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The map label for this gene is clpA [C]

Identifier: 85375462

GI number: 85375462

Start: 2652919

End: 2655297

Strand: Reverse

Name: clpA [C]

Synonym: ELI_13175

Alternate gene names: 85375462

Gene position: 2655297-2652919 (Counterclockwise)

Preceding gene: 85375463

Following gene: 85375461

Centisome position: 86.99

GC content: 62.21

Gene sequence:

>2379_bases
ATGCCCAGTTTCGCCCAGAACCTCGAAAAGACGCTCCATGCCGCGATCGATTCAGCGCGCGAGCGTCGCCACGAATACGC
CACGCTCGAGCACCTGCTGCTCGCGCTGGTCGCAGACGAGGATGCGACCGAGGTGATGACCGCTTGCGGGGTCGACCTGG
AAGAGCTGTCCAGTGTCGTGAAGGCCTATCTCGACCAGGAATACCAGTCGCTGCAGACCGAGGAAGGCAGCGAGCCGCAG
CCGACCGCCGGATTCCAGCGCGTGATCCAGCGGGCGATCCTGCACGTCCAGTCCTCGGGCAAGGACACCGTGACAGGCGC
CAACGTGCTGGTCGCTTTGTTCAGCGAGCGCGACAGCTATGCAGTTTATTTCCTGCAACAGCAAGACATGAGCCGGCTCG
ATGCCGTCAGCTTTATCAGCCACGGCATCGGCAAGGGCGGCAAGCAATTGGAGAGCCGCGCGCCGCAGGGGTCCGACGAA
GGCCAGGCCGAAGACAGCAAGTCCGACGGCGGCAACAAGAAGGAAACCGCGCTCGACCAGTTCACGGTCAATCTCAACAA
AAAGGCCGAGGACGGCCGCATCGATCCGCTGATCGGCCGCGGGCCCGAAGTGGACCGGACGGTCCAGATTCTGTGCCGCC
GCAGCAAGAACAACCCGCTCTATGTCGGCGATCCCGGCGTCGGAAAAACCGCCATTGCCGAAGGTCTCGCACGCAAGATC
GTCGAAGGCGACGTTCCCGAAGTCTTGGAAGACGCTGTGATCTACTCGCTCGACATGGGCGCGCTGCTCGCCGGGACGCG
CTATCGCGGCGATTTCGAGGAGCGTTTGAAGCAGGTCGTCTCCGAACTCGAAAAGATGCCCGAAGCGATCCTGTTTATCG
ACGAGATTCACACGGTCATCGGTGCCGGTGCGACCAGTGGTGGGGCGATGGATGCTTCCAACCTGCTCAAGCCCGCGCTT
TCGGGCGGGACCATCCGCTGCATCGGATCGACCACCTACAAGGAATTCCGCAATCACTTCGAAAAGGATCGCGCGCTGCT
GCGCCGGTTCCAGAAGATCGATGTCAACGAACCGACGATCGAAGATACGGTGAAGATCCTCAAGGGCCTCAAGAGCGCCT
TCGAAGATCACCACAAAGTCAAATACACGCTCGATGCGCTCAAGACCGCCGTCGAGCTCTCGGCGCGGTACATCAACGAC
CGCAAGCTGCCCGACAAGGCGATCGATGTGGTCGACGAAGTGGGCGCGATGCAGATGCTGGTGCCGCCGAGCCGCCGCAA
GAAGAAGATCACCGCCAAGGAGATCGAGCAGGTCATCGCGACCATGGCACGCATCCCGCCGAAATCGGTATCGAAGGACG
ACAAGAAGGCGCTGGAAAATCTCGAGCGCGACCTTAAGCATGTCGTCTTCGGGCAGGATCCGGCGGTGAAGAAGCTCTCG
ACCGCGATGAAGCTCAGCCGCGCGGGCCTGCGCGATCCGGACAAGCCGATCGGTTCGTTCCTGTTCTCCGGCCCGACCGG
TGTCGGCAAGACCGAGGTCGCGCGCCAGCTCGCATCGATCATGGGTATCGAGCTCAAGCGCTTCGACATGTCCGAATATA
TGGAGCGCCACAGCGTCTCGCGCCTGATCGGCGCGCCTCCGGGCTACGTCGGTTACGACCAGGGGGGGCTGCTGACCGAT
GCGGTCGACCAGAACCCGCATTGCGTGCTGCTGCTCGACGAGATCGAGAAAGCCCATCCGGACCTGTTCAACATCCTGCT
GCAGGTGATGGATAACGGCCGCCTGACTGACCACCACGGCAAGACGGTCGATTTCCGCAATGTCGTGCTGATCATGACGA
CCAATGCCGGTGCCGCCGACATGGCGCGCCAGGGCATCGGCTTCGGCGACGTGTCGAAGGAAGACGCCAGCGAAGAGGCC
GTGAAGCGCATGTTCACGCCGGAATTCCGCAACCGCTTGGATGCCATCGTGCCGTTCGGCTATCTCGGCAAGGACACCGT
CGCCCGCGTGGTCGACAAGTTCATCCTGCAGCTCGAATTGCAGCTGGCCGAGCAGAATGTCGATATCCAGTTCGACGCGG
ACGCTCGTGCGTGGCTGGCCGACAAGGGCTACGACCGTCTCTATGGCGCGCGCCCGATGGGCCGCCTGTTGCAGGAGAAG
ATCAAGCAGCCGCTGGCCGAGGAACTGCTGTTCGGCAAGCTCGCCGATGGCGGTGAAGTGCAGGTCAGCATCAAGGACGG
CAAGCCGAATTTCGAGCTTACGCCTGCACCGCCCAAAGCTAAGCGCGCTGCGCCCAAGCGCAAACCTGCGGCGAAGAAAG
CTTCGCCGAAGAAGGCCGAACCCGAAGCTGGTGACAGCAAGGACGAAGGCGGAGGCTGA

Upstream 100 bases:

>100_bases
TCCACGCGTCCCCCGACACACCGCGATTTAGGATTGGTTAACCATACCTTCTCATACTCTCCGTTCGGAGAGGCATTTCT
CCCGCAGTGAAAGTGATCTG

Downstream 100 bases:

>100_bases
TTCCCCGCTTGGGGAAAACTCCATCACGACTATTTGACCGAATCGCCTCAATCAGCCTTCATGGCTGATGGTCGTGTGAC
CCCTTTTTTCTGAACCTCCG

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 792; Mature: 791

Protein sequence:

>792_residues
MPSFAQNLEKTLHAAIDSARERRHEYATLEHLLLALVADEDATEVMTACGVDLEELSSVVKAYLDQEYQSLQTEEGSEPQ
PTAGFQRVIQRAILHVQSSGKDTVTGANVLVALFSERDSYAVYFLQQQDMSRLDAVSFISHGIGKGGKQLESRAPQGSDE
GQAEDSKSDGGNKKETALDQFTVNLNKKAEDGRIDPLIGRGPEVDRTVQILCRRSKNNPLYVGDPGVGKTAIAEGLARKI
VEGDVPEVLEDAVIYSLDMGALLAGTRYRGDFEERLKQVVSELEKMPEAILFIDEIHTVIGAGATSGGAMDASNLLKPAL
SGGTIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVNEPTIEDTVKILKGLKSAFEDHHKVKYTLDALKTAVELSARYIND
RKLPDKAIDVVDEVGAMQMLVPPSRRKKKITAKEIEQVIATMARIPPKSVSKDDKKALENLERDLKHVVFGQDPAVKKLS
TAMKLSRAGLRDPDKPIGSFLFSGPTGVGKTEVARQLASIMGIELKRFDMSEYMERHSVSRLIGAPPGYVGYDQGGLLTD
AVDQNPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKTVDFRNVVLIMTTNAGAADMARQGIGFGDVSKEDASEEA
VKRMFTPEFRNRLDAIVPFGYLGKDTVARVVDKFILQLELQLAEQNVDIQFDADARAWLADKGYDRLYGARPMGRLLQEK
IKQPLAEELLFGKLADGGEVQVSIKDGKPNFELTPAPPKAKRAAPKRKPAAKKASPKKAEPEAGDSKDEGGG

Sequences:

>Translated_792_residues
MPSFAQNLEKTLHAAIDSARERRHEYATLEHLLLALVADEDATEVMTACGVDLEELSSVVKAYLDQEYQSLQTEEGSEPQ
PTAGFQRVIQRAILHVQSSGKDTVTGANVLVALFSERDSYAVYFLQQQDMSRLDAVSFISHGIGKGGKQLESRAPQGSDE
GQAEDSKSDGGNKKETALDQFTVNLNKKAEDGRIDPLIGRGPEVDRTVQILCRRSKNNPLYVGDPGVGKTAIAEGLARKI
VEGDVPEVLEDAVIYSLDMGALLAGTRYRGDFEERLKQVVSELEKMPEAILFIDEIHTVIGAGATSGGAMDASNLLKPAL
SGGTIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVNEPTIEDTVKILKGLKSAFEDHHKVKYTLDALKTAVELSARYIND
RKLPDKAIDVVDEVGAMQMLVPPSRRKKKITAKEIEQVIATMARIPPKSVSKDDKKALENLERDLKHVVFGQDPAVKKLS
TAMKLSRAGLRDPDKPIGSFLFSGPTGVGKTEVARQLASIMGIELKRFDMSEYMERHSVSRLIGAPPGYVGYDQGGLLTD
AVDQNPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKTVDFRNVVLIMTTNAGAADMARQGIGFGDVSKEDASEEA
VKRMFTPEFRNRLDAIVPFGYLGKDTVARVVDKFILQLELQLAEQNVDIQFDADARAWLADKGYDRLYGARPMGRLLQEK
IKQPLAEELLFGKLADGGEVQVSIKDGKPNFELTPAPPKAKRAAPKRKPAAKKASPKKAEPEAGDSKDEGGG
>Mature_791_residues
PSFAQNLEKTLHAAIDSARERRHEYATLEHLLLALVADEDATEVMTACGVDLEELSSVVKAYLDQEYQSLQTEEGSEPQP
TAGFQRVIQRAILHVQSSGKDTVTGANVLVALFSERDSYAVYFLQQQDMSRLDAVSFISHGIGKGGKQLESRAPQGSDEG
QAEDSKSDGGNKKETALDQFTVNLNKKAEDGRIDPLIGRGPEVDRTVQILCRRSKNNPLYVGDPGVGKTAIAEGLARKIV
EGDVPEVLEDAVIYSLDMGALLAGTRYRGDFEERLKQVVSELEKMPEAILFIDEIHTVIGAGATSGGAMDASNLLKPALS
GGTIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVNEPTIEDTVKILKGLKSAFEDHHKVKYTLDALKTAVELSARYINDR
KLPDKAIDVVDEVGAMQMLVPPSRRKKKITAKEIEQVIATMARIPPKSVSKDDKKALENLERDLKHVVFGQDPAVKKLST
AMKLSRAGLRDPDKPIGSFLFSGPTGVGKTEVARQLASIMGIELKRFDMSEYMERHSVSRLIGAPPGYVGYDQGGLLTDA
VDQNPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHGKTVDFRNVVLIMTTNAGAADMARQGIGFGDVSKEDASEEAV
KRMFTPEFRNRLDAIVPFGYLGKDTVARVVDKFILQLELQLAEQNVDIQFDADARAWLADKGYDRLYGARPMGRLLQEKI
KQPLAEELLFGKLADGGEVQVSIKDGKPNFELTPAPPKAKRAAPKRKPAAKKASPKKAEPEAGDSKDEGGG

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=342, Percent_Identity=32.4561403508772, Blast_Score=176, Evalue=8e-44,
Organism=Escherichia coli, GI1787109, Length=750, Percent_Identity=59.2, Blast_Score=904, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=396, Percent_Identity=41.6666666666667, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=327, Percent_Identity=46.177370030581, Blast_Score=289, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6323002, Length=338, Percent_Identity=39.9408284023669, Blast_Score=242, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: 3.4.21.92

Molecular weight: Translated: 86966; Mature: 86835

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFAQNLEKTLHAAIDSARERRHEYATLEHLLLALVADEDATEVMTACGVDLEELSSVV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHH
KAYLDQEYQSLQTEEGSEPQPTAGFQRVIQRAILHVQSSGKDTVTGANVLVALFSERDSY
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCE
AVYFLQQQDMSRLDAVSFISHGIGKGGKQLESRAPQGSDEGQAEDSKSDGGNKKETALDQ
EEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
FTVNLNKKAEDGRIDPLIGRGPEVDRTVQILCRRSKNNPLYVGDPGVGKTAIAEGLARKI
HEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHH
VEGDVPEVLEDAVIYSLDMGALLAGTRYRGDFEERLKQVVSELEKMPEAILFIDEIHTVI
HCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAGATSGGAMDASNLLKPALSGGTIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVNEPTI
HCCCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
EDTVKILKGLKSAFEDHHKVKYTLDALKTAVELSARYINDRKLPDKAIDVVDEVGAMQML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEE
VPPSRRKKKITAKEIEQVIATMARIPPKSVSKDDKKALENLERDLKHVVFGQDPAVKKLS
CCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TAMKLSRAGLRDPDKPIGSFLFSGPTGVGKTEVARQLASIMGIELKRFDMSEYMERHSVS
HHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHH
RLIGAPPGYVGYDQGGLLTDAVDQNPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHG
HHHCCCCCCCCCCCCCCEECCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHCCCCEECCCC
KTVDFRNVVLIMTTNAGAADMARQGIGFGDVSKEDASEEAVKRMFTPEFRNRLDAIVPFG
CEEEECCEEEEEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCC
YLGKDTVARVVDKFILQLELQLAEQNVDIQFDADARAWLADKGYDRLYGARPMGRLLQEK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCHHHHHCCCHHHHHHHHH
IKQPLAEELLFGKLADGGEVQVSIKDGKPNFELTPAPPKAKRAAPKRKPAAKKASPKKAE
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEECCCCCHHHHCCCCCCCCCCCCCCCCCC
PEAGDSKDEGGG
CCCCCCCCCCCC
>Mature Secondary Structure 
PSFAQNLEKTLHAAIDSARERRHEYATLEHLLLALVADEDATEVMTACGVDLEELSSVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHH
KAYLDQEYQSLQTEEGSEPQPTAGFQRVIQRAILHVQSSGKDTVTGANVLVALFSERDSY
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCE
AVYFLQQQDMSRLDAVSFISHGIGKGGKQLESRAPQGSDEGQAEDSKSDGGNKKETALDQ
EEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
FTVNLNKKAEDGRIDPLIGRGPEVDRTVQILCRRSKNNPLYVGDPGVGKTAIAEGLARKI
HEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHH
VEGDVPEVLEDAVIYSLDMGALLAGTRYRGDFEERLKQVVSELEKMPEAILFIDEIHTVI
HCCCHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GAGATSGGAMDASNLLKPALSGGTIRCIGSTTYKEFRNHFEKDRALLRRFQKIDVNEPTI
HCCCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
EDTVKILKGLKSAFEDHHKVKYTLDALKTAVELSARYINDRKLPDKAIDVVDEVGAMQML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEE
VPPSRRKKKITAKEIEQVIATMARIPPKSVSKDDKKALENLERDLKHVVFGQDPAVKKLS
CCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TAMKLSRAGLRDPDKPIGSFLFSGPTGVGKTEVARQLASIMGIELKRFDMSEYMERHSVS
HHHHHHHCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHH
RLIGAPPGYVGYDQGGLLTDAVDQNPHCVLLLDEIEKAHPDLFNILLQVMDNGRLTDHHG
HHHCCCCCCCCCCCCCCEECCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHCCCCEECCCC
KTVDFRNVVLIMTTNAGAADMARQGIGFGDVSKEDASEEAVKRMFTPEFRNRLDAIVPFG
CEEEECCEEEEEECCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCC
YLGKDTVARVVDKFILQLELQLAEQNVDIQFDADARAWLADKGYDRLYGARPMGRLLQEK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCHHHHHCCCHHHHHHHHH
IKQPLAEELLFGKLADGGEVQVSIKDGKPNFELTPAPPKAKRAAPKRKPAAKKASPKKAE
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCCEECCCCCHHHHCCCCCCCCCCCCCCCCCC
PEAGDSKDEGGG
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]