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The map label for this gene is rnd [H]

Identifier: 85373619

GI number: 85373619

Start: 816161

End: 817366

Strand: Reverse

Name: rnd [H]

Synonym: ELI_03960

Alternate gene names: 85373619

Gene position: 817366-816161 (Counterclockwise)

Preceding gene: 85373621

Following gene: 85373618

Centisome position: 26.78

GC content: 62.6

Gene sequence:

>1206_bases
ATGAAGATACACGACCTGATCACCGATACCGCAACGCTGGCCGAGCTGTGCGATCGCCTCGCTCAACACGAATTCGTCTG
CATCGACACCGAATTCATGCGCGAGAACACTTATTGGCCCGAACTCTGCCTGATCCAGATCGGCAATGAGGAAGAAGCCG
CCGCGGTCGATCCGCTGGCCGACGGGATCGATCTGCAGCCCCTGCTCGACCTGATGTGCGAGAATGAGGATATCCTTAAA
GTCTTCCATGCCGGCGGGCAGGATGTGGAGATCGTCTACAACCTCACGGGCAAGACGCCCTTCCCCATCTTCGACACGCA
GATCGCGATGATGGCGATCAGCCAGTCCGAACAGATCGGCTACGCCAACCTCGTCGAAAGCTGGCTCAACAAGACGATCG
ACAAGGGCGCGCGCTTCACCGACTGGAGCCGCCGCCCGCTGACCGACCGGCAGATCGAATATGCCATCGGCGACGTCACC
TATCTCGCCAAGATCTTCCCCAAGATCCTGAACAAGCTGGTGAAGACCGGCCGCGGGGCGTGGCTCAATGCCGAAATGGA
CAAGCTCGCCGATCCGGCCAATTACGAGAACGACCCCAGCGTCTCGTGGCGCCGCATCCGCTCTCAGGGGCGCAACCCGC
AGGTACTGGGACGCCTGAAAGCGTTGGCGGCGTGGCGCGAAGGCGAAGCGCAACACAAGAACATCCCGCGCGGCCGGATC
GTGCGCGACGAGACGTTGGCCGATATCGCCAGCCATCCGCCCAAGAAGCAGAGCGACCTCGCCAAGGTGCGCGGCCTCAG
CCAAGCCTGGCGCGACAACGATATCGGCAAGCGGCTGATGAAAGTGCTGGCCAATGCCGAGCCGCTGCCCAAGGAAGAAA
TGCCCGCCAAGGTGAAGCGCGGCGCCCCGCTCGGCAAGGAAGGCGCCTTGGTGGCGGACCTGTTGAAGCTCCTCCTCAAG
ATTCGCGCCCGCGAGATCGACATCGCCCCACGGCTGCTGACCAAGGCCGACGAGATGGAAGCCCTCGCCGCCGGCGTCCG
CGACCTGCCGATCCTGCAGGGCTGGCGTTACGATGTCTTCGGCAAGGACGCGCTGGAACTGGTCGAAGGAAAGACGGCCT
TCGCGGTCAAGGACGGCAAGCTCATCATGACCCATGTGGACGATATGGCCGGCGAACTGGAAGAAGCGCAGCAGGCAGCG
GAATAG

Upstream 100 bases:

>100_bases
AGGGGAAGCTCTGCCCTTTGTCAAGCCATGCTTGGCCTCGGGCAGGCTCCGAATGGGATCATTCCCGAGGGCGGTACTCC
GCCCAACCGAAGAAAGACCG

Downstream 100 bases:

>100_bases
TGCACGCCCATGTCCACGTACCTCCCCACCATCAAGCAGTTGCAGTATCTCGTCGCGTTGCACGAGCATGGCCATTTCGG
CCGGGCGGCAGAGGCGAGCT

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKIHDLITDTATLAELCDRLAQHEFVCIDTEFMRENTYWPELCLIQIGNEEEAAAVDPLADGIDLQPLLDLMCENEDILK
VFHAGGQDVEIVYNLTGKTPFPIFDTQIAMMAISQSEQIGYANLVESWLNKTIDKGARFTDWSRRPLTDRQIEYAIGDVT
YLAKIFPKILNKLVKTGRGAWLNAEMDKLADPANYENDPSVSWRRIRSQGRNPQVLGRLKALAAWREGEAQHKNIPRGRI
VRDETLADIASHPPKKQSDLAKVRGLSQAWRDNDIGKRLMKVLANAEPLPKEEMPAKVKRGAPLGKEGALVADLLKLLLK
IRAREIDIAPRLLTKADEMEALAAGVRDLPILQGWRYDVFGKDALELVEGKTAFAVKDGKLIMTHVDDMAGELEEAQQAA
E

Sequences:

>Translated_401_residues
MKIHDLITDTATLAELCDRLAQHEFVCIDTEFMRENTYWPELCLIQIGNEEEAAAVDPLADGIDLQPLLDLMCENEDILK
VFHAGGQDVEIVYNLTGKTPFPIFDTQIAMMAISQSEQIGYANLVESWLNKTIDKGARFTDWSRRPLTDRQIEYAIGDVT
YLAKIFPKILNKLVKTGRGAWLNAEMDKLADPANYENDPSVSWRRIRSQGRNPQVLGRLKALAAWREGEAQHKNIPRGRI
VRDETLADIASHPPKKQSDLAKVRGLSQAWRDNDIGKRLMKVLANAEPLPKEEMPAKVKRGAPLGKEGALVADLLKLLLK
IRAREIDIAPRLLTKADEMEALAAGVRDLPILQGWRYDVFGKDALELVEGKTAFAVKDGKLIMTHVDDMAGELEEAQQAA
E
>Mature_401_residues
MKIHDLITDTATLAELCDRLAQHEFVCIDTEFMRENTYWPELCLIQIGNEEEAAAVDPLADGIDLQPLLDLMCENEDILK
VFHAGGQDVEIVYNLTGKTPFPIFDTQIAMMAISQSEQIGYANLVESWLNKTIDKGARFTDWSRRPLTDRQIEYAIGDVT
YLAKIFPKILNKLVKTGRGAWLNAEMDKLADPANYENDPSVSWRRIRSQGRNPQVLGRLKALAAWREGEAQHKNIPRGRI
VRDETLADIASHPPKKQSDLAKVRGLSQAWRDNDIGKRLMKVLANAEPLPKEEMPAKVKRGAPLGKEGALVADLLKLLLK
IRAREIDIAPRLLTKADEMEALAAGVRDLPILQGWRYDVFGKDALELVEGKTAFAVKDGKLIMTHVDDMAGELEEAQQAA
E

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=310, Percent_Identity=24.5161290322581, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI50301240, Length=310, Percent_Identity=24.5161290322581, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1788105, Length=298, Percent_Identity=35.2348993288591, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324574, Length=174, Percent_Identity=29.3103448275862, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161078302, Length=261, Percent_Identity=22.2222222222222, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 44912; Mature: 44912

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHDLITDTATLAELCDRLAQHEFVCIDTEFMRENTYWPELCLIQIGNEEEAAAVDPLA
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCEEEEEECCCCCHHHHCHHH
DGIDLQPLLDLMCENEDILKVFHAGGQDVEIVYNLTGKTPFPIFDTQIAMMAISQSEQIG
CCCCHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
YANLVESWLNKTIDKGARFTDWSRRPLTDRQIEYAIGDVTYLAKIFPKILNKLVKTGRGA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WLNAEMDKLADPANYENDPSVSWRRIRSQGRNPQVLGRLKALAAWREGEAQHKNIPRGRI
EECCCHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCE
VRDETLADIASHPPKKQSDLAKVRGLSQAWRDNDIGKRLMKVLANAEPLPKEEMPAKVKR
ECHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCCHHHHC
GAPLGKEGALVADLLKLLLKIRAREIDIAPRLLTKADEMEALAAGVRDLPILQGWRYDVF
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCC
GKDALELVEGKTAFAVKDGKLIMTHVDDMAGELEEAQQAAE
CHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIHDLITDTATLAELCDRLAQHEFVCIDTEFMRENTYWPELCLIQIGNEEEAAAVDPLA
CCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCCCCCCEEEEEECCCCCHHHHCHHH
DGIDLQPLLDLMCENEDILKVFHAGGQDVEIVYNLTGKTPFPIFDTQIAMMAISQSEQIG
CCCCHHHHHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCC
YANLVESWLNKTIDKGARFTDWSRRPLTDRQIEYAIGDVTYLAKIFPKILNKLVKTGRGA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
WLNAEMDKLADPANYENDPSVSWRRIRSQGRNPQVLGRLKALAAWREGEAQHKNIPRGRI
EECCCHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCE
VRDETLADIASHPPKKQSDLAKVRGLSQAWRDNDIGKRLMKVLANAEPLPKEEMPAKVKR
ECHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHCCHHHHC
GAPLGKEGALVADLLKLLLKIRAREIDIAPRLLTKADEMEALAAGVRDLPILQGWRYDVF
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCC
GKDALELVEGKTAFAVKDGKLIMTHVDDMAGELEEAQQAAE
CHHHHHHHCCCEEEEEECCCEEEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]