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The map label for this gene is mutL

Identifier: 85373986

GI number: 85373986

Start: 1196815

End: 1198638

Strand: Direct

Name: mutL

Synonym: ELI_05795

Alternate gene names: 85373986

Gene position: 1196815-1198638 (Clockwise)

Preceding gene: 85373978

Following gene: 85373987

Centisome position: 39.21

GC content: 65.24

Gene sequence:

>1824_bases
ATGCCGACTATTCGCCGCCTTCCCGAAGCCCTCGTCAACCGTATTGCCGCGGGTGAAGTGGTAGAGCGTCCTTCGGCGGC
GCTCAAGGAACTGGTCGAGAATGCCGTCGATGCCGGTGCCACGCGGATTGCCGTTCACCTGATCGATGGCGGGCTGACGC
GGATCGAAGTCACCGACGATGGCTGCGGTATGGATCCGGCGGCGATGGAACTGGCGCTGGAGCGACACGCAACGTCCAAA
CTACCCGACGATTTGATCGGTGAGGCGCAGGCGATCGAACGGGTGGCGACGCTGGGTTTTCGGGGCGAGGCCCTGCCATC
GATCGGCAGCGTTTCGCGCTTTGCTCTGGAAAGCAGGCCGCACGGTTCGGAGCAGGGCTGGCGACGGGTCGTCGATCACG
GCACTTTGGTAGAGGAAGGTCCTGCCGCGCTTCCACCGGGAACGCGCGCCCGGATCGAACAGGTTTTCGCCAAGGTGCCC
GCACGGCGCAAGTTCCTGCGCACGCCGCGCAGCGAGTACGGCGCCTGTCTCGACGTCATCCGCCGCCTTGCCATGGCACG
GCCCGACATCGGCTTCACGCTCGATCATGGCGAACGACGGGTCTTCGCGCTGCAACCGGGTGAAGAACTGCCCGATCGCG
TCGCGCAAATCGTCGCGCCCGAGCTCAAGGACAATGCCGTGCTGCTCGACATGCAGCGCGATACGATGACGCTGACCGGG
ATCGCAGGCCTACCGACCTACAATCGCGGCGTTGCGGATCACCAGTACCTGTTCGTCAACGGGCGTCCGGTGAAGGATCG
CCTGCTGGTCGGCGCGGTGCGCGGGGCCTATTCGGACATGCTGGCGCGTGACCGGCATGCGGTGCTGGCGCTCTTCCTCG
ACCTGCCTTCCGAGGATGTCGATGTAAACGTTCACCCGGCCAAAACCGAAGTACGCTTCCGTGATGCTCAGGCCGTGCGC
GGGTTTATCGTATCGGGTCTGAGGCAAGCGCTCTCGACCGGCGACAGACGAAGCGCGCAGGGGCCGGACCGCACGGCGAT
GAAGCGCTGGCAGCAGGAGCCTGTCAGGGAAGAACCATCACCGGCGCTTCGCTCCATCTTCGAAGGCCGCGGCTGGAGCA
AGCCCGGCACAGGGGTCCGCGAACCCTCGCACGAATGGCACAGCCACGAAGGCGAGGTCATCGCTTCACCGCAGGGTAGG
GCGGTTGAAGCAGAAGACATCGCCGCGGATGCGAAACAGCATTTTCCGTTGGGTGTGGCGCGGGGGCAGGTCGCCAATAC
CTACATCGTGGCCGAGGCCGCGGACGGGCTGGTGCTGGTCGATCAGCACGCTGCGCATGAGCGGCTTGTGCTGGAAAGGC
TCAAGGCCGCCGGAGCGGGCGAGGCGGTTTCCCGGAGCCAAGCGCTGTTGATGCCCGAAGTCGTCGAACTGGACGAGCCG
TCCTGCGACCGACTCGAAAGCGCTGCCGAGAAGCTCGACGCCATGGGTCTTTCGATCGAGCGTTTCGGACCCGGCGCGAT
GCTGGTTCGGTCGCTGCCACACGCGCTGGCAGGCTCCAACCCGGGCAAGCTGCTGCAGGATATTGCCGACGACCTCGCCA
AGCATGGCGATGCGCTGTGGCTCGAGGAGAAACTCGATCTCGTTCTAGGGACCATGGCCTGCCACGGTTCGGTCAGGGCG
GGGCGCACCCTGCGGGTCGACGAGATGAACGCGCTGCTGCGCGAGATGGAGCGCACGCCGCGTTCGGGCCAGTGCAATCA
CGGGCGCCCGACATGGGTCAAGCTCAGTATGGAAGACGTCGAGAAACTGTTCGGGAGGCATTGA

Upstream 100 bases:

>100_bases
ACCGAGTCGCGCCGCAAAAGGCCAAGAATTTATCCCCAGTTCCGGTGCAAAATTCGCACCTCGGCTCGAAATCCAAGCGG
CTCGTCGTTAGGTTGCGCAA

Downstream 100 bases:

>100_bases
TGCGCTTGGTTTGTATTGCTCCCGTCCTCATCATCTCTGCCTGTACGGAACCGGAGATGAGCGAGGCCGAGCGGCAGGAG
ATCGTGGCGGACGTCAAGGA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MPTIRRLPEALVNRIAAGEVVERPSAALKELVENAVDAGATRIAVHLIDGGLTRIEVTDDGCGMDPAAMELALERHATSK
LPDDLIGEAQAIERVATLGFRGEALPSIGSVSRFALESRPHGSEQGWRRVVDHGTLVEEGPAALPPGTRARIEQVFAKVP
ARRKFLRTPRSEYGACLDVIRRLAMARPDIGFTLDHGERRVFALQPGEELPDRVAQIVAPELKDNAVLLDMQRDTMTLTG
IAGLPTYNRGVADHQYLFVNGRPVKDRLLVGAVRGAYSDMLARDRHAVLALFLDLPSEDVDVNVHPAKTEVRFRDAQAVR
GFIVSGLRQALSTGDRRSAQGPDRTAMKRWQQEPVREEPSPALRSIFEGRGWSKPGTGVREPSHEWHSHEGEVIASPQGR
AVEAEDIAADAKQHFPLGVARGQVANTYIVAEAADGLVLVDQHAAHERLVLERLKAAGAGEAVSRSQALLMPEVVELDEP
SCDRLESAAEKLDAMGLSIERFGPGAMLVRSLPHALAGSNPGKLLQDIADDLAKHGDALWLEEKLDLVLGTMACHGSVRA
GRTLRVDEMNALLREMERTPRSGQCNHGRPTWVKLSMEDVEKLFGRH

Sequences:

>Translated_607_residues
MPTIRRLPEALVNRIAAGEVVERPSAALKELVENAVDAGATRIAVHLIDGGLTRIEVTDDGCGMDPAAMELALERHATSK
LPDDLIGEAQAIERVATLGFRGEALPSIGSVSRFALESRPHGSEQGWRRVVDHGTLVEEGPAALPPGTRARIEQVFAKVP
ARRKFLRTPRSEYGACLDVIRRLAMARPDIGFTLDHGERRVFALQPGEELPDRVAQIVAPELKDNAVLLDMQRDTMTLTG
IAGLPTYNRGVADHQYLFVNGRPVKDRLLVGAVRGAYSDMLARDRHAVLALFLDLPSEDVDVNVHPAKTEVRFRDAQAVR
GFIVSGLRQALSTGDRRSAQGPDRTAMKRWQQEPVREEPSPALRSIFEGRGWSKPGTGVREPSHEWHSHEGEVIASPQGR
AVEAEDIAADAKQHFPLGVARGQVANTYIVAEAADGLVLVDQHAAHERLVLERLKAAGAGEAVSRSQALLMPEVVELDEP
SCDRLESAAEKLDAMGLSIERFGPGAMLVRSLPHALAGSNPGKLLQDIADDLAKHGDALWLEEKLDLVLGTMACHGSVRA
GRTLRVDEMNALLREMERTPRSGQCNHGRPTWVKLSMEDVEKLFGRH
>Mature_606_residues
PTIRRLPEALVNRIAAGEVVERPSAALKELVENAVDAGATRIAVHLIDGGLTRIEVTDDGCGMDPAAMELALERHATSKL
PDDLIGEAQAIERVATLGFRGEALPSIGSVSRFALESRPHGSEQGWRRVVDHGTLVEEGPAALPPGTRARIEQVFAKVPA
RRKFLRTPRSEYGACLDVIRRLAMARPDIGFTLDHGERRVFALQPGEELPDRVAQIVAPELKDNAVLLDMQRDTMTLTGI
AGLPTYNRGVADHQYLFVNGRPVKDRLLVGAVRGAYSDMLARDRHAVLALFLDLPSEDVDVNVHPAKTEVRFRDAQAVRG
FIVSGLRQALSTGDRRSAQGPDRTAMKRWQQEPVREEPSPALRSIFEGRGWSKPGTGVREPSHEWHSHEGEVIASPQGRA
VEAEDIAADAKQHFPLGVARGQVANTYIVAEAADGLVLVDQHAAHERLVLERLKAAGAGEAVSRSQALLMPEVVELDEPS
CDRLESAAEKLDAMGLSIERFGPGAMLVRSLPHALAGSNPGKLLQDIADDLAKHGDALWLEEKLDLVLGTMACHGSVRAG
RTLRVDEMNALLREMERTPRSGQCNHGRPTWVKLSMEDVEKLFGRH

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=320, Percent_Identity=32.1875, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI4505913, Length=357, Percent_Identity=27.7310924369748, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI310128478, Length=357, Percent_Identity=27.7310924369748, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI189458898, Length=333, Percent_Identity=24.6246246246246, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI4505911, Length=333, Percent_Identity=24.6246246246246, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI189458896, Length=323, Percent_Identity=24.4582043343653, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI310128480, Length=314, Percent_Identity=25.1592356687898, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI263191589, Length=221, Percent_Identity=26.6968325791855, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI91992162, Length=357, Percent_Identity=23.8095238095238, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI91992160, Length=357, Percent_Identity=23.8095238095238, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1790612, Length=572, Percent_Identity=33.2167832167832, Blast_Score=242, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI71991825, Length=329, Percent_Identity=33.7386018237082, Blast_Score=155, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17562796, Length=343, Percent_Identity=27.9883381924198, Blast_Score=143, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323819, Length=339, Percent_Identity=31.2684365781711, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6324247, Length=392, Percent_Identity=27.0408163265306, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136968, Length=318, Percent_Identity=33.3333333333333, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17136970, Length=360, Percent_Identity=25, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 66223; Mature: 66092

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTIRRLPEALVNRIAAGEVVERPSAALKELVENAVDAGATRIAVHLIDGGLTRIEVTDD
CCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCC
GCGMDPAAMELALERHATSKLPDDLIGEAQAIERVATLGFRGEALPSIGSVSRFALESRP
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCC
HGSEQGWRRVVDHGTLVEEGPAALPPGTRARIEQVFAKVPARRKFLRTPRSEYGACLDVI
CCCHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHH
RRLAMARPDIGFTLDHGERRVFALQPGEELPDRVAQIVAPELKDNAVLLDMQRDTMTLTG
HHHHHCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEE
IAGLPTYNRGVADHQYLFVNGRPVKDRLLVGAVRGAYSDMLARDRHAVLALFLDLPSEDV
ECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
DVNVHPAKTEVRFRDAQAVRGFIVSGLRQALSTGDRRSAQGPDRTAMKRWQQEPVREEPS
EEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCC
PALRSIFEGRGWSKPGTGVREPSHEWHSHEGEVIASPQGRAVEAEDIAADAKQHFPLGVA
HHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCEEECCCCCEECHHHHHHHHHHCCCCCCC
RGQVANTYIVAEAADGLVLVDQHAAHERLVLERLKAAGAGEAVSRSQALLMPEVVELDEP
CCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHCCHHHHCCHHHCCCCC
SCDRLESAAEKLDAMGLSIERFGPGAMLVRSLPHALAGSNPGKLLQDIADDLAKHGDALW
CHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEE
LEEKLDLVLGTMACHGSVRAGRTLRVDEMNALLREMERTPRSGQCNHGRPTWVKLSMEDV
HHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECHHHH
EKLFGRH
HHHHCCC
>Mature Secondary Structure 
PTIRRLPEALVNRIAAGEVVERPSAALKELVENAVDAGATRIAVHLIDGGLTRIEVTDD
CHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEECCC
GCGMDPAAMELALERHATSKLPDDLIGEAQAIERVATLGFRGEALPSIGSVSRFALESRP
CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCC
HGSEQGWRRVVDHGTLVEEGPAALPPGTRARIEQVFAKVPARRKFLRTPRSEYGACLDVI
CCCHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHH
RRLAMARPDIGFTLDHGERRVFALQPGEELPDRVAQIVAPELKDNAVLLDMQRDTMTLTG
HHHHHCCCCCCEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEE
IAGLPTYNRGVADHQYLFVNGRPVKDRLLVGAVRGAYSDMLARDRHAVLALFLDLPSEDV
ECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCC
DVNVHPAKTEVRFRDAQAVRGFIVSGLRQALSTGDRRSAQGPDRTAMKRWQQEPVREEPS
EEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCC
PALRSIFEGRGWSKPGTGVREPSHEWHSHEGEVIASPQGRAVEAEDIAADAKQHFPLGVA
HHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCEEECCCCCEECHHHHHHHHHHCCCCCCC
RGQVANTYIVAEAADGLVLVDQHAAHERLVLERLKAAGAGEAVSRSQALLMPEVVELDEP
CCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHCCHHHHCCHHHCCCCC
SCDRLESAAEKLDAMGLSIERFGPGAMLVRSLPHALAGSNPGKLLQDIADDLAKHGDALW
CHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEE
LEEKLDLVLGTMACHGSVRAGRTLRVDEMNALLREMERTPRSGQCNHGRPTWVKLSMEDV
HHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECHHHH
EKLFGRH
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA