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The map label for this gene is crt [H]

Identifier: 85375255

GI number: 85375255

Start: 2455816

End: 2456448

Strand: Reverse

Name: crt [H]

Synonym: ELI_12140

Alternate gene names: 85375255

Gene position: 2456448-2455816 (Counterclockwise)

Preceding gene: 85375256

Following gene: 85375249

Centisome position: 80.48

GC content: 64.77

Gene sequence:

>633_bases
GTGGTCCTGACCGGGGCGGGGGAGCGCGCCTTTACCGCCGGCCTCGATCTGAAAGAACTGGGTGCGGAAGAAGGCGCGCT
GGGTGCCGCCAATGCCGAAGGGGCGGAGGAAAACCCGGTCAAGGCGGTAGAGCTCTGCCGCAAGCCCGTGATCGGTGCGA
TCAACGGCGTGGCGATCACCGGCGGCTTCGAGCTGGCGCTGGCCTGCGACGTGCTGATCGCCAGCGAGAAGGCGCGCTTT
GCCGACACCCATGCCCGCGTCGGCATCCTGCCTGGCTGGGGCCTCAGCCAGAAACTGAGCCGCATGATCGGTATCGCCCG
CGCCAAGGAACTGAGCTTCACCGGCAATTTCCTGCAGGCGGAAAAGGCGCTCGAATGGGGCCTGGTCAACCGCGTCGTCG
GGCCGTCCGAACTGATGCGATCTGCCCTCCGGCTGGCGGCCGATATGGCCAGCATCGATCCCGCCTTTCTCGCGCAATAC
AAGCGTCTGATCGACGATGGCTATGCGATGAATTTCGGCGACGCGATGGCGCTCGAAAACGAGATATCGAGCGCCGCCAA
TGCGCAGGTTTCACCGGAAGAGATCAACGAACGCCGCATCGAAGTGCAGTCGCGGGGACGCGGGCAAAAGTGA

Upstream 100 bases:

>100_bases
CGCTCAACCGGCCCGAGGCGATGAATGCGCTCAGCAAGGCGCTCCGCCATCGGCTCTATCATGTGATGAAACAGGTCGAC
GCGGACGACGCCGTGCGTGC

Downstream 100 bases:

>100_bases
GAGCTCGCACCCGCCGCACATTGTCTGTCTGTTAGAACGTCTTGGTCAGCCGCAGCCCGGCGGTGACACCCGTGTCGCGG
AAGACGATCGCGCCATCGAC

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MVLTGAGERAFTAGLDLKELGAEEGALGAANAEGAEENPVKAVELCRKPVIGAINGVAITGGFELALACDVLIASEKARF
ADTHARVGILPGWGLSQKLSRMIGIARAKELSFTGNFLQAEKALEWGLVNRVVGPSELMRSALRLAADMASIDPAFLAQY
KRLIDDGYAMNFGDAMALENEISSAANAQVSPEEINERRIEVQSRGRGQK

Sequences:

>Translated_210_residues
MVLTGAGERAFTAGLDLKELGAEEGALGAANAEGAEENPVKAVELCRKPVIGAINGVAITGGFELALACDVLIASEKARF
ADTHARVGILPGWGLSQKLSRMIGIARAKELSFTGNFLQAEKALEWGLVNRVVGPSELMRSALRLAADMASIDPAFLAQY
KRLIDDGYAMNFGDAMALENEISSAANAQVSPEEINERRIEVQSRGRGQK
>Mature_210_residues
MVLTGAGERAFTAGLDLKELGAEEGALGAANAEGAEENPVKAVELCRKPVIGAINGVAITGGFELALACDVLIASEKARF
ADTHARVGILPGWGLSQKLSRMIGIARAKELSFTGNFLQAEKALEWGLVNRVVGPSELMRSALRLAADMASIDPAFLAQY
KRLIDDGYAMNFGDAMALENEISSAANAQVSPEEINERRIEVQSRGRGQK

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=182, Percent_Identity=33.5164835164835, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI31542718, Length=184, Percent_Identity=28.804347826087, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI20127408, Length=136, Percent_Identity=31.6176470588235, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI70995211, Length=152, Percent_Identity=32.8947368421053, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI116235487, Length=173, Percent_Identity=29.4797687861272, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI68989263, Length=146, Percent_Identity=33.5616438356164, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI221136756, Length=186, Percent_Identity=29.5698924731183, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI221136753, Length=186, Percent_Identity=29.5698924731183, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI221307494, Length=186, Percent_Identity=29.5698924731183, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI221142681, Length=165, Percent_Identity=40, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787659, Length=182, Percent_Identity=34.6153846153846, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1788597, Length=162, Percent_Identity=34.5679012345679, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788682, Length=148, Percent_Identity=35.1351351351351, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082183, Length=169, Percent_Identity=27.2189349112426, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787660, Length=190, Percent_Identity=35.2631578947368, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790281, Length=94, Percent_Identity=38.2978723404255, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=188, Percent_Identity=34.0425531914894, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25145438, Length=199, Percent_Identity=33.1658291457286, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17540714, Length=181, Percent_Identity=33.1491712707182, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17558304, Length=137, Percent_Identity=32.8467153284672, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560910, Length=150, Percent_Identity=34, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=137, Percent_Identity=32.1167883211679, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17508953, Length=137, Percent_Identity=32.1167883211679, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=137, Percent_Identity=32.1167883211679, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI20129971, Length=179, Percent_Identity=32.9608938547486, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653477, Length=179, Percent_Identity=32.9608938547486, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653139, Length=176, Percent_Identity=34.0909090909091, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357171, Length=185, Percent_Identity=30.2702702702703, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24650670, Length=194, Percent_Identity=30.9278350515464, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24654903, Length=178, Percent_Identity=30.3370786516854, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 22272; Mature: 22272

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLTGAGERAFTAGLDLKELGAEEGALGAANAEGAEENPVKAVELCRKPVIGAINGVAIT
CEECCCCCCCEECCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEE
GGFELALACDVLIASEKARFADTHARVGILPGWGLSQKLSRMIGIARAKELSFTGNFLQA
CCHHHHHHHHHHHHCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
EKALEWGLVNRVVGPSELMRSALRLAADMASIDPAFLAQYKRLIDDGYAMNFGDAMALEN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCHHHHHH
EISSAANAQVSPEEINERRIEVQSRGRGQK
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVLTGAGERAFTAGLDLKELGAEEGALGAANAEGAEENPVKAVELCRKPVIGAINGVAIT
CEECCCCCCCEECCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEE
GGFELALACDVLIASEKARFADTHARVGILPGWGLSQKLSRMIGIARAKELSFTGNFLQA
CCHHHHHHHHHHHHCCCHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHH
EKALEWGLVNRVVGPSELMRSALRLAADMASIDPAFLAQYKRLIDDGYAMNFGDAMALEN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCHHHHHH
EISSAANAQVSPEEINERRIEVQSRGRGQK
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]