Click here to switch to the map view.

The map label for this gene is ptrB [H]

Identifier: 85375206

GI number: 85375206

Start: 2398832

End: 2401009

Strand: Reverse

Name: ptrB [H]

Synonym: ELI_11895

Alternate gene names: 85375206

Gene position: 2401009-2398832 (Counterclockwise)

Preceding gene: 85375214

Following gene: 85375205

Centisome position: 78.66

GC content: 62.9

Gene sequence:

>2178_bases
ATGAAACCAGCACTGACTGCCGCACTCGCCACTGCAGCCTGCCTGATCGCAAGCCCGACGCTGGCGCAGCCCGCGGCCAG
CCAAGAGGAAACCACCAGCGTGAGCAAAGCGGCACCCACCGCCCGTCCCGTCGCCGAGAAGCGCGACCATTCCTACACCC
ATCACGGGATCACCATCGAAGACCCGTATTTCTGGCTCAAGGACCAATCCTACCCGACCATCGATGACGAGGACATTCTC
GACTATGTGAAGGCCGAGAATGCGTGGTTCGAAGCGCGCATGGCCTCGCAGAAGGACTTCACCGAGAAGCTCTTCGAAGA
GATGAAGGGCCGCATCAAGGAAGACGACAGCACCGTCCCGCAAAAGGATGGCGCCTGGCTCTACTGGTCCGAATTCGAAG
AGGGCGCGCAATATCGCAAGCACTACCGCAGGCCGGTCGCGGGCGGCGATGCGGTGCTGATCCTCGACGAGAACGCGCTG
GCCGAGGGTCAGGAATATTTCCGCCTCGGCGCTGCCTCGGTCAGCCATAACGGGCGCTATCTCGCCTACTCGACCGACAC
CAACGGGTCCGAGCGCTACACCGCGCGGATCAAGGATTTGCAGACCGGCGAGTTGCTGCCGGACGAGCTCACCAACCTGC
GCGGCGGGCTGACCTGGGTGATGGGCGACACGGCGCTGGTCTATGGCCCCTCGACCGAGGAATGGCGCACGCTGGAAGCC
AAGCTGCACGTGCTTGGCACGCCCAACGAAAGCGATGTCACGCTGTACGAGGAAGAGGACCAGAGTTTCAGCGTGAACGC
CGGCCTGTCGGCGCAGGAAGACTGGCTGATCATCTCGACCGGCGACAACGAGACGAGCGAAGTGCGGCTGGTCCGCGCCG
ACGATCCGACCGGCGAGCAGATCCTGATCAAGCCGCGGCAGAAGGGCCGCGAATATTCGGTCGATGTCCGCACCGACGAA
GCCGGCGACACCACGATCTTCGTCTGGACCAACGACGATCACATCAATTTCCGCCTCGCCAAGGCACCGCTCGGCGCGCC
GGGCGAATGGGAAACCGTGATCGCGGGATCGGACGAATTCTACCTGACAGATTTCGAGCTCTACAAGGATTTCTTCGTCA
CCGAAGGGCGTCTCGACGGTCTGGACCAGATCCAGCTGCGCACCTACGATGCGCCGCTCGATGCCAAGCCCATCGCCTTC
CCCGAGGCGAGCTACAATGCGGGCCTTTCCAACAATCCCGAATACGATGTCGGCAAGCTGCGCCTTGCCTATGAAAGCAT
GGTCACACCGGATTCGGTCTATGACTACGATGTCGCCAGCGGCGCGCTCGAACTGCTCAAGCAGCAGGAAATCCCGAGCG
GCTACGATGCTTCGCTCTACACCACCGAACGCGTCAGCGTGCAGGCGCGCGACGGGACGATGATCCCGGTCAGCGTGGTC
TATCGCAAGGACAGGCCACAAGGCGGCCCGCTGCATCTCTATGCCTATGGCGCCTATGGCTATGCCGTGCCGCCGGGCTT
CTCGACCACGCGCCTCAGCCTCATCGATCGCGGCTTCGCCTATGCCATTGCGCATATCCGTGGCGGCGACGATCTCGGGC
GGCGCTGGTATCTGCAGGGCAAGCTGTTCGAGCGCGCCAATACTTTCAACGATTTCGTCGATGCCGGGCGCGGGCTGATC
GATATGGGCTACACCGCCGAAGGCAAGATCACCGCCAGCGGCGGCTCGGCGGGCGGCGAGCTGATGGGTGCGATCATCAA
CCAGGACCCGGCGCAATATGGCGCGGTCGTCGCGCATGTGCCTTTCGTCGACGTGCTCAACACCATGCTCGACAAGGACC
TGCCACTGACGCCCGGCGAATGGCAGGAATGGGGCAACCCGATCGAGGACAAGGCGGCCTTCGCGTACATCCTCAGCTAT
TCGCCCTACGACCAGGTCAAGGCGCAGGACTATCCGCCGATGCTGGTGACCGCCGGTCTCAACGATCCGCGCGTGACCTA
TTGGGAGCCCGCGAAATGGGTCGCCAAGCTGCGCGATGTGAAGACCGACGATAACGAACTGCTGCTCAAAACCAATATGG
GCGCGGGCCACGGCGGCAAGTCGGGCCGCTGGAGCGCCGTCTATGAAGTGGCGGAGGAATACGCCTTCATCCTGTGGCAG
ATGGGCTTGGCCGAGTGA

Upstream 100 bases:

>100_bases
GGTAATCGGTTGTGCGCTCTTGTGCGCGTCATGTCTCTATCATAGGCCTTGCGAGTGAGGCTTTCCAGCCGACCTTTCGG
ACATCACGGAACCACAAGCC

Downstream 100 bases:

>100_bases
TTGGCCTCACGCAGCGAAGCGGTAGGCCGGCAGCACTTCCTCGAGCAGCGCAGCGATAGGTCAATAAGTATGCCGATCAG
GAACGTCGTCTTCGACATCG

Product: protease II

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 725; Mature: 725

Protein sequence:

>725_residues
MKPALTAALATAACLIASPTLAQPAASQEETTSVSKAAPTARPVAEKRDHSYTHHGITIEDPYFWLKDQSYPTIDDEDIL
DYVKAENAWFEARMASQKDFTEKLFEEMKGRIKEDDSTVPQKDGAWLYWSEFEEGAQYRKHYRRPVAGGDAVLILDENAL
AEGQEYFRLGAASVSHNGRYLAYSTDTNGSERYTARIKDLQTGELLPDELTNLRGGLTWVMGDTALVYGPSTEEWRTLEA
KLHVLGTPNESDVTLYEEEDQSFSVNAGLSAQEDWLIISTGDNETSEVRLVRADDPTGEQILIKPRQKGREYSVDVRTDE
AGDTTIFVWTNDDHINFRLAKAPLGAPGEWETVIAGSDEFYLTDFELYKDFFVTEGRLDGLDQIQLRTYDAPLDAKPIAF
PEASYNAGLSNNPEYDVGKLRLAYESMVTPDSVYDYDVASGALELLKQQEIPSGYDASLYTTERVSVQARDGTMIPVSVV
YRKDRPQGGPLHLYAYGAYGYAVPPGFSTTRLSLIDRGFAYAIAHIRGGDDLGRRWYLQGKLFERANTFNDFVDAGRGLI
DMGYTAEGKITASGGSAGGELMGAIINQDPAQYGAVVAHVPFVDVLNTMLDKDLPLTPGEWQEWGNPIEDKAAFAYILSY
SPYDQVKAQDYPPMLVTAGLNDPRVTYWEPAKWVAKLRDVKTDDNELLLKTNMGAGHGGKSGRWSAVYEVAEEYAFILWQ
MGLAE

Sequences:

>Translated_725_residues
MKPALTAALATAACLIASPTLAQPAASQEETTSVSKAAPTARPVAEKRDHSYTHHGITIEDPYFWLKDQSYPTIDDEDIL
DYVKAENAWFEARMASQKDFTEKLFEEMKGRIKEDDSTVPQKDGAWLYWSEFEEGAQYRKHYRRPVAGGDAVLILDENAL
AEGQEYFRLGAASVSHNGRYLAYSTDTNGSERYTARIKDLQTGELLPDELTNLRGGLTWVMGDTALVYGPSTEEWRTLEA
KLHVLGTPNESDVTLYEEEDQSFSVNAGLSAQEDWLIISTGDNETSEVRLVRADDPTGEQILIKPRQKGREYSVDVRTDE
AGDTTIFVWTNDDHINFRLAKAPLGAPGEWETVIAGSDEFYLTDFELYKDFFVTEGRLDGLDQIQLRTYDAPLDAKPIAF
PEASYNAGLSNNPEYDVGKLRLAYESMVTPDSVYDYDVASGALELLKQQEIPSGYDASLYTTERVSVQARDGTMIPVSVV
YRKDRPQGGPLHLYAYGAYGYAVPPGFSTTRLSLIDRGFAYAIAHIRGGDDLGRRWYLQGKLFERANTFNDFVDAGRGLI
DMGYTAEGKITASGGSAGGELMGAIINQDPAQYGAVVAHVPFVDVLNTMLDKDLPLTPGEWQEWGNPIEDKAAFAYILSY
SPYDQVKAQDYPPMLVTAGLNDPRVTYWEPAKWVAKLRDVKTDDNELLLKTNMGAGHGGKSGRWSAVYEVAEEYAFILWQ
MGLAE
>Mature_725_residues
MKPALTAALATAACLIASPTLAQPAASQEETTSVSKAAPTARPVAEKRDHSYTHHGITIEDPYFWLKDQSYPTIDDEDIL
DYVKAENAWFEARMASQKDFTEKLFEEMKGRIKEDDSTVPQKDGAWLYWSEFEEGAQYRKHYRRPVAGGDAVLILDENAL
AEGQEYFRLGAASVSHNGRYLAYSTDTNGSERYTARIKDLQTGELLPDELTNLRGGLTWVMGDTALVYGPSTEEWRTLEA
KLHVLGTPNESDVTLYEEEDQSFSVNAGLSAQEDWLIISTGDNETSEVRLVRADDPTGEQILIKPRQKGREYSVDVRTDE
AGDTTIFVWTNDDHINFRLAKAPLGAPGEWETVIAGSDEFYLTDFELYKDFFVTEGRLDGLDQIQLRTYDAPLDAKPIAF
PEASYNAGLSNNPEYDVGKLRLAYESMVTPDSVYDYDVASGALELLKQQEIPSGYDASLYTTERVSVQARDGTMIPVSVV
YRKDRPQGGPLHLYAYGAYGYAVPPGFSTTRLSLIDRGFAYAIAHIRGGDDLGRRWYLQGKLFERANTFNDFVDAGRGLI
DMGYTAEGKITASGGSAGGELMGAIINQDPAQYGAVVAHVPFVDVLNTMLDKDLPLTPGEWQEWGNPIEDKAAFAYILSY
SPYDQVKAQDYPPMLVTAGLNDPRVTYWEPAKWVAKLRDVKTDDNELLLKTNMGAGHGGKSGRWSAVYEVAEEYAFILWQ
MGLAE

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=714, Percent_Identity=27.03081232493, Blast_Score=186, Evalue=8e-47,
Organism=Homo sapiens, GI284172420, Length=615, Percent_Identity=26.9918699186992, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI284172413, Length=615, Percent_Identity=26.9918699186992, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI70778815, Length=615, Percent_Identity=26.9918699186992, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI284172438, Length=575, Percent_Identity=27.1304347826087, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI284172431, Length=575, Percent_Identity=27.1304347826087, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI108860686, Length=289, Percent_Identity=33.2179930795848, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI108860692, Length=212, Percent_Identity=38.2075471698113, Blast_Score=143, Evalue=6e-34,
Organism=Escherichia coli, GI1788150, Length=686, Percent_Identity=38.3381924198251, Blast_Score=471, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24583414, Length=765, Percent_Identity=24.5751633986928, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI221510989, Length=750, Percent_Identity=25.0666666666667, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 80562; Mature: 80562

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPALTAALATAACLIASPTLAQPAASQEETTSVSKAAPTARPVAEKRDHSYTHHGITIE
CCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHCCCCEEECCEEEE
DPYFWLKDQSYPTIDDEDILDYVKAENAWFEARMASQKDFTEKLFEEMKGRIKEDDSTVP
CCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCC
QKDGAWLYWSEFEEGAQYRKHYRRPVAGGDAVLILDENALAEGQEYFRLGAASVSHNGRY
CCCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHCCHHHHEECCCEECCCCEE
LAYSTDTNGSERYTARIKDLQTGELLPDELTNLRGGLTWVMGDTALVYGPSTEEWRTLEA
EEEECCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCEEEEECCCCHHHEEEEE
KLHVLGTPNESDVTLYEEEDQSFSVNAGLSAQEDWLIISTGDNETSEVRLVRADDPTGEQ
EEEEEECCCCCCEEEEECCCCCEEEECCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCE
ILIKPRQKGREYSVDVRTDEAGDTTIFVWTNDDHINFRLAKAPLGAPGEWETVIAGSDEF
EEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEEEEEEECCCCCCCCCEEEEECCCCE
YLTDFELYKDFFVTEGRLDGLDQIQLRTYDAPLDAKPIAFPEASYNAGLSNNPEYDVGKL
EEEHHHHHHHHHEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHE
RLAYESMVTPDSVYDYDVASGALELLKQQEIPSGYDASLYTTERVSVQARDGTMIPVSVV
EEEHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCEEEEEEE
YRKDRPQGGPLHLYAYGAYGYAVPPGFSTTRLSLIDRGFAYAIAHIRGGDDLGRRWYLQG
EECCCCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHCCCEEEEEEEECCCCCCCEEEEEC
KLFERANTFNDFVDAGRGLIDMGYTAEGKITASGGSAGGELMGAIINQDPAQYGAVVAHV
HHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCHHHHHHHHCCCCHHHCEEEEEC
PFVDVLNTMLDKDLPLTPGEWQEWGNPIEDKAAFAYILSYSPYDQVKAQDYPPMLVTAGL
CHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCEEEEEEECCCHHHCCCCCCCCEEEEECC
NDPRVTYWEPAKWVAKLRDVKTDDNELLLKTNMGAGHGGKSGRWSAVYEVAEEYAFILWQ
CCCCEEEECHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
MGLAE
HCCCC
>Mature Secondary Structure
MKPALTAALATAACLIASPTLAQPAASQEETTSVSKAAPTARPVAEKRDHSYTHHGITIE
CCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHCCCCEEECCEEEE
DPYFWLKDQSYPTIDDEDILDYVKAENAWFEARMASQKDFTEKLFEEMKGRIKEDDSTVP
CCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCC
QKDGAWLYWSEFEEGAQYRKHYRRPVAGGDAVLILDENALAEGQEYFRLGAASVSHNGRY
CCCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHCCHHHHEECCCEECCCCEE
LAYSTDTNGSERYTARIKDLQTGELLPDELTNLRGGLTWVMGDTALVYGPSTEEWRTLEA
EEEECCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCEEEEECCEEEEECCCCHHHEEEEE
KLHVLGTPNESDVTLYEEEDQSFSVNAGLSAQEDWLIISTGDNETSEVRLVRADDPTGEQ
EEEEEECCCCCCEEEEECCCCCEEEECCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCE
ILIKPRQKGREYSVDVRTDEAGDTTIFVWTNDDHINFRLAKAPLGAPGEWETVIAGSDEF
EEECCCCCCCEEEEEEEECCCCCEEEEEEECCCEEEEEEEECCCCCCCCCEEEEECCCCE
YLTDFELYKDFFVTEGRLDGLDQIQLRTYDAPLDAKPIAFPEASYNAGLSNNPEYDVGKL
EEEHHHHHHHHHEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHE
RLAYESMVTPDSVYDYDVASGALELLKQQEIPSGYDASLYTTERVSVQARDGTMIPVSVV
EEEHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCEEEEEEE
YRKDRPQGGPLHLYAYGAYGYAVPPGFSTTRLSLIDRGFAYAIAHIRGGDDLGRRWYLQG
EECCCCCCCCEEEEEEECCCCCCCCCCCCEEHHHHHCCCEEEEEEEECCCCCCCEEEEEC
KLFERANTFNDFVDAGRGLIDMGYTAEGKITASGGSAGGELMGAIINQDPAQYGAVVAHV
HHHHHHHHHHHHHHCCCCEEECCCCCCCEEEECCCCCCHHHHHHHHCCCCHHHCEEEEEC
PFVDVLNTMLDKDLPLTPGEWQEWGNPIEDKAAFAYILSYSPYDQVKAQDYPPMLVTAGL
CHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCEEEEEEECCCHHHCCCCCCCCEEEEECC
NDPRVTYWEPAKWVAKLRDVKTDDNELLLKTNMGAGHGGKSGRWSAVYEVAEEYAFILWQ
CCCCEEEECHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
MGLAE
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1769955; 9097040; 9278503 [H]