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The map label for this gene is wecB [H]

Identifier: 85375480

GI number: 85375480

Start: 2670302

End: 2671435

Strand: Direct

Name: wecB [H]

Synonym: ELI_13265

Alternate gene names: 85375480

Gene position: 2670302-2671435 (Clockwise)

Preceding gene: 85375479

Following gene: 85375482

Centisome position: 87.48

GC content: 64.55

Gene sequence:

>1134_bases
ATGGCGCTGATCATGAGCGGCACGCGCAAAATCGTCACTGTCTTCGGCACGCGTCCCGAAGCGATCAAGTTGTTTCCGCT
GGTTCACGCGCTGGACGCCGACCTGCGGTTCGACAGCCGCGTGCTCGTTTCCGGACAGCATCGCGGCATGCTCGACCAGG
TGCTGGAGATCGCAGGCATCGCGCCGCATCACGACCTCGATGTCATGCAGCCCAACCAGTCGCTCGACGCGCTGACTGCC
CGTCTACTGACCGGGATCGGCGAAGTGTTGGATCGCGAACGGCCCGACTGGGTCGTGGTGCAGGGCGATACCGCGACCGC
CATGTGCGGCGCGCTTGCGGCCTATTTTCGCCAGATCGATGTCTGCCATATCGAAGCGGGTCTCCGCAGCGGCGACATCT
ATCATCCCTTCCCCGAGGAGGTGAACCGCAAGGTCATCGGCACGCTGGCCAAGCTGCACGCGGCGCCGACTGAAACCTCG
GCGGCGTCGCTGCGCGCGGAGAATGTCGTTCCGGACGCGATCCATGTCACCGGCAACACGGTGATCGACGCGCTACACTG
GATCACCACTAAAGTGGCGAAAACGCCGGCGCTTGTGGCCGATCTCGCCGAGGTCGAAGCGCGTTTCGCCGGCAAGCGGA
TCATCGGCGTGACCTCACACCGCCGGGAGAATTTCGGCGATGGCATGCGGGGAATCGCCAATGCGATCAAGCGCCTGGCC
GCGCGCGAAGACGTAGCGCTTATCTTTCCGGTGCATCTCAATCCCAATGTCCGCGCGATCATGAACGAGGAACTGGCGGG
CTTCGACAATATCGCTTTGCTCGAGCCGCTCGACTACCCGCATTTTGCGCGGCTGCTCGACATCTGCACGCTGATGCTGA
CCGACAGTGGCGGCGTGCAGGAAGAGGCGCCAGCGCTGGGCAAGCCGGTCCTGGTCATGCGCGAAACGACGGAACGCCCC
GAAGGCGTCGAAGCGGGCACCGCGCGGCTGGTTGGCACCGACGAAGATGCTATCGTTGCCGAAGTCACGCGCTTGCTCGA
CGACGATTCCGCCTACGCCGCCATGGCGCGGGCGCACAATCCCTTCGGCGACGGCAAATCCGCAGCGCGCATCGCGGACC
TGCTGGCGCGCTGA

Upstream 100 bases:

>100_bases
CAAGCCGCCGACGATGGCAGCGAAGACGCTTCCGGTCTCGATCGCCCGCCGGAGCAATAATTCGCTCCAAGGCTAGGCAG
CGCTTAACTTCTTTTGGTTA

Downstream 100 bases:

>100_bases
GCGGCACTATCAGATCCCGTGATAAGATTTGAACCACTCGACAAACCGCGGAAAACCGACATCGACTGGCGTAGTGGGCG
AATAGCCGTGATCGCGCTCC

Product: udp-n-acetylglucosamine 2-epimerase protein

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MALIMSGTRKIVTVFGTRPEAIKLFPLVHALDADLRFDSRVLVSGQHRGMLDQVLEIAGIAPHHDLDVMQPNQSLDALTA
RLLTGIGEVLDRERPDWVVVQGDTATAMCGALAAYFRQIDVCHIEAGLRSGDIYHPFPEEVNRKVIGTLAKLHAAPTETS
AASLRAENVVPDAIHVTGNTVIDALHWITTKVAKTPALVADLAEVEARFAGKRIIGVTSHRRENFGDGMRGIANAIKRLA
AREDVALIFPVHLNPNVRAIMNEELAGFDNIALLEPLDYPHFARLLDICTLMLTDSGGVQEEAPALGKPVLVMRETTERP
EGVEAGTARLVGTDEDAIVAEVTRLLDDDSAYAAMARAHNPFGDGKSAARIADLLAR

Sequences:

>Translated_377_residues
MALIMSGTRKIVTVFGTRPEAIKLFPLVHALDADLRFDSRVLVSGQHRGMLDQVLEIAGIAPHHDLDVMQPNQSLDALTA
RLLTGIGEVLDRERPDWVVVQGDTATAMCGALAAYFRQIDVCHIEAGLRSGDIYHPFPEEVNRKVIGTLAKLHAAPTETS
AASLRAENVVPDAIHVTGNTVIDALHWITTKVAKTPALVADLAEVEARFAGKRIIGVTSHRRENFGDGMRGIANAIKRLA
AREDVALIFPVHLNPNVRAIMNEELAGFDNIALLEPLDYPHFARLLDICTLMLTDSGGVQEEAPALGKPVLVMRETTERP
EGVEAGTARLVGTDEDAIVAEVTRLLDDDSAYAAMARAHNPFGDGKSAARIADLLAR
>Mature_376_residues
ALIMSGTRKIVTVFGTRPEAIKLFPLVHALDADLRFDSRVLVSGQHRGMLDQVLEIAGIAPHHDLDVMQPNQSLDALTAR
LLTGIGEVLDRERPDWVVVQGDTATAMCGALAAYFRQIDVCHIEAGLRSGDIYHPFPEEVNRKVIGTLAKLHAAPTETSA
ASLRAENVVPDAIHVTGNTVIDALHWITTKVAKTPALVADLAEVEARFAGKRIIGVTSHRRENFGDGMRGIANAIKRLAA
REDVALIFPVHLNPNVRAIMNEELAGFDNIALLEPLDYPHFARLLDICTLMLTDSGGVQEEAPALGKPVLVMRETTERPE
GVEAGTARLVGTDEDAIVAEVTRLLDDDSAYAAMARAHNPFGDGKSAARIADLLAR

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=368, Percent_Identity=52.445652173913, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 40764; Mature: 40633

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIMSGTRKIVTVFGTRPEAIKLFPLVHALDADLRFDSRVLVSGQHRGMLDQVLEIAGI
CEEEECCCCEEEEEECCCCCCEEHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCC
APHHDLDVMQPNQSLDALTARLLTGIGEVLDRERPDWVVVQGDTATAMCGALAAYFRQID
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCC
VCHIEAGLRSGDIYHPFPEEVNRKVIGTLAKLHAAPTETSAASLRAENVVPDAIHVTGNT
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEECCHH
VIDALHWITTKVAKTPALVADLAEVEARFAGKRIIGVTSHRRENFGDGMRGIANAIKRLA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHHHHHH
AREDVALIFPVHLNPNVRAIMNEELAGFDNIALLEPLDYPHFARLLDICTLMLTDSGGVQ
CCCCEEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
EEAPALGKPVLVMRETTERPEGVEAGTARLVGTDEDAIVAEVTRLLDDDSAYAAMARAHN
CCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCC
PFGDGKSAARIADLLAR
CCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ALIMSGTRKIVTVFGTRPEAIKLFPLVHALDADLRFDSRVLVSGQHRGMLDQVLEIAGI
EEEECCCCEEEEEECCCCCCEEHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCC
APHHDLDVMQPNQSLDALTARLLTGIGEVLDRERPDWVVVQGDTATAMCGALAAYFRQID
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCC
VCHIEAGLRSGDIYHPFPEEVNRKVIGTLAKLHAAPTETSAASLRAENVVPDAIHVTGNT
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEECCHH
VIDALHWITTKVAKTPALVADLAEVEARFAGKRIIGVTSHRRENFGDGMRGIANAIKRLA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHHHHHH
AREDVALIFPVHLNPNVRAIMNEELAGFDNIALLEPLDYPHFARLLDICTLMLTDSGGVQ
CCCCEEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
EEAPALGKPVLVMRETTERPEGVEAGTARLVGTDEDAIVAEVTRLLDDDSAYAAMARAHN
CCCCCCCCCEEEEECCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCHHHHHHHHCCC
PFGDGKSAARIADLLAR
CCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]