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The map label for this gene is yegE [H]

Identifier: 85858780

GI number: 85858780

Start: 971072

End: 971956

Strand: Direct

Name: yegE [H]

Synonym: SYN_02722

Alternate gene names: 85858780

Gene position: 971072-971956 (Clockwise)

Preceding gene: 85858779

Following gene: 85858781

Centisome position: 30.54

GC content: 46.33

Gene sequence:

>885_bases
ATGGAAAAAGAATCACGGGATATGCTGACTTTCTTGAAGACCCTTATAGATGCCATTCCAAGTCCAATATTTTATCAGGA
TATCAGTGGCCTCTATCTGGGCTGCAACAGGGCGTTCGAGGAATTCCTCGGCCTCAAAAAGGAAAAGTTGGTTGGAAAGT
CCGTCTATGACGTCTTTCCGAAAGATTTGGCTGAAAAATATTACACAATGGATTCGTTATTGGCTCATCAAGGGGGGCAA
CAGACATATGAAGATCAGATCATTGATGCCAACGGAAAAACGCACGATGTCATCTTCATCAAAGTTACCTACCTGAATAC
TGACGGCGTCCCCGCAGGGTTGGTTGGCGTCATGGTAGACATTACAGAACGAAAGCGGATGGAGGCGGAATTATTGTCAA
TGTCGCTCCGTGATCAGCTCACGGGAATATATAACCGTCGGGGGTTCATCAATCTTGCGGAGCAGTGGATCAAGACGGCA
AACAGAGCGAAACGTCAGATGCTGCTTTCCTTTATTGATGTTGATGATTTGAAAAAAATCAACGATACGCTGGGACATGA
GGGAGGGGATAAGGCTCTGGTCGAGACGGCAAACATTCTCAGGCAGACGTTTCGGGAATCTGATATCGTTGCCCGCATAG
GAGGTGATGAATTTGCTGTTCTGGTTCTCGATATGACAGACTTGAATCCTGAGATCCTGTCAAGACGCCTCCAGCATAAC
ATTGATGAATGGAACGCAAAAGTGTCGCGACAATACAAGCTCGCGATGAGTTGGGGCATGACCCTGTATGATCCTGAGTC
TCCCATATCCCTGAACCAGCTGATGTCGCTATCGGACAAATTAATGTACGCCCGGAAAAAAGCCAAAATGAACAAAAGCA
TCTGA

Upstream 100 bases:

>100_bases
GTTATGCTTTTCACTGCGACCAGCCGGATGCTGCCCCCATGAAAGGCGTATCTTATTGATGTTCGGGGCGATTTTGACAG
ACATTACGGAGCACCAATAG

Downstream 100 bases:

>100_bases
ACCTGTAAGTGAGCAGCCGTTGACTGTCGACTGAACAAAAGCAACACTGAATGAATTATTATTCCTTTTAGGAATTAAAA
TCTGCGTTATAGAATGGTTC

Product: sensory box/GGDEF family protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MEKESRDMLTFLKTLIDAIPSPIFYQDISGLYLGCNRAFEEFLGLKKEKLVGKSVYDVFPKDLAEKYYTMDSLLAHQGGQ
QTYEDQIIDANGKTHDVIFIKVTYLNTDGVPAGLVGVMVDITERKRMEAELLSMSLRDQLTGIYNRRGFINLAEQWIKTA
NRAKRQMLLSFIDVDDLKKINDTLGHEGGDKALVETANILRQTFRESDIVARIGGDEFAVLVLDMTDLNPEILSRRLQHN
IDEWNAKVSRQYKLAMSWGMTLYDPESPISLNQLMSLSDKLMYARKKAKMNKSI

Sequences:

>Translated_294_residues
MEKESRDMLTFLKTLIDAIPSPIFYQDISGLYLGCNRAFEEFLGLKKEKLVGKSVYDVFPKDLAEKYYTMDSLLAHQGGQ
QTYEDQIIDANGKTHDVIFIKVTYLNTDGVPAGLVGVMVDITERKRMEAELLSMSLRDQLTGIYNRRGFINLAEQWIKTA
NRAKRQMLLSFIDVDDLKKINDTLGHEGGDKALVETANILRQTFRESDIVARIGGDEFAVLVLDMTDLNPEILSRRLQHN
IDEWNAKVSRQYKLAMSWGMTLYDPESPISLNQLMSLSDKLMYARKKAKMNKSI
>Mature_294_residues
MEKESRDMLTFLKTLIDAIPSPIFYQDISGLYLGCNRAFEEFLGLKKEKLVGKSVYDVFPKDLAEKYYTMDSLLAHQGGQ
QTYEDQIIDANGKTHDVIFIKVTYLNTDGVPAGLVGVMVDITERKRMEAELLSMSLRDQLTGIYNRRGFINLAEQWIKTA
NRAKRQMLLSFIDVDDLKKINDTLGHEGGDKALVETANILRQTFRESDIVARIGGDEFAVLVLDMTDLNPEILSRRLQHN
IDEWNAKVSRQYKLAMSWGMTLYDPESPISLNQLMSLSDKLMYARKKAKMNKSI

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=284, Percent_Identity=27.4647887323944, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787262, Length=161, Percent_Identity=31.6770186335404, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1786584, Length=173, Percent_Identity=33.5260115606936, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87081974, Length=163, Percent_Identity=32.5153374233129, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI87081977, Length=183, Percent_Identity=28.9617486338798, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787541, Length=237, Percent_Identity=26.1603375527426, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI87081881, Length=179, Percent_Identity=31.8435754189944, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082007, Length=169, Percent_Identity=28.4023668639053, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788085, Length=165, Percent_Identity=29.0909090909091, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI145693134, Length=157, Percent_Identity=28.0254777070064, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48994928, Length=134, Percent_Identity=32.8358208955224, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787802, Length=168, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788956, Length=166, Percent_Identity=31.3253012048193, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 33562; Mature: 33562

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKESRDMLTFLKTLIDAIPSPIFYQDISGLYLGCNRAFEEFLGLKKEKLVGKSVYDVFP
CCCHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCH
KDLAEKYYTMDSLLAHQGGQQTYEDQIIDANGKTHDVIFIKVTYLNTDGVPAGLVGVMVD
HHHHHHHHHHHHHHHHCCCCCCHHCCEECCCCCEEEEEEEEEEEEECCCCCHHHHHHHHH
ITERKRMEAELLSMSLRDQLTGIYNRRGFINLAEQWIKTANRAKRQMLLSFIDVDDLKKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
NDTLGHEGGDKALVETANILRQTFRESDIVARIGGDEFAVLVLDMTDLNPEILSRRLQHN
HHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEECCCCHHHHHHHHHCC
IDEWNAKVSRQYKLAMSWGMTLYDPESPISLNQLMSLSDKLMYARKKAKMNKSI
HHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKESRDMLTFLKTLIDAIPSPIFYQDISGLYLGCNRAFEEFLGLKKEKLVGKSVYDVFP
CCCHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCH
KDLAEKYYTMDSLLAHQGGQQTYEDQIIDANGKTHDVIFIKVTYLNTDGVPAGLVGVMVD
HHHHHHHHHHHHHHHHCCCCCCHHCCEECCCCCEEEEEEEEEEEEECCCCCHHHHHHHHH
ITERKRMEAELLSMSLRDQLTGIYNRRGFINLAEQWIKTANRAKRQMLLSFIDVDDLKKI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
NDTLGHEGGDKALVETANILRQTFRESDIVARIGGDEFAVLVLDMTDLNPEILSRRLQHN
HHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEECCCCHHHHHHHHHCC
IDEWNAKVSRQYKLAMSWGMTLYDPESPISLNQLMSLSDKLMYARKKAKMNKSI
HHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]