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The map label for this gene is tesB [H]

Identifier: 85373338

GI number: 85373338

Start: 552756

End: 553682

Strand: Reverse

Name: tesB [H]

Synonym: ELI_02555

Alternate gene names: 85373338

Gene position: 553682-552756 (Counterclockwise)

Preceding gene: 85373339

Following gene: 85373337

Centisome position: 18.14

GC content: 69.04

Gene sequence:

>927_bases
ATGAGTGATACCGTCCCTCCCGAAAAACTCGTCGGCGGCCTGGTCAAGCTGCTGACGGTCGAGAAACGCGCGACCGACGT
CTACCAGGGCCGGCCGCAGAAGGGCGGCACGGGCCGGGTCTTCGGCGGGCAGGTCATCGCGCAGGCGCTGCAGGCGGCGC
AGGCCACGGTCGGAGGCTCTGGCACCGACGGCAAACAGGCCCACTCGCTCCACGCCTATTTCCTGCGCGGCGGCAAGGAA
GGCCCGCCGATCGAATACCGCATCGAGCGCGATTTCGACGGCCGCAGCTTCGCCAACCGCCGCGTCGTCGCAAGCCAGGA
GAACGAGGACGGCACCAGCACCCCGATCCTCAACCTCACCGCCAGCTTCCAGGCCCCGGAAGACGGCATGGAGCACGAGG
ATGCGCCCATGCCCGACGTCCCCGCCCCGGACGACTTGCGCAGCGACATGGAGGTCCGCCGCGAGATCGCCGAGAAGGCC
GGCGACAAGCTCTCCGAAGCCCAGCGCAACATGATGCTGCGCCCGCGCCCGATCGACATGCGCACCTGCGACCGGCTGCA
CTGGATGAACCGCGAACCGAGCGAGCCGCGCGCGCACAGCTGGTTCAGGACGGTCGCCCCGCTGCCGGACGATCCACAGC
TGCACCGCGCGATCATCAGCTATGCCAGCGATTACACGCTGCTCGGCACCAGCGCCCTGCCCCACGGCCTCAGCTGGATG
CGCGGCGAACTGGTCGGCGCGAGCCTCGACCACGCGCTGTGGTTCCACCGCCCCGCCCGCGCCGACGAATGGCTGCTCTA
CGCCACGCAAAGCCCGTGGAGCGGATCGGGCCGCGGCATGAACCTCGGGCGCATCTTCAACCAGCGCGGAGAGCTTGTCG
CCAGCGTCGCGCAGGAAGGGATGATGCGGAAGCGGAAGTCCAAATAG

Upstream 100 bases:

>100_bases
GGCCTATGCCTATCGCGCGCTGCGCAAGACGGGCCTGGTTGCCTAAGACCTTGCACAGACCGGATTGACCTCGCCGCGCC
TTCCCCGCAGGAGGCGTGGC

Downstream 100 bases:

>100_bases
TTCCGAGTCGCAGCGTGACGATGCCGCTAAGTTTACGAACTTTGCGCATGGAGAGATTCAAAACCCAAAAGTTTGCCCCG
CTGCGCGCGGTTTCGGGAGG

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MSDTVPPEKLVGGLVKLLTVEKRATDVYQGRPQKGGTGRVFGGQVIAQALQAAQATVGGSGTDGKQAHSLHAYFLRGGKE
GPPIEYRIERDFDGRSFANRRVVASQENEDGTSTPILNLTASFQAPEDGMEHEDAPMPDVPAPDDLRSDMEVRREIAEKA
GDKLSEAQRNMMLRPRPIDMRTCDRLHWMNREPSEPRAHSWFRTVAPLPDDPQLHRAIISYASDYTLLGTSALPHGLSWM
RGELVGASLDHALWFHRPARADEWLLYATQSPWSGSGRGMNLGRIFNQRGELVASVAQEGMMRKRKSK

Sequences:

>Translated_308_residues
MSDTVPPEKLVGGLVKLLTVEKRATDVYQGRPQKGGTGRVFGGQVIAQALQAAQATVGGSGTDGKQAHSLHAYFLRGGKE
GPPIEYRIERDFDGRSFANRRVVASQENEDGTSTPILNLTASFQAPEDGMEHEDAPMPDVPAPDDLRSDMEVRREIAEKA
GDKLSEAQRNMMLRPRPIDMRTCDRLHWMNREPSEPRAHSWFRTVAPLPDDPQLHRAIISYASDYTLLGTSALPHGLSWM
RGELVGASLDHALWFHRPARADEWLLYATQSPWSGSGRGMNLGRIFNQRGELVASVAQEGMMRKRKSK
>Mature_307_residues
SDTVPPEKLVGGLVKLLTVEKRATDVYQGRPQKGGTGRVFGGQVIAQALQAAQATVGGSGTDGKQAHSLHAYFLRGGKEG
PPIEYRIERDFDGRSFANRRVVASQENEDGTSTPILNLTASFQAPEDGMEHEDAPMPDVPAPDDLRSDMEVRREIAEKAG
DKLSEAQRNMMLRPRPIDMRTCDRLHWMNREPSEPRAHSWFRTVAPLPDDPQLHRAIISYASDYTLLGTSALPHGLSWMR
GELVGASLDHALWFHRPARADEWLLYATQSPWSGSGRGMNLGRIFNQRGELVASVAQEGMMRKRKSK

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=308, Percent_Identity=35.0649350649351, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1786657, Length=286, Percent_Identity=38.4615384615385, Blast_Score=201, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI71988741, Length=311, Percent_Identity=33.1189710610932, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17558508, Length=323, Percent_Identity=33.7461300309598, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17531889, Length=285, Percent_Identity=30.8771929824561, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI115532456, Length=285, Percent_Identity=30.8771929824561, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17531885, Length=285, Percent_Identity=30.8771929824561, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71982224, Length=310, Percent_Identity=31.2903225806452, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI212645202, Length=279, Percent_Identity=29.3906810035842, Blast_Score=104, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 34166; Mature: 34035

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTVPPEKLVGGLVKLLTVEKRATDVYQGRPQKGGTGRVFGGQVIAQALQAAQATVGGS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCC
GTDGKQAHSLHAYFLRGGKEGPPIEYRIERDFDGRSFANRRVVASQENEDGTSTPILNLT
CCCCHHHHHHHHHHEECCCCCCCEEEEEECCCCCCHHCCCCEEECCCCCCCCCCCEEEEE
ASFQAPEDGMEHEDAPMPDVPAPDDLRSDMEVRREIAEKAGDKLSEAQRNMMLRPRPIDM
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCH
RTCDRLHWMNREPSEPRAHSWFRTVAPLPDDPQLHRAIISYASDYTLLGTSALPHGLSWM
HHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHH
RGELVGASLDHALWFHRPARADEWLLYATQSPWSGSGRGMNLGRIFNQRGELVASVAQEG
HHHHHCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MMRKRKSK
HHHHHCCC
>Mature Secondary Structure 
SDTVPPEKLVGGLVKLLTVEKRATDVYQGRPQKGGTGRVFGGQVIAQALQAAQATVGGS
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCC
GTDGKQAHSLHAYFLRGGKEGPPIEYRIERDFDGRSFANRRVVASQENEDGTSTPILNLT
CCCCHHHHHHHHHHEECCCCCCCEEEEEECCCCCCHHCCCCEEECCCCCCCCCCCEEEEE
ASFQAPEDGMEHEDAPMPDVPAPDDLRSDMEVRREIAEKAGDKLSEAQRNMMLRPRPIDM
ECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCH
RTCDRLHWMNREPSEPRAHSWFRTVAPLPDDPQLHRAIISYASDYTLLGTSALPHGLSWM
HHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHH
RGELVGASLDHALWFHRPARADEWLLYATQSPWSGSGRGMNLGRIFNQRGELVASVAQEG
HHHHHCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MMRKRKSK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]