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The map label for this gene is dxs

Identifier: 85375331

GI number: 85375331

Start: 2532773

End: 2534695

Strand: Reverse

Name: dxs

Synonym: ELI_12520

Alternate gene names: 85375331

Gene position: 2534695-2532773 (Counterclockwise)

Preceding gene: 85375332

Following gene: 85375330

Centisome position: 83.04

GC content: 65.0

Gene sequence:

>1923_bases
ATGAGTGCACGACCCGATACCCCCCTTCTCGACACGGTGTCCTATCCCGAGGACTTGCGGAAGCTTGAGCCCGGCCAACT
CCGCCAGCTGAGCGACGAACTTCGCGCCGAGATGATCAGCGCCGTCGGCGTCACGGGCGGGCATTTGGGGTCGGGGCTCG
GGGTGGTCGAACTGACTGCGGCGATCCACTATGTCTTCAACACGCCTGAGGACCGGCTGATCTGGGATGTCGGGCACCAG
TGCTATCCGCACAAGATACTGACGGGGCGGCGCGACCGCATCCGCACGCTGCGTCAGGGCGGCGGCCTTTCCGGCTTCAC
CAAGCGCAGCGAGAGCGAATACGATCCGTTCGGCGCGGCGCACAGCTCGACCTCGATATCGGCCGGGCTCGGCTTCGCAG
TCGCCAACAAGCTGAAGGGCGAACCGGGCAAGGCTATCGCGGTAATCGGCGACGGCGCGATGAGCGCGGGCATGGCCTAC
GAGGCGATGAACAATGCCGAACAGGCCGGCAATCGGCTGATCGTGATCCTCAACGATAACGACATGTCGATCGCGCCGCC
GGTGGGCGGCCTGTCGGGCTATCTCGCGCGGCTGATGAGCTCGAGCGAGTATCTCGGCCTGCGCAGCCTGGCCTCGCGCA
TGACCGCGAAGGTCAGCCGCCGCGTTCACACGTCGCTCGGCAAGGCCGAGGAATATACCAAGGGCTTGGTCACCGGCGGG
ACGCTGTTCGAGGAACTGGGCTTCTACTATGTCGGCCCGATCGACGGGCACAATCTCGACCACCTGATCCCGGTGCTGGA
GAATGTCCGCGATGCCGAGGAAGGGCCGTTTCTCATCCATGTCCGCACGGTCAAGGGCAAGGGCTATGCACCGGCCGAAA
ACAGCGCCGACAAATACCACGGCGTTGCCAAGTTCGATGTCGTCACCGGCGAGCAGAAGAAATCGACCGGCGGCCCGCCT
GCCTACCAGAACGTGTTCGGCGAAACGCTGGCCAAGCTGGCCGACAGCGACCCGCGCATCTGCGCCATCACCGCCGCCAT
GCCGAGCGGCACCGGCGTGGACAAATTCGCCAAGGCGCATCCGGACAGGGCCTTCGATGTCGGCATTGCCGAGCAGCATG
GCGTCACCTTTGCAGCAGGCCTCGCGGCGCAGGGCATGCGGCCCTTCGCGGCGATCTATTCGACCTTCCTGCAGCGCGCC
TACGACCAGGTCGTGCATGACGTCGCGATCCAGAACCTGCCGGTGCGTTTCGCCATCGACAGGGCCGGACTGGTGGGCGC
CGATGGCAGCACCCATGCGGGCAGCTTCGACGTCACCTATCTCGCCACCTTGCCCAATTTCGTCGTCATGGCGGCGGCGG
ACGAGGCCGAGCTGGTCCATATGACCTACACGGCGGCAGAACATGACTCCGGCCCTATCGCCTTCCGCTATCCGCGCGGT
GGCGGTATCGGCATCGACCTGCCCGAAACGCCCGAGAAGCTTGAAATCGGCAAGGGCCGGATCGTCAAACATGGCAGCAA
GGTTGCGCTGCTGAGCCTCGGCACGCGGCTCGAAGAAGCGAAAAGGGCGGCGGACGAGCTGGAAGCCAAGGGCCTCAGCA
CCACCATCGCCGACATGCGTTTCGCCAAGCCGCTCGATACCGAGTTGATCGCACAGCTGATGAAGAACCACGAGGTCGTG
GTCACGATCGAGGAAGCCAGCATCGGCGGCCTCGGCGCGCATGTGCTGACTTATGCCTCGGACGAAGGGTTGACCGATGC
GGGCCTCAAGATCCGCACCATGCGCCTGCCCGACGCCTTCATCGAGCAGGACGCGCCCGAAAAGCAATATGACGAGGCCG
GCCTCACTGCGCCGCACATCGTCGACACCGTGCTCAAGGCGCTGCGCCAAAACAGCGCCGGCGTCGAAGAGGCGCGGGCC
TGA

Upstream 100 bases:

>100_bases
GAACTACGCGGATTGTGCAGCGACTGCGCCTGACCGGCAGGCGAAAGCCAGCTGAACTGGTTCATCGACAAGCACACATT
GTCGGTGTAACCGCCAAGGC

Downstream 100 bases:

>100_bases
CCCTCGCGGAGTTGCGAACCCTGCTGACGGTGCTGGCCATCGTGGCGGGGATTTATCTCGCCATCGCTCTGGCGGCCTGG
GCAGCGCAGGGACAGCTCAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MSARPDTPLLDTVSYPEDLRKLEPGQLRQLSDELRAEMISAVGVTGGHLGSGLGVVELTAAIHYVFNTPEDRLIWDVGHQ
CYPHKILTGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAAHSSTSISAGLGFAVANKLKGEPGKAIAVIGDGAMSAGMAY
EAMNNAEQAGNRLIVILNDNDMSIAPPVGGLSGYLARLMSSSEYLGLRSLASRMTAKVSRRVHTSLGKAEEYTKGLVTGG
TLFEELGFYYVGPIDGHNLDHLIPVLENVRDAEEGPFLIHVRTVKGKGYAPAENSADKYHGVAKFDVVTGEQKKSTGGPP
AYQNVFGETLAKLADSDPRICAITAAMPSGTGVDKFAKAHPDRAFDVGIAEQHGVTFAAGLAAQGMRPFAAIYSTFLQRA
YDQVVHDVAIQNLPVRFAIDRAGLVGADGSTHAGSFDVTYLATLPNFVVMAAADEAELVHMTYTAAEHDSGPIAFRYPRG
GGIGIDLPETPEKLEIGKGRIVKHGSKVALLSLGTRLEEAKRAADELEAKGLSTTIADMRFAKPLDTELIAQLMKNHEVV
VTIEEASIGGLGAHVLTYASDEGLTDAGLKIRTMRLPDAFIEQDAPEKQYDEAGLTAPHIVDTVLKALRQNSAGVEEARA

Sequences:

>Translated_640_residues
MSARPDTPLLDTVSYPEDLRKLEPGQLRQLSDELRAEMISAVGVTGGHLGSGLGVVELTAAIHYVFNTPEDRLIWDVGHQ
CYPHKILTGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAAHSSTSISAGLGFAVANKLKGEPGKAIAVIGDGAMSAGMAY
EAMNNAEQAGNRLIVILNDNDMSIAPPVGGLSGYLARLMSSSEYLGLRSLASRMTAKVSRRVHTSLGKAEEYTKGLVTGG
TLFEELGFYYVGPIDGHNLDHLIPVLENVRDAEEGPFLIHVRTVKGKGYAPAENSADKYHGVAKFDVVTGEQKKSTGGPP
AYQNVFGETLAKLADSDPRICAITAAMPSGTGVDKFAKAHPDRAFDVGIAEQHGVTFAAGLAAQGMRPFAAIYSTFLQRA
YDQVVHDVAIQNLPVRFAIDRAGLVGADGSTHAGSFDVTYLATLPNFVVMAAADEAELVHMTYTAAEHDSGPIAFRYPRG
GGIGIDLPETPEKLEIGKGRIVKHGSKVALLSLGTRLEEAKRAADELEAKGLSTTIADMRFAKPLDTELIAQLMKNHEVV
VTIEEASIGGLGAHVLTYASDEGLTDAGLKIRTMRLPDAFIEQDAPEKQYDEAGLTAPHIVDTVLKALRQNSAGVEEARA
>Mature_639_residues
SARPDTPLLDTVSYPEDLRKLEPGQLRQLSDELRAEMISAVGVTGGHLGSGLGVVELTAAIHYVFNTPEDRLIWDVGHQC
YPHKILTGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAAHSSTSISAGLGFAVANKLKGEPGKAIAVIGDGAMSAGMAYE
AMNNAEQAGNRLIVILNDNDMSIAPPVGGLSGYLARLMSSSEYLGLRSLASRMTAKVSRRVHTSLGKAEEYTKGLVTGGT
LFEELGFYYVGPIDGHNLDHLIPVLENVRDAEEGPFLIHVRTVKGKGYAPAENSADKYHGVAKFDVVTGEQKKSTGGPPA
YQNVFGETLAKLADSDPRICAITAAMPSGTGVDKFAKAHPDRAFDVGIAEQHGVTFAAGLAAQGMRPFAAIYSTFLQRAY
DQVVHDVAIQNLPVRFAIDRAGLVGADGSTHAGSFDVTYLATLPNFVVMAAADEAELVHMTYTAAEHDSGPIAFRYPRGG
GIGIDLPETPEKLEIGKGRIVKHGSKVALLSLGTRLEEAKRAADELEAKGLSTTIADMRFAKPLDTELIAQLMKNHEVVV
TIEEASIGGLGAHVLTYASDEGLTDAGLKIRTMRLPDAFIEQDAPEKQYDEAGLTAPHIVDTVLKALRQNSAGVEEARA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI225637463, Length=516, Percent_Identity=23.6434108527132, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI225637459, Length=516, Percent_Identity=23.6434108527132, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI225637461, Length=516, Percent_Identity=23.6434108527132, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI133778974, Length=371, Percent_Identity=26.4150943396226, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI205277463, Length=348, Percent_Identity=24.4252873563218, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4507521, Length=348, Percent_Identity=24.4252873563218, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786622, Length=614, Percent_Identity=50.9771986970684, Blast_Score=587, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17539652, Length=448, Percent_Identity=27.9017857142857, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24645119, Length=432, Percent_Identity=26.8518518518519, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551847, Length=432, Percent_Identity=26.8518518518519, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550715, Length=432, Percent_Identity=26.8518518518519, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24666278, Length=374, Percent_Identity=26.4705882352941, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_ERYLH (Q2N6U5)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_459393.1
- ProteinModelPortal:   Q2N6U5
- SMR:   Q2N6U5
- STRING:   Q2N6U5
- GeneID:   3870516
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_12520
- NMPDR:   fig|314225.3.peg.519
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   ILITIEE
- PhylomeDB:   Q2N6U5
- ProtClustDB:   PRK05444
- BioCyc:   ELIT314225:ELI_12520-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68286; Mature: 68155

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARPDTPLLDTVSYPEDLRKLEPGQLRQLSDELRAEMISAVGVTGGHLGSGLGVVELTA
CCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
AIHYVFNTPEDRLIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAA
HHHHEECCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
HSSTSISAGLGFAVANKLKGEPGKAIAVIGDGAMSAGMAYEAMNNAEQAGNRLIVILNDN
CCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCHHCCHHHHHHCCHHHCCCEEEEEECCC
DMSIAPPVGGLSGYLARLMSSSEYLGLRSLASRMTAKVSRRVHTSLGKAEEYTKGLVTGG
CCEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
TLFEELGFYYVGPIDGHNLDHLIPVLENVRDAEEGPFLIHVRTVKGKGYAPAENSADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCHHHC
GVAKFDVVTGEQKKSTGGPPAYQNVFGETLAKLADSDPRICAITAAMPSGTGVDKFAKAH
CEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHCC
PDRAFDVGIAEQHGVTFAAGLAAQGMRPFAAIYSTFLQRAYDQVVHDVAIQNLPVRFAID
CCCCEECCCCCCCCCEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
RAGLVGADGSTHAGSFDVTYLATLPNFVVMAAADEAELVHMTYTAAEHDSGPIAFRYPRG
CCCEECCCCCCCCCCCCEEEHHHCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEECCCC
GGIGIDLPETPEKLEIGKGRIVKHGSKVALLSLGTRLEEAKRAADELEAKGLSTTIADMR
CCCCCCCCCCCCHHCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FAKPLDTELIAQLMKNHEVVVTIEEASIGGLGAHVLTYASDEGLTDAGLKIRTMRLPDAF
HCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHEEEECCCCCCCCCCEEEEEECCHHH
IEQDAPEKQYDEAGLTAPHIVDTVLKALRQNSAGVEEARA
HCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure 
SARPDTPLLDTVSYPEDLRKLEPGQLRQLSDELRAEMISAVGVTGGHLGSGLGVVELTA
CCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
AIHYVFNTPEDRLIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAA
HHHHEECCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
HSSTSISAGLGFAVANKLKGEPGKAIAVIGDGAMSAGMAYEAMNNAEQAGNRLIVILNDN
CCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCHHCCHHHHHHCCHHHCCCEEEEEECCC
DMSIAPPVGGLSGYLARLMSSSEYLGLRSLASRMTAKVSRRVHTSLGKAEEYTKGLVTGG
CCEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
TLFEELGFYYVGPIDGHNLDHLIPVLENVRDAEEGPFLIHVRTVKGKGYAPAENSADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCHHHC
GVAKFDVVTGEQKKSTGGPPAYQNVFGETLAKLADSDPRICAITAAMPSGTGVDKFAKAH
CEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHCC
PDRAFDVGIAEQHGVTFAAGLAAQGMRPFAAIYSTFLQRAYDQVVHDVAIQNLPVRFAID
CCCCEECCCCCCCCCEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
RAGLVGADGSTHAGSFDVTYLATLPNFVVMAAADEAELVHMTYTAAEHDSGPIAFRYPRG
CCCEECCCCCCCCCCCCEEEHHHCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEECCCC
GGIGIDLPETPEKLEIGKGRIVKHGSKVALLSLGTRLEEAKRAADELEAKGLSTTIADMR
CCCCCCCCCCCCHHCCCCCEEEECCCEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
FAKPLDTELIAQLMKNHEVVVTIEEASIGGLGAHVLTYASDEGLTDAGLKIRTMRLPDAF
HCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHEEEECCCCCCCCCCEEEEEECCHHH
IEQDAPEKQYDEAGLTAPHIVDTVLKALRQNSAGVEEARA
HCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA