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The map label for this gene is dxr [H]

Identifier: 85373588

GI number: 85373588

Start: 787072

End: 788226

Strand: Direct

Name: dxr [H]

Synonym: ELI_03805

Alternate gene names: 85373588

Gene position: 787072-788226 (Clockwise)

Preceding gene: 85373587

Following gene: 85373589

Centisome position: 25.79

GC content: 67.71

Gene sequence:

>1155_bases
ATGCGTTCGATTACCATCCTTGGCGCTACGGGCTCGGTCGGGGCTTCGACGCTCGACCTGATCCGCCGCGAGCGCGAGGT
GTGGCGCGTCGAAGCGCTGACCGCCAATTGCAGCGCGAAGGAGCTTGCCGCGCTGGCGCGCGAATTCGATGCCAAGGTTG
CAGTAGTGGGCGACGAGGGGTGCCTCGCCGACCTGCGCGAGGCGCTGTCGGGTAGCGGGATCGAAGCGGCTGGTGGCCGC
TCGGCTTTGTGCGAAGCGGCGGCGCGTCCGGTCGATATCACCGTCGCGGCGATCGTCGGCTGCGCGGGGCTCGGCCCGGT
CATGGCGGCGATCGAGCAGGGCGGCACCATCGCGCTTGCCAACAAGGAAGCGCTGGTTTCCGCGGGCGACGTCATGACGG
CGGCGGTCGCGAAGCACGGCGCGACGTTGCTGCCGGTCGACAGCGAGCACAACGCAATCTTCCAGTGCCTGCAGGGCAAC
ACTATCGAGGAAGTGCGCTGGATCACGCTGACCGCCAGCGGGGGCCCGCTGCGCACGCTCTCGGCAGACGAGCTTCACGC
CGTCACACCCGCGCAAGCCGTGGCGCATCCCAATTGGGACATGGGTGCCAAGATCAGCGTCGATTCAGCCACGATGATGA
ACAAGGGCCTTGAGTTCATCGAGGCGCACCACCTGTTCCCGGTCGGGCTCGACAGGATCCGGATCGTCGTTCATCCGCAA
AGCGTGATCCATTCCATGGTCGAATATCGCGACGGCTCGACCCTCGCGCAGCTCGGGCCATCGGACATGAAAGTGCCGAT
CGCCTCGTGCCTCGCCTGGCCGCGGCGGATGGAAACGGGCTGCGAACCGCTCGACCTAGTGGCACAGGGCGAGCTGACCT
TTTTCGCTCCCGACGAGGAGCGCTTCCCGGCCACGCGGCTGGCGCGCGAGGCGGCGGAGGCGGGCGGGTCGGCCCCGGCG
GTGCTGAATGCCGCCAACGAGATCGCGGTCGCCGCCTTCCTCGACGGTCAGATACCGTTCACGCGCATTGCCCTATCGGT
CGAGGACACCCTCGCGCAATCCGACCTGCCACCGGCACCGACTTCGCTCGACGACGTTCTTGCGGTAGACAGTGCCGCAC
GAGAGCGGGCCCGCGCCCTTCTGGAGATCGCCTGA

Upstream 100 bases:

>100_bases
CTGATTCCCGGCCATGGCGGCGTGTTCGACAGGATCGACGGACTCTTGCCTGTCAGCATCGTTGTCGGTGCGCTCGCCAA
TATATTCGCGGGCTAAGGCG

Downstream 100 bases:

>100_bases
CCGATGTTCGAATCGCCGCCTTTCTGGATGTATATCCTCGGTTTCCTGCTGCTGCTGGGGCCGCTGATTACGCTGCACGA
GCTGGGCCATTACCTCGTCG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MRSITILGATGSVGASTLDLIRREREVWRVEALTANCSAKELAALAREFDAKVAVVGDEGCLADLREALSGSGIEAAGGR
SALCEAAARPVDITVAAIVGCAGLGPVMAAIEQGGTIALANKEALVSAGDVMTAAVAKHGATLLPVDSEHNAIFQCLQGN
TIEEVRWITLTASGGPLRTLSADELHAVTPAQAVAHPNWDMGAKISVDSATMMNKGLEFIEAHHLFPVGLDRIRIVVHPQ
SVIHSMVEYRDGSTLAQLGPSDMKVPIASCLAWPRRMETGCEPLDLVAQGELTFFAPDEERFPATRLAREAAEAGGSAPA
VLNAANEIAVAAFLDGQIPFTRIALSVEDTLAQSDLPPAPTSLDDVLAVDSAARERARALLEIA

Sequences:

>Translated_384_residues
MRSITILGATGSVGASTLDLIRREREVWRVEALTANCSAKELAALAREFDAKVAVVGDEGCLADLREALSGSGIEAAGGR
SALCEAAARPVDITVAAIVGCAGLGPVMAAIEQGGTIALANKEALVSAGDVMTAAVAKHGATLLPVDSEHNAIFQCLQGN
TIEEVRWITLTASGGPLRTLSADELHAVTPAQAVAHPNWDMGAKISVDSATMMNKGLEFIEAHHLFPVGLDRIRIVVHPQ
SVIHSMVEYRDGSTLAQLGPSDMKVPIASCLAWPRRMETGCEPLDLVAQGELTFFAPDEERFPATRLAREAAEAGGSAPA
VLNAANEIAVAAFLDGQIPFTRIALSVEDTLAQSDLPPAPTSLDDVLAVDSAARERARALLEIA
>Mature_384_residues
MRSITILGATGSVGASTLDLIRREREVWRVEALTANCSAKELAALAREFDAKVAVVGDEGCLADLREALSGSGIEAAGGR
SALCEAAARPVDITVAAIVGCAGLGPVMAAIEQGGTIALANKEALVSAGDVMTAAVAKHGATLLPVDSEHNAIFQCLQGN
TIEEVRWITLTASGGPLRTLSADELHAVTPAQAVAHPNWDMGAKISVDSATMMNKGLEFIEAHHLFPVGLDRIRIVVHPQ
SVIHSMVEYRDGSTLAQLGPSDMKVPIASCLAWPRRMETGCEPLDLVAQGELTFFAPDEERFPATRLAREAAEAGGSAPA
VLNAANEIAVAAFLDGQIPFTRIALSVEDTLAQSDLPPAPTSLDDVLAVDSAARERARALLEIA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=391, Percent_Identity=51.150895140665, Blast_Score=335, Evalue=3e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 40119; Mature: 40119

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSITILGATGSVGASTLDLIRREREVWRVEALTANCSAKELAALAREFDAKVAVVGDEG
CCEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHCCEEEEEECCC
CLADLREALSGSGIEAAGGRSALCEAAARPVDITVAAIVGCAGLGPVMAAIEQGGTIALA
HHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHCCCEEEEE
NKEALVSAGDVMTAAVAKHGATLLPVDSEHNAIFQCLQGNTIEEVRWITLTASGGPLRTL
CCHHHHCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCEEEEEEEECCCCEEEC
SADELHAVTPAQAVAHPNWDMGAKISVDSATMMNKGLEFIEAHHLFPVGLDRIRIVVHPQ
CCCCHHCCCCHHHHCCCCCCCCCEEEECHHHHHHHCHHHHHHHCCCEECCCEEEEEECCH
SVIHSMVEYRDGSTLAQLGPSDMKVPIASCLAWPRRMETGCEPLDLVAQGELTFFAPDEE
HHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCEEEECCCCC
RFPATRLAREAAEAGGSAPAVLNAANEIAVAAFLDGQIPFTRIALSVEDTLAQSDLPPAP
CCCHHHHHHHHHHCCCCCCHHEECCCCEEEEEEECCCCCCEEEEEEHHHHHHHCCCCCCC
TSLDDVLAVDSAARERARALLEIA
CCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRSITILGATGSVGASTLDLIRREREVWRVEALTANCSAKELAALAREFDAKVAVVGDEG
CCEEEEEECCCCCCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHCCEEEEEECCC
CLADLREALSGSGIEAAGGRSALCEAAARPVDITVAAIVGCAGLGPVMAAIEQGGTIALA
HHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHCCHHHHHHHHHCCCEEEEE
NKEALVSAGDVMTAAVAKHGATLLPVDSEHNAIFQCLQGNTIEEVRWITLTASGGPLRTL
CCHHHHCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCEEEEEEEECCCCEEEC
SADELHAVTPAQAVAHPNWDMGAKISVDSATMMNKGLEFIEAHHLFPVGLDRIRIVVHPQ
CCCCHHCCCCHHHHCCCCCCCCCEEEECHHHHHHHCHHHHHHHCCCEECCCEEEEEECCH
SVIHSMVEYRDGSTLAQLGPSDMKVPIASCLAWPRRMETGCEPLDLVAQGELTFFAPDEE
HHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEECCCEEEECCCCC
RFPATRLAREAAEAGGSAPAVLNAANEIAVAAFLDGQIPFTRIALSVEDTLAQSDLPPAP
CCCHHHHHHHHHHCCCCCCHHEECCCCEEEEEEECCCCCCEEEEEEHHHHHHHCCCCCCC
TSLDDVLAVDSAARERARALLEIA
CCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11004410 [H]