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The map label for this gene is fadA [H]

Identifier: 85375245

GI number: 85375245

Start: 2438930

End: 2440111

Strand: Reverse

Name: fadA [H]

Synonym: ELI_12090

Alternate gene names: 85375245

Gene position: 2440111-2438930 (Counterclockwise)

Preceding gene: 85375246

Following gene: 85375244

Centisome position: 79.94

GC content: 64.97

Gene sequence:

>1182_bases
ATGTCACGTGACGCAGTCATCGTTTCCACCGCCCGCACCCCTATCGGCCGCGCCTACAAGGGCGGCTTCAATGCCACCCC
CGGCGCGACGCTCGGTTCGTTCTCGCTTGCCCCGGCAGTCGAACGCGCCGGGATCGAAGGCGGCGAGATCGACGATGTCG
TGTGGGGCTGCGTCCTCACCCAGGGTACCCAGTCGGGCAATATCGGCCGCCAGGTCGCGCTGCGTGCGGGTCTTCCCGTC
AGCGTCGCGGCGCAGACGATCGACCGCCAGTGCTCCTCGGGCCTGATGGCGATCAGCACCGCGGCCAAGCAGATCATCGT
CGACAATATGGATATCGTCGTCGGCGGCGGTCAGGATTCGATTTCGATGGTCCAGACCCCGGAAATGCGCGTCGCGCCCG
ACAAGTCGCTGATCGCGATGCACAAGGATGTCTACATGCCGATGCTCCAGACCGCCGAGACGGTGGCCGAGCGCTACGGC
ATCAGCCGCGAAGCGCAGGACGAATACGCGCTGCAGTCGCAGATGCGCACCGCCGCCGGGCAGGAAGCGGGCAAGTTCGA
CGACGAGATCGTGCCGGTCAACACCACCATGATGGTGAAGGACAAGGAGACGGGCGAAGTCTCCAGCCAGGAAGTCACCA
TCACCAAGGATGAAGGCAACCGCCCCTCGACCACGCTGGAAGGGCTGCAGTCGCTAAATCCGGTCATGGGCCCGGACAAG
GTCATCACCGCCGGTAACGCTTCGCAGCTCTCGGACGGGTCCTCGGCCAGCGTGCTGATGGAAGCGAAGGTTGCCGAGCA
GAAGGGCCTCGAGCCGCTCGGTCGCTATGTCGGCATGGCGGTGGCGGGGACGGAGCCCGACGAAATGGGCATCGGCCCGG
TCTTCGCGATCCCCAAGCTGCTCGAACAGACCGGCATCAAGCACGACGACGTCGGCCTGTGGGAATTGAACGAAGCCTTC
GCGGTGCAGGTCCTCTATTGCCGCGACAAGCTCGGGATCGACAACGATATCCTCAACGTCAACGGCGGCTCGATCTCGAT
CGGCCACCCCTACGGCATGACCGGCGCGCGCTGCGTCGGCCACGCGCTGATCGAAGGCAAGCGCCGCGGCGCGAAATATG
TCGTCGTCACCATGTGCGTCGGTGGCGGCATGGGCGCTGCGGGCATGTTCGAGGTGTTTTAA

Upstream 100 bases:

>100_bases
GTCTGACCGTCATCCCAGCGAAGGCTGGGATCTCCCTCGACCAAGCACCAGATTTAACCAGATCCCAGCCTTCGCTGGGA
TGACGAAATAGGAATTTCCC

Downstream 100 bases:

>100_bases
TGAGTCTCTTGCGCTCGCGGTAGGCGCGTCGCGCCACCTCCGCGGAGGCGGCCTGACCGGCCGACGCGCAGTCGCGCTTT
GATGCCGTGACCAAGATCAA

Product: putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSRDAVIVSTARTPIGRAYKGGFNATPGATLGSFSLAPAVERAGIEGGEIDDVVWGCVLTQGTQSGNIGRQVALRAGLPV
SVAAQTIDRQCSSGLMAISTAAKQIIVDNMDIVVGGGQDSISMVQTPEMRVAPDKSLIAMHKDVYMPMLQTAETVAERYG
ISREAQDEYALQSQMRTAAGQEAGKFDDEIVPVNTTMMVKDKETGEVSSQEVTITKDEGNRPSTTLEGLQSLNPVMGPDK
VITAGNASQLSDGSSASVLMEAKVAEQKGLEPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLEQTGIKHDDVGLWELNEAF
AVQVLYCRDKLGIDNDILNVNGGSISIGHPYGMTGARCVGHALIEGKRRGAKYVVVTMCVGGGMGAAGMFEVF

Sequences:

>Translated_393_residues
MSRDAVIVSTARTPIGRAYKGGFNATPGATLGSFSLAPAVERAGIEGGEIDDVVWGCVLTQGTQSGNIGRQVALRAGLPV
SVAAQTIDRQCSSGLMAISTAAKQIIVDNMDIVVGGGQDSISMVQTPEMRVAPDKSLIAMHKDVYMPMLQTAETVAERYG
ISREAQDEYALQSQMRTAAGQEAGKFDDEIVPVNTTMMVKDKETGEVSSQEVTITKDEGNRPSTTLEGLQSLNPVMGPDK
VITAGNASQLSDGSSASVLMEAKVAEQKGLEPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLEQTGIKHDDVGLWELNEAF
AVQVLYCRDKLGIDNDILNVNGGSISIGHPYGMTGARCVGHALIEGKRRGAKYVVVTMCVGGGMGAAGMFEVF
>Mature_392_residues
SRDAVIVSTARTPIGRAYKGGFNATPGATLGSFSLAPAVERAGIEGGEIDDVVWGCVLTQGTQSGNIGRQVALRAGLPVS
VAAQTIDRQCSSGLMAISTAAKQIIVDNMDIVVGGGQDSISMVQTPEMRVAPDKSLIAMHKDVYMPMLQTAETVAERYGI
SREAQDEYALQSQMRTAAGQEAGKFDDEIVPVNTTMMVKDKETGEVSSQEVTITKDEGNRPSTTLEGLQSLNPVMGPDKV
ITAGNASQLSDGSSASVLMEAKVAEQKGLEPLGRYVGMAVAGTEPDEMGIGPVFAIPKLLEQTGIKHDDVGLWELNEAFA
VQVLYCRDKLGIDNDILNVNGGSISIGHPYGMTGARCVGHALIEGKRRGAKYVVVTMCVGGGMGAAGMFEVF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=43.0379746835443, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI167614485, Length=401, Percent_Identity=37.1571072319202, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI4557237, Length=399, Percent_Identity=37.0927318295739, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=35.8208955223881, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI4504327, Length=441, Percent_Identity=28.7981859410431, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=31.5384615384615, Blast_Score=146, Evalue=4e-35,
Organism=Escherichia coli, GI1787663, Length=408, Percent_Identity=39.9509803921569, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI87082165, Length=403, Percent_Identity=36.9727047146402, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=37.6237623762376, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI48994986, Length=392, Percent_Identity=35.969387755102, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1788683, Length=418, Percent_Identity=28.9473684210526, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI133906874, Length=397, Percent_Identity=35.5163727959698, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=35.929648241206, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=404, Percent_Identity=35.6435643564356, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17551802, Length=439, Percent_Identity=28.9293849658314, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=30.379746835443, Blast_Score=157, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6322031, Length=407, Percent_Identity=37.5921375921376, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6325229, Length=404, Percent_Identity=33.9108910891089, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=39.2947103274559, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=36.0493827160494, Blast_Score=234, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=35.8395989974937, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI17137578, Length=439, Percent_Identity=30.2961275626424, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41306; Mature: 41174

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRDAVIVSTARTPIGRAYKGGFNATPGATLGSFSLAPAVERAGIEGGEIDDVVWGCVLT
CCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHEE
QGTQSGNIGRQVALRAGLPVSVAAQTIDRQCSSGLMAISTAAKQIIVDNMDIVVGGGQDS
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEHHHHHHHHEECCCEEEEECCCCC
ISMVQTPEMRVAPDKSLIAMHKDVYMPMLQTAETVAERYGISREAQDEYALQSQMRTAAG
CEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
QEAGKFDDEIVPVNTTMMVKDKETGEVSSQEVTITKDEGNRPSTTLEGLQSLNPVMGPDK
CCCCCCCCCEEECCEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCC
VITAGNASQLSDGSSASVLMEAKVAEQKGLEPLGRYVGMAVAGTEPDEMGIGPVFAIPKL
EEECCCCHHCCCCCCCEEEEEEHHHHHCCCCHHHHHHEEEEECCCCHHCCCCHHHHHHHH
LEQTGIKHDDVGLWELNEAFAVQVLYCRDKLGIDNDILNVNGGSISIGHPYGMTGARCVG
HHHHCCCCCCCCEEEECCCCEEEEEEEECCCCCCCCEEEECCCEEEECCCCCCCHHHHHH
HALIEGKRRGAKYVVVTMCVGGGMGAAGMFEVF
HHHHHHHCCCCCEEEEEEEECCCCCCCCCEECC
>Mature Secondary Structure 
SRDAVIVSTARTPIGRAYKGGFNATPGATLGSFSLAPAVERAGIEGGEIDDVVWGCVLT
CCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHEE
QGTQSGNIGRQVALRAGLPVSVAAQTIDRQCSSGLMAISTAAKQIIVDNMDIVVGGGQDS
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEHHHHHHHHEECCCEEEEECCCCC
ISMVQTPEMRVAPDKSLIAMHKDVYMPMLQTAETVAERYGISREAQDEYALQSQMRTAAG
CEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
QEAGKFDDEIVPVNTTMMVKDKETGEVSSQEVTITKDEGNRPSTTLEGLQSLNPVMGPDK
CCCCCCCCCEEECCEEEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCC
VITAGNASQLSDGSSASVLMEAKVAEQKGLEPLGRYVGMAVAGTEPDEMGIGPVFAIPKL
EEECCCCHHCCCCCCCEEEEEEHHHHHCCCCHHHHHHEEEEECCCCHHCCCCHHHHHHHH
LEQTGIKHDDVGLWELNEAFAVQVLYCRDKLGIDNDILNVNGGSISIGHPYGMTGARCVG
HHHHCCCCCCCCEEEECCCCEEEEEEEECCCCCCCCEEEECCCEEEECCCCCCCHHHHHH
HALIEGKRRGAKYVVVTMCVGGGMGAAGMFEVF
HHHHHHHCCCCCEEEEEEEECCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]