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The map label for this gene is hppA

Identifier: 85373341

GI number: 85373341

Start: 555925

End: 558057

Strand: Reverse

Name: hppA

Synonym: ELI_02570

Alternate gene names: 85373341

Gene position: 558057-555925 (Counterclockwise)

Preceding gene: 85373344

Following gene: 85373340

Centisome position: 18.28

GC content: 63.24

Gene sequence:

>2133_bases
GTGAATCTCGTATTGATCGCGATTGGCCTGGGACTGCTTGCCGTAATCTACGGCTTCGTCACCAGCCGTCAGGTTCTCGG
CGCCAGTGCCGGGAACGCAAAAATGCAGGAAATCGCCGGCGCTATCCAGGAAGGGGCGCAGGCTTACCTCAACCGCCAAT
ACACCACCATCGGCATCGTCGGCGTGATCGCCGCTATCGTCCTCGGCCTGCTCCTGGGCGTGGTACCGGCCGTCGGTTTC
GTGATCGGCGCGGTGCTTTCGGGTGTCGCCGGCTATATCGGCATGAACATCTCGGTACGCTCTAACGTGCGTACGGCTGC
GGCGGCGGAAAAGAGCCTGCAGAGCGGCCTGACCATCGCCTTCCGCGCCGGCGCCATCACCGGCATGCTCGTGGCAGGCC
TTGCGCTGCTCGCCATCGCTGTGTTCTTCTACGCGTTGATCGGCCCGATGGGTTACGAAGTGACCAGCCGTACGGTGATC
GATGGCCTCGTCGGCCTCGCCTTTGGTGCATCGCTGATCTCGATCTTCGCGCGTCTCGGCGGCGGTATCTTCACCAAGGC
TGCTGACGTCGGCGCCGACCTGGTCGGCAAGGTCGAAGCAGGCATCCCGGAAGACGATCCCCGCAACCCGGCGACCATCG
CCGATAACGTAGGCGACAACGTCGGCGACTGTGCCGGCATGGCCGCCGACCTGTTCGAGACCTACGTCGTCACCGTCGGT
GCGACCATGGTTCTGACCGCCCTGCTGCTGCCTTCTATCGGCGACCTGTTGTTGCCGCTGATGGCGCTGCCGCTGCTGAT
CGGCGGGGCGTGCATCGTGACCTCGATCATCGGCACCTACTTCGTCCGTCTCGGAGGCGGCACGAATGTCATGGGCGCGA
TGTACAAGGGCTTTCTTGTCTCGGCTGTCGGCGCGATCCCGCTGATCTATCTCGTCACGCAATACGCGCTGGGCGAGATG
GACAGCGTAATCAATGCCGGTACCGGCATGGTCGAGTTTACCGGCATGGACCTGTTTCTGTGCGCGCTGCTCGGTCTTGT
CATCACCGGCCTGATCATCTGGATCACCGAATATTACACCGGTACGAACTTCCGTCCGGTGCGGTCGATCGCGAAAGCAT
CGGAAACGGGCCACGGCACCAATGTGATCCAGGGTCTCGCCATCAGCCTCGAATCGACGGCGCTGCCAACGATCGTCATC
GCTGGCGGTATCATCATCGCGTACCAGCTCGCTGGCCTGATGGGCATTGCCTATGGTGCAACCGCCATGCTCGCGCTCGC
CGGCATGGTCGTCGCGCTCGACGCCTATGGTCCGGTGACGGATAACGCCGGCGGCATCGCCGAAATGGCCGGTCTCGACG
ATAGCGTTCGTGAGAAGACCGACCTGCTCGACGCGGTCGGCAACACCACCAAGGCCGTGACCAAGGGGTATGCGATCGGT
TCGGCGGGCCTCGGCGCGCTGGTTCTGTTTGCCGCCTACACGACCGACCTTCGCGTGTTCTTCCCGGAATTCCTGGATGG
CGACCTTACCAATGGTGAAGTCTCCTTCAGCCTGGAGAACCCCTATGTGATCGTCGGCCTGTTCCTAGGGGCGCTGCTCC
CGTACCTGTTCGGTGCGATGGGCATGACCGCTGTGGGTCGCGCAGCCGGTGACGTGGTGAAGGACGTGCGCGAGCAGTTC
GCTGCCGACAAGGGCATCATGGCCGGGACCAGCCGTCCCGACTACGCCCGCACGGTCGATCTCGTGACCAAGGCTGCGAT
CAAGGAAATGATCATCCCGTCGCTGCTGCCGGTGCTGTCGCCGGTAGTCGTGTACTTCGTGATCACCGCGATCGCGGGCC
AGGACAACGGCTTCGCCGCGCTTGGCGCGATGCTGCTCGGCGTCATCGTCGGCGGTCTCTTCGTCGCACTTTCCATGACC
GCCGGTGGCGGCGCGTGGGATAACGCGAAGAAGTACATCGAAGACGGCAACCATGGCGGCAAGGGTTCGGAAGCGCACAA
GGCTGCCGTGACCGGTGACACCGTCGGTGATCCCTACAAGGATACCGCCGGCCCGGCCGTGAACCCGATGATCAAGATCA
CCAACATCGTCGCGCTGCTGCTGCTGGCGGTGCTGGCAGGTGGACACGCTTAA

Upstream 100 bases:

>100_bases
GCCTCTCTTTCCAAGCCGCTCTAGCGATACGCGCCACATGGCCCCGTGCGTGCGGGGCTTTTGGGTTTGTACGAATAGAC
AAAATCTGAGGGGAATTTTC

Downstream 100 bases:

>100_bases
GCAACGAGAGTTCGCAAGACACCAAGAGGGGGCGCGGGAACTTCGTTTTTCGCGCCCTTTTTGGCAGCAGCGTTAACATC
TCTTGAGAAGATCGCGTGTA

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 710; Mature: 710

Protein sequence:

>710_residues
MNLVLIAIGLGLLAVIYGFVTSRQVLGASAGNAKMQEIAGAIQEGAQAYLNRQYTTIGIVGVIAAIVLGLLLGVVPAVGF
VIGAVLSGVAGYIGMNISVRSNVRTAAAAEKSLQSGLTIAFRAGAITGMLVAGLALLAIAVFFYALIGPMGYEVTSRTVI
DGLVGLAFGASLISIFARLGGGIFTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYVVTVG
ATMVLTALLLPSIGDLLLPLMALPLLIGGACIVTSIIGTYFVRLGGGTNVMGAMYKGFLVSAVGAIPLIYLVTQYALGEM
DSVINAGTGMVEFTGMDLFLCALLGLVITGLIIWITEYYTGTNFRPVRSIAKASETGHGTNVIQGLAISLESTALPTIVI
AGGIIIAYQLAGLMGIAYGATAMLALAGMVVALDAYGPVTDNAGGIAEMAGLDDSVREKTDLLDAVGNTTKAVTKGYAIG
SAGLGALVLFAAYTTDLRVFFPEFLDGDLTNGEVSFSLENPYVIVGLFLGALLPYLFGAMGMTAVGRAAGDVVKDVREQF
AADKGIMAGTSRPDYARTVDLVTKAAIKEMIIPSLLPVLSPVVVYFVITAIAGQDNGFAALGAMLLGVIVGGLFVALSMT
AGGGAWDNAKKYIEDGNHGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLAGGHA

Sequences:

>Translated_710_residues
MNLVLIAIGLGLLAVIYGFVTSRQVLGASAGNAKMQEIAGAIQEGAQAYLNRQYTTIGIVGVIAAIVLGLLLGVVPAVGF
VIGAVLSGVAGYIGMNISVRSNVRTAAAAEKSLQSGLTIAFRAGAITGMLVAGLALLAIAVFFYALIGPMGYEVTSRTVI
DGLVGLAFGASLISIFARLGGGIFTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYVVTVG
ATMVLTALLLPSIGDLLLPLMALPLLIGGACIVTSIIGTYFVRLGGGTNVMGAMYKGFLVSAVGAIPLIYLVTQYALGEM
DSVINAGTGMVEFTGMDLFLCALLGLVITGLIIWITEYYTGTNFRPVRSIAKASETGHGTNVIQGLAISLESTALPTIVI
AGGIIIAYQLAGLMGIAYGATAMLALAGMVVALDAYGPVTDNAGGIAEMAGLDDSVREKTDLLDAVGNTTKAVTKGYAIG
SAGLGALVLFAAYTTDLRVFFPEFLDGDLTNGEVSFSLENPYVIVGLFLGALLPYLFGAMGMTAVGRAAGDVVKDVREQF
AADKGIMAGTSRPDYARTVDLVTKAAIKEMIIPSLLPVLSPVVVYFVITAIAGQDNGFAALGAMLLGVIVGGLFVALSMT
AGGGAWDNAKKYIEDGNHGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLAGGHA
>Mature_710_residues
MNLVLIAIGLGLLAVIYGFVTSRQVLGASAGNAKMQEIAGAIQEGAQAYLNRQYTTIGIVGVIAAIVLGLLLGVVPAVGF
VIGAVLSGVAGYIGMNISVRSNVRTAAAAEKSLQSGLTIAFRAGAITGMLVAGLALLAIAVFFYALIGPMGYEVTSRTVI
DGLVGLAFGASLISIFARLGGGIFTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYVVTVG
ATMVLTALLLPSIGDLLLPLMALPLLIGGACIVTSIIGTYFVRLGGGTNVMGAMYKGFLVSAVGAIPLIYLVTQYALGEM
DSVINAGTGMVEFTGMDLFLCALLGLVITGLIIWITEYYTGTNFRPVRSIAKASETGHGTNVIQGLAISLESTALPTIVI
AGGIIIAYQLAGLMGIAYGATAMLALAGMVVALDAYGPVTDNAGGIAEMAGLDDSVREKTDLLDAVGNTTKAVTKGYAIG
SAGLGALVLFAAYTTDLRVFFPEFLDGDLTNGEVSFSLENPYVIVGLFLGALLPYLFGAMGMTAVGRAAGDVVKDVREQF
AADKGIMAGTSRPDYARTVDLVTKAAIKEMIIPSLLPVLSPVVVYFVITAIAGQDNGFAALGAMLLGVIVGGLFVALSMT
AGGGAWDNAKKYIEDGNHGGKGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLAGGHA

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 72288; Mature: 72288

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVLIAIGLGLLAVIYGFVTSRQVLGASAGNAKMQEIAGAIQEGAQAYLNRQYTTIGIV
CCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GVIAAIVLGLLLGVVPAVGFVIGAVLSGVAGYIGMNISVRSNVRTAAAAEKSLQSGLTIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCEEE
FRAGAITGMLVAGLALLAIAVFFYALIGPMGYEVTSRTVIDGLVGLAFGASLISIFARLG
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGIFTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYVVTVG
CCHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLTALLLPSIGDLLLPLMALPLLIGGACIVTSIIGTYFVRLGGGTNVMGAMYKGFLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SAVGAIPLIYLVTQYALGEMDSVINAGTGMVEFTGMDLFLCALLGLVITGLIIWITEYYT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHC
GTNFRPVRSIAKASETGHGTNVIQGLAISLESTALPTIVIAGGIIIAYQLAGLMGIAYGA
CCCCHHHHHHHHHHCCCCCHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TAMLALAGMVVALDAYGPVTDNAGGIAEMAGLDDSVREKTDLLDAVGNTTKAVTKGYAIG
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCC
SAGLGALVLFAAYTTDLRVFFPEFLDGDLTNGEVSFSLENPYVIVGLFLGALLPYLFGAM
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
GMTAVGRAAGDVVKDVREQFAADKGIMAGTSRPDYARTVDLVTKAAIKEMIIPSLLPVLS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PVVVYFVITAIAGQDNGFAALGAMLLGVIVGGLFVALSMTAGGGAWDNAKKYIEDGNHGG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
KGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLAGGHA
CCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNLVLIAIGLGLLAVIYGFVTSRQVLGASAGNAKMQEIAGAIQEGAQAYLNRQYTTIGIV
CCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
GVIAAIVLGLLLGVVPAVGFVIGAVLSGVAGYIGMNISVRSNVRTAAAAEKSLQSGLTIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHCCCEEE
FRAGAITGMLVAGLALLAIAVFFYALIGPMGYEVTSRTVIDGLVGLAFGASLISIFARLG
EEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGIFTKAADVGADLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYVVTVG
CCHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLTALLLPSIGDLLLPLMALPLLIGGACIVTSIIGTYFVRLGGGTNVMGAMYKGFLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
SAVGAIPLIYLVTQYALGEMDSVINAGTGMVEFTGMDLFLCALLGLVITGLIIWITEYYT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHC
GTNFRPVRSIAKASETGHGTNVIQGLAISLESTALPTIVIAGGIIIAYQLAGLMGIAYGA
CCCCHHHHHHHHHHCCCCCHHHHHHHHHEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TAMLALAGMVVALDAYGPVTDNAGGIAEMAGLDDSVREKTDLLDAVGNTTKAVTKGYAIG
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCC
SAGLGALVLFAAYTTDLRVFFPEFLDGDLTNGEVSFSLENPYVIVGLFLGALLPYLFGAM
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
GMTAVGRAAGDVVKDVREQFAADKGIMAGTSRPDYARTVDLVTKAAIKEMIIPSLLPVLS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
PVVVYFVITAIAGQDNGFAALGAMLLGVIVGGLFVALSMTAGGGAWDNAKKYIEDGNHGG
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCC
KGSEAHKAAVTGDTVGDPYKDTAGPAVNPMIKITNIVALLLLAVLAGGHA
CCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9630689; 11956221 [H]