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The map label for this gene is norM [H]

Identifier: 85375710

GI number: 85375710

Start: 2899875

End: 2901410

Strand: Reverse

Name: norM [H]

Synonym: ELI_14415

Alternate gene names: 85375710

Gene position: 2901410-2899875 (Counterclockwise)

Preceding gene: 85375711

Following gene: 85375708

Centisome position: 95.05

GC content: 65.3

Gene sequence:

>1536_bases
ATGTATGCGATCGGTGTGGCCCGGCAGTCGCAGAGCGTCCACAATATCGGCGTGAGGACGGGCCTGATCTGTCATATGGC
CAGGCTGATCTCTATCCGGGCCGGCTGCATGCATGAAATGGCGCCCGAAGTGGACACGGCGGACAGCTGGCGAGCCGAGA
TTGCCGCGACCTTCAGGCTCGCGTGGCCGCTGGCGCTCGCCAATCTGTTGCAGATGCTGATCTGGGCGATCGACGTGTTC
TTCGTCGCGCGGCTCGGCGAGTTCGAATTGGCCGCCTCCAGCCTCGCTGTGTCGCTGTTCAGCATCCTTGGCTGGGCGAC
CATCACCCTGGTGAGCATGGTCTCGGCCCTGATCGCAGCCGAACTGGGCCGCTCGCGCTATGCCATTGCTGAGGTCCGGC
GCAGCGTGCGCATGGGCGTCTGGCTCTGCGTGATCTGCGGCGTACTCGTCATGCTGATCCTGAGCCAGGCCGAAGCCATC
CTGCTCGCCAGCGGGCAGAGGGCGGAACTGGCGGCCCGCGCTTACGACTACATGGGCATCGTCCTGTGGGCGATGATCCC
CTTGCTGGTGGCGAGCGTGCTGAGGAGCTTTGTTTCCGCGCTCGGCCGCCCGATCTTCGCTACCGCGATCACGGCGCTCG
CCATCGGCGTCAATGCGCTGGGCAATTACGCGCTGGTCTTCGGCAATCTCGGCGCGCCCGCGCTGGGCCTCGAAGGTTCG
GCCATCGCCACCGTCGTCACGTCGATATTCATCGTGTTGGCTTATGTGGTGGCGATCCAGCAGGACCGGCGCTTGCGGCG
CTATGCCATCTGGGGCCGGTTCTGGCGGCCGGAATGGGATCGGCTGCGCGACCTGGTGGTGCTGGGCACGCCGGTGTTCT
TCACGACGATCGCCGAAGCGGGGCTGTTCGGCGGTGCGGCCCTGCTGATGGGGCTGATCGGGGAATCCGAGCTGGCCGGC
CACACCATCGCGCTGCAAATCGCCGCTTTCGCCTTCCAGGTGCCGTTCGGTGTGAGCCAGGCGGCGACTATTCGCGTCGG
CTATTTCTACGGCGCGCGCGATCACGAAGCGATCAAGCGCGCAGGGGCGGTTGCGCTGCTGATAGCGGTGGCCTTCATGG
CCTTCACCGCTTCGGTCATGTTGCTGATGCCGGAGGCGATACTGGGTCTCTATATCGATACGTCGAAATCAGTGAATGCG
GCGATGATGGCCTTCGCGCTGCAATACATCGTGATCGCCGCACTTTTCCAGCTGGTCGATGGCCTCCAGGTCGTCGCTGC
CGGGGCCCTGCGCGGGCTGCAGGACACGCGCGTGCCGATGGTGATGGCGATCTTCAGCTACTGGGTGCCCGGCTTCGGCA
CGTCCTATTATCTCGGCTTCTACACGCCGCTCAAAGGCACTGGCGTGTGGATCGGTTTTGCCGTCGGCCTGACCTTTGCC
ACCGTGCTGCTGACCGGGCGCTGGCTGATGCGCGAGCGGCTGGGCCTTGCGCACCGCCCCGCACGCAAGCCGGGCGCTAA
ACCGCCCGCTGCGTAA

Upstream 100 bases:

>100_bases
TGCCCCTGCGCAGGCAGGGGATCCGGGATCTCGCTCCGCCTGGTCGACCCGACGAGGCGAAGAACACAAGGGGGCGGTGC
CGCAAGGCGCCGCCCTTTTC

Downstream 100 bases:

>100_bases
TCTCGCGCTGCGGGAACGGGATCGAGATGCCGACATCGTCGAAGCGGGCCTTGACCGCCTCGGTCATATCCCACCCGACG
GCTACGTAATCTGCGGTGGT

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MYAIGVARQSQSVHNIGVRTGLICHMARLISIRAGCMHEMAPEVDTADSWRAEIAATFRLAWPLALANLLQMLIWAIDVF
FVARLGEFELAASSLAVSLFSILGWATITLVSMVSALIAAELGRSRYAIAEVRRSVRMGVWLCVICGVLVMLILSQAEAI
LLASGQRAELAARAYDYMGIVLWAMIPLLVASVLRSFVSALGRPIFATAITALAIGVNALGNYALVFGNLGAPALGLEGS
AIATVVTSIFIVLAYVVAIQQDRRLRRYAIWGRFWRPEWDRLRDLVVLGTPVFFTTIAEAGLFGGAALLMGLIGESELAG
HTIALQIAAFAFQVPFGVSQAATIRVGYFYGARDHEAIKRAGAVALLIAVAFMAFTASVMLLMPEAILGLYIDTSKSVNA
AMMAFALQYIVIAALFQLVDGLQVVAAGALRGLQDTRVPMVMAIFSYWVPGFGTSYYLGFYTPLKGTGVWIGFAVGLTFA
TVLLTGRWLMRERLGLAHRPARKPGAKPPAA

Sequences:

>Translated_511_residues
MYAIGVARQSQSVHNIGVRTGLICHMARLISIRAGCMHEMAPEVDTADSWRAEIAATFRLAWPLALANLLQMLIWAIDVF
FVARLGEFELAASSLAVSLFSILGWATITLVSMVSALIAAELGRSRYAIAEVRRSVRMGVWLCVICGVLVMLILSQAEAI
LLASGQRAELAARAYDYMGIVLWAMIPLLVASVLRSFVSALGRPIFATAITALAIGVNALGNYALVFGNLGAPALGLEGS
AIATVVTSIFIVLAYVVAIQQDRRLRRYAIWGRFWRPEWDRLRDLVVLGTPVFFTTIAEAGLFGGAALLMGLIGESELAG
HTIALQIAAFAFQVPFGVSQAATIRVGYFYGARDHEAIKRAGAVALLIAVAFMAFTASVMLLMPEAILGLYIDTSKSVNA
AMMAFALQYIVIAALFQLVDGLQVVAAGALRGLQDTRVPMVMAIFSYWVPGFGTSYYLGFYTPLKGTGVWIGFAVGLTFA
TVLLTGRWLMRERLGLAHRPARKPGAKPPAA
>Mature_511_residues
MYAIGVARQSQSVHNIGVRTGLICHMARLISIRAGCMHEMAPEVDTADSWRAEIAATFRLAWPLALANLLQMLIWAIDVF
FVARLGEFELAASSLAVSLFSILGWATITLVSMVSALIAAELGRSRYAIAEVRRSVRMGVWLCVICGVLVMLILSQAEAI
LLASGQRAELAARAYDYMGIVLWAMIPLLVASVLRSFVSALGRPIFATAITALAIGVNALGNYALVFGNLGAPALGLEGS
AIATVVTSIFIVLAYVVAIQQDRRLRRYAIWGRFWRPEWDRLRDLVVLGTPVFFTTIAEAGLFGGAALLMGLIGESELAG
HTIALQIAAFAFQVPFGVSQAATIRVGYFYGARDHEAIKRAGAVALLIAVAFMAFTASVMLLMPEAILGLYIDTSKSVNA
AMMAFALQYIVIAALFQLVDGLQVVAAGALRGLQDTRVPMVMAIFSYWVPGFGTSYYLGFYTPLKGTGVWIGFAVGLTFA
TVLLTGRWLMRERLGLAHRPARKPGAKPPAA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=446, Percent_Identity=26.9058295964126, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI153792564, Length=436, Percent_Identity=22.4770642201835, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI38261960, Length=470, Percent_Identity=21.2765957446809, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI48994890, Length=443, Percent_Identity=28.6681715575621, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321821, Length=411, Percent_Identity=23.6009732360097, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 54986; Mature: 54986

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYAIGVARQSQSVHNIGVRTGLICHMARLISIRAGCMHEMAPEVDTADSWRAEIAATFRL
CCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
AWPLALANLLQMLIWAIDVFFVARLGEFELAASSLAVSLFSILGWATITLVSMVSALIAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELGRSRYAIAEVRRSVRMGVWLCVICGVLVMLILSQAEAILLASGQRAELAARAYDYMGI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHH
VLWAMIPLLVASVLRSFVSALGRPIFATAITALAIGVNALGNYALVFGNLGAPALGLEGS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCH
AIATVVTSIFIVLAYVVAIQQDRRLRRYAIWGRFWRPEWDRLRDLVVLGTPVFFTTIAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHH
GLFGGAALLMGLIGESELAGHTIALQIAAFAFQVPFGVSQAATIRVGYFYGARDHEAIKR
HCCHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHH
AGAVALLIAVAFMAFTASVMLLMPEAILGLYIDTSKSVNAAMMAFALQYIVIAALFQLVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLQVVAAGALRGLQDTRVPMVMAIFSYWVPGFGTSYYLGFYTPLKGTGVWIGFAVGLTFA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
TVLLTGRWLMRERLGLAHRPARKPGAKPPAA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYAIGVARQSQSVHNIGVRTGLICHMARLISIRAGCMHEMAPEVDTADSWRAEIAATFRL
CCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
AWPLALANLLQMLIWAIDVFFVARLGEFELAASSLAVSLFSILGWATITLVSMVSALIAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELGRSRYAIAEVRRSVRMGVWLCVICGVLVMLILSQAEAILLASGQRAELAARAYDYMGI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHH
VLWAMIPLLVASVLRSFVSALGRPIFATAITALAIGVNALGNYALVFGNLGAPALGLEGS
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCH
AIATVVTSIFIVLAYVVAIQQDRRLRRYAIWGRFWRPEWDRLRDLVVLGTPVFFTTIAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHH
GLFGGAALLMGLIGESELAGHTIALQIAAFAFQVPFGVSQAATIRVGYFYGARDHEAIKR
HCCHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHH
AGAVALLIAVAFMAFTASVMLLMPEAILGLYIDTSKSVNAAMMAFALQYIVIAALFQLVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLQVVAAGALRGLQDTRVPMVMAIFSYWVPGFGTSYYLGFYTPLKGTGVWIGFAVGLTFA
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
TVLLTGRWLMRERLGLAHRPARKPGAKPPAA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]