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The map label for this gene is sdhA

Identifier: 85374258

GI number: 85374258

Start: 1481179

End: 1483011

Strand: Reverse

Name: sdhA

Synonym: ELI_07155

Alternate gene names: 85374258

Gene position: 1483011-1481179 (Counterclockwise)

Preceding gene: 85374259

Following gene: 85374257

Centisome position: 48.59

GC content: 64.05

Gene sequence:

>1833_bases
ATGGCGACCGACACTAACGCTGCCCCCGCTTACCAGATTATCGACCACACCTTCGATGTCGTCGTCGTCGGCGCAGGCGG
CTCGGGCCTGCGCGCCACCATGGGTGCCGCCGAGGCCGGGCTGAAAACCGCCAATATCTCCAAGGTCTTTCCGACCCGCT
CGCACACCGTCGCGGCTCAGGGCGGCATCGCCGCATCGCTCGGCAACAACACGCCCGATCATTGGTCGTGGCACATGTAC
GACACCGTGAAGGGTGCCGACTGGCTGGGCGACCAGGACGCGATCGAATATCTGGCGCGCGAGGCTCCGGCCGCGGTTTA
TGAGCTCGAACACGCAGGCGTACCCTTCAGCCGCAACGAAGATGGGACGATTTACCAGCGCCCGTTCGGCGGCCACATGC
AGAACATGGGCGAAGGCCCGCCGGTCCAGCGCACCTGCGCCGCGGCCGACCGCACCGGCCACGCCATGCTGCACGCGCTC
TACCAGCAGAGCCTCAAGTATGACGCGGATTTCTTCATCGAGTATTTCGCGCTCGACCTGATCATGGAAGATACGCCCGA
GGGCAAGAAATGCCGCGGCGTGATCGCGATGTGCCTGGATGACGGTACGATCCACCGTTTCAAGGCGCATGCCGTGGTGC
TGGCGACCGGCGGTTATGGCCGGTGCTATTACACCGCGACCAGCGCGCACACCTGCACCGGCGATGGCGGCGGCATGGTG
CTGCGCGCCGGCTTGCCGTTGCAGGACATGGAATTCGTCCAGTTCCACCCGACCGGCATCTACGGAGCGGGCGTGCTCAT
CACCGAAGGCGCACGCGGCGAGGGCGGGTATCTCACCAATTCCGAAGGCGAGCGCTTCATGGAGCGCTATGCGCCGAGCG
CGAAGGACCTTGCCTCGCGCGATGTCGTCAGCCGTTCGATGGCGCTGGAAATGCGCGAAGGGCGCGGCGTCGGCGAAGAT
GGCGATCACATCTACCTGCACCTCGATCACATCGATCCCAAGGTGCTGGCCGAGCGCCTGCCGGGCATTACCGAGAGCGG
CAAGATCTTTGCCGGTGTCGATTTGACGCGCCAGCCGCTGCCGGTGACGCCGACCGTCCACTACAACATGGGCGGGATTC
CCTGTAATTATCACGGGCAAGTCGTGGCCGGTAAGGCGGGCGATCCCGATGCCGTCGTGCCGGGGCTTTATGCGGTCGGC
GAAGCGGCCTGTGTCAGCGTCCATGGCGCCAACCGCCTGGGTTCCAATTCGCTGATCGACCTGGTGGTGTTCGGCCGCGC
AACCGGCCTGCACCTGAAGGAAAACTTGAAGCCCAATGCTGCGCATGACGCGCTGCCTTCGGACAGTGCGGAACTGGCGC
TCGCCCGCGTCGATCACTTCCGCCACGCCAAGGGTGGCACGCCGACCGCGAAGATTCGCGAGAACATGCAGAAGGGCATG
CAGAAGCACGCCGCCGTGTTCCGCGACAGCAAGCTGCTGAGTGAAGGCGTCGAACTGCTGGCCGAGGTCAACAAGAGCAT
GGAGGACATCGCTGTCTCCGACCGCTCGCTGATCTGGAACAGCGACCTGATCGAAACGCTCGAGCTCGACAACCTGATGG
CCCAAGCCAATGTCACCATCGCCAGCGCGGAAAACCGCAAGGAGAGCCGCGGCGCACATGCGCACGAGGATTTCCCCGAG
CGCGACGACAAGGAATGGATGAAGCACACCATCACTTGGTTCGACGGCTGGGGCGGAAGCGGCGGCGCGATGCGGATCGA
TTATCGCCCGGTGCACGAATATACGCTCACCGACGACGCCGAGTATATCGAACCGAAAAAGCGGGTGTACTGA

Upstream 100 bases:

>100_bases
TCAAATTCGCCGCACTCGCGGCGCTCAACCTTGCTGCGGTCGCAGGCGGTGTCTTCGGCATCTTCTGCATCGCCCGTCTT
GCTCTTGGAGGTGTTGCCTG

Downstream 100 bases:

>100_bases
TTGGATATAGCTAAAAAGGGACAGGTTATGAACATCGGTACGTCAAAATCGAAACTGGTTGTGGTAGCCGCTCTGACAAT
CGCACTTTCCGGTTGTTTTG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MATDTNAAPAYQIIDHTFDVVVVGAGGSGLRATMGAAEAGLKTANISKVFPTRSHTVAAQGGIAASLGNNTPDHWSWHMY
DTVKGADWLGDQDAIEYLAREAPAAVYELEHAGVPFSRNEDGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHAL
YQQSLKYDADFFIEYFALDLIMEDTPEGKKCRGVIAMCLDDGTIHRFKAHAVVLATGGYGRCYYTATSAHTCTGDGGGMV
LRAGLPLQDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMALEMREGRGVGED
GDHIYLHLDHIDPKVLAERLPGITESGKIFAGVDLTRQPLPVTPTVHYNMGGIPCNYHGQVVAGKAGDPDAVVPGLYAVG
EAACVSVHGANRLGSNSLIDLVVFGRATGLHLKENLKPNAAHDALPSDSAELALARVDHFRHAKGGTPTAKIRENMQKGM
QKHAAVFRDSKLLSEGVELLAEVNKSMEDIAVSDRSLIWNSDLIETLELDNLMAQANVTIASAENRKESRGAHAHEDFPE
RDDKEWMKHTITWFDGWGGSGGAMRIDYRPVHEYTLTDDAEYIEPKKRVY

Sequences:

>Translated_610_residues
MATDTNAAPAYQIIDHTFDVVVVGAGGSGLRATMGAAEAGLKTANISKVFPTRSHTVAAQGGIAASLGNNTPDHWSWHMY
DTVKGADWLGDQDAIEYLAREAPAAVYELEHAGVPFSRNEDGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHAL
YQQSLKYDADFFIEYFALDLIMEDTPEGKKCRGVIAMCLDDGTIHRFKAHAVVLATGGYGRCYYTATSAHTCTGDGGGMV
LRAGLPLQDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMALEMREGRGVGED
GDHIYLHLDHIDPKVLAERLPGITESGKIFAGVDLTRQPLPVTPTVHYNMGGIPCNYHGQVVAGKAGDPDAVVPGLYAVG
EAACVSVHGANRLGSNSLIDLVVFGRATGLHLKENLKPNAAHDALPSDSAELALARVDHFRHAKGGTPTAKIRENMQKGM
QKHAAVFRDSKLLSEGVELLAEVNKSMEDIAVSDRSLIWNSDLIETLELDNLMAQANVTIASAENRKESRGAHAHEDFPE
RDDKEWMKHTITWFDGWGGSGGAMRIDYRPVHEYTLTDDAEYIEPKKRVY
>Mature_609_residues
ATDTNAAPAYQIIDHTFDVVVVGAGGSGLRATMGAAEAGLKTANISKVFPTRSHTVAAQGGIAASLGNNTPDHWSWHMYD
TVKGADWLGDQDAIEYLAREAPAAVYELEHAGVPFSRNEDGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALY
QQSLKYDADFFIEYFALDLIMEDTPEGKKCRGVIAMCLDDGTIHRFKAHAVVLATGGYGRCYYTATSAHTCTGDGGGMVL
RAGLPLQDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMALEMREGRGVGEDG
DHIYLHLDHIDPKVLAERLPGITESGKIFAGVDLTRQPLPVTPTVHYNMGGIPCNYHGQVVAGKAGDPDAVVPGLYAVGE
AACVSVHGANRLGSNSLIDLVVFGRATGLHLKENLKPNAAHDALPSDSAELALARVDHFRHAKGGTPTAKIRENMQKGMQ
KHAAVFRDSKLLSEGVELLAEVNKSMEDIAVSDRSLIWNSDLIETLELDNLMAQANVTIASAENRKESRGAHAHEDFPER
DDKEWMKHTITWFDGWGGSGGAMRIDYRPVHEYTLTDDAEYIEPKKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=618, Percent_Identity=57.6051779935275, Blast_Score=701, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=556, Percent_Identity=55.0359712230216, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1790597, Length=586, Percent_Identity=40.6143344709898, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1788928, Length=562, Percent_Identity=29.8932384341637, Blast_Score=207, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17550100, Length=618, Percent_Identity=58.7378640776699, Blast_Score=712, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=629, Percent_Identity=55.9618441971383, Blast_Score=692, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=602, Percent_Identity=60.4651162790698, Blast_Score=743, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=612, Percent_Identity=59.8039215686275, Blast_Score=731, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=617, Percent_Identity=59.967585089141, Blast_Score=741, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=617, Percent_Identity=59.967585089141, Blast_Score=741, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=617, Percent_Identity=59.967585089141, Blast_Score=741, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=626, Percent_Identity=52.8753993610224, Blast_Score=649, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66137; Mature: 66006

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDTNAAPAYQIIDHTFDVVVVGAGGSGLRATMGAAEAGLKTANISKVFPTRSHTVAAQ
CCCCCCCCCHHHHHCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCHHCCCCCCCEEEEC
GGIAASLGNNTPDHWSWHMYDTVKGADWLGDQDAIEYLAREAPAAVYELEHAGVPFSRNE
CCEEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCCCCCCC
DGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQSLKYDADFFIEYFALDL
CCEEEECCCCCHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
IMEDTPEGKKCRGVIAMCLDDGTIHRFKAHAVVLATGGYGRCYYTATSAHTCTGDGGGMV
HHCCCCCCCHHCEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEEECCCCEEECCCCCEE
LRAGLPLQDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASR
EECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHH
DVVSRSMALEMREGRGVGEDGDHIYLHLDHIDPKVLAERLPGITESGKIFAGVDLTRQPL
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCCCCC
PVTPTVHYNMGGIPCNYHGQVVAGKAGDPDAVVPGLYAVGEAACVSVHGANRLGSNSLID
CCCCEEEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCEEEEEEECCCCCCCCCEEE
LVVFGRATGLHLKENLKPNAAHDALPSDSAELALARVDHFRHAKGGTPTAKIRENMQKGM
EEEECCCCCCEECCCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QKHAAVFRDSKLLSEGVELLAEVNKSMEDIAVSDRSLIWNSDLIETLELDNLMAQANVTI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEECCHHHHHHHHHHHHHHCCEEE
ASAENRKESRGAHAHEDFPERDDKEWMKHTITWFDGWGGSGGAMRIDYRPVHEYTLTDDA
EECCCCHHHCCCCCCCCCCCCCHHHHHHHEEEEEECCCCCCCEEEEEEEECCCEEECCCH
EYIEPKKRVY
HHCCCHHCCC
>Mature Secondary Structure 
ATDTNAAPAYQIIDHTFDVVVVGAGGSGLRATMGAAEAGLKTANISKVFPTRSHTVAAQ
CCCCCCCCHHHHHCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCHHCCCCCCCEEEEC
GGIAASLGNNTPDHWSWHMYDTVKGADWLGDQDAIEYLAREAPAAVYELEHAGVPFSRNE
CCEEEECCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCHHEEEHHHCCCCCCCCC
DGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQSLKYDADFFIEYFALDL
CCEEEECCCCCHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
IMEDTPEGKKCRGVIAMCLDDGTIHRFKAHAVVLATGGYGRCYYTATSAHTCTGDGGGMV
HHCCCCCCCHHCEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEEECCCCEEECCCCCEE
LRAGLPLQDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASR
EECCCCCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHH
DVVSRSMALEMREGRGVGEDGDHIYLHLDHIDPKVLAERLPGITESGKIFAGVDLTRQPL
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCCCCC
PVTPTVHYNMGGIPCNYHGQVVAGKAGDPDAVVPGLYAVGEAACVSVHGANRLGSNSLID
CCCCEEEECCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCEEEEEEECCCCCCCCCEEE
LVVFGRATGLHLKENLKPNAAHDALPSDSAELALARVDHFRHAKGGTPTAKIRENMQKGM
EEEECCCCCCEECCCCCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
QKHAAVFRDSKLLSEGVELLAEVNKSMEDIAVSDRSLIWNSDLIETLELDNLMAQANVTI
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEECCHHHHHHHHHHHHHHCCEEE
ASAENRKESRGAHAHEDFPERDDKEWMKHTITWFDGWGGSGGAMRIDYRPVHEYTLTDDA
EECCCCHHHCCCCCCCCCCCCCHHHHHHHEEEEEECCCCCCCEEEEEEEECCCEEECCCH
EYIEPKKRVY
HHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA