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The map label for this gene is lig [H]

Identifier: 85375461

GI number: 85375461

Start: 2651413

End: 2652444

Strand: Reverse

Name: lig [H]

Synonym: ELI_13170

Alternate gene names: 85375461

Gene position: 2652444-2651413 (Counterclockwise)

Preceding gene: 85375462

Following gene: 85375460

Centisome position: 86.9

GC content: 67.73

Gene sequence:

>1032_bases
GTGAGCCCTCCCTTTTCCTGGATCAGGCCCGAACCGTGGGGCATCCATATCGAGCCTGCCGATTGCTGGATCGATCCCGG
CCGCCCGGTAGAGCGCGCGCTGGTGACGCATGGCCATGCCGATCACGCGCGCGGCGGCCACGGCGAAACCGTCGCCACGC
CTGAAACGCTGGCCATCATGAAGCTGCGCTATCGCACCGGGGCCGAGGACGAGAACGGCGAGATCCCGACCAAGGCGGTG
CCGGTCGAATATGGCGAAACCATCCGGCTGAAGGGCGGCGTCGATGCGACCTATGTCCCAGCGGGTCACGTGCTGGGCAG
CGCGCAGATCCTGCTCGAACATGCCGGTGAGCGGGTCGTGATTACCGGCGATTACAAGCGCCGCCCCGATCCCACCTGTC
CGCCCTTCCAGGTCACGCCCTGCGACATCTTCATCACCGAGGCGACCTTTGGCTTGCCGGTCTTCACCCATCCCCCGATC
GAGGACGAGATGGCGAAACTGCTCGAGCGGCTGGCGGCGCACCCCGAGCGATGCGTGCTGGTCGGTGCTTATGCGCTGGG
CAAGGCGCAGCGGGTGATCGCGGAACTGCGCGCCGCAGGGCACCACCAGCCGATCTATCTCCACGGCGCGATGGAGAAGA
TGTGCAGGCTCTATGAGGAGCACGGCGTCGATCTCGGCGAATTGCGGCTGGTGAGCGACGCCAAGAAGGACGAGATGCGC
GGCCACATCGTCGTCAGCCCGCCCAGCGCGCTGAACGACCGCTGGAGCCGCCGCCTGCCCGAACCGATCACCGCCATGGC
GAGCGGCTGGATGCGCGTGCGCCAGCGCGCCCGCCAGCGCAACGTCGAGCTGCCGCTCGTCATCTCCGACCACGCCGATT
GGGGCGAGCTCACCCGCACCGTCGAGGAAGTCGATCCGCACGAGACCTGGATCACCCATGGCCGCGAGGAAGCGCTGCTG
CGCTGGCACCAACTGCACCAGCGCCGCGCTCGGGCGCTGGCGCTCGTAGGCCGGGAGGATGAGGATGAATAG

Upstream 100 bases:

>100_bases
ATACGCCGAATCGCCGATCAAGATAACCCAGAGCTATTTTTTCGAGAGTCAATGACTCTGATTGATGGAACTCCACAGGT
TTCTTCACATTTCATCCATT

Downstream 100 bases:

>100_bases
AATCCACCCCTCATCCGTTCGGGCTGAGCCTGTCGAAGCCCAAGCCTTTTTTTTGGCAATCGGGGCGCTTGAAGAAAGTA
CGGCCCTTCGACAGGCTCAG

Product: hypothetical protein

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MSPPFSWIRPEPWGIHIEPADCWIDPGRPVERALVTHGHADHARGGHGETVATPETLAIMKLRYRTGAEDENGEIPTKAV
PVEYGETIRLKGGVDATYVPAGHVLGSAQILLEHAGERVVITGDYKRRPDPTCPPFQVTPCDIFITEATFGLPVFTHPPI
EDEMAKLLERLAAHPERCVLVGAYALGKAQRVIAELRAAGHHQPIYLHGAMEKMCRLYEEHGVDLGELRLVSDAKKDEMR
GHIVVSPPSALNDRWSRRLPEPITAMASGWMRVRQRARQRNVELPLVISDHADWGELTRTVEEVDPHETWITHGREEALL
RWHQLHQRRARALALVGREDEDE

Sequences:

>Translated_343_residues
MSPPFSWIRPEPWGIHIEPADCWIDPGRPVERALVTHGHADHARGGHGETVATPETLAIMKLRYRTGAEDENGEIPTKAV
PVEYGETIRLKGGVDATYVPAGHVLGSAQILLEHAGERVVITGDYKRRPDPTCPPFQVTPCDIFITEATFGLPVFTHPPI
EDEMAKLLERLAAHPERCVLVGAYALGKAQRVIAELRAAGHHQPIYLHGAMEKMCRLYEEHGVDLGELRLVSDAKKDEMR
GHIVVSPPSALNDRWSRRLPEPITAMASGWMRVRQRARQRNVELPLVISDHADWGELTRTVEEVDPHETWITHGREEALL
RWHQLHQRRARALALVGREDEDE
>Mature_342_residues
SPPFSWIRPEPWGIHIEPADCWIDPGRPVERALVTHGHADHARGGHGETVATPETLAIMKLRYRTGAEDENGEIPTKAVP
VEYGETIRLKGGVDATYVPAGHVLGSAQILLEHAGERVVITGDYKRRPDPTCPPFQVTPCDIFITEATFGLPVFTHPPIE
DEMAKLLERLAAHPERCVLVGAYALGKAQRVIAELRAAGHHQPIYLHGAMEKMCRLYEEHGVDLGELRLVSDAKKDEMRG
HIVVSPPSALNDRWSRRLPEPITAMASGWMRVRQRARQRNVELPLVISDHADWGELTRTVEEVDPHETWITHGREEALLR
WHQLHQRRARALALVGREDEDE

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent DNA ligase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323307, Length=151, Percent_Identity=33.112582781457, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648013, Length=167, Percent_Identity=29.940119760479, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR011108 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N; PF07521 RMMBL [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 38547; Mature: 38416

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPPFSWIRPEPWGIHIEPADCWIDPGRPVERALVTHGHADHARGGHGETVATPETLAIM
CCCCCCCCCCCCCEEEECHHHCEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHEEHE
KLRYRTGAEDENGEIPTKAVPVEYGETIRLKGGVDATYVPAGHVLGSAQILLEHAGERVV
EEHHHCCCCCCCCCCCCEEECCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHCCCCEEE
ITGDYKRRPDPTCPPFQVTPCDIFITEATFGLPVFTHPPIEDEMAKLLERLAAHPERCVL
EECCCCCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEE
VGAYALGKAQRVIAELRAAGHHQPIYLHGAMEKMCRLYEEHGVDLGELRLVSDAKKDEMR
EEHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCHHHEEEHHCCCHHHCC
GHIVVSPPSALNDRWSRRLPEPITAMASGWMRVRQRARQRNVELPLVISDHADWGELTRT
CCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
VEEVDPHETWITHGREEALLRWHQLHQRRARALALVGREDEDE
HHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure 
SPPFSWIRPEPWGIHIEPADCWIDPGRPVERALVTHGHADHARGGHGETVATPETLAIM
CCCCCCCCCCCCEEEECHHHCEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHEEHE
KLRYRTGAEDENGEIPTKAVPVEYGETIRLKGGVDATYVPAGHVLGSAQILLEHAGERVV
EEHHHCCCCCCCCCCCCEEECCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHCCCCEEE
ITGDYKRRPDPTCPPFQVTPCDIFITEATFGLPVFTHPPIEDEMAKLLERLAAHPERCVL
EECCCCCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEE
VGAYALGKAQRVIAELRAAGHHQPIYLHGAMEKMCRLYEEHGVDLGELRLVSDAKKDEMR
EEHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCHHHEEEHHCCCHHHCC
GHIVVSPPSALNDRWSRRLPEPITAMASGWMRVRQRARQRNVELPLVISDHADWGELTRT
CCEEECCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
VEEVDPHETWITHGREEALLRWHQLHQRRARALALVGREDEDE
HHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA