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The map label for this gene is copA [H]

Identifier: 85375703

GI number: 85375703

Start: 2893463

End: 2895199

Strand: Reverse

Name: copA [H]

Synonym: ELI_14380

Alternate gene names: 85375703

Gene position: 2895199-2893463 (Counterclockwise)

Preceding gene: 85375705

Following gene: 85375702

Centisome position: 94.85

GC content: 63.21

Gene sequence:

>1737_bases
ATGTCCCGGATTATCAAGCCAGCATCGCCGATGCTTTCCAGGCGCGGCCTGATTGCCAGCACCGCCGCGCTCGCAGCGGC
ATCCGCACTGCCCTCGCCCGCTTGGGCCAAGGGCGGCTCGATGCGCGAAGCGAAGAAAGGTTTCGGCACCTATTCGGGCG
AAAGCATCGACCTTGCCATCGGGCACGCGCGCTATTCGACCGGGGGGCGCAGCGGCCATGCGATCGCCGTCGACGGGATG
ATCCCCGGTCCGCTGATCAAGCTGCGCGAAGGCCAGAATGTCCGGCTCAACGTCACCAATCATCTGGACGAAGACAGTTC
GATCCACTGGCATGGGCTATTGCTGCCTTTCCAGTTCGACGGCGTGCCCGGGGTCAGTTTCCCGGGCATCAAGCCGGGCG
AAACCTTCACCTATGAATTCCCGGTCCGGCAGGCGGGCACATATTGGTGGCACAGCCATTCCGGCCTGCAGGAGCAGATG
GGGCATTACGGCCCGCTGGTAATCGAAGCCGCCGACGGTTCGGATGCGCGTTTCGACCGTGACTATATCGTGCTGCTGAG
CGAGTTCTCGCCGATACATCCGCACGAAATCATGCGTAAGCTCAAGGTGGGCGAGCACTACTTCAACAACCAGATGATGA
CCGCAACCGACGGCGCAATGTCCGGCGAGGAGCGGCGCATGTGGGGCGCGATGCGAATGAACCCGCGCGACATCGCCGAC
GTGTCCGCACCCGCCTACACCTATCTCGTCAACGGGCACGGCCCGGCGGACGATCTCGAATATCTCTTCAATCCCGGCGA
AAAGGTGCGCCTGCGCATCATCAACGGCTCGGCCATGACCTTCTTCAACATGCGCATCCCCGGCGTGCCGATGACGGTGA
TCCAGGCCGACGGGCAGGATGTCGAGGACGTCGAAGTCGACGAGTTGCAGATCGGGGTGGCCGAAACCTACGATGTCGTC
GTCACGCCGCCGGCGGGCAGCCATGCACTGGTCGCGGAATCGATGGACCGCAGCGGCATGGGCATCGCCAGCCTGACCTC
GCAGGCCGGACAGCGCGCGGTCGCGCCGCCACTGCGTGAAATACCGACGCTGACCATGGTCGATATGGGCATGGGCGCGA
TGGATCATGGCTCCGGCGATGGCGGTATGGATCACGGCTCGGGCGGGATGGATCATCCCATGCGCGACAAAAGCCTGGTG
CCGCCCGACGTGAAGGTCGGCCCCGGCGTCGACATGATCGCGCCGATGCCGATGGACCGAATGGATTTCCCCGGCCTCGG
CCTCGACACCGTCGATCACCGCGTGCTGCGCTACACCAATCTGAAGTCGAAAAAGGCGAACCCGCATCGCATGCCCGAGC
GGACGATGCAGATTCACCTGACCGGCAATATGGAACGCTACATGTGGTCCTTCGACGGCAAGAAATTCACCGCCGTCACC
GACGATCCGATCCGCTTCGCCTATGACGAGCGCGTGCGGGTGAAGCTCGTCAACGACACGATGATGGCGCACCCGATCCA
CCTGCACGGCCATTTCTTCGAACTGGTCAATGGCGGCGAGCACAACATGCACCAGCCGCGCAAGCACACGGTGATCGTGC
AGCCAGGCAGTAGCGCTACCTTCGACCTAACCGCCGACGAACCCGGCGACTGGGCTTTTCACTGCCACCTGCTCTACCAC
ATGCATGCCGGGATGATGCAGGTGGTGACGGTGCGGCCGTTCCCCGAGGTCACATGA

Upstream 100 bases:

>100_bases
AGCCGGTTGACGGTCTTGCGCTCGGTTGCAGATTCAATTTCGTGCGACATGGCCCAAAAGACCCCTTTCAAATACCCTAG
GGGGGTATATATAGGCGCGC

Downstream 100 bases:

>100_bases
TGAGGCCGCTGCTCGCCCTGTCCCTTGCCGCGCTCGCGGCTCCGCTCGCTGCGCAGGACCATGATCATGGCGCTGGTGCC
AAGAAGCAGGAGAACCCCAG

Product: copper-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MSRIIKPASPMLSRRGLIASTAALAAASALPSPAWAKGGSMREAKKGFGTYSGESIDLAIGHARYSTGGRSGHAIAVDGM
IPGPLIKLREGQNVRLNVTNHLDEDSSIHWHGLLLPFQFDGVPGVSFPGIKPGETFTYEFPVRQAGTYWWHSHSGLQEQM
GHYGPLVIEAADGSDARFDRDYIVLLSEFSPIHPHEIMRKLKVGEHYFNNQMMTATDGAMSGEERRMWGAMRMNPRDIAD
VSAPAYTYLVNGHGPADDLEYLFNPGEKVRLRIINGSAMTFFNMRIPGVPMTVIQADGQDVEDVEVDELQIGVAETYDVV
VTPPAGSHALVAESMDRSGMGIASLTSQAGQRAVAPPLREIPTLTMVDMGMGAMDHGSGDGGMDHGSGGMDHPMRDKSLV
PPDVKVGPGVDMIAPMPMDRMDFPGLGLDTVDHRVLRYTNLKSKKANPHRMPERTMQIHLTGNMERYMWSFDGKKFTAVT
DDPIRFAYDERVRVKLVNDTMMAHPIHLHGHFFELVNGGEHNMHQPRKHTVIVQPGSSATFDLTADEPGDWAFHCHLLYH
MHAGMMQVVTVRPFPEVT

Sequences:

>Translated_578_residues
MSRIIKPASPMLSRRGLIASTAALAAASALPSPAWAKGGSMREAKKGFGTYSGESIDLAIGHARYSTGGRSGHAIAVDGM
IPGPLIKLREGQNVRLNVTNHLDEDSSIHWHGLLLPFQFDGVPGVSFPGIKPGETFTYEFPVRQAGTYWWHSHSGLQEQM
GHYGPLVIEAADGSDARFDRDYIVLLSEFSPIHPHEIMRKLKVGEHYFNNQMMTATDGAMSGEERRMWGAMRMNPRDIAD
VSAPAYTYLVNGHGPADDLEYLFNPGEKVRLRIINGSAMTFFNMRIPGVPMTVIQADGQDVEDVEVDELQIGVAETYDVV
VTPPAGSHALVAESMDRSGMGIASLTSQAGQRAVAPPLREIPTLTMVDMGMGAMDHGSGDGGMDHGSGGMDHPMRDKSLV
PPDVKVGPGVDMIAPMPMDRMDFPGLGLDTVDHRVLRYTNLKSKKANPHRMPERTMQIHLTGNMERYMWSFDGKKFTAVT
DDPIRFAYDERVRVKLVNDTMMAHPIHLHGHFFELVNGGEHNMHQPRKHTVIVQPGSSATFDLTADEPGDWAFHCHLLYH
MHAGMMQVVTVRPFPEVT
>Mature_577_residues
SRIIKPASPMLSRRGLIASTAALAAASALPSPAWAKGGSMREAKKGFGTYSGESIDLAIGHARYSTGGRSGHAIAVDGMI
PGPLIKLREGQNVRLNVTNHLDEDSSIHWHGLLLPFQFDGVPGVSFPGIKPGETFTYEFPVRQAGTYWWHSHSGLQEQMG
HYGPLVIEAADGSDARFDRDYIVLLSEFSPIHPHEIMRKLKVGEHYFNNQMMTATDGAMSGEERRMWGAMRMNPRDIADV
SAPAYTYLVNGHGPADDLEYLFNPGEKVRLRIINGSAMTFFNMRIPGVPMTVIQADGQDVEDVEVDELQIGVAETYDVVV
TPPAGSHALVAESMDRSGMGIASLTSQAGQRAVAPPLREIPTLTMVDMGMGAMDHGSGDGGMDHGSGGMDHPMRDKSLVP
PDVKVGPGVDMIAPMPMDRMDFPGLGLDTVDHRVLRYTNLKSKKANPHRMPERTMQIHLTGNMERYMWSFDGKKFTAVTD
DPIRFAYDERVRVKLVNDTMMAHPIHLHGHFFELVNGGEHNMHQPRKHTVIVQPGSSATFDLTADEPGDWAFHCHLLYHM
HAGMMQVVTVRPFPEVT

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=345, Percent_Identity=26.9565217391304, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17539950, Length=609, Percent_Identity=22.1674876847291, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321067, Length=548, Percent_Identity=22.0802919708029, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320714, Length=269, Percent_Identity=24.907063197026, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323703, Length=316, Percent_Identity=26.2658227848101, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24585842, Length=559, Percent_Identity=25.0447227191413, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281360167, Length=559, Percent_Identity=25.0447227191413, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI221330000, Length=558, Percent_Identity=25.2688172043011, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI221329998, Length=551, Percent_Identity=25.2268602540835, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI18859919, Length=543, Percent_Identity=23.9410681399632, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28574104, Length=297, Percent_Identity=28.2828282828283, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24650186, Length=268, Percent_Identity=25.7462686567164, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 63577; Mature: 63446

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIIKPASPMLSRRGLIASTAALAAASALPSPAWAKGGSMREAKKGFGTYSGESIDLAI
CCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEE
GHARYSTGGRSGHAIAVDGMIPGPLIKLREGQNVRLNVTNHLDEDSSIHWHGLLLPFQFD
ECEEECCCCCCCCEEEECCCCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEEEEEEEEC
GVPGVSFPGIKPGETFTYEFPVRQAGTYWWHSHSGLQEQMGHYGPLVIEAADGSDARFDR
CCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHCCCCCEEEEECCCCCCCCCC
DYIVLLSEFSPIHPHEIMRKLKVGEHYFNNQMMTATDGAMSGEERRMWGAMRMNPRDIAD
CEEEEEECCCCCCHHHHHHHHHHCHHHHCCEEEEECCCCCCCCHHHHHHEECCCCHHHHH
VSAPAYTYLVNGHGPADDLEYLFNPGEKVRLRIINGSAMTFFNMRIPGVPMTVIQADGQD
CCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEEECCEEEEEEEECCCCCEEEEECCCCC
VEDVEVDELQIGVAETYDVVVTPPAGSHALVAESMDRSGMGIASLTSQAGQRAVAPPLRE
CCCCCCCCEEEEEECEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCCHHH
IPTLTMVDMGMGAMDHGSGDGGMDHGSGGMDHPMRDKSLVPPDVKVGPGVDMIAPMPMDR
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEECCCCCCC
MDFPGLGLDTVDHRVLRYTNLKSKKANPHRMPERTMQIHLTGNMERYMWSFDGKKFTAVT
CCCCCCCCCHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCCEEEEEC
DDPIRFAYDERVRVKLVNDTMMAHPIHLHGHFFELVNGGEHNMHQPRKHTVIVQPGSSAT
CCCEEEEECCEEEEEEECCCEEECEEEECCEEEEEECCCCCCCCCCCCCEEEEECCCCCE
FDLTADEPGDWAFHCHLLYHMHAGMMQVVTVRPFPEVT
EEEECCCCCCEEEEEEEEEHHHCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SRIIKPASPMLSRRGLIASTAALAAASALPSPAWAKGGSMREAKKGFGTYSGESIDLAI
CCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEEE
GHARYSTGGRSGHAIAVDGMIPGPLIKLREGQNVRLNVTNHLDEDSSIHWHGLLLPFQFD
ECEEECCCCCCCCEEEECCCCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEEEEEEEEC
GVPGVSFPGIKPGETFTYEFPVRQAGTYWWHSHSGLQEQMGHYGPLVIEAADGSDARFDR
CCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCHHHHHCCCCCEEEEECCCCCCCCCC
DYIVLLSEFSPIHPHEIMRKLKVGEHYFNNQMMTATDGAMSGEERRMWGAMRMNPRDIAD
CEEEEEECCCCCCHHHHHHHHHHCHHHHCCEEEEECCCCCCCCHHHHHHEECCCCHHHHH
VSAPAYTYLVNGHGPADDLEYLFNPGEKVRLRIINGSAMTFFNMRIPGVPMTVIQADGQD
CCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEEECCEEEEEEEECCCCCEEEEECCCCC
VEDVEVDELQIGVAETYDVVVTPPAGSHALVAESMDRSGMGIASLTSQAGQRAVAPPLRE
CCCCCCCCEEEEEECEEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHCCCCCCCCCHHH
IPTLTMVDMGMGAMDHGSGDGGMDHGSGGMDHPMRDKSLVPPDVKVGPGVDMIAPMPMDR
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCEECCCCCCC
MDFPGLGLDTVDHRVLRYTNLKSKKANPHRMPERTMQIHLTGNMERYMWSFDGKKFTAVT
CCCCCCCCCHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCCEEEEEC
DDPIRFAYDERVRVKLVNDTMMAHPIHLHGHFFELVNGGEHNMHQPRKHTVIVQPGSSAT
CCCEEEEECCEEEEEEECCCEEECEEEECCEEEEEECCCCCCCCCCCCCEEEEECCCCCE
FDLTADEPGDWAFHCHLLYHMHAGMMQVVTVRPFPEVT
EEEECCCCCCEEEEEEEEEHHHCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]