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The map label for this gene is blaA [H]

Identifier: 85374476

GI number: 85374476

Start: 1695726

End: 1696517

Strand: Reverse

Name: blaA [H]

Synonym: ELI_08245

Alternate gene names: 85374476

Gene position: 1696517-1695726 (Counterclockwise)

Preceding gene: 85374477

Following gene: 85374471

Centisome position: 55.58

GC content: 68.06

Gene sequence:

>792_bases
ATGAAGCGGACCCATCTCCCCCTCAACGCCTTGCGCGTTTACGATGCTGCGGCGCGGCACCTCTCGTTCACCCGCGCGGC
AGACGAGCTGGCGGTGACGCCCGCCGCGGTCGGCCAGCAGATCCGCGCGCTGGAAGATCATCTCGGCACCGTGCTGTTCC
GCCGCACCTCCAAGGGCCTCGAACTCACCGAGGAAGGCGCCAGCGGCCTCGACGCCTTGCGCGAAGGTTTCCTCAAGTTC
GAGGAATCGGTTCAGAACATGCAGGCCGGTCAGGCGAGCGACCGCTACACCATCGCCGCCCCGCGCGAATTCTACGCCCA
ATGGCTCGCCCCCAGGCTCGCCGCCTTCCGCGAGCAGAGCCCCGGCGTGCACTATTCGCTGGTCGAGAACGAAAACGCCG
ATTTCACCGAGGCCAACCTGGACGTCGCGATCCGGCTGGTCGACGGCCCGGGCGATCTCGAGGGAGTCGAGCTTGCCCCT
GCGCGCCGCGTGGTGGTGGCCGAGCCCGGCTATGAGGGCGACGACTGGATCGACTGGCCCGGCGCGCCGCTGCCCGAAGG
CGTCAAGGCGACGGTGCAGGTCGGCAATGCCGGCCAGGCGCTCAGCAGCGCGATCAGCGGCCTCGGCAAGGCGGTGTTGC
CCTATTTGCTGGTCGAGGAGAGCATCGAAGCGGGCAAAGCCGAGATCCTCGAAGGCCCCGACGAAGGCCGCCGCGCCTAC
TGGCTGGTCGCGCCGCTGCCGCAATGGCGGCAGAAGAAGGTCAAGGCGCTGATCGCCTTTCTGACTTCTTAG

Upstream 100 bases:

>100_bases
CGCTCGCCGCGCCGGAGACGGCCGAGAGGTAGGTTCGCGAAGGGACGCCTCGTCCTTCGCAGTTGCGGTATTGAAATCGT
CCCTCTAAATCCCCCGCACG

Downstream 100 bases:

>100_bases
TTTGTCGCAGCCACATCCGTGGCTGCGTCCCCGGTGCTGTTCCTCCTTTCAGTCGGGCACCTGCGGGCGGGCGCCTCCGG
CGGGCTACCGCCTGACGGCT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Beta-lactamase regulatory protein BlaA [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKRTHLPLNALRVYDAAARHLSFTRAADELAVTPAAVGQQIRALEDHLGTVLFRRTSKGLELTEEGASGLDALREGFLKF
EESVQNMQAGQASDRYTIAAPREFYAQWLAPRLAAFREQSPGVHYSLVENENADFTEANLDVAIRLVDGPGDLEGVELAP
ARRVVVAEPGYEGDDWIDWPGAPLPEGVKATVQVGNAGQALSSAISGLGKAVLPYLLVEESIEAGKAEILEGPDEGRRAY
WLVAPLPQWRQKKVKALIAFLTS

Sequences:

>Translated_263_residues
MKRTHLPLNALRVYDAAARHLSFTRAADELAVTPAAVGQQIRALEDHLGTVLFRRTSKGLELTEEGASGLDALREGFLKF
EESVQNMQAGQASDRYTIAAPREFYAQWLAPRLAAFREQSPGVHYSLVENENADFTEANLDVAIRLVDGPGDLEGVELAP
ARRVVVAEPGYEGDDWIDWPGAPLPEGVKATVQVGNAGQALSSAISGLGKAVLPYLLVEESIEAGKAEILEGPDEGRRAY
WLVAPLPQWRQKKVKALIAFLTS
>Mature_263_residues
MKRTHLPLNALRVYDAAARHLSFTRAADELAVTPAAVGQQIRALEDHLGTVLFRRTSKGLELTEEGASGLDALREGFLKF
EESVQNMQAGQASDRYTIAAPREFYAQWLAPRLAAFREQSPGVHYSLVENENADFTEANLDVAIRLVDGPGDLEGVELAP
ARRVVVAEPGYEGDDWIDWPGAPLPEGVKATVQVGNAGQALSSAISGLGKAVLPYLLVEESIEAGKAEILEGPDEGRRAY
WLVAPLPQWRQKKVKALIAFLTS

Specific function: Positive regulator of the expression of the gene (blaB) for beta-lactamase [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=154, Percent_Identity=45.4545454545455, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786448, Length=247, Percent_Identity=27.9352226720648, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1788706, Length=145, Percent_Identity=31.7241379310345, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1786401, Length=186, Percent_Identity=30.6451612903226, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI145693193, Length=291, Percent_Identity=24.7422680412371, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 28599; Mature: 28599

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTHLPLNALRVYDAAARHLSFTRAADELAVTPAAVGQQIRALEDHLGTVLFRRTSKGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
ELTEEGASGLDALREGFLKFEESVQNMQAGQASDRYTIAAPREFYAQWLAPRLAAFREQS
EECHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCC
PGVHYSLVENENADFTEANLDVAIRLVDGPGDLEGVELAPARRVVVAEPGYEGDDWIDWP
CCEEEEEEECCCCCCEECCCEEEEEEECCCCCCCCEEECCCCEEEEECCCCCCCCCCCCC
GAPLPEGVKATVQVGNAGQALSSAISGLGKAVLPYLLVEESIEAGKAEILEGPDEGRRAY
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEE
WLVAPLPQWRQKKVKALIAFLTS
EEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRTHLPLNALRVYDAAARHLSFTRAADELAVTPAAVGQQIRALEDHLGTVLFRRTSKGL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
ELTEEGASGLDALREGFLKFEESVQNMQAGQASDRYTIAAPREFYAQWLAPRLAAFREQS
EECHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCC
PGVHYSLVENENADFTEANLDVAIRLVDGPGDLEGVELAPARRVVVAEPGYEGDDWIDWP
CCEEEEEEECCCCCCEECCCEEEEEEECCCCCCCCEEECCCCEEEEECCCCCCCCCCCCC
GAPLPEGVKATVQVGNAGQALSSAISGLGKAVLPYLLVEESIEAGKAEILEGPDEGRRAY
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCEEE
WLVAPLPQWRQKKVKALIAFLTS
EEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7957242 [H]