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The map label for this gene is xerC

Identifier: 85373824

GI number: 85373824

Start: 1025561

End: 1026481

Strand: Direct

Name: xerC

Synonym: ELI_04985

Alternate gene names: 85373824

Gene position: 1025561-1026481 (Clockwise)

Preceding gene: 85373823

Following gene: 85373825

Centisome position: 33.6

GC content: 65.91

Gene sequence:

>921_bases
GTGGCCAAGGCTTCCGCCGCCATCGAGGAATTTCTCGCCATGCTGGCGGCCGAACGCGGTGCGGCTGCCAATACGCTGGC
GGCCTACAGGCGCGATCTCGAAGGGGCAGAGGCGCTTGCAGGTGACTTGGCAACCGCCAGGCGACCTGCGCTTTCCAGGC
TCGGTTCGGCATGGTCCGATCTTGCGCCGGCTACCGTAGCGCGGAAGGCATCGGCCCTCAGGCAGTTCTATGGTTTTCTC
GTCGACGAAGGTCTGCGCGAGGACGATCCTTCGTCCGCGCTTCCGCGCCCGACGATGCGCAGGCCGCTGCCCAAGACTTT
ATCGCACAAGGAGGTCGAGCGCCTGTTCGAGCAGGCCGAACGGGAGGCGGAGACCAGTCGCCCCCTGCCGGTGCGGCTCC
TGGCCCTGATCGAATTGCTGTATGGTTCGGGCCTTCGTGCGACCGAACTGGTTTCCCTGCCGGTCGCTGCCGTGCCCCGC
GACGCACCATTTCTCACGGTCACCGGCAAGGGCGGCGTCGCCCGCATGGTGCCGGTGAGCGGCCGCGCGCGAGAGGCGCT
GCAAAGCTGGATGGGGCTTCGGGGCAGCGATTCCCCGTACCTGTTCCCATCGCGAAAGGCGCACATCACGCGTGTTCGCC
TGTTCCAGATGCTCAAGGAACTGGCGGTGCGTGCCGATCTGAATCCGGACAAGGTCAGCCCGCATGTCTTGCGCCATGCC
TTTGCGACGCATCTGCTGGAAGGGGGCGCGGATTTGCGTGTCCTGCAGACGCTGCTCGGCCACGCGGACATTTCGACGAC
GCAAATCTACACCCATGTCGATGCCGCGCGGCTCGTCGCGCTGGTCAACGAGCGCCATCCGCTGTCGGCGCGGGCAGCTG
GCAAACGCAGCACGCTTGCAGAAAAGCGAACGGAGGACTAG

Upstream 100 bases:

>100_bases
CGTCACCTCTTCCATATCGTCCGCGCTCTCGACCGAGCAGGACTTTCCGCCGAAGCACGGATGATCGCCGCGGAGGCGGT
CGCGAGGGCCTGAGGCAAAG

Downstream 100 bases:

>100_bases
CGCACCGGCATGAATTCCTATCTCGAATTCGAGAAGCCCGTTGCCCAGCTCGAAGCGCGGATCGCAGAATTGCGGTCGGC
TGCCGAAGGCGACGAGGTCG

Product: integrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MAKASAAIEEFLAMLAAERGAAANTLAAYRRDLEGAEALAGDLATARRPALSRLGSAWSDLAPATVARKASALRQFYGFL
VDEGLREDDPSSALPRPTMRRPLPKTLSHKEVERLFEQAEREAETSRPLPVRLLALIELLYGSGLRATELVSLPVAAVPR
DAPFLTVTGKGGVARMVPVSGRAREALQSWMGLRGSDSPYLFPSRKAHITRVRLFQMLKELAVRADLNPDKVSPHVLRHA
FATHLLEGGADLRVLQTLLGHADISTTQIYTHVDAARLVALVNERHPLSARAAGKRSTLAEKRTED

Sequences:

>Translated_306_residues
MAKASAAIEEFLAMLAAERGAAANTLAAYRRDLEGAEALAGDLATARRPALSRLGSAWSDLAPATVARKASALRQFYGFL
VDEGLREDDPSSALPRPTMRRPLPKTLSHKEVERLFEQAEREAETSRPLPVRLLALIELLYGSGLRATELVSLPVAAVPR
DAPFLTVTGKGGVARMVPVSGRAREALQSWMGLRGSDSPYLFPSRKAHITRVRLFQMLKELAVRADLNPDKVSPHVLRHA
FATHLLEGGADLRVLQTLLGHADISTTQIYTHVDAARLVALVNERHPLSARAAGKRSTLAEKRTED
>Mature_305_residues
AKASAAIEEFLAMLAAERGAAANTLAAYRRDLEGAEALAGDLATARRPALSRLGSAWSDLAPATVARKASALRQFYGFLV
DEGLREDDPSSALPRPTMRRPLPKTLSHKEVERLFEQAEREAETSRPLPVRLLALIELLYGSGLRATELVSLPVAAVPRD
APFLTVTGKGGVARMVPVSGRAREALQSWMGLRGSDSPYLFPSRKAHITRVRLFQMLKELAVRADLNPDKVSPHVLRHAF
ATHLLEGGADLRVLQTLLGHADISTTQIYTHVDAARLVALVNERHPLSARAAGKRSTLAEKRTED

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4974

COG function: function code L; Site-specific recombinase XerD

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1789261, Length=303, Percent_Identity=41.9141914191419, Blast_Score=196, Evalue=1e-51,
Organism=Escherichia coli, GI1790244, Length=306, Percent_Identity=33.9869281045752, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1790767, Length=181, Percent_Identity=28.1767955801105, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790768, Length=191, Percent_Identity=30.3664921465969, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_ERYLH (Q2NB52)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457886.1
- ProteinModelPortal:   Q2NB52
- SMR:   Q2NB52
- STRING:   Q2NB52
- GeneID:   3870160
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_04985
- NMPDR:   fig|314225.3.peg.2073
- eggNOG:   COG4974
- HOGENOM:   HBG727654
- OMA:   DASEFCH
- PhylomeDB:   Q2NB52
- ProtClustDB:   CLSK835199
- BioCyc:   ELIT314225:ELI_04985-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 33285; Mature: 33153

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: PS00334 MYB_2

Important sites: ACT_SITE 146-146 ACT_SITE 170-170 ACT_SITE 235-235 ACT_SITE 238-238 ACT_SITE 261-261 ACT_SITE 270-270

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKASAAIEEFLAMLAAERGAAANTLAAYRRDLEGAEALAGDLATARRPALSRLGSAWSD
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPATVARKASALRQFYGFLVDEGLREDDPSSALPRPTMRRPLPKTLSHKEVERLFEQAE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCHHCCHHHHHHHHHHHH
REAETSRPLPVRLLALIELLYGSGLRATELVSLPVAAVPRDAPFLTVTGKGGVARMVPVS
HHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCHHHCCCCCCEEEEECCCCCEEEECCC
GRAREALQSWMGLRGSDSPYLFPSRKAHITRVRLFQMLKELAVRADLNPDKVSPHVLRHA
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
FATHLLEGGADLRVLQTLLGHADISTTQIYTHVDAARLVALVNERHPLSARAAGKRSTLA
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHH
EKRTED
HHCCCC
>Mature Secondary Structure 
AKASAAIEEFLAMLAAERGAAANTLAAYRRDLEGAEALAGDLATARRPALSRLGSAWSD
CHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LAPATVARKASALRQFYGFLVDEGLREDDPSSALPRPTMRRPLPKTLSHKEVERLFEQAE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCHHCCHHHHHHHHHHHH
REAETSRPLPVRLLALIELLYGSGLRATELVSLPVAAVPRDAPFLTVTGKGGVARMVPVS
HHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHCCHHHCCCCCCEEEEECCCCCEEEECCC
GRAREALQSWMGLRGSDSPYLFPSRKAHITRVRLFQMLKELAVRADLNPDKVSPHVLRHA
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
FATHLLEGGADLRVLQTLLGHADISTTQIYTHVDAARLVALVNERHPLSARAAGKRSTLA
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHH
EKRTED
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA