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The map label for this gene is sucC [H]

Identifier: 85857865

GI number: 85857865

Start: 22960

End: 24102

Strand: Direct

Name: sucC [H]

Synonym: SYN_03227

Alternate gene names: 85857865

Gene position: 22960-24102 (Clockwise)

Preceding gene: 85857863

Following gene: 85857866

Centisome position: 0.72

GC content: 56.69

Gene sequence:

>1143_bases
ATGAGACTTCATGAATACGAGGCTTTGGATATTTTTGAACGGAACGGCATTCCCGTTCCCCGACGCGGTGTCGCCTCCAC
CATGCACGAAGCCCTTCGTGTGGCAGGCGAAATCGGGTATCCCGTTATACTGAAGGCCCAGGTCCTTGTCGGGGGCCGTG
GCCTCGCCGGCGGAATCAAAACCGCTTCTTCGCCGGATGAGTTGAAGGAGGTCGCCGAAGCCCTGCTGTCCTCCGACGTC
AAGGGACTGCCTGTCCTCAAGCTTCTTGTCTGCGAGAAGGTGGAGGTTGCCAAGGAACTCTACGTGGGCATTACAATCGA
TGGATATTCAGGCAAACCGGTTATCGTGGCGAGCACCGAAGGCGGCATGCTGATTGAAGAGACGGCGAGGACCTCGCCTG
AAAAGATTGCCGCGATTCATGTCGACTCGTCCCTGGAATTTTACCCCTATCAGGCCCGTACCATGCTGGGGCGGCTCAGC
GGCATCAATCAGCAGCTTCTCACTTCCTGGACGGATGTCATCGGCCAGCTGTACAACGTTGTGATGCGTTACGAGCCCCT
GATCTGTGAAATCAATCCCCTGGTCGTCCTTCCCAACGGAGGACTGATCGCCGTCGATGCCGTGCTGGAGGTAGACGATT
CGGCCATATCGCGGGTGCGTTTTCCCCTGCCGGATCGTGTCGAAAGGATCGAGAATCCGCTGGAACGCAGAGGGAGAGAG
ATCGGTGTCACCTACGTGGACCTTGATGGGGATATCGGATTGATCTCTTCGGGCGCCGGACTGGGCATGGCCTCTACGGA
CATTATCGGCGAAAGAATGAAACCCGCCAACTTCCTGGAGACGGGCGGCGGCATTACCGCGGACCTGCTCTATAAGTGCA
TGGAGCTCATCATGATGAAACCGGGACTCCGGGCCGTGTTCATCAATGTTTACGGCGGCATCAATCCCATCCACGAAGGA
GCTAAGGGCGTTGTGCGTTACATACAGGAGCACAATGTCAAGATACCCATTGTCGCCAAGGCACTCGGAAACCGTCAGGA
GGAGACCTGGGAGATCTTCCGGTCCGCCGGGGTGCATGTCGTCACGGAAGCGGCAACTGAAAAAGCGATCGATCGCTTAT
ATGAACTGGTAGGACGAGGTTAA

Upstream 100 bases:

>100_bases
TTATTTCCATTGACATATCAGCACAGCAATTTTATGTATGGCGCACCGTGCACCGAAGATGTTTTCCTGAATCACTATTT
ATTTAAAGGAATAAACCGCT

Downstream 100 bases:

>100_bases
GCATGAGCATACTGATGAACGATTCAACACGTGTTATCGTGCAGGGCATTACGGGCCGCATCGGAAAGGCGCAGGCCCAC
TGGATGCTTGAATACGGAAC

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MRLHEYEALDIFERNGIPVPRRGVASTMHEALRVAGEIGYPVILKAQVLVGGRGLAGGIKTASSPDELKEVAEALLSSDV
KGLPVLKLLVCEKVEVAKELYVGITIDGYSGKPVIVASTEGGMLIEETARTSPEKIAAIHVDSSLEFYPYQARTMLGRLS
GINQQLLTSWTDVIGQLYNVVMRYEPLICEINPLVVLPNGGLIAVDAVLEVDDSAISRVRFPLPDRVERIENPLERRGRE
IGVTYVDLDGDIGLISSGAGLGMASTDIIGERMKPANFLETGGGITADLLYKCMELIMMKPGLRAVFINVYGGINPIHEG
AKGVVRYIQEHNVKIPIVAKALGNRQEETWEIFRSAGVHVVTEAATEKAIDRLYELVGRG

Sequences:

>Translated_380_residues
MRLHEYEALDIFERNGIPVPRRGVASTMHEALRVAGEIGYPVILKAQVLVGGRGLAGGIKTASSPDELKEVAEALLSSDV
KGLPVLKLLVCEKVEVAKELYVGITIDGYSGKPVIVASTEGGMLIEETARTSPEKIAAIHVDSSLEFYPYQARTMLGRLS
GINQQLLTSWTDVIGQLYNVVMRYEPLICEINPLVVLPNGGLIAVDAVLEVDDSAISRVRFPLPDRVERIENPLERRGRE
IGVTYVDLDGDIGLISSGAGLGMASTDIIGERMKPANFLETGGGITADLLYKCMELIMMKPGLRAVFINVYGGINPIHEG
AKGVVRYIQEHNVKIPIVAKALGNRQEETWEIFRSAGVHVVTEAATEKAIDRLYELVGRG
>Mature_380_residues
MRLHEYEALDIFERNGIPVPRRGVASTMHEALRVAGEIGYPVILKAQVLVGGRGLAGGIKTASSPDELKEVAEALLSSDV
KGLPVLKLLVCEKVEVAKELYVGITIDGYSGKPVIVASTEGGMLIEETARTSPEKIAAIHVDSSLEFYPYQARTMLGRLS
GINQQLLTSWTDVIGQLYNVVMRYEPLICEINPLVVLPNGGLIAVDAVLEVDDSAISRVRFPLPDRVERIENPLERRGRE
IGVTYVDLDGDIGLISSGAGLGMASTDIIGERMKPANFLETGGGITADLLYKCMELIMMKPGLRAVFINVYGGINPIHEG
AKGVVRYIQEHNVKIPIVAKALGNRQEETWEIFRSAGVHVVTEAATEKAIDRLYELVGRG

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI157779135, Length=380, Percent_Identity=31.3157894736842, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI294862256, Length=366, Percent_Identity=31.9672131147541, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI11321583, Length=380, Percent_Identity=30.7894736842105, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1786948, Length=388, Percent_Identity=34.5360824742268, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17567829, Length=383, Percent_Identity=31.0704960835509, Blast_Score=180, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17539378, Length=398, Percent_Identity=29.1457286432161, Blast_Score=171, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321683, Length=396, Percent_Identity=30.3030303030303, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI161078106, Length=396, Percent_Identity=31.3131313131313, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24645208, Length=396, Percent_Identity=31.3131313131313, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281361397, Length=397, Percent_Identity=31.2342569269521, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281361395, Length=397, Percent_Identity=31.2342569269521, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21356231, Length=392, Percent_Identity=28.5714285714286, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 41284; Mature: 41284

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLHEYEALDIFERNGIPVPRRGVASTMHEALRVAGEIGYPVILKAQVLVGGRGLAGGIK
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCC
TASSPDELKEVAEALLSSDVKGLPVLKLLVCEKVEVAKELYVGITIDGYSGKPVIVASTE
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEEECC
GGMLIEETARTSPEKIAAIHVDSSLEFYPYQARTMLGRLSGINQQLLTSWTDVIGQLYNV
CCEEEEHHHCCCCCCEEEEEECCCCEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VMRYEPLICEINPLVVLPNGGLIAVDAVLEVDDSAISRVRFPLPDRVERIENPLERRGRE
HHHCCCEEEECCCEEEECCCCEEEEEEEEECCHHHHHHCCCCCCHHHHHHCCHHHHCCCE
IGVTYVDLDGDIGLISSGAGLGMASTDIIGERMKPANFLETGGGITADLLYKCMELIMMK
ECEEEEEECCCEEEEECCCCCCCCHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHCC
PGLRAVFINVYGGINPIHEGAKGVVRYIQEHNVKIPIVAKALGNRQEETWEIFRSAGVHV
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCHHHHHHHHHCCCEE
VTEAATEKAIDRLYELVGRG
EEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLHEYEALDIFERNGIPVPRRGVASTMHEALRVAGEIGYPVILKAQVLVGGRGLAGGIK
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCC
TASSPDELKEVAEALLSSDVKGLPVLKLLVCEKVEVAKELYVGITIDGYSGKPVIVASTE
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCCEEEEEECC
GGMLIEETARTSPEKIAAIHVDSSLEFYPYQARTMLGRLSGINQQLLTSWTDVIGQLYNV
CCEEEEHHHCCCCCCEEEEEECCCCEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
VMRYEPLICEINPLVVLPNGGLIAVDAVLEVDDSAISRVRFPLPDRVERIENPLERRGRE
HHHCCCEEEECCCEEEECCCCEEEEEEEEECCHHHHHHCCCCCCHHHHHHCCHHHHCCCE
IGVTYVDLDGDIGLISSGAGLGMASTDIIGERMKPANFLETGGGITADLLYKCMELIMMK
ECEEEEEECCCEEEEECCCCCCCCHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHCC
PGLRAVFINVYGGINPIHEGAKGVVRYIQEHNVKIPIVAKALGNRQEETWEIFRSAGVHV
CCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCHHHHHHHHHCCCEE
VTEAATEKAIDRLYELVGRG
EEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034208; 2204576 [H]