGATCGTCTTTTCCGTGCCGTCTGGAAACTTCGGAGACGCCCTGGGATGTGAATACGCACGGC
GCATGGGCCTGCCCGTCGCCCAACTGGTGATGCCCACCAACGAGAACGACGAGTTTCCCCGTTTTCTGAAAACCGGCCGT
TACGAAAAGATATCGCCTTCTCTTGCCTGTCTGTCGAATGCCATGAACGTCGGCCATCCGAGCAATCTGGCCCGGTTTTT
TGACTTATACGGGGGGACAGTGGACCGGACAGGTCGTGTGCACAAGATGCCGGATCTGGAAGAGATGAGGAACAATATCT
TCTCCGTTTCTGTCTCCGATGAGGAAACCCGGCGGACGATCCGAAGGGCTTACGATTCGTACGGACTGATTCTGGAACCA
CATGGAGCTGTGGGCTGGCGGGGTCTTGAACTCTATCTGGAACAGACCGGGAGGAAAGTGCTCTGTGTATCCCTGGAAAC
GGCTCATCCGGCAAAATTCCCCGAAGAAATCGTTTCGCTGCTGGGCATCAGTCCCGAGTTGCCGGCAAGCATGCGGGATA
TCGACTCGCGAACCGGCGAACCCCTGCCGATGACAGGCGATTACAATGTATTTCGTAAATTTTTGGAAAAAACGTTAAAG
GCCATGGATTGA

Upstream 100 bases:

>100_bases
GAAGTCATAAAATTCATCGGGAACAGCTCCCTGCTTAGAAGGTTCAACGTTCCAAATTCTATGTCTCTCATCGGGAAATG
CTATCCTGGAACTTCGAACT

Downstream 100 bases:

>100_bases
AATGGCCATTCCCTGGGCTGAAATCAAGCCTGTCCAAGGCGATGAACAGGCTTGCTGAAAATCCCGTTTTGCCCTATCCG
CCCTTTTCAAACTGGGATTT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MKVEFSVPRRREKLHRMGEFMRERILYYSTNCYLDNVEGMEPFKDRVSFREALLLGQAPDEGLFMPESIPQLSLDEILNL
KGRPYTAAALLVAEAYLGADLPLETLKAVIESSYNYEVPLERVVDRRYVLRLDRGPTASFKDFAARMMARLMSHFRDPGK
RLNVLVATSGDTGSAVGEAFKGVAGIDVYILYPREEVSGRQKKQLDTIGGNVRTLSVEGKFDDCQDLVKQAFADPALAGL
NLTSANSINFGRILPQMIYYVYAYAQLAERGEEIVFSVPSGNFGDALGCEYARRMGLPVAQLVMPTNENDEFPRFLKTGR
YEKISPSLACLSNAMNVGHPSNLARFFDLYGGTVDRTGRVHKMPDLEEMRNNIFSVSVSDEETRRTIRRAYDSYGLILEP
HGAVGWRGLELYLEQTGRKVLCVSLETAHPAKFPEEIVSLLGISPELPASMRDIDSRTGEPLPMTGDYNVFRKFLEKTLK
AMD

Sequences:

>Translated_483_residues
MKVEFSVPRRREKLHRMGEFMRERILYYSTNCYLDNVEGMEPFKDRVSFREALLLGQAPDEGLFMPESIPQLSLDEILNL
KGRPYTAAALLVAEAYLGADLPLETLKAVIESSYNYEVPLERVVDRRYVLRLDRGPTASFKDFAARMMARLMSHFRDPGK
RLNVLVATSGDTGSAVGEAFKGVAGIDVYILYPREEVSGRQKKQLDTIGGNVRTLSVEGKFDDCQDLVKQAFADPALAGL
NLTSANSINFGRILPQMIYYVYAYAQLAERGEEIVFSVPSGNFGDALGCEYARRMGLPVAQLVMPTNENDEFPRFLKTGR
YEKISPSLACLSNAMNVGHPSNLARFFDLYGGTVDRTGRVHKMPDLEEMRNNIFSVSVSDEETRRTIRRAYDSYGLILEP
HGAVGWRGLELYLEQTGRKVLCVSLETAHPAKFPEEIVSLLGISPELPASMRDIDSRTGEPLPMTGDYNVFRKFLEKTLK
AMD
>Mature_483_residues
MKVEFSVPRRREKLHRMGEFMRERILYYSTNCYLDNVEGMEPFKDRVSFREALLLGQAPDEGLFMPESIPQLSLDEILNL
KGRPYTAAALLVAEAYLGADLPLETLKAVIESSYNYEVPLERVVDRRYVLRLDRGPTASFKDFAARMMARLMSHFRDPGK
RLNVLVATSGDTGSAVGEAFKGVAGIDVYILYPREEVSGRQKKQLDTIGGNVRTLSVEGKFDDCQDLVKQAFADPALAGL
NLTSANSINFGRILPQMIYYVYAYAQLAERGEEIVFSVPSGNFGDALGCEYARRMGLPVAQLVMPTNENDEFPRFLKTGR
YEKISPSLACLSNAMNVGHPSNLARFFDLYGGTVDRTGRVHKMPDLEEMRNNIFSVSVSDEETRRTIRRAYDSYGLILEP
HGAVGWRGLELYLEQTGRKVLCVSLETAHPAKFPEEIVSLLGISPELPASMRDIDSRTGEPLPMTGDYNVFRKFLEKTLK
AMD

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=473, Percent_Identity=31.0782241014799, Blast_Score=198, Evalue=9e-51,
Organism=Homo sapiens, GI149193323, Length=443, Percent_Identity=31.3769751693002, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1786185, Length=441, Percent_Identity=37.4149659863946, Blast_Score=264, Evalue=9e-72,
Organism=Saccharomyces cerevisiae, GI6319901, Length=446, Percent_Identity=36.0986547085202, Blast_Score=236, Evalue=8e-63,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 54243; Mature: 54243

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00962 RIBOSOMAL_S2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVEFSVPRRREKLHRMGEFMRERILYYSTNCYLDNVEGMEPFKDRVSFREALLLGQAPD
CCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCCHHHHHHHHHHHHHHCCCCC
EGLFMPESIPQLSLDEILNLKGRPYTAAALLVAEAYLGADLPLETLKAVIESSYNYEVPL
CCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCH
ERVVDRRYVLRLDRGPTASFKDFAARMMARLMSHFRDPGKRLNVLVATSGDTGSAVGEAF
HHHHCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHH
KGVAGIDVYILYPREEVSGRQKKQLDTIGGNVRTLSVEGKFDDCQDLVKQAFADPALAGL
CCCCCCEEEEEECCHHHCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHCC
NLTSANSINFGRILPQMIYYVYAYAQLAERGEEIVFSVPSGNFGDALGCEYARRMGLPVA
EECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCHH
QLVMPTNENDEFPRFLKTGRYEKISPSLACLSNAMNVGHPSNLARFFDLYGGTVDRTGRV
HHEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
HKMPDLEEMRNNIFSVSVSDEETRRTIRRAYDSYGLILEPHGAVGWRGLELYLEQTGRKV
CCCCCHHHHHCCEEEEEECCHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCEE
LCVSLETAHPAKFPEEIVSLLGISPELPASMRDIDSRTGEPLPMTGDYNVFRKFLEKTLK
EEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
AMD
HCC
>Mature Secondary Structure
MKVEFSVPRRREKLHRMGEFMRERILYYSTNCYLDNVEGMEPFKDRVSFREALLLGQAPD
CCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCEEECCCCCCHHHHHHHHHHHHHHCCCCC
EGLFMPESIPQLSLDEILNLKGRPYTAAALLVAEAYLGADLPLETLKAVIESSYNYEVPL
CCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCH
ERVVDRRYVLRLDRGPTASFKDFAARMMARLMSHFRDPGKRLNVLVATSGDTGSAVGEAF
HHHHCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHH
KGVAGIDVYILYPREEVSGRQKKQLDTIGGNVRTLSVEGKFDDCQDLVKQAFADPALAGL
CCCCCCEEEEEECCHHHCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCHHHCC
NLTSANSINFGRILPQMIYYVYAYAQLAERGEEIVFSVPSGNFGDALGCEYARRMGLPVA
EECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHCCCHH
QLVMPTNENDEFPRFLKTGRYEKISPSLACLSNAMNVGHPSNLARFFDLYGGTVDRTGRV
HHEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
HKMPDLEEMRNNIFSVSVSDEETRRTIRRAYDSYGLILEPHGAVGWRGLELYLEQTGRKV
CCCCCHHHHHCCEEEEEECCHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCEE
LCVSLETAHPAKFPEEIVSLLGISPELPASMRDIDSRTGEPLPMTGDYNVFRKFLEKTLK
EEEEECCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
AMD
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]