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The map label for this gene is ung [H]

Identifier: 85375258

GI number: 85375258

Start: 2457209

End: 2457895

Strand: Reverse

Name: ung [H]

Synonym: ELI_12155

Alternate gene names: 85375258

Gene position: 2457895-2457209 (Counterclockwise)

Preceding gene: 85375269

Following gene: 85375257

Centisome position: 80.52

GC content: 69.14

Gene sequence:

>687_bases
ATGGCCGGTACCGTCCCCGAAAGCTGGAAACCCGCGCTCGACCCGGCGCTGGAAACGCCCGAGGCGCGGCAGCTGGGCGG
CTGGCTGCGGGCGGAAGAGGAGGCTGGCAAGACGATCTATCCGCCGCGCGGGCAGAGGCTGAGCGCGCTGGAACTGACGC
CGCTCGATGCGGTGAAGGTCGTGATCCTGGGGCAGGACCCCTATCACGGCCCTGGACAGGCGCACGGGCTGTGCTTTTCC
GTCGCCCAAGGCATCCCGCCGCCGCCGAGCCTCGTCAATATTTTCAAGGAGCTGGAGAGCGATCTCGGCTTGCCGCGTCC
GTCGCATGGGTGCCTGGAGGCGTGGGCGAGGCAGGGCGTGCTGCTGCTCAACAATTCGCTCACGGTCGAAGCGCGCAGGG
CGGGCAGCCATGCGGGCAGGGGCTGGGATGCCATCACCGATGCGGCGGTGGCGGCGGTGGCGGCATCCGACAGGCCGACC
GCCTTCGTTTTGTGGGGGAGCCATGCCCAGAAGAAGGCGGCGCGCATCCCGGGCCTGACAGGCGGGCGACACCTGGTTCT
CAAGAGCCCGCATCCCAGCCCGCTCTCGGCCCATCGCGGCTTCTTCGGCTCGCGCCCCTTCAGCCAGGTCAATGCTTTCC
TCGAGGCACATGGGCGCGGAGCCATCGACTGGTCCTTGCCAGGGTGA

Upstream 100 bases:

>100_bases
CATGAAAATGTACAGCCATAGAGCCAAGCGCTCTAGGCCGATTGGGGAAAGAGGGAAAGGGGACATGGCGAGGCGTTTTG
CGACGCTGTAGTCTCGGCCC

Downstream 100 bases:

>100_bases
CACAGGTTACACCCTGTCACCCTGCCTTCCTGAGGTTATATCACTGTTTTCATTGCTGAAACCGGGTTGGAGTGACAGGT
TACACTCCGCGCCCGATTAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MAGTVPESWKPALDPALETPEARQLGGWLRAEEEAGKTIYPPRGQRLSALELTPLDAVKVVILGQDPYHGPGQAHGLCFS
VAQGIPPPPSLVNIFKELESDLGLPRPSHGCLEAWARQGVLLLNNSLTVEARRAGSHAGRGWDAITDAAVAAVAASDRPT
AFVLWGSHAQKKAARIPGLTGGRHLVLKSPHPSPLSAHRGFFGSRPFSQVNAFLEAHGRGAIDWSLPG

Sequences:

>Translated_228_residues
MAGTVPESWKPALDPALETPEARQLGGWLRAEEEAGKTIYPPRGQRLSALELTPLDAVKVVILGQDPYHGPGQAHGLCFS
VAQGIPPPPSLVNIFKELESDLGLPRPSHGCLEAWARQGVLLLNNSLTVEARRAGSHAGRGWDAITDAAVAAVAASDRPT
AFVLWGSHAQKKAARIPGLTGGRHLVLKSPHPSPLSAHRGFFGSRPFSQVNAFLEAHGRGAIDWSLPG
>Mature_227_residues
AGTVPESWKPALDPALETPEARQLGGWLRAEEEAGKTIYPPRGQRLSALELTPLDAVKVVILGQDPYHGPGQAHGLCFSV
AQGIPPPPSLVNIFKELESDLGLPRPSHGCLEAWARQGVLLLNNSLTVEARRAGSHAGRGWDAITDAAVAAVAASDRPTA
FVLWGSHAQKKAARIPGLTGGRHLVLKSPHPSPLSAHRGFFGSRPFSQVNAFLEAHGRGAIDWSLPG

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=219, Percent_Identity=51.1415525114155, Blast_Score=215, Evalue=3e-56,
Organism=Homo sapiens, GI6224979, Length=220, Percent_Identity=50.9090909090909, Blast_Score=214, Evalue=4e-56,
Organism=Escherichia coli, GI1788934, Length=218, Percent_Identity=52.7522935779816, Blast_Score=220, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17556304, Length=221, Percent_Identity=45.7013574660633, Blast_Score=203, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6323620, Length=240, Percent_Identity=42.9166666666667, Blast_Score=174, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24176; Mature: 24044

Theoretical pI: Translated: 8.77; Mature: 8.77

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGTVPESWKPALDPALETPEARQLGGWLRAEEEAGKTIYPPRGQRLSALELTPLDAVKV
CCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEE
VILGQDPYHGPGQAHGLCFSVAQGIPPPPSLVNIFKELESDLGLPRPSHGCLEAWARQGV
EEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCE
LLLNNSLTVEARRAGSHAGRGWDAITDAAVAAVAASDRPTAFVLWGSHAQKKAARIPGLT
EEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCC
GGRHLVLKSPHPSPLSAHRGFFGSRPFSQVNAFLEAHGRGAIDWSLPG
CCCEEEEECCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCEEECCCCC
>Mature Secondary Structure 
AGTVPESWKPALDPALETPEARQLGGWLRAEEEAGKTIYPPRGQRLSALELTPLDAVKV
CCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEE
VILGQDPYHGPGQAHGLCFSVAQGIPPPPSLVNIFKELESDLGLPRPSHGCLEAWARQGV
EEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCE
LLLNNSLTVEARRAGSHAGRGWDAITDAAVAAVAASDRPTAFVLWGSHAQKKAARIPGLT
EEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCC
GGRHLVLKSPHPSPLSAHRGFFGSRPFSQVNAFLEAHGRGAIDWSLPG
CCCEEEEECCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]