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The map label for this gene is groEL

Identifier: 85373658

GI number: 85373658

Start: 857499

End: 859118

Strand: Reverse

Name: groEL

Synonym: ELI_04155

Alternate gene names: 85373658

Gene position: 859118-857499 (Counterclockwise)

Preceding gene: 85373659

Following gene: 85373657

Centisome position: 28.15

GC content: 61.98

Gene sequence:

>1620_bases
ATGGCTGCGAAAGAAGTAAAATTTGCGTCGGATGCGCGTGATCGCATGCTCCGCGGCGTGGATACGCTTGCGAATGCGGT
CAAGGTAACTCTCGGCCCCAAGGGCCGCAATGTGGTGATCGAGAAGAGCTTCGGCGCGCCGCGCATCACCAAGGACGGCG
TGACTGTCGCCAAGGAAATCGAACTCAAGGACAAGTTCGAAAACATGGGCGCACAGATGCTACGCGAAGTCGCCAGCAAG
CAGAACGACAAGGCGGGCGATGGCACCACGACTGCCACCGTTCTCGCGCAGGCCATCGTCCGCGAAGGTGCCAAGGCCGT
TGCTGCCGGCATGAACCCGATAGACCTCAAGCGCGGCATCGACCTTGCCGTCGGCACCGTAGTCAAGGACCTCGAAAGCC
ATGCCAAGAAGGTGTCCGCCAACAGCGAAATCGCACAGGTCGCGACCATTTCCGCCAATGGCGACGAAACCGTCGGTCGC
TTCCTTGCCGAAGCCATGGACAAAGTCGGCAATGAAGGCGTGATCACGGTCGAGGAAGCCAAGAGCCTCGAAACCGAGCT
CGAAACGGTCGAGGGCATGCAGTTCGATCGCGGCTATCTCTCGCCCTACTTCGTGACCAACACCGAAAAGCTGAAGGTGG
AACTCGAGGATCCCTACATCCTCATCCATGAGAAGAAGCTGTCGAACCTGCAAGCGCTGATCCCGCTGCTCGAACAGGTC
GTGCAGTCTGGCAAGCCGTTGCTGATCATCGCGGAGGATGTCGAGGGCGAAGCCCTGGCAACCCTGGTGGTGAACAAGCT
TCGTGGCGGCCTCAAGGTCGCGGCGGTCAAGGCACCCGGCTTCGGCGATCGCCGCAAGGCCATGCTGGAGGATGTTGCTA
TCCTCACCGCCGGCAATGTGGTCAGCGAGGAACTTGGCACCAAGCTGGAAAATGTCACGATCGGCATGCTCGGCCGGGCC
AAGAAGGTCATTATCGACAAGGACAACACGACAATCGTCGATGGTGCCGGCAACAAGGCGGACATCGACGCCCGGGTCAG
CCAGATCCGCGCCCAGATCGAGACCACGACCAGCGACTACGACCGTGAAAAACTTCAGGAACGCGTGGCCAAGCTGGCTG
GCGGGGTGGCCGTCATCCGCGTCGGCGGGGCCACCGAAGTCGAGGTCAAGGAGCGCAAGGACCGGGTCGACGACGCGCTG
CATGCAACTCGTGCGGCTGTCGAAGAGGGCATCCTTCCGGGCGGCGGTATAGCCCTGCTCCGGGCGCTCAAGTCGCTCGA
TGGCCTCAAGGCCGCCAATGACGACCAGCAGTCTGGCATCGACATCGTGCGCCGCGCCCTGCGCGCTCCGGCTCGCCAAA
TAGCCGAGAACGCGGGTGAGGACGGTGCCTATATCGTCGGCAAGCTGCTTGAAGGCGACGACTACAACCACGGCTTCAAC
GCCGCGACCGGCGAATATGAAGACCTGGTGAAGTCGGGTGTCATCGATCCGGCGAAGGTGGTGCGCACTGCGCTGCAGGA
CGCGGCTTCGGTTGCCTCGCTGCTGATCACCACCGAGGCGCTGGTGGCCGAACTGCCCAAGGAAGACACGCCCGCACCGA
TGCCGGCGATGGACTTCTAA

Upstream 100 bases:

>100_bases
CGGCATCATCGAAACCACCGCTGAGCTCAAGAAGGCGGCGTAAGCACGATACGTTGAGACTTCTGTTCAACCGAAAGAAG
CATAGAAGGGAGCAGGCCAA

Downstream 100 bases:

>100_bases
CAAGGTTAGGAGAGCGCGGAATTAAGCTGCGCTCTCCCAACCTCCACGCACGGCTGGCGGCAGTGCTGCCTGGCGTCTCC
ACACGCCCTCTTGTGCAAGG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MAAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELKDKFENMGAQMLREVASK
QNDKAGDGTTTATVLAQAIVREGAKAVAAGMNPIDLKRGIDLAVGTVVKDLESHAKKVSANSEIAQVATISANGDETVGR
FLAEAMDKVGNEGVITVEEAKSLETELETVEGMQFDRGYLSPYFVTNTEKLKVELEDPYILIHEKKLSNLQALIPLLEQV
VQSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDVAILTAGNVVSEELGTKLENVTIGMLGRA
KKVIIDKDNTTIVDGAGNKADIDARVSQIRAQIETTTSDYDREKLQERVAKLAGGVAVIRVGGATEVEVKERKDRVDDAL
HATRAAVEEGILPGGGIALLRALKSLDGLKAANDDQQSGIDIVRRALRAPARQIAENAGEDGAYIVGKLLEGDDYNHGFN
AATGEYEDLVKSGVIDPAKVVRTALQDAASVASLLITTEALVAELPKEDTPAPMPAMDF

Sequences:

>Translated_539_residues
MAAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELKDKFENMGAQMLREVASK
QNDKAGDGTTTATVLAQAIVREGAKAVAAGMNPIDLKRGIDLAVGTVVKDLESHAKKVSANSEIAQVATISANGDETVGR
FLAEAMDKVGNEGVITVEEAKSLETELETVEGMQFDRGYLSPYFVTNTEKLKVELEDPYILIHEKKLSNLQALIPLLEQV
VQSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDVAILTAGNVVSEELGTKLENVTIGMLGRA
KKVIIDKDNTTIVDGAGNKADIDARVSQIRAQIETTTSDYDREKLQERVAKLAGGVAVIRVGGATEVEVKERKDRVDDAL
HATRAAVEEGILPGGGIALLRALKSLDGLKAANDDQQSGIDIVRRALRAPARQIAENAGEDGAYIVGKLLEGDDYNHGFN
AATGEYEDLVKSGVIDPAKVVRTALQDAASVASLLITTEALVAELPKEDTPAPMPAMDF
>Mature_538_residues
AAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELKDKFENMGAQMLREVASKQ
NDKAGDGTTTATVLAQAIVREGAKAVAAGMNPIDLKRGIDLAVGTVVKDLESHAKKVSANSEIAQVATISANGDETVGRF
LAEAMDKVGNEGVITVEEAKSLETELETVEGMQFDRGYLSPYFVTNTEKLKVELEDPYILIHEKKLSNLQALIPLLEQVV
QSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDVAILTAGNVVSEELGTKLENVTIGMLGRAK
KVIIDKDNTTIVDGAGNKADIDARVSQIRAQIETTTSDYDREKLQERVAKLAGGVAVIRVGGATEVEVKERKDRVDDALH
ATRAAVEEGILPGGGIALLRALKSLDGLKAANDDQQSGIDIVRRALRAPARQIAENAGEDGAYIVGKLLEGDDYNHGFNA
ATGEYEDLVKSGVIDPAKVVRTALQDAASVASLLITTEALVAELPKEDTPAPMPAMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=54.9242424242424, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=54.9242424242424, Blast_Score=582, Evalue=1e-166,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=66.5406427221172, Blast_Score=699, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=53.5984848484849, Blast_Score=567, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=53.8095238095238, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI25144674, Length=170, Percent_Identity=27.0588235294118, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=58.7786259541985, Blast_Score=612, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6322524, Length=122, Percent_Identity=31.1475409836066, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=57.3863636363636, Blast_Score=608, Evalue=1e-174,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=57.3863636363636, Blast_Score=608, Evalue=1e-174,
Organism=Drosophila melanogaster, GI45550936, Length=530, Percent_Identity=54.5283018867924, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI45550132, Length=530, Percent_Identity=54.5283018867924, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI45550935, Length=530, Percent_Identity=54.5283018867924, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI17864606, Length=531, Percent_Identity=46.7043314500942, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24584129, Length=527, Percent_Identity=37.9506641366224, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI19921262, Length=527, Percent_Identity=37.9506641366224, Blast_Score=348, Evalue=5e-96,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_ERYLH (Q2NBL8)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457720.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q2NBL8
- SMR:   Q2NBL8
- STRING:   Q2NBL8
- GeneID:   3870772
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_04155
- NMPDR:   fig|314225.3.peg.2245
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   DVKFHDS
- PhylomeDB:   Q2NBL8
- ProtClustDB:   PRK00013
- BioCyc:   ELIT314225:ELI_04155-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57345; Mature: 57214

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEI
CCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHH
ELKDKFENMGAQMLREVASKQNDKAGDGTTTATVLAQAIVREGAKAVAAGMNPIDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCCHHHHHCCC
DLAVGTVVKDLESHAKKVSANSEIAQVATISANGDETVGRFLAEAMDKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEHHH
KSLETELETVEGMQFDRGYLSPYFVTNTEKLKVELEDPYILIHEKKLSNLQALIPLLEQV
HHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHH
VQSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDVAILTAGNV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCH
VSEELGTKLENVTIGMLGRAKKVIIDKDNTTIVDGAGNKADIDARVSQIRAQIETTTSDY
HHHHHCCHHHHEEEEECCCCEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHH
DREKLQERVAKLAGGVAVIRVGGATEVEVKERKDRVDDALHATRAAVEEGILPGGGIALL
HHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RALKSLDGLKAANDDQQSGIDIVRRALRAPARQIAENAGEDGAYIVGKLLEGDDYNHGFN
HHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
AATGEYEDLVKSGVIDPAKVVRTALQDAASVASLLITTEALVAELPKEDTPAPMPAMDF
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAKEVKFASDARDRMLRGVDTLANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEI
CCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCCHHHHH
ELKDKFENMGAQMLREVASKQNDKAGDGTTTATVLAQAIVREGAKAVAAGMNPIDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCCHHHHHCCC
DLAVGTVVKDLESHAKKVSANSEIAQVATISANGDETVGRFLAEAMDKVGNEGVITVEEA
HHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEHHH
KSLETELETVEGMQFDRGYLSPYFVTNTEKLKVELEDPYILIHEKKLSNLQALIPLLEQV
HHHHHHHHHHCCCCCCCCCCCCEEEECCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHH
VQSGKPLLIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDVAILTAGNV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCH
VSEELGTKLENVTIGMLGRAKKVIIDKDNTTIVDGAGNKADIDARVSQIRAQIETTTSDY
HHHHHCCHHHHEEEEECCCCEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCHH
DREKLQERVAKLAGGVAVIRVGGATEVEVKERKDRVDDALHATRAAVEEGILPGGGIALL
HHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RALKSLDGLKAANDDQQSGIDIVRRALRAPARQIAENAGEDGAYIVGKLLEGDDYNHGFN
HHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCC
AATGEYEDLVKSGVIDPAKVVRTALQDAASVASLLITTEALVAELPKEDTPAPMPAMDF
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA