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The map label for this gene is smeA [H]

Identifier: 85375695

GI number: 85375695

Start: 2882974

End: 2883990

Strand: Reverse

Name: smeA [H]

Synonym: ELI_14340

Alternate gene names: 85375695

Gene position: 2883990-2882974 (Counterclockwise)

Preceding gene: 85375696

Following gene: 85375693

Centisome position: 94.48

GC content: 66.86

Gene sequence:

>1017_bases
ATGAAGCATCCATTTTTCCGCACACTTTCGTCCGTCGCAGCCGGTGCGCTCGCTTTCCTTGCCAGCCCTGCTGCGGCCGA
TAGTCCGGATCTGGAAGCTGCCTTCGACCGTACCTTCGGAACGGAAGTCCGCGCGCCGCAGAGCTTCGTCGCGCGTTACG
ATACGCCGTTCGAACAGCGGGTCGCGCAACTCGCCGACGGCACCGACGGCCGCATCGGCGTCTATGCGCTGGACCTGTCG
ACGGGGCGCGAGATCGGTGTTCTGGCCGACCAGCCGTTCCCGATGGCCAGCACCAGCAAGGTCGCCATTGCCGCGGTCTA
TCTGGCGGGCGTCGATGCCGGCAAATGGAGCCTGAGCAGCGAATGGCGACTCCCCCGCCCGGGCGGGAAATACGTGCCCG
CCAAGACGCTGCTCGACCTGATGGTCAGCAAGAGCTGCAACGATTGCACCGATGCGCTGCTGAGCGCGGTGGGCGGGCCG
GAAGCGGTCAACCGCTGGATGCGCCAGGCGGGTATCTCGGGCTTCCAGCTGAACCGCACGATCCGCACGCTGATCAACGA
AGACGGGCGCGTCGATCCGGCCTCGCAGATCGACCACCGTGACGCCGCCACGCCGCGCGCCATGGGCCAGTTCCTCGCCG
GCATCCACCAGGGCCGCTGGCTCAGCGCTTCTTCGCGCCGGGTGCTGCTCGATGCCATGCTCGGCACGACGACGGGCGAC
CGGCGCATGCGCTCGGCCCTGCCGATGAGCGCCAATCTGGCCCACAAAACCGGCACGCTCAGCCGTACGGCAAGCGATAT
CGGCCTGTTCCGCACTTCGGATGGCCGGATCATCGCCGCAGCAATCTACGTCACCGGGCAGAGCAGCTCGATGTCGGCCG
AGAACAGCAATCGCGGCCTCAAGCTGGCAGCGCGCCGTAACCGCGATGCGCGGATCGCATCGATCGCCAACGCGCTCTAT
TACGGTTTCGACGAAGGCCGCCGCGCCCATGCGGTAGCCGATTACGGCGGCGAGTAA

Upstream 100 bases:

>100_bases
CTGTCGTGCAAAGCGCCTGATTTTGCGCGCAACAGTTGATCGACCCCTGCCGGTTTCGCATTAATCTGCTGCAAACCATG
CATATGATAGGGGTCGCTGC

Downstream 100 bases:

>100_bases
GCTGCGGCAGATACCGACCGGGCGGGTATCGGACGGGCCGGTATCGAACGGGCATAGAAAAAGGGCGGCGCCGCAAGGCA
CCGCCCTTTTCTTTTTCGGC

Product: Beta-lactamase class A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKHPFFRTLSSVAAGALAFLASPAAADSPDLEAAFDRTFGTEVRAPQSFVARYDTPFEQRVAQLADGTDGRIGVYALDLS
TGREIGVLADQPFPMASTSKVAIAAVYLAGVDAGKWSLSSEWRLPRPGGKYVPAKTLLDLMVSKSCNDCTDALLSAVGGP
EAVNRWMRQAGISGFQLNRTIRTLINEDGRVDPASQIDHRDAATPRAMGQFLAGIHQGRWLSASSRRVLLDAMLGTTTGD
RRMRSALPMSANLAHKTGTLSRTASDIGLFRTSDGRIIAAAIYVTGQSSSMSAENSNRGLKLAARRNRDARIASIANALY
YGFDEGRRAHAVADYGGE

Sequences:

>Translated_338_residues
MKHPFFRTLSSVAAGALAFLASPAAADSPDLEAAFDRTFGTEVRAPQSFVARYDTPFEQRVAQLADGTDGRIGVYALDLS
TGREIGVLADQPFPMASTSKVAIAAVYLAGVDAGKWSLSSEWRLPRPGGKYVPAKTLLDLMVSKSCNDCTDALLSAVGGP
EAVNRWMRQAGISGFQLNRTIRTLINEDGRVDPASQIDHRDAATPRAMGQFLAGIHQGRWLSASSRRVLLDAMLGTTTGD
RRMRSALPMSANLAHKTGTLSRTASDIGLFRTSDGRIIAAAIYVTGQSSSMSAENSNRGLKLAARRNRDARIASIANALY
YGFDEGRRAHAVADYGGE
>Mature_338_residues
MKHPFFRTLSSVAAGALAFLASPAAADSPDLEAAFDRTFGTEVRAPQSFVARYDTPFEQRVAQLADGTDGRIGVYALDLS
TGREIGVLADQPFPMASTSKVAIAAVYLAGVDAGKWSLSSEWRLPRPGGKYVPAKTLLDLMVSKSCNDCTDALLSAVGGP
EAVNRWMRQAGISGFQLNRTIRTLINEDGRVDPASQIDHRDAATPRAMGQFLAGIHQGRWLSASSRRVLLDAMLGTTTGD
RRMRSALPMSANLAHKTGTLSRTASDIGLFRTSDGRIIAAAIYVTGQSSSMSAENSNRGLKLAARRNRDARIASIANALY
YGFDEGRRAHAVADYGGE

Specific function: Can hydrolyze carbapenem compounds [H]

COG id: COG2367

COG function: function code V; Beta-lactamase class A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-A beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR000871 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 36172; Mature: 36172

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHPFFRTLSSVAAGALAFLASPAAADSPDLEAAFDRTFGTEVRAPQSFVARYDTPFEQR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCHHHH
VAQLADGTDGRIGVYALDLSTGREIGVLADQPFPMASTSKVAIAAVYLAGVDAGKWSLSS
HHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHEEEHHHHCCCCCCCCCCC
EWRLPRPGGKYVPAKTLLDLMVSKSCNDCTDALLSAVGGPEAVNRWMRQAGISGFQLNRT
CCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEHHHH
IRTLINEDGRVDPASQIDHRDAATPRAMGQFLAGIHQGRWLSASSRRVLLDAMLGTTTGD
HHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCCCCH
RRMRSALPMSANLAHKTGTLSRTASDIGLFRTSDGRIIAAAIYVTGQSSSMSAENSNRGL
HHHHHHCCCCCCCCCCCCCCHHHHHHCCEEECCCCCEEEEEEEEECCCCCCCCCCCCCCE
KLAARRNRDARIASIANALYYGFDEGRRAHAVADYGGE
EEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MKHPFFRTLSSVAAGALAFLASPAAADSPDLEAAFDRTFGTEVRAPQSFVARYDTPFEQR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCHHHH
VAQLADGTDGRIGVYALDLSTGREIGVLADQPFPMASTSKVAIAAVYLAGVDAGKWSLSS
HHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCCCHHHEEEHHHHCCCCCCCCCCC
EWRLPRPGGKYVPAKTLLDLMVSKSCNDCTDALLSAVGGPEAVNRWMRQAGISGFQLNRT
CCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEHHHH
IRTLINEDGRVDPASQIDHRDAATPRAMGQFLAGIHQGRWLSASSRRVLLDAMLGTTTGD
HHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCEECCCCCHHHHHHHHCCCCCH
RRMRSALPMSANLAHKTGTLSRTASDIGLFRTSDGRIIAAAIYVTGQSSSMSAENSNRGL
HHHHHHCCCCCCCCCCCCCCHHHHHHCCEEECCCCCEEEEEEEEECCCCCCCCCCCCCCE
KLAARRNRDARIASIANALYYGFDEGRRAHAVADYGGE
EEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8092824; 7793864 [H]