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The map label for this gene is fabB [H]

Identifier: 85374175

GI number: 85374175

Start: 1394192

End: 1395397

Strand: Reverse

Name: fabB [H]

Synonym: ELI_06740

Alternate gene names: 85374175

Gene position: 1395397-1394192 (Counterclockwise)

Preceding gene: 85374176

Following gene: 85374174

Centisome position: 45.71

GC content: 64.51

Gene sequence:

>1206_bases
TTGGGGATCGTCTCCTCGATCGGCAACAATGCAGATGAGGTGCTCGCCGCGCTGAAAGCGGGCAAGTCGGGCATTTCCTT
CAACGAAGAGATGGCCGAGCATGGCTTCCGCTCGCAGATTGCCGGAGCGGTCGATCTCGACGTGGCGGAGCATGTCGACA
AGCGCACGCTGCGCTTCATGGGGCCGGGCGCGGCCTATTCCTATATCGCCATGGGCCAGGCCATCGCCGATGCCGGGCTG
GAGCAGAAGGACGTCGTCAATCCGATGACCGGTGTGATCGCCGGATCGGGCGGGCCATCGACCTCGGCCATGCTCGCTGC
GCACCAGACGGTGCTCAAAACCGGCGCGACCAAGCGCATCGGGCCGTTCGCGGTGCCGAAATGCATGTCCTCCACGATCA
GTGCCAACCTCGCGACCGCTTACCAGATCAAGGGCATGAACTTCTCGATCACCTCGGCCTGTTCGACCTCGCTGCATTGC
ATCGGCATGGCTGCGCAGCAGATTGCGCTGGGCCAGCAGGACGTGATGTTCGGCGGCGGCGGCGAGGAGCTCGACTGGAC
GCTTTCCTGCCTGTTCGATGCAATGGGCGCGATGTCGAGCAAATATAACGATACGCCCGAGCGCGCATCCCGCGCCTTCG
ATGCCGATCGCGACGGTTTCGTGATCGGCGGCGGTGGCGCCATTCTGGTGCTGGAAGCGCTCGAACACGCGCAGGCGCGC
GGTGCGAAGATCTACGCCGAAGTCACCGGCTTCTGCGCCACCTCCGACGGGGCCGACATGGTCGCCCCGTCCGGCGAAGG
CGGCGAGCGAGCCATGTGCGGGGCGCTCGGAACGCTCGGCGACGATCGCACGGTCAGCTATATCAACGCGCACGGCACTT
CGACGCCGGTCGGCGATGTCGGCGAGATCGAAGCGGTGCGCCGGGTCTTCGGCGAAGGCTCGACGCCGCCGGTCAGCTCG
ACCAAATCGATGACCGGCCACAGCCAGGGCGCGACCGGAGCGCAGGAGGCGGTTTATTGCCTGCTGGCGCTGGAGAACGA
CTTCATCATCCCATCGATCAATGTCGAAACGCTCGATCCGGCGCTGAAGCCGGAAGAGATCGCGACCGAACTGGTCGAGG
ATGCGGGTCTTGACACGGTGATGACCAATTCGTTCGGCTTCGGCGGCACCAACGGCACTATGCTGCTGTCGAAGTTTCAC
GGCTAG

Upstream 100 bases:

>100_bases
GGGTCGAGGCCGACGGTGAAGTCATCTACCAGGTCAAAGACATGAAAGTGGCCCTTTCGGAGGCCTGAGGGGGATTATGC
GTCGCGTAGTAGTCACCGGA

Downstream 100 bases:

>100_bases
GAGGTAGGGATCATGGGCGCACTAGCGGGAAAACGCGGCCTGGTGATGGGCGTCGCCAACGAACGGTCGATCGCCTGGGG
CATCGCCAAGGCCTGCGCCG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MGIVSSIGNNADEVLAALKAGKSGISFNEEMAEHGFRSQIAGAVDLDVAEHVDKRTLRFMGPGAAYSYIAMGQAIADAGL
EQKDVVNPMTGVIAGSGGPSTSAMLAAHQTVLKTGATKRIGPFAVPKCMSSTISANLATAYQIKGMNFSITSACSTSLHC
IGMAAQQIALGQQDVMFGGGGEELDWTLSCLFDAMGAMSSKYNDTPERASRAFDADRDGFVIGGGGAILVLEALEHAQAR
GAKIYAEVTGFCATSDGADMVAPSGEGGERAMCGALGTLGDDRTVSYINAHGTSTPVGDVGEIEAVRRVFGEGSTPPVSS
TKSMTGHSQGATGAQEAVYCLLALENDFIIPSINVETLDPALKPEEIATELVEDAGLDTVMTNSFGFGGTNGTMLLSKFH
G

Sequences:

>Translated_401_residues
MGIVSSIGNNADEVLAALKAGKSGISFNEEMAEHGFRSQIAGAVDLDVAEHVDKRTLRFMGPGAAYSYIAMGQAIADAGL
EQKDVVNPMTGVIAGSGGPSTSAMLAAHQTVLKTGATKRIGPFAVPKCMSSTISANLATAYQIKGMNFSITSACSTSLHC
IGMAAQQIALGQQDVMFGGGGEELDWTLSCLFDAMGAMSSKYNDTPERASRAFDADRDGFVIGGGGAILVLEALEHAQAR
GAKIYAEVTGFCATSDGADMVAPSGEGGERAMCGALGTLGDDRTVSYINAHGTSTPVGDVGEIEAVRRVFGEGSTPPVSS
TKSMTGHSQGATGAQEAVYCLLALENDFIIPSINVETLDPALKPEEIATELVEDAGLDTVMTNSFGFGGTNGTMLLSKFH
G
>Mature_400_residues
GIVSSIGNNADEVLAALKAGKSGISFNEEMAEHGFRSQIAGAVDLDVAEHVDKRTLRFMGPGAAYSYIAMGQAIADAGLE
QKDVVNPMTGVIAGSGGPSTSAMLAAHQTVLKTGATKRIGPFAVPKCMSSTISANLATAYQIKGMNFSITSACSTSLHCI
GMAAQQIALGQQDVMFGGGGEELDWTLSCLFDAMGAMSSKYNDTPERASRAFDADRDGFVIGGGGAILVLEALEHAQARG
AKIYAEVTGFCATSDGADMVAPSGEGGERAMCGALGTLGDDRTVSYINAHGTSTPVGDVGEIEAVRRVFGEGSTPPVSST
KSMTGHSQGATGAQEAVYCLLALENDFIIPSINVETLDPALKPEEIATELVEDAGLDTVMTNSFGFGGTNGTMLLSKFHG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=298, Percent_Identity=39.9328859060403, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI223972627, Length=177, Percent_Identity=38.9830508474576, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI41872631, Length=336, Percent_Identity=27.9761904761905, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1788663, Length=400, Percent_Identity=55.5, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1787337, Length=406, Percent_Identity=38.6699507389163, Blast_Score=251, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=31.9612590799031, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=37.8378378378378, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI212642053, Length=359, Percent_Identity=28.4122562674095, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=276, Percent_Identity=26.0869565217391, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=29.2792792792793, Blast_Score=162, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24644341, Length=411, Percent_Identity=35.7664233576642, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI19920632, Length=338, Percent_Identity=26.6272189349112, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI221330659, Length=338, Percent_Identity=26.6272189349112, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24581345, Length=383, Percent_Identity=24.2819843342037, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 41248; Mature: 41117

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIVSSIGNNADEVLAALKAGKSGISFNEEMAEHGFRSQIAGAVDLDVAEHVDKRTLRFM
CCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHCCCEECHHHHHHHHHHHHEE
GPGAAYSYIAMGQAIADAGLEQKDVVNPMTGVIAGSGGPSTSAMLAAHQTVLKTGATKRI
CCCCHHHHHHHHHHHHHCCCCHHHHCCCHHHEEECCCCCCHHHHHHHHHHHHHCCCCCCC
GPFAVPKCMSSTISANLATAYQIKGMNFSITSACSTSLHCIGMAAQQIALGQQDVMFGGG
CCCHHHHHHHHHHHCCCEEEEEECCCCEEEHHHHCCCHHHHHHHHHHHHCCCCCEEECCC
GEELDWTLSCLFDAMGAMSSKYNDTPERASRAFDADRDGFVIGGGGAILVLEALEHAQAR
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHC
GAKIYAEVTGFCATSDGADMVAPSGEGGERAMCGALGTLGDDRTVSYINAHGTSTPVGDV
CCEEEEEEEEEEECCCCCCEECCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
GEIEAVRRVFGEGSTPPVSSTKSMTGHSQGATGAQEAVYCLLALENDFIIPSINVETLDP
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCEEECCCCHHHCCC
ALKPEEIATELVEDAGLDTVMTNSFGFGGTNGTMLLSKFHG
CCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCC
>Mature Secondary Structure 
GIVSSIGNNADEVLAALKAGKSGISFNEEMAEHGFRSQIAGAVDLDVAEHVDKRTLRFM
CCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHCCCEECHHHHHHHHHHHHEE
GPGAAYSYIAMGQAIADAGLEQKDVVNPMTGVIAGSGGPSTSAMLAAHQTVLKTGATKRI
CCCCHHHHHHHHHHHHHCCCCHHHHCCCHHHEEECCCCCCHHHHHHHHHHHHHCCCCCCC
GPFAVPKCMSSTISANLATAYQIKGMNFSITSACSTSLHCIGMAAQQIALGQQDVMFGGG
CCCHHHHHHHHHHHCCCEEEEEECCCCEEEHHHHCCCHHHHHHHHHHHHCCCCCEEECCC
GEELDWTLSCLFDAMGAMSSKYNDTPERASRAFDADRDGFVIGGGGAILVLEALEHAQAR
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHC
GAKIYAEVTGFCATSDGADMVAPSGEGGERAMCGALGTLGDDRTVSYINAHGTSTPVGDV
CCEEEEEEEEEEECCCCCCEECCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCC
GEIEAVRRVFGEGSTPPVSSTKSMTGHSQGATGAQEAVYCLLALENDFIIPSINVETLDP
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCEEECCCCHHHCCC
ALKPEEIATELVEDAGLDTVMTNSFGFGGTNGTMLLSKFHG
CCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]