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The map label for this gene is fabF [H]

Identifier: 85373625

GI number: 85373625

Start: 822541

End: 823800

Strand: Direct

Name: fabF [H]

Synonym: ELI_03990

Alternate gene names: 85373625

Gene position: 822541-823800 (Clockwise)

Preceding gene: 85373624

Following gene: 85373626

Centisome position: 26.95

GC content: 64.6

Gene sequence:

>1260_bases
ATGCGCCGCGTAGTCGTCACCGGTCTTGGCCTCGTCACCCCGCTGGGCGGCGATGTCGAAACATCGTGGAAGAACCTGAT
CGCCGGGGAAAGCGGCGCCGGGCAGATTACGAGCTTCGATGCCACGGACCAGAAGTGCACAATCGCCTGCGAGGTGAAAC
CAAAGGATCATCCCTGGGGCTTCGATCCCGACAAGCGCGTCGACGGCAAGATCCAGCGCCAGGTCGATCCGTTCATCGTC
TATGGCATCGATGCGGCCGGACAGGCCCTCGAAGATGCCGGCCTCACCGACATGAGCGACGAGGAAAAGCGCCGCACCGG
CTGTTCGATCGGTTCGGGGATCGGCGGACTGCCGGGGATCGAGAAGGAATCGGTCAACTTGCACGAGCGTGGCCCGGGCC
GGGTCAGCCCGCACTTCGTCCACGGGCGACTGATCAATCTCGTCACAGGCCAGGTGACGATCAAATATGGCTTCATGGGG
CCCAACCACGCGGTCGTGACGGCGTGCTCCACCGGTGCGCATTCGATCGGCGATGCGGCGCGCATGATCGCGCTCGATGA
TGCCGACGTGATGCTGGCGGGCGGGGCTGAAAGCACCGTCAATCCGCTCGGTATCGCAGGCTTCGCGCAGGCCCGCGCGC
TCAACACCAGCATGAATGACCGCCCGACCGAAGCGAGCCGCCCCTATGACAGGGACCGCGACGGATTCGTCATGGGCGAG
GGCGCAGGCGTGGTCGTGCTCGAGGAATACGAACGCGCCAAGGCGCGCGGCGCGAAAATCTACGGCGAAGTGACCGGGTA
TGGCCTGTCCGGCGATGCCTACCACGTGACCGCGCCGCATCCGGAAGGTCTCGGCGCACAATATGCGATGGAGATGGCGC
TCAAGAAGGCGGGGCTGAAGGCGGGCGACATCGACTATGTCAATGCCCACGGCACCTCGACCATGGCCGACACGATCGAA
CTGGCGGCGGTCAAGCGCGTGCTGGGCGATGATCTGAGCGGCGCTTCGATGAGCAGCACCAAGTCCGCCATCGGCCACTT
GCTCGGCGGGGCAGGGGCAGTCGAAGCCATCTTCTGCCTGCTCGCCATGCGCGACCAGATCGTCCCTCCGACGCTCAACC
TGCATAATCCCGACGAAGGCACCGAAGGCGTCGATCTCGTGCCGCTCAAGGCCAAGCAACGCCAAGTGCACGCCGTCCTC
AACAACAGCTTCGGCTTCGGCGGCACCAATGCGTCGCTGGTGATGCAGAAGGTCGACTGA

Upstream 100 bases:

>100_bases
AGCCCATTCGCGCTTATCACCCCGCCAGCCGCGCTGGCGGGGCCTGACAGGCCCGACCCCATCCGCGGGCCGGGCCTGTG
TCATTTCGACGGAGAATTGC

Downstream 100 bases:

>100_bases
TGCGCAAGCTGGGCTGCCTTGTCGCGGCGGCGGTCCTGATCGTGCTGGCTGCCGGGGTGTGGTTTGCCGGGGGCTGGTAC
GGCTCGGCGGCAATCGAGGA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MRRVVVTGLGLVTPLGGDVETSWKNLIAGESGAGQITSFDATDQKCTIACEVKPKDHPWGFDPDKRVDGKIQRQVDPFIV
YGIDAAGQALEDAGLTDMSDEEKRRTGCSIGSGIGGLPGIEKESVNLHERGPGRVSPHFVHGRLINLVTGQVTIKYGFMG
PNHAVVTACSTGAHSIGDAARMIALDDADVMLAGGAESTVNPLGIAGFAQARALNTSMNDRPTEASRPYDRDRDGFVMGE
GAGVVVLEEYERAKARGAKIYGEVTGYGLSGDAYHVTAPHPEGLGAQYAMEMALKKAGLKAGDIDYVNAHGTSTMADTIE
LAAVKRVLGDDLSGASMSSTKSAIGHLLGGAGAVEAIFCLLAMRDQIVPPTLNLHNPDEGTEGVDLVPLKAKQRQVHAVL
NNSFGFGGTNASLVMQKVD

Sequences:

>Translated_419_residues
MRRVVVTGLGLVTPLGGDVETSWKNLIAGESGAGQITSFDATDQKCTIACEVKPKDHPWGFDPDKRVDGKIQRQVDPFIV
YGIDAAGQALEDAGLTDMSDEEKRRTGCSIGSGIGGLPGIEKESVNLHERGPGRVSPHFVHGRLINLVTGQVTIKYGFMG
PNHAVVTACSTGAHSIGDAARMIALDDADVMLAGGAESTVNPLGIAGFAQARALNTSMNDRPTEASRPYDRDRDGFVMGE
GAGVVVLEEYERAKARGAKIYGEVTGYGLSGDAYHVTAPHPEGLGAQYAMEMALKKAGLKAGDIDYVNAHGTSTMADTIE
LAAVKRVLGDDLSGASMSSTKSAIGHLLGGAGAVEAIFCLLAMRDQIVPPTLNLHNPDEGTEGVDLVPLKAKQRQVHAVL
NNSFGFGGTNASLVMQKVD
>Mature_419_residues
MRRVVVTGLGLVTPLGGDVETSWKNLIAGESGAGQITSFDATDQKCTIACEVKPKDHPWGFDPDKRVDGKIQRQVDPFIV
YGIDAAGQALEDAGLTDMSDEEKRRTGCSIGSGIGGLPGIEKESVNLHERGPGRVSPHFVHGRLINLVTGQVTIKYGFMG
PNHAVVTACSTGAHSIGDAARMIALDDADVMLAGGAESTVNPLGIAGFAQARALNTSMNDRPTEASRPYDRDRDGFVMGE
GAGVVVLEEYERAKARGAKIYGEVTGYGLSGDAYHVTAPHPEGLGAQYAMEMALKKAGLKAGDIDYVNAHGTSTMADTIE
LAAVKRVLGDDLSGASMSSTKSAIGHLLGGAGAVEAIFCLLAMRDQIVPPTLNLHNPDEGTEGVDLVPLKAKQRQVHAVL
NNSFGFGGTNASLVMQKVD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=47.3684210526316, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI223972627, Length=187, Percent_Identity=38.5026737967914, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI41872631, Length=432, Percent_Identity=21.9907407407407, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1787337, Length=419, Percent_Identity=52.9832935560859, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1788663, Length=427, Percent_Identity=37.0023419203747, Blast_Score=241, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71983541, Length=429, Percent_Identity=38.4615384615385, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71983535, Length=257, Percent_Identity=45.5252918287938, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=354, Percent_Identity=24.0112994350282, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17550940, Length=280, Percent_Identity=28.2142857142857, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=40.3587443946188, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=44.1247002398081, Blast_Score=332, Evalue=3e-91,
Organism=Drosophila melanogaster, GI19920632, Length=363, Percent_Identity=23.9669421487603, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221330659, Length=363, Percent_Identity=23.9669421487603, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24581345, Length=354, Percent_Identity=23.728813559322, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43923; Mature: 43923

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGLVTPLGGDVETSWKNLIAGESGAGQITSFDATDQKCTIACEVKPKDHPWG
CCEEEEECCCEECCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCC
FDPDKRVDGKIQRQVDPFIVYGIDAAGQALEDAGLTDMSDEEKRRTGCSIGSGIGGLPGI
CCCCCCCCCHHHHCCCCEEEEEECHHCHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCC
EKESVNLHERGPGRVSPHFVHGRLINLVTGQVTIKYGFMGPNHAVVTACSTGAHSIGDAA
CCCCCCCCCCCCCCCCCEEECCEEEEEEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCE
RMIALDDADVMLAGGAESTVNPLGIAGFAQARALNTSMNDRPTEASRPYDRDRDGFVMGE
EEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEC
GAGVVVLEEYERAKARGAKIYGEVTGYGLSGDAYHVTAPHPEGLGAQYAMEMALKKAGLK
CCCEEEECCHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCC
AGDIDYVNAHGTSTMADTIELAAVKRVLGDDLSGASMSSTKSAIGHLLGGAGAVEAIFCL
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
LAMRDQIVPPTLNLHNPDEGTEGVDLVPLKAKQRQVHAVLNNSFGFGGTNASLVMQKVD
HHHHHCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MRRVVVTGLGLVTPLGGDVETSWKNLIAGESGAGQITSFDATDQKCTIACEVKPKDHPWG
CCEEEEECCCEECCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCC
FDPDKRVDGKIQRQVDPFIVYGIDAAGQALEDAGLTDMSDEEKRRTGCSIGSGIGGLPGI
CCCCCCCCCHHHHCCCCEEEEEECHHCHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCC
EKESVNLHERGPGRVSPHFVHGRLINLVTGQVTIKYGFMGPNHAVVTACSTGAHSIGDAA
CCCCCCCCCCCCCCCCCEEECCEEEEEEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCE
RMIALDDADVMLAGGAESTVNPLGIAGFAQARALNTSMNDRPTEASRPYDRDRDGFVMGE
EEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEC
GAGVVVLEEYERAKARGAKIYGEVTGYGLSGDAYHVTAPHPEGLGAQYAMEMALKKAGLK
CCCEEEECCHHHHHHCCCEEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCC
AGDIDYVNAHGTSTMADTIELAAVKRVLGDDLSGASMSSTKSAIGHLLGGAGAVEAIFCL
CCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHH
LAMRDQIVPPTLNLHNPDEGTEGVDLVPLKAKQRQVHAVLNNSFGFGGTNASLVMQKVD
HHHHHCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]