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The map label for this gene is panC

Identifier: 85375567

GI number: 85375567

Start: 2762536

End: 2763396

Strand: Reverse

Name: panC

Synonym: ELI_13700

Alternate gene names: 85375567

Gene position: 2763396-2762536 (Counterclockwise)

Preceding gene: 85375573

Following gene: 85375566

Centisome position: 90.53

GC content: 67.94

Gene sequence:

>861_bases
GTGCAAACGATCGACCGGCTCGACATGTTGAGAACATCCGTCGCCGCGCTCCGCCAGGGCGGGGGCACGGTGGCGCTGGT
GCCGACCATGGGCGCTCTGCACGAAGGCCATCTGACGCTGGTGCGCGAAGCGGCGGGCCGGGCCGATCACGTCGTCGCGT
CGATCTTCGTCAACCCGACCCAGTTCGGCCCCAACGAGGATCTCGATGCCTATCCCCGCCAACTGGCCGAGGATTGCGCG
ATGCTGGAAGCCGAAGGAGTGGCCTTGGTCTGGGCACCGACGGTCGAACAAATGTATCCCGAGGGCTTTGCCAGCAGCAT
TTCGGTTTCCGGCGTCAGCGAAGGCCTGTGCGGCGCGGATCGGCCGGGGCATTTCGATGGCGTCGCCACCGTGGTGTGCA
AGCTGTTTCACCAGGTGCTGCCCGACATGGCCTTCTTCGGGGAGAAGGACTGGCAGCAGCTCGCGGTGATCCGCGTCATG
GCGCGCGACCTCGACCTCACCCGGCCGCACGTTGCGGCGATCCGCGGTGTGGCCACCGTGCGCGAGGAAGATGGCCTGGC
GATGTCGAGCCGCAACCGCTATCTCTCGCCGGAGCATCGCCAAGCCGCCGCGATCCTGCCGCGGGCCATGAAGGAAGCGA
TCGGAGCGATCGAAAACGGCGCGGCCGTCGCCCCGACGCTCGCTTCGCTCGAAGCCGCGCTGCTGCAGGCCGGCTTCGAC
AGCGTCGACTACGCCACGCTTGCCGATGCTGCGAACCTGCAGCCGCTCGAGCGGCTTGCCATGCGCCCCGCACGCCTGCT
GGTGGCCGCCCGGATCGGGGGCACGCGGCTGATCGACAATATGGCCGTAGGCAAGGTCTGA

Upstream 100 bases:

>100_bases
CGACGCGGTGCGGGGCGGTTGCGGTCACGAATGGGGCCTTTCTCGGCGGTTGCGGGGGCGCTAGGGCGGTGCCGGGAAAC
ATACGGGAGGCCACTCAGCC

Downstream 100 bases:

>100_bases
AATTCCGACCAGGGCTAACACCGCTCAATCGCTTTACTGTGCCCGAAAGAGGCAGGCGCGCAGCTATACTTGCCTAGCAC
CGACGAATTGGCCATTCTGG

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MQTIDRLDMLRTSVAALRQGGGTVALVPTMGALHEGHLTLVREAAGRADHVVASIFVNPTQFGPNEDLDAYPRQLAEDCA
MLEAEGVALVWAPTVEQMYPEGFASSISVSGVSEGLCGADRPGHFDGVATVVCKLFHQVLPDMAFFGEKDWQQLAVIRVM
ARDLDLTRPHVAAIRGVATVREEDGLAMSSRNRYLSPEHRQAAAILPRAMKEAIGAIENGAAVAPTLASLEAALLQAGFD
SVDYATLADAANLQPLERLAMRPARLLVAARIGGTRLIDNMAVGKV

Sequences:

>Translated_286_residues
MQTIDRLDMLRTSVAALRQGGGTVALVPTMGALHEGHLTLVREAAGRADHVVASIFVNPTQFGPNEDLDAYPRQLAEDCA
MLEAEGVALVWAPTVEQMYPEGFASSISVSGVSEGLCGADRPGHFDGVATVVCKLFHQVLPDMAFFGEKDWQQLAVIRVM
ARDLDLTRPHVAAIRGVATVREEDGLAMSSRNRYLSPEHRQAAAILPRAMKEAIGAIENGAAVAPTLASLEAALLQAGFD
SVDYATLADAANLQPLERLAMRPARLLVAARIGGTRLIDNMAVGKV
>Mature_286_residues
MQTIDRLDMLRTSVAALRQGGGTVALVPTMGALHEGHLTLVREAAGRADHVVASIFVNPTQFGPNEDLDAYPRQLAEDCA
MLEAEGVALVWAPTVEQMYPEGFASSISVSGVSEGLCGADRPGHFDGVATVVCKLFHQVLPDMAFFGEKDWQQLAVIRVM
ARDLDLTRPHVAAIRGVATVREEDGLAMSSRNRYLSPEHRQAAAILPRAMKEAIGAIENGAAVAPTLASLEAALLQAGFD
SVDYATLADAANLQPLERLAMRPARLLVAARIGGTRLIDNMAVGKV

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=285, Percent_Identity=45.2631578947368, Blast_Score=217, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6322046, Length=310, Percent_Identity=35.1612903225806, Blast_Score=182, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_ERYLH (Q2N659)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_459629.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q2N659
- SMR:   Q2N659
- STRING:   Q2N659
- GeneID:   3870692
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_13700
- NMPDR:   fig|314225.3.peg.278
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   EDFGSYP
- PhylomeDB:   Q2N659
- ProtClustDB:   PRK00380
- BioCyc:   ELIT314225:ELI_13700-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30489; Mature: 30489

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 180-180

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIDRLDMLRTSVAALRQGGGTVALVPTMGALHEGHLTLVREAAGRADHVVASIFVNPT
CCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCHHHHHHHHCCCHHHEEEEEEECCC
QFGPNEDLDAYPRQLAEDCAMLEAEGVALVWAPTVEQMYPEGFASSISVSGVSEGLCGAD
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCHHCCEECCCCCCCCCCCC
RPGHFDGVATVVCKLFHQVLPDMAFFGEKDWQQLAVIRVMARDLDLTRPHVAAIRGVATV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
REEDGLAMSSRNRYLSPEHRQAAAILPRAMKEAIGAIENGAAVAPTLASLEAALLQAGFD
HHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
SVDYATLADAANLQPLERLAMRPARLLVAARIGGTRLIDNMAVGKV
CCCHHHHHCCCCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure
MQTIDRLDMLRTSVAALRQGGGTVALVPTMGALHEGHLTLVREAAGRADHVVASIFVNPT
CCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCHHHHHHHHCCCHHHEEEEEEECCC
QFGPNEDLDAYPRQLAEDCAMLEAEGVALVWAPTVEQMYPEGFASSISVSGVSEGLCGAD
CCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCCHHCCEECCCCCCCCCCCC
RPGHFDGVATVVCKLFHQVLPDMAFFGEKDWQQLAVIRVMARDLDLTRPHVAAIRGVATV
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
REEDGLAMSSRNRYLSPEHRQAAAILPRAMKEAIGAIENGAAVAPTLASLEAALLQAGFD
HHCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
SVDYATLADAANLQPLERLAMRPARLLVAARIGGTRLIDNMAVGKV
CCCHHHHHCCCCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA