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The map label for this gene is yngE [H]

Identifier: 85375180

GI number: 85375180

Start: 2369216

End: 2370871

Strand: Reverse

Name: yngE [H]

Synonym: ELI_11765

Alternate gene names: 85375180

Gene position: 2370871-2369216 (Counterclockwise)

Preceding gene: 85375181

Following gene: 85375179

Centisome position: 77.67

GC content: 64.79

Gene sequence:

>1656_bases
GTGACCGCACCCGTTCTTACCACCAAGCTCGACCGCGAAGACCCGCAAGCCAGGGCGCGCTTCCAGCATAACCGGAACCT
TGCAGAAGACCTTCGTGCGACAGTGGCCGAGGCCGCGCTGGGCGGGTCGGAGGGTAGCCGCGAACGCCATCTGTCGCGCG
GCAAACTGCTTCCCCGCGAGCGGGTCGAACGGCTGCTCGATCCGGGTTCTCCCTTCCTCGAAATCGGCCAGCTTGCCGCC
AACGGCATGTATGAGGGCGACATCAACGGCGCCTCGCTGATCTGCGGGATCGGGCGCATCTCGGGCCGTCAGGTGATGAT
CGTGTGCAACGATGCCACGGTGAAGGGCGGCACCTATTACCCGATGACGGTCAAGAAGCATCTGCGCGCACAGGAGATCG
CGCAGGAGAACCGCCTGCCGTGCATCTACCTCGTCGATAGCGGCGGGGCGAACCTGCCGCACCAGGCAGAAGTCTTCCCC
GACCGCGATCATTTCGGGCGAATATTCTTCAACCAGGCGAACATGAGCGCGCTCGGCATCCCGCAGATCGCCTGTGTGAT
GGGGAGTTGCACGGCGGGCGGGGCTTACGTTCCGGCGATGTCCGACGAGACGGTGATCGTGCGCAACCAAGGCACGATCT
TCCTCGCCGGCCCGCCGCTGGTGAAGGCCGCAACGGGCGAGGAGATCAGCGCCGAGGACCTTGGTGGCGGCGACCTTCAC
GCCAGGAAATCGGGCGTAGTCGATCACTTGGCCGAGAACGACGAGCACGCGCTCACCATCGTGCGCGATATCGTTTCGCA
CCTTGGAAACTTGCGAGCCCCAGTGAAGGCTGGGGCCTCCCTCTACCCGCACGAGGTCCCAGCCTCCGCTGGGGCTCAGT
CTTATCTGAAGGACCCGCGCCCGCCCAAATACGACGCGGACGACCTCTACGCGCTCGTGCCGGAGGACGTCCGCGCGCCC
TACGATGTGAAAGAGGTGATCGCGCGGCTGGTCGATGGCAGCGAGTTTCACGAGTTCAAGCAGCATTTCGGCAGCACACT
GGTGTGCGGCTTCGCGCATATCTGGGGCATGCCGGTGGCAATCCTCGCCAACAACGGCGTGCTGTTTTCGGAGAGCGCGC
AGAAAGGCGCGCATTTCATCGAGCTCGCCTGCCAGCGCCGCATCCCGCTGCTGTTCCTGCAGAACATCTCCGGCTTCATG
GTCGGCGGGAAGTACGAGGCGGAAGGCATCGCCAAGCATGGCGCGAAACTTGTCACCGCCGTCGCCACCGCCACCGTGCC
CAAAGTCACCGTGGTGATCGGCGGCAGCTTCGGCGCAGGCAACTACGGCATGTGCGGCCGCGCCTATTCTCCGCGCTTCC
TCTTCACCTGGCCCAATGCGCGCATTTCAGTGATGGGCGGCGAACAGGCCGCGAGCGTCCTCGCCACCGTCCACCGCGAT
GCAGATAAGTGGTCGGACGAACAGGCCGAGGAATTCAAGGCCCCGATCCGCCAGAAATACGAAGACGAAGGCAACCCCTA
TCACGCCACCGCGCGGTTGTGGGATGACGGGGTGATCGACCCGGTCCAGACCCGCGACGTGCTGGGACTGGCCTTTGCGG
CGGCGCTCGAGGCACCGATTGCTGGGCGGCCCGCCTTTGGCGTGTTCAGGATGTAG

Upstream 100 bases:

>100_bases
CGTGGCAGAATGTCGGCCTGCTTTGCATCAATTGCATCGGCGTCTATCGCTACCTGTTTACCGACAAGGCCGAAAAAGAG
GCCGAATCCACGGAGACCAC

Downstream 100 bases:

>100_bases
TCGGGATATTTTCGCCGACAGACGCGTTGGGCGGGTCAGGAACAGGAGATCCATCCCCATGCAAAAGCTTCTTGTAATCG
CTGCGCTTTCACCGCTCGCC

Product: propionyl-CoA carboxylase, beta subunit, putative

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MTAPVLTTKLDREDPQARARFQHNRNLAEDLRATVAEAALGGSEGSRERHLSRGKLLPRERVERLLDPGSPFLEIGQLAA
NGMYEGDINGASLICGIGRISGRQVMIVCNDATVKGGTYYPMTVKKHLRAQEIAQENRLPCIYLVDSGGANLPHQAEVFP
DRDHFGRIFFNQANMSALGIPQIACVMGSCTAGGAYVPAMSDETVIVRNQGTIFLAGPPLVKAATGEEISAEDLGGGDLH
ARKSGVVDHLAENDEHALTIVRDIVSHLGNLRAPVKAGASLYPHEVPASAGAQSYLKDPRPPKYDADDLYALVPEDVRAP
YDVKEVIARLVDGSEFHEFKQHFGSTLVCGFAHIWGMPVAILANNGVLFSESAQKGAHFIELACQRRIPLLFLQNISGFM
VGGKYEAEGIAKHGAKLVTAVATATVPKVTVVIGGSFGAGNYGMCGRAYSPRFLFTWPNARISVMGGEQAASVLATVHRD
ADKWSDEQAEEFKAPIRQKYEDEGNPYHATARLWDDGVIDPVQTRDVLGLAFAAALEAPIAGRPAFGVFRM

Sequences:

>Translated_551_residues
MTAPVLTTKLDREDPQARARFQHNRNLAEDLRATVAEAALGGSEGSRERHLSRGKLLPRERVERLLDPGSPFLEIGQLAA
NGMYEGDINGASLICGIGRISGRQVMIVCNDATVKGGTYYPMTVKKHLRAQEIAQENRLPCIYLVDSGGANLPHQAEVFP
DRDHFGRIFFNQANMSALGIPQIACVMGSCTAGGAYVPAMSDETVIVRNQGTIFLAGPPLVKAATGEEISAEDLGGGDLH
ARKSGVVDHLAENDEHALTIVRDIVSHLGNLRAPVKAGASLYPHEVPASAGAQSYLKDPRPPKYDADDLYALVPEDVRAP
YDVKEVIARLVDGSEFHEFKQHFGSTLVCGFAHIWGMPVAILANNGVLFSESAQKGAHFIELACQRRIPLLFLQNISGFM
VGGKYEAEGIAKHGAKLVTAVATATVPKVTVVIGGSFGAGNYGMCGRAYSPRFLFTWPNARISVMGGEQAASVLATVHRD
ADKWSDEQAEEFKAPIRQKYEDEGNPYHATARLWDDGVIDPVQTRDVLGLAFAAALEAPIAGRPAFGVFRM
>Mature_550_residues
TAPVLTTKLDREDPQARARFQHNRNLAEDLRATVAEAALGGSEGSRERHLSRGKLLPRERVERLLDPGSPFLEIGQLAAN
GMYEGDINGASLICGIGRISGRQVMIVCNDATVKGGTYYPMTVKKHLRAQEIAQENRLPCIYLVDSGGANLPHQAEVFPD
RDHFGRIFFNQANMSALGIPQIACVMGSCTAGGAYVPAMSDETVIVRNQGTIFLAGPPLVKAATGEEISAEDLGGGDLHA
RKSGVVDHLAENDEHALTIVRDIVSHLGNLRAPVKAGASLYPHEVPASAGAQSYLKDPRPPKYDADDLYALVPEDVRAPY
DVKEVIARLVDGSEFHEFKQHFGSTLVCGFAHIWGMPVAILANNGVLFSESAQKGAHFIELACQRRIPLLFLQNISGFMV
GGKYEAEGIAKHGAKLVTAVATATVPKVTVVIGGSFGAGNYGMCGRAYSPRFLFTWPNARISVMGGEQAASVLATVHRDA
DKWSDEQAEEFKAPIRQKYEDEGNPYHATARLWDDGVIDPVQTRDVLGLAFAAALEAPIAGRPAFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=556, Percent_Identity=60.7913669064748, Blast_Score=663, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=32.6810176125245, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=31.0734463276836, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI310133460, Length=147, Percent_Identity=52.3809523809524, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17552936, Length=555, Percent_Identity=58.9189189189189, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=531, Percent_Identity=32.7683615819209, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI25147359, Length=524, Percent_Identity=32.824427480916, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24586065, Length=560, Percent_Identity=60.7142857142857, Blast_Score=684, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 59405; Mature: 59274

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPVLTTKLDREDPQARARFQHNRNLAEDLRATVAEAALGGSEGSRERHLSRGKLLPRE
CCCCCEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHH
RVERLLDPGSPFLEIGQLAANGMYEGDINGASLICGIGRISGRQVMIVCNDATVKGGTYY
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEECCCEEC
PMTVKKHLRAQEIAQENRLPCIYLVDSGGANLPHQAEVFPDRDHFGRIFFNQANMSALGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
PQIACVMGSCTAGGAYVPAMSDETVIVRNQGTIFLAGPPLVKAATGEEISAEDLGGGDLH
CHHHHHHCCCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCCCCCCCCCCCCCC
ARKSGVVDHLAENDEHALTIVRDIVSHLGNLRAPVKAGASLYPHEVPASAGAQSYLKDPR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCHHHHCCCC
PPKYDADDLYALVPEDVRAPYDVKEVIARLVDGSEFHEFKQHFGSTLVCGFAHIWGMPVA
CCCCCCCCEEEECCHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCEE
ILANNGVLFSESAQKGAHFIELACQRRIPLLFLQNISGFMVGGKYEAEGIAKHGAKLVTA
EEECCCEEEECCHHCCHHHHHHHHHCCCCEEEECCCCCEEECCEECCCHHHHHHHHHHHH
VATATVPKVTVVIGGSFGAGNYGMCGRAYSPRFLFTWPNARISVMGGEQAASVLATVHRD
HHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHH
ADKWSDEQAEEFKAPIRQKYEDEGNPYHATARLWDDGVIDPVQTRDVLGLAFAAALEAPI
HHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCC
AGRPAFGVFRM
CCCCCCCCCCC
>Mature Secondary Structure 
TAPVLTTKLDREDPQARARFQHNRNLAEDLRATVAEAALGGSEGSRERHLSRGKLLPRE
CCCCEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHH
RVERLLDPGSPFLEIGQLAANGMYEGDINGASLICGIGRISGRQVMIVCNDATVKGGTYY
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCEECCCEEC
PMTVKKHLRAQEIAQENRLPCIYLVDSGGANLPHQAEVFPDRDHFGRIFFNQANMSALGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
PQIACVMGSCTAGGAYVPAMSDETVIVRNQGTIFLAGPPLVKAATGEEISAEDLGGGDLH
CHHHHHHCCCCCCCEEECCCCCCEEEEEECCEEEEECCCEEEECCCCCCCCCCCCCCCCC
ARKSGVVDHLAENDEHALTIVRDIVSHLGNLRAPVKAGASLYPHEVPASAGAQSYLKDPR
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCHHHHCCCC
PPKYDADDLYALVPEDVRAPYDVKEVIARLVDGSEFHEFKQHFGSTLVCGFAHIWGMPVA
CCCCCCCCEEEECCHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCEE
ILANNGVLFSESAQKGAHFIELACQRRIPLLFLQNISGFMVGGKYEAEGIAKHGAKLVTA
EEECCCEEEECCHHCCHHHHHHHHHCCCCEEEECCCCCEEECCEECCCHHHHHHHHHHHH
VATATVPKVTVVIGGSFGAGNYGMCGRAYSPRFLFTWPNARISVMGGEQAASVLATVHRD
HHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCHHHHHHHHHHHHH
ADKWSDEQAEEFKAPIRQKYEDEGNPYHATARLWDDGVIDPVQTRDVLGLAFAAALEAPI
HHHCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCC
AGRPAFGVFRM
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]