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The map label for this gene is nuoF1 [H]

Identifier: 85374157

GI number: 85374157

Start: 1380429

End: 1381721

Strand: Reverse

Name: nuoF1 [H]

Synonym: ELI_06650

Alternate gene names: 85374157

Gene position: 1381721-1380429 (Counterclockwise)

Preceding gene: 85374158

Following gene: 85374156

Centisome position: 45.27

GC content: 63.65

Gene sequence:

>1293_bases
ATGCTGGCTGACAAGGACCGCATCTTCACCAACGTCTACGGTTTCCAGGACTGGGGGCTGAAGGCTGCGCAGGCGCGCGG
GGACTGGGACGATACCAAGGCCCTGATCGCGCGCGGCGAAGAGAATATCATCGAAGAGATCAAGACCTCCGGCCTGCGCG
GGCGGGGCGGGGCGGGCTTCCCGACCGGCCTCAAATGGTCGTTTATGCCGAAAGAATCGAAAGACGGTCGCCCGAGCTTC
CTCGTGATCAATGCCGACGAATCCGAACCCGGTTCGTGCAAGGACCGCGAGATCATCCGCCACGATCCGCACAAGCTGAT
CGAAGGCGCACTCGTCGCCGGTTTCGCGATGCGCGCGCGCGCCGCCTATATCTACATCCGCGGCGAGTATATCCGCGAGG
CCGAGACGCTGCAGGCGGCCATCGACGAGGCTTATGACGCGGGCCTGATCGGCAAGAATGCCAGCGGCTCGGGTTTCGAT
TACGATGTCTTCCTGCACCGCGGCGCGGGCGCCTATATCTGCGGCGAAGAAACCGCGATGATCGAGAGCCTGGAAGGCAA
AAAGGGCCAGCCCCGCCTGAAGCCGCCATTCCCGGCCGGCGCGGGCCTCTATGGCTGCCCGACCACTGTCAACAATGTCG
AGAGCATCGCGGTCGTGCCGACGATCCTGCGGCGCGGCGGCAACTGGTTCGCGAGCTTCGGGCGCGAAAACAATCACGGC
ACCAAGCTCTTCCAGATCAGCGGTCATGTCGAAAAGCCCTGCGTCGTCGAAGAAGCGATGAGCATTCCCTTCGAGGAGCT
GATCGAAAAGCATTGCGGCGGCATTACCGGCGGGTGGGACAATCTGCTGGCGGTGATCCCTGGCGGCAGCTCGGTGCCGC
TCGTCCCCGCCGAGCAGATCCGCCAAGCGCCGATGGATTTCGACGGGCTGAAAGACGTCGGCTCCGGCCTCGGCACGGCG
GCGGTGATCGTGATGGACAAGTCGACCGATATCGTCCGCGCGATCAGCCGCATCAGCTATTTCTACAAACATGAATCTTG
CGGCCAATGCACGCCCTGCCGCGAAGGCACCGGCTGGATGTGGCGCATGATGGAGCGCCTGCGCACCGGCGATGCGGCGA
TCGAGGAAATCGACATGCTGCAGCAAGTGACCAAGCAGGTCGAAGGCCACACCATCTGCGCGCTCGGCGATGCCGCGGCG
TGGCCGATCCAGGGCCTTATCCGCCACTTCCGCCCGGAACTGGAGCGCCGGATCGAAGAGCATAACACCAAATTCGCGGA
GGCTGCGGAATGA

Upstream 100 bases:

>100_bases
GGCAATCGCACCGCCGGTATCGCCATGCTGGCAATGGGCCTGATCTTTCAGGTGCTGTGCCTGCGGCAGCTGAGGGCGGG
AAACAGGAAGGATATCGACG

Downstream 100 bases:

>100_bases
AGTGGGTCGTCGCCCTTGCCGTCGCAGCGAGCCTTTTGGCTGGAGCAGCCCATGCGCAGCCCAAGAAGATGGAACGCAGC
GTCGAAAAGCAGCGTGAAGC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MLADKDRIFTNVYGFQDWGLKAAQARGDWDDTKALIARGEENIIEEIKTSGLRGRGGAGFPTGLKWSFMPKESKDGRPSF
LVINADESEPGSCKDREIIRHDPHKLIEGALVAGFAMRARAAYIYIRGEYIREAETLQAAIDEAYDAGLIGKNASGSGFD
YDVFLHRGAGAYICGEETAMIESLEGKKGQPRLKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGGNWFASFGRENNHG
TKLFQISGHVEKPCVVEEAMSIPFEELIEKHCGGITGGWDNLLAVIPGGSSVPLVPAEQIRQAPMDFDGLKDVGSGLGTA
AVIVMDKSTDIVRAISRISYFYKHESCGQCTPCREGTGWMWRMMERLRTGDAAIEEIDMLQQVTKQVEGHTICALGDAAA
WPIQGLIRHFRPELERRIEEHNTKFAEAAE

Sequences:

>Translated_430_residues
MLADKDRIFTNVYGFQDWGLKAAQARGDWDDTKALIARGEENIIEEIKTSGLRGRGGAGFPTGLKWSFMPKESKDGRPSF
LVINADESEPGSCKDREIIRHDPHKLIEGALVAGFAMRARAAYIYIRGEYIREAETLQAAIDEAYDAGLIGKNASGSGFD
YDVFLHRGAGAYICGEETAMIESLEGKKGQPRLKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGGNWFASFGRENNHG
TKLFQISGHVEKPCVVEEAMSIPFEELIEKHCGGITGGWDNLLAVIPGGSSVPLVPAEQIRQAPMDFDGLKDVGSGLGTA
AVIVMDKSTDIVRAISRISYFYKHESCGQCTPCREGTGWMWRMMERLRTGDAAIEEIDMLQQVTKQVEGHTICALGDAAA
WPIQGLIRHFRPELERRIEEHNTKFAEAAE
>Mature_430_residues
MLADKDRIFTNVYGFQDWGLKAAQARGDWDDTKALIARGEENIIEEIKTSGLRGRGGAGFPTGLKWSFMPKESKDGRPSF
LVINADESEPGSCKDREIIRHDPHKLIEGALVAGFAMRARAAYIYIRGEYIREAETLQAAIDEAYDAGLIGKNASGSGFD
YDVFLHRGAGAYICGEETAMIESLEGKKGQPRLKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGGNWFASFGRENNHG
TKLFQISGHVEKPCVVEEAMSIPFEELIEKHCGGITGGWDNLLAVIPGGSSVPLVPAEQIRQAPMDFDGLKDVGSGLGTA
AVIVMDKSTDIVRAISRISYFYKHESCGQCTPCREGTGWMWRMMERLRTGDAAIEEIDMLQQVTKQVEGHTICALGDAAA
WPIQGLIRHFRPELERRIEEHNTKFAEAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=418, Percent_Identity=71.0526315789474, Blast_Score=627, Evalue=1e-180,
Organism=Homo sapiens, GI260656005, Length=418, Percent_Identity=71.0526315789474, Blast_Score=626, Evalue=1e-179,
Organism=Escherichia coli, GI1788620, Length=390, Percent_Identity=43.3333333333333, Blast_Score=328, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17531727, Length=427, Percent_Identity=68.8524590163934, Blast_Score=623, Evalue=1e-179,
Organism=Drosophila melanogaster, GI19920794, Length=426, Percent_Identity=69.0140845070423, Blast_Score=637, Evalue=0.0,
Organism=Drosophila melanogaster, GI45550452, Length=429, Percent_Identity=66.8997668997669, Blast_Score=603, Evalue=1e-173,
Organism=Drosophila melanogaster, GI24653819, Length=429, Percent_Identity=47.3193473193473, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24653817, Length=429, Percent_Identity=44.0559440559441, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47138; Mature: 47138

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLADKDRIFTNVYGFQDWGLKAAQARGDWDDTKALIARGEENIIEEIKTSGLRGRGGAGF
CCCCCHHHHHHCCCCHHCCCHHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKESKDGRPSFLVINADESEPGSCKDREIIRHDPHKLIEGALVAGFAMRAR
CCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCE
AAYIYIRGEYIREAETLQAAIDEAYDAGLIGKNASGSGFDYDVFLHRGAGAYICGEETAM
EEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHH
IESLEGKKGQPRLKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGGNWFASFGRENNHG
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCC
TKLFQISGHVEKPCVVEEAMSIPFEELIEKHCGGITGGWDNLLAVIPGGSSVPLVPAEQI
CEEEEECCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHH
RQAPMDFDGLKDVGSGLGTAAVIVMDKSTDIVRAISRISYFYKHESCGQCTPCREGTGWM
HCCCCCCCHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
WRMMERLRTGDAAIEEIDMLQQVTKQVEGHTICALGDAAAWPIQGLIRHFRPELERRIEE
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
HNTKFAEAAE
HCCCHHHCCC
>Mature Secondary Structure
MLADKDRIFTNVYGFQDWGLKAAQARGDWDDTKALIARGEENIIEEIKTSGLRGRGGAGF
CCCCCHHHHHHCCCCHHCCCHHHHCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKESKDGRPSFLVINADESEPGSCKDREIIRHDPHKLIEGALVAGFAMRAR
CCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCE
AAYIYIRGEYIREAETLQAAIDEAYDAGLIGKNASGSGFDYDVFLHRGAGAYICGEETAM
EEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCEEEECCHHHH
IESLEGKKGQPRLKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGGNWFASFGRENNHG
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCC
TKLFQISGHVEKPCVVEEAMSIPFEELIEKHCGGITGGWDNLLAVIPGGSSVPLVPAEQI
CEEEEECCCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHH
RQAPMDFDGLKDVGSGLGTAAVIVMDKSTDIVRAISRISYFYKHESCGQCTPCREGTGWM
HCCCCCCCHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
WRMMERLRTGDAAIEEIDMLQQVTKQVEGHTICALGDAAAWPIQGLIRHFRPELERRIEE
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
HNTKFAEAAE
HCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]