| Definition | Erythrobacter litoralis HTCC2594 chromosome, complete genome. |
|---|---|
| Accession | NC_007722 |
| Length | 3,052,398 |
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The map label for this gene is topA [H]
Identifier: 85373789
GI number: 85373789
Start: 993531
End: 996068
Strand: Direct
Name: topA [H]
Synonym: ELI_04810
Alternate gene names: 85373789
Gene position: 993531-996068 (Clockwise)
Preceding gene: 85373788
Following gene: 85373790
Centisome position: 32.55
GC content: 63.83
Gene sequence:
>2538_bases ATGCAACTTGTTATCGTTGAATCGCCGGCCAAGGCGAAAACCATCGAGAAATATCTCGGCAAGGACTTCAAGGTTCTCGC CAGCTACGGCCATGTCCGCGACCTGCCGCCCAAGGATGGCAGCGTGCGGCCGGACGAGGATTTCGCGATGGACTGGGAGC TCTATCGCGACAAGCAGAAGCGCTTCAAGGAAATCAGCGACGCGGCCAAGCAGGCCGACCGGCTGGTGCTCGCAACCGAC CCCGACCGCGAAGGCGAGGCGATCAGCTGGCACGTCCAAGAATTGCTGGCCAAGCGCAAGGCGCTACCCGCCAAGGTCGA TCGCGTCACTTTCAACGCCATCACCAAGAGCGCCGTTACCGAGGCGATGGGCAGGCCCCGCGAGCTCGACCAACCGCTGA TCGACGCCTATCTGGCACGCCGCGCGCTCGACTACCTGTTCGGCTTTACGCTTTCGCCCGTTCTGTGGCGCAAGCTGCCC GGTGCGAAATCGGCGGGCCGCGTGCAGTCGGTTGCGCTGCGACTGATCGTCGATCGCGAGCGCGAGATCGAAGCGTTCAA GCCCGAAGAATACTGGTCCGTCCTCGCCAGGTTCGAACATGACGGGACCGAATTCGATGCACGCATGGTGCGCTTCGACG GCAAGAAGCTCGACAAGATGACGCTGGGCAATGAAGGTTCGGCGCTGGCGGCCAAGGCCGCCGTTGATGCCGGGCGCTTC ACGGTCTCGGACATCGAGACCAAGCCATTGAAGCGCAATCCCGCGCCGCCGTTCACGACATCGACGCTGCAACAGGAAGC TGCGCGCAAGCTCGGCTTCTCGGCCAGCCACACGATGCGGTGCGCCCAGTCGCTCTATGAAGCGGGCGCGATCACCTACA TGCGGACCGACGGCGTGCAGATGGACGGCAGCGCGATCGCCGCCTGCCGCCACGCGATCGAAGAGCGATACGAAAGCGCG TACCTGCCCGAGAAACCGCGCTTCTACGCCACCAAGGCCAAGAACGCGCAGGAAGCCCACGAAGCGATCCGGCCGACCAA TTTCAACCGCGACAGTGCTGGATCGGGCGACGAGGCCAAGCTCTACGGCCTGATCTTCAAGCGCGCGATGGCGAGCCAGA TGGCGACCGCGCAGCTGGAGCGCACGACCATTACGCTGGAAGACCCGACCGGCCAGCACGCGCTGCGGGCCACCGGGCAG GTGGTGAAGTTCCCCGGCTTCTTTGCGGTCTACCAGGAAGGCTTCGACGACAAGTCCGATGAGGACGAAGACGGCCTGCT GCCCGCCATGCACAAGGGCGATGCGCCCGCCAAGAAGGGTGTCGAGGCCAACCAGCATTTCACCCAGCCGCCACCGCGTT TCTCCGAGGCCTCGCTGGTCAAGCGGCTGGAGGAGCTCGGCATCGGTCGGCCATCGACCTACGCCTCGACCATCCAGACT TTGCGCGACCGCGACTATGTGCGGATGGAGAAAAACCGTTTCTTTGCCGAGGAATCGGGCCGATTGCTCACAGCGTTCCT CGAACGGTTCTTCCCCAACTACGTCGCCTACGAATTCACCGCCGGGATGGAGGAAGAGCTCGACACCGTCAGCGACGGGC GCGAGGAATACAAGGAATTGCTCGCCAAGTTCTGGGCCGACTTCAAGCCCAAGGCCGACGAAGTCATGGAGAAACTGCCC TCGGAAGTAACCGAGGTGCTGGACGACTATCTCTCCGACTATCTCTTCCCGCCGACCGAAGACGGCACCGAACCACGCGC CTGCCCGCTGTGCCGGGACGAAGGGCGCGAGGGCGGGAGGCTTGCCTTGCGCGGCGGCCGCTATGGCGCGTTCGTCGCCT GCGCCAACTATCCAGAATGCAAGTATACCCGCCGCTTCGCCCAGCCGGGCGGCAACGAAAGCGCGGCGGACGACGGCATC ATGGGCCAGCACCCGGAGACCGGCGAGGACATCGAGCGAAAGTCCGGCCGCTTCGGACCATACGTCCAGATGGGCGAGGG CAAGGAAGCCAAGCGCGCGAGCATCCCCAAGGACCTCGACGATTTCGATCTCGACTGGGCGGTCAAGCTGCTCGACCTGC CGCGCATCGTCGGCGCGCATCCGGAGACGGGCAAGGAAATCGAAGCGGCGATCGGGCGCTATGGCCCCTACCTCCGCCAC GACGGCAAATACGGCAAGCTGCAGAGCACGCGCGACGTGTTCGAAGTCGGCATGAACGCCGCCGTCACGATCCTCGCCGA AGCCGCCAATCGCAAGGGTGGCGGTCGCGGCAAGGCGGAGCCTATCAAGACGCTCGGCGAACACCCGACCAGCGGCGGCG AGATGAAGGTCATGCCGGGGCGCTATGGTCCCTATGTCACCGATGGCACCACCAATGCGACCATCCCCAAAGACATGAAG CCCGAGGATGTGAGTGAAGCGCAGGCGATCGAACTGATCGATGCCCGCGCCGCCAAAGGGCCGGTGAAGAAGAAACGCAA GAAAGCTCCTGCGAAGAAGAAAGCTGCACCCAAGAAGAAAGCAGCGGCGAAGAAGTGA
Upstream 100 bases:
>100_bases TTTTGATTGAACTGAACGCGCGGGGTTGACGGATCGATTCCGTCGACCCCACCTTCGCGCGTACATGCACGTATACGCGT AAGGGACAGCGACCACCTCC
Downstream 100 bases:
>100_bases GCAAGGACCGCTTTGAACGGCACAAGCAACCATGGAATGGCGAAGAGGCGGGCAAATTGCGCCTCCTTGCATCCAAGGGG CAGGGCCTGAAGCAGATCGC
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 845; Mature: 845
Protein sequence:
>845_residues MQLVIVESPAKAKTIEKYLGKDFKVLASYGHVRDLPPKDGSVRPDEDFAMDWELYRDKQKRFKEISDAAKQADRLVLATD PDREGEAISWHVQELLAKRKALPAKVDRVTFNAITKSAVTEAMGRPRELDQPLIDAYLARRALDYLFGFTLSPVLWRKLP GAKSAGRVQSVALRLIVDREREIEAFKPEEYWSVLARFEHDGTEFDARMVRFDGKKLDKMTLGNEGSALAAKAAVDAGRF TVSDIETKPLKRNPAPPFTTSTLQQEAARKLGFSASHTMRCAQSLYEAGAITYMRTDGVQMDGSAIAACRHAIEERYESA YLPEKPRFYATKAKNAQEAHEAIRPTNFNRDSAGSGDEAKLYGLIFKRAMASQMATAQLERTTITLEDPTGQHALRATGQ VVKFPGFFAVYQEGFDDKSDEDEDGLLPAMHKGDAPAKKGVEANQHFTQPPPRFSEASLVKRLEELGIGRPSTYASTIQT LRDRDYVRMEKNRFFAEESGRLLTAFLERFFPNYVAYEFTAGMEEELDTVSDGREEYKELLAKFWADFKPKADEVMEKLP SEVTEVLDDYLSDYLFPPTEDGTEPRACPLCRDEGREGGRLALRGGRYGAFVACANYPECKYTRRFAQPGGNESAADDGI MGQHPETGEDIERKSGRFGPYVQMGEGKEAKRASIPKDLDDFDLDWAVKLLDLPRIVGAHPETGKEIEAAIGRYGPYLRH DGKYGKLQSTRDVFEVGMNAAVTILAEAANRKGGGRGKAEPIKTLGEHPTSGGEMKVMPGRYGPYVTDGTTNATIPKDMK PEDVSEAQAIELIDARAAKGPVKKKRKKAPAKKKAAPKKKAAAKK
Sequences:
>Translated_845_residues MQLVIVESPAKAKTIEKYLGKDFKVLASYGHVRDLPPKDGSVRPDEDFAMDWELYRDKQKRFKEISDAAKQADRLVLATD PDREGEAISWHVQELLAKRKALPAKVDRVTFNAITKSAVTEAMGRPRELDQPLIDAYLARRALDYLFGFTLSPVLWRKLP GAKSAGRVQSVALRLIVDREREIEAFKPEEYWSVLARFEHDGTEFDARMVRFDGKKLDKMTLGNEGSALAAKAAVDAGRF TVSDIETKPLKRNPAPPFTTSTLQQEAARKLGFSASHTMRCAQSLYEAGAITYMRTDGVQMDGSAIAACRHAIEERYESA YLPEKPRFYATKAKNAQEAHEAIRPTNFNRDSAGSGDEAKLYGLIFKRAMASQMATAQLERTTITLEDPTGQHALRATGQ VVKFPGFFAVYQEGFDDKSDEDEDGLLPAMHKGDAPAKKGVEANQHFTQPPPRFSEASLVKRLEELGIGRPSTYASTIQT LRDRDYVRMEKNRFFAEESGRLLTAFLERFFPNYVAYEFTAGMEEELDTVSDGREEYKELLAKFWADFKPKADEVMEKLP SEVTEVLDDYLSDYLFPPTEDGTEPRACPLCRDEGREGGRLALRGGRYGAFVACANYPECKYTRRFAQPGGNESAADDGI MGQHPETGEDIERKSGRFGPYVQMGEGKEAKRASIPKDLDDFDLDWAVKLLDLPRIVGAHPETGKEIEAAIGRYGPYLRH DGKYGKLQSTRDVFEVGMNAAVTILAEAANRKGGGRGKAEPIKTLGEHPTSGGEMKVMPGRYGPYVTDGTTNATIPKDMK PEDVSEAQAIELIDARAAKGPVKKKRKKAPAKKKAAPKKKAAAKK >Mature_845_residues MQLVIVESPAKAKTIEKYLGKDFKVLASYGHVRDLPPKDGSVRPDEDFAMDWELYRDKQKRFKEISDAAKQADRLVLATD PDREGEAISWHVQELLAKRKALPAKVDRVTFNAITKSAVTEAMGRPRELDQPLIDAYLARRALDYLFGFTLSPVLWRKLP GAKSAGRVQSVALRLIVDREREIEAFKPEEYWSVLARFEHDGTEFDARMVRFDGKKLDKMTLGNEGSALAAKAAVDAGRF TVSDIETKPLKRNPAPPFTTSTLQQEAARKLGFSASHTMRCAQSLYEAGAITYMRTDGVQMDGSAIAACRHAIEERYESA YLPEKPRFYATKAKNAQEAHEAIRPTNFNRDSAGSGDEAKLYGLIFKRAMASQMATAQLERTTITLEDPTGQHALRATGQ VVKFPGFFAVYQEGFDDKSDEDEDGLLPAMHKGDAPAKKGVEANQHFTQPPPRFSEASLVKRLEELGIGRPSTYASTIQT LRDRDYVRMEKNRFFAEESGRLLTAFLERFFPNYVAYEFTAGMEEELDTVSDGREEYKELLAKFWADFKPKADEVMEKLP SEVTEVLDDYLSDYLFPPTEDGTEPRACPLCRDEGREGGRLALRGGRYGAFVACANYPECKYTRRFAQPGGNESAADDGI MGQHPETGEDIERKSGRFGPYVQMGEGKEAKRASIPKDLDDFDLDWAVKLLDLPRIVGAHPETGKEIEAAIGRYGPYLRH DGKYGKLQSTRDVFEVGMNAAVTILAEAANRKGGGRGKAEPIKTLGEHPTSGGEMKVMPGRYGPYVTDGTTNATIPKDMK PEDVSEAQAIELIDARAAKGPVKKKRKKAPAKKKAAPKKKAAAKK
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=591, Percent_Identity=26.9035532994924, Blast_Score=145, Evalue=2e-34, Organism=Homo sapiens, GI4507635, Length=580, Percent_Identity=25.1724137931034, Blast_Score=116, Evalue=7e-26, Organism=Escherichia coli, GI1787529, Length=658, Percent_Identity=40.7294832826748, Blast_Score=443, Evalue=1e-125, Organism=Escherichia coli, GI1788061, Length=534, Percent_Identity=26.0299625468165, Blast_Score=118, Evalue=1e-27, Organism=Caenorhabditis elegans, GI32563869, Length=552, Percent_Identity=27.536231884058, Blast_Score=135, Evalue=7e-32, Organism=Caenorhabditis elegans, GI17555378, Length=507, Percent_Identity=25.4437869822485, Blast_Score=119, Evalue=7e-27, Organism=Saccharomyces cerevisiae, GI6323263, Length=488, Percent_Identity=25, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI24585251, Length=580, Percent_Identity=25.1724137931034, Blast_Score=120, Evalue=5e-27, Organism=Drosophila melanogaster, GI24640096, Length=559, Percent_Identity=24.1502683363148, Blast_Score=98, Evalue=2e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 93939; Mature: 93939
Theoretical pI: Translated: 7.62; Mature: 7.62
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MQLVIVESPAKAKTIEKYLGKDFKVLASYGHVRDLPPKDGSVRPDEDFAMDWELYRDKQK CEEEEECCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH RFKEISDAAKQADRLVLATDPDREGEAISWHVQELLAKRKALPAKVDRVTFNAITKSAVT HHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH EAMGRPRELDQPLIDAYLARRALDYLFGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDRE HHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC REIEAFKPEEYWSVLARFEHDGTEFDARMVRFDGKKLDKMTLGNEGSALAAKAAVDAGRF HHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHEECCCCCCHHHHHHHHCCCCE TVSDIETKPLKRNPAPPFTTSTLQQEAARKLGFSASHTMRCAQSLYEAGAITYMRTDGVQ EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCE MDGSAIAACRHAIEERYESAYLPEKPRFYATKAKNAQEAHEAIRPTNFNRDSAGSGDEAK ECCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCHH LYGLIFKRAMASQMATAQLERTTITLEDPTGQHALRATGQVVKFPGFFAVYQEGFDDKSD HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHCCCEEECCCHHHHHHHCCCCCCC EDEDGLLPAMHKGDAPAKKGVEANQHFTQPPPRFSEASLVKRLEELGIGRPSTYASTIQT CCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH LRDRDYVRMEKNRFFAEESGRLLTAFLERFFPNYVAYEFTAGMEEELDTVSDGREEYKEL HHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEHHCCCCHHHHHHHHCCHHHHHHH LAKFWADFKPKADEVMEKLPSEVTEVLDDYLSDYLFPPTEDGTEPRACPLCRDEGREGGR HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCE LALRGGRYGAFVACANYPECKYTRRFAQPGGNESAADDGIMGQHPETGEDIERKSGRFGP EEEECCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC YVQMGEGKEAKRASIPKDLDDFDLDWAVKLLDLPRIVGAHPETGKEIEAAIGRYGPYLRH EEECCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHC DGKYGKLQSTRDVFEVGMNAAVTILAEAANRKGGGRGKAEPIKTLGEHPTSGGEMKVMPG CCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCEEECCC RYGPYVTDGTTNATIPKDMKPEDVSEAQAIELIDARAAKGPVKKKRKKAPAKKKAAPKKK CCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCCCHHH AAAKK HCCCC >Mature Secondary Structure MQLVIVESPAKAKTIEKYLGKDFKVLASYGHVRDLPPKDGSVRPDEDFAMDWELYRDKQK CEEEEECCCHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH RFKEISDAAKQADRLVLATDPDREGEAISWHVQELLAKRKALPAKVDRVTFNAITKSAVT HHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH EAMGRPRELDQPLIDAYLARRALDYLFGFTLSPVLWRKLPGAKSAGRVQSVALRLIVDRE HHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC REIEAFKPEEYWSVLARFEHDGTEFDARMVRFDGKKLDKMTLGNEGSALAAKAAVDAGRF HHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHEECCCCCCHHHHHHHHCCCCE TVSDIETKPLKRNPAPPFTTSTLQQEAARKLGFSASHTMRCAQSLYEAGAITYMRTDGVQ EECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCE MDGSAIAACRHAIEERYESAYLPEKPRFYATKAKNAQEAHEAIRPTNFNRDSAGSGDEAK ECCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCHH LYGLIFKRAMASQMATAQLERTTITLEDPTGQHALRATGQVVKFPGFFAVYQEGFDDKSD HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHCCCEEECCCHHHHHHHCCCCCCC EDEDGLLPAMHKGDAPAKKGVEANQHFTQPPPRFSEASLVKRLEELGIGRPSTYASTIQT CCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHH LRDRDYVRMEKNRFFAEESGRLLTAFLERFFPNYVAYEFTAGMEEELDTVSDGREEYKEL HHCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEHHCCCCHHHHHHHHCCHHHHHHH LAKFWADFKPKADEVMEKLPSEVTEVLDDYLSDYLFPPTEDGTEPRACPLCRDEGREGGR HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCE LALRGGRYGAFVACANYPECKYTRRFAQPGGNESAADDGIMGQHPETGEDIERKSGRFGP EEEECCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC YVQMGEGKEAKRASIPKDLDDFDLDWAVKLLDLPRIVGAHPETGKEIEAAIGRYGPYLRH EEECCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHC DGKYGKLQSTRDVFEVGMNAAVTILAEAANRKGGGRGKAEPIKTLGEHPTSGGEMKVMPG CCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCEEECCC RYGPYVTDGTTNATIPKDMKPEDVSEAQAIELIDARAAKGPVKKKRKKAPAKKKAAPKKK CCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHCCCHHH AAAKK HCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA