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The map label for this gene is lysA [H]

Identifier: 85374200

GI number: 85374200

Start: 1424020

End: 1425282

Strand: Reverse

Name: lysA [H]

Synonym: ELI_06865

Alternate gene names: 85374200

Gene position: 1425282-1424020 (Counterclockwise)

Preceding gene: 85374201

Following gene: 85374199

Centisome position: 46.69

GC content: 63.9

Gene sequence:

>1263_bases
ATGAGCAGCGCTGCCGCAGAGACGGAAAAGCCGCCTGGCAAGCCGCTGGGGCCGATACCGGAGAATTTCGAGGCACAGGA
CGGCGAGTTGGCAATCGGCGGCAAAACCGCCACGCAATTGGTTGAAGAAGCAGGCGGAACGCCTCTCTTCGTGTATTCGC
GCGACATTATCGCGGGGACCATGCGGCACCTGCGCGAGGCGATGCCGGAGCGGCTGCACATCAACTATGCGATCAAGGCC
AATTCGCATCCCGAGGTTCTCGCTTTCATGGCCGATCTCGTCGAGGGCTACGATATCGCCTCCGGCGGCGAGCTCGAGAA
GATCCAGGCCGCCGGGATCGATACCAGGCGGGTCAGCTTTGCCGGTCCCGGCAAGCGCGATCGCGAGCTAGAGGCGGCCA
TTGAGGCGGGCGTAACTCTCAATCTCGAATCCGAAGGCGAAGCGCGCCGCGCGCTGGAGATCGCGGAGCGGCTCGGCCAA
ACGCCGCGCCTGGCGATCCGCGTCAATCCGGACTTCGATATGAAGGGTTCGGGCATGAAGATGGGCGGGGGTGCCAAACC
CTTCGGCATCGACGCCGAGCGCGTACCTGCGCTGGGTAGCGAGATCATTGCAGCCGGCGGCGAGTGGCGGGGCTTGCACA
TCTACACCGGCAGCCAGGCGCTTTCAGCTGAAGCAATCATTGAAACCCAAGCCAATGTCCTTGCGTTGGCGGACAAGATC
GCCAGCGAAATGGGCGAAGCGCTGCCAAAGCTCAATATGGGCGGCGGGTTTGGCATTCCCTATTTTCATGGCGACGAGCC
GCTCGATATCGAAGCCATTGGCTCCGCCTTGGAAGAGCGCTTCGGCGACCTGCCGGAAACACTGGCCGATGCGCACCTGT
GCATCGAACTCGGCCGCTACCTGGTCGGGCTGGCCGGCGTGTATCTGTGCCGGATCGTCGACCGCAAGGTGAGCCACGGC
GAGACATTCCTCGTCACCGATGGCGGATTGCATCACCAGCTCGCAGCTTCCGGCAACTTCGGCACGGTCGTCCGCCGCAA
CTATCCCGCCGCCATCGCAACGCGCTTCGACGCGCCCCCGGTAGAGGTCCAGCACGTGGTCGGATGCCTTTGCACCCCGC
TCGATAGGCTTTCGGACAAGGCATTTCTTCCGCGCGCCGATGTCGGCGACATCGTCGCCATTTTCTGCGCCGGAGCCTAC
GGCGCGAGCGCCTCTCCGGCGGAATTCCTGGGCCAGGGCCCTGCGCGCGAAGTGCTGGTTTAG

Upstream 100 bases:

>100_bases
CCAATTTCATGTTGCCGCAGAAGGTCCATTGGCGCGAGACCCTGCCGCTCAATCCAAACGGCAAGCTTGACCGTACCGCG
ATCGCGCGCGAGATCGGGGC

Downstream 100 bases:

>100_bases
GTAACCGCGCGCTTAACCTTTACGCGCGCCCTGTCCCGTTTCGGGAACGCCCCTAAGATCCTGAAGAAAGCTAACGGGAT
ATTCACCCTTTTTGGCGAGA

Product: ornithine/diaminopimelate/arginine decarboxylase,family protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSSAAAETEKPPGKPLGPIPENFEAQDGELAIGGKTATQLVEEAGGTPLFVYSRDIIAGTMRHLREAMPERLHINYAIKA
NSHPEVLAFMADLVEGYDIASGGELEKIQAAGIDTRRVSFAGPGKRDRELEAAIEAGVTLNLESEGEARRALEIAERLGQ
TPRLAIRVNPDFDMKGSGMKMGGGAKPFGIDAERVPALGSEIIAAGGEWRGLHIYTGSQALSAEAIIETQANVLALADKI
ASEMGEALPKLNMGGGFGIPYFHGDEPLDIEAIGSALEERFGDLPETLADAHLCIELGRYLVGLAGVYLCRIVDRKVSHG
ETFLVTDGGLHHQLAASGNFGTVVRRNYPAAIATRFDAPPVEVQHVVGCLCTPLDRLSDKAFLPRADVGDIVAIFCAGAY
GASASPAEFLGQGPAREVLV

Sequences:

>Translated_420_residues
MSSAAAETEKPPGKPLGPIPENFEAQDGELAIGGKTATQLVEEAGGTPLFVYSRDIIAGTMRHLREAMPERLHINYAIKA
NSHPEVLAFMADLVEGYDIASGGELEKIQAAGIDTRRVSFAGPGKRDRELEAAIEAGVTLNLESEGEARRALEIAERLGQ
TPRLAIRVNPDFDMKGSGMKMGGGAKPFGIDAERVPALGSEIIAAGGEWRGLHIYTGSQALSAEAIIETQANVLALADKI
ASEMGEALPKLNMGGGFGIPYFHGDEPLDIEAIGSALEERFGDLPETLADAHLCIELGRYLVGLAGVYLCRIVDRKVSHG
ETFLVTDGGLHHQLAASGNFGTVVRRNYPAAIATRFDAPPVEVQHVVGCLCTPLDRLSDKAFLPRADVGDIVAIFCAGAY
GASASPAEFLGQGPAREVLV
>Mature_419_residues
SSAAAETEKPPGKPLGPIPENFEAQDGELAIGGKTATQLVEEAGGTPLFVYSRDIIAGTMRHLREAMPERLHINYAIKAN
SHPEVLAFMADLVEGYDIASGGELEKIQAAGIDTRRVSFAGPGKRDRELEAAIEAGVTLNLESEGEARRALEIAERLGQT
PRLAIRVNPDFDMKGSGMKMGGGAKPFGIDAERVPALGSEIIAAGGEWRGLHIYTGSQALSAEAIIETQANVLALADKIA
SEMGEALPKLNMGGGFGIPYFHGDEPLDIEAIGSALEERFGDLPETLADAHLCIELGRYLVGLAGVYLCRIVDRKVSHGE
TFLVTDGGLHHQLAASGNFGTVVRRNYPAAIATRFDAPPVEVQHVVGCLCTPLDRLSDKAFLPRADVGDIVAIFCAGAYG
ASASPAEFLGQGPAREVLV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=396, Percent_Identity=22.979797979798, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1789203, Length=376, Percent_Identity=26.063829787234, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322664, Length=263, Percent_Identity=24.3346007604563, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24586472, Length=353, Percent_Identity=23.5127478753541, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586474, Length=362, Percent_Identity=26.5193370165746, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44404; Mature: 44273

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAAAETEKPPGKPLGPIPENFEAQDGELAIGGKTATQLVEEAGGTPLFVYSRDIIAGT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCCEEEEEECHHHHHH
MRHLREAMPERLHINYAIKANSHPEVLAFMADLVEGYDIASGGELEKIQAAGIDTRRVSF
HHHHHHHCCHHEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEE
AGPGKRDRELEAAIEAGVTLNLESEGEARRALEIAERLGQTPRLAIRVNPDFDMKGSGMK
CCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEE
MGGGAKPFGIDAERVPALGSEIIAAGGEWRGLHIYTGSQALSAEAIIETQANVLALADKI
CCCCCCCCCCCHHHHCCCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
ASEMGEALPKLNMGGGFGIPYFHGDEPLDIEAIGSALEERFGDLPETLADAHLCIELGRY
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVGLAGVYLCRIVDRKVSHGETFLVTDGGLHHQLAASGNFGTVVRRNYPAAIATRFDAPP
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCCEEEECCCCCCEEECCCCCC
VEVQHVVGCLCTPLDRLSDKAFLPRADVGDIVAIFCAGAYGASASPAEFLGQGPAREVLV
HHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHCCC
>Mature Secondary Structure 
SSAAAETEKPPGKPLGPIPENFEAQDGELAIGGKTATQLVEEAGGTPLFVYSRDIIAGT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHCCCCEEEEEECHHHHHH
MRHLREAMPERLHINYAIKANSHPEVLAFMADLVEGYDIASGGELEKIQAAGIDTRRVSF
HHHHHHHCCHHEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEE
AGPGKRDRELEAAIEAGVTLNLESEGEARRALEIAERLGQTPRLAIRVNPDFDMKGSGMK
CCCCCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEE
MGGGAKPFGIDAERVPALGSEIIAAGGEWRGLHIYTGSQALSAEAIIETQANVLALADKI
CCCCCCCCCCCHHHHCCCCHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
ASEMGEALPKLNMGGGFGIPYFHGDEPLDIEAIGSALEERFGDLPETLADAHLCIELGRY
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVGLAGVYLCRIVDRKVSHGETFLVTDGGLHHQLAASGNFGTVVRRNYPAAIATRFDAPP
HHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCCEEEECCCCCCEEECCCCCC
VEVQHVVGCLCTPLDRLSDKAFLPRADVGDIVAIFCAGAYGASASPAEFLGQGPAREVLV
HHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]