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The map label for this gene is argH [H]

Identifier: 85373234

GI number: 85373234

Start: 451920

End: 453257

Strand: Reverse

Name: argH [H]

Synonym: ELI_02035

Alternate gene names: 85373234

Gene position: 453257-451920 (Counterclockwise)

Preceding gene: 85373238

Following gene: 85373233

Centisome position: 14.85

GC content: 66.59

Gene sequence:

>1338_bases
ATGCGCGAAATCAACGCTTCTATCCCGTTCGACAAGGCGCTGTGGCGGCAGGATATCGCCGGCAGCCGCGCGCATGTGGC
GATGCTGGCGAAGCAGGGGATCGTCAGCGCCGAGGATGCGAAGGCGATCGACGATGGCCTGCAGCAGGTCGCGGCGGAGT
ATGAGCGCGATGGCGTGCCCGAGGACTGGGACCTCGAGGACATTCACATGACCGTCGAGGCGCGGCTGACCGAGCTGATC
GGCCCGGTCGCCGGGCGGCTGCACACCGCGCGCAGCCGCAACGACCAGGTCGCGACCGATTTCAAGCTGTGGGTGCGCGA
AGCGACGAACTGTGCGCTCGATGGCATCGCAGCGCTGCAACGCGCGCTTGTTGTCCGTGCCGGCGAGCATGCCGACAGCG
TCATGCCGGGCTTTACCCATCTTCAGACCGCGCAGCCGGTGACGCTCGGCCATCATCTATTGGCCTATTATGAGATGCTG
CGCCGCGACGCTTCGCGGTTCGGCGACAACCTTGCGCGCGCCGATGAATGCCCGCTCGGCGCAGCGGCGCTGGCAGGGAC
CGGTTTCGATCTCGATCGCACCATGACTGCCGATGCACTCGGTTTCGCGCGGCCCACCGCCAACAGCCTCGACACCGTCT
CCGATCGCGATTTCGCGCTCGATTACCTGCAGGCGGCAAGCCAGTGCGCTCTGCATCTGTCACGCCTCGCGGAGGAATTG
ATCCTGTGGGCGAGCCAGCCATTCGGCTTCGTGCGGCTGCCCGACAGCCTCTCCACCGGCAGCTCGATCATGCCGCAGAA
GAAGAACCCGGACGCCGCCGAGCTGGTGCGCGGCCATGCCGGGCGGATCGTCGGCGCTACGACAGCGCTGATCGTGACAA
TGAAAGGCCTGCCGCTGGCCTATTCGAAGGACATGCAGGACGACAAGCCGCCGGTTTTCGAAGCGGCCGGGCTACTCGAC
CTGTGCCTGGCAGCAATGGAAGGCATGATCGCAGGCGCCGACTTCAACGCCGAGCGCATGCGCCATGCAGCGGGGCTCGG
TCATGCCACCGCGACCGATCTCGCCGACTGGCTGGTGCGCGAGGCCGATATTCCCTTCCGCGAGGCGCATCATATTACCG
GCGCAGCGGTGAAGCTTGCGGACAGAAAAGAATGCACGCTGGAGGACCTCTCGCTCGACGATCTCAAGGGCATCGACGCG
CGGCTCGACGAGCGCGTGCGCGCGGTCCTGACGCTCGATGCCTCGGTCGCGGCGCGCGCTTCCTATGGCGGGACCGCGCC
CGATCGGGTACGCGAACAAGTCGCCGCAGCGCGCCGGGCGCTGGGGATGGAGGAATGA

Upstream 100 bases:

>100_bases
GAGCGCAAGAAGGACGATTGCAAGCGTGAGCGACACTCGGGACACGAAAGGCTCCAACCAGATGTGGGGCGGCAGGTTCG
CTGAAGGACCTAGTGCGATC

Downstream 100 bases:

>100_bases
TGCGTCACACCCGCCACAGCATTGTACTGCTTGCGCTTGTAGCACTCGCCGCGTGCGGGCAGCAGGCCGACCTCAAGCCG
GTCGCGGGAGCCGAGCTGCC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MREINASIPFDKALWRQDIAGSRAHVAMLAKQGIVSAEDAKAIDDGLQQVAAEYERDGVPEDWDLEDIHMTVEARLTELI
GPVAGRLHTARSRNDQVATDFKLWVREATNCALDGIAALQRALVVRAGEHADSVMPGFTHLQTAQPVTLGHHLLAYYEML
RRDASRFGDNLARADECPLGAAALAGTGFDLDRTMTADALGFARPTANSLDTVSDRDFALDYLQAASQCALHLSRLAEEL
ILWASQPFGFVRLPDSLSTGSSIMPQKKNPDAAELVRGHAGRIVGATTALIVTMKGLPLAYSKDMQDDKPPVFEAAGLLD
LCLAAMEGMIAGADFNAERMRHAAGLGHATATDLADWLVREADIPFREAHHITGAAVKLADRKECTLEDLSLDDLKGIDA
RLDERVRAVLTLDASVAARASYGGTAPDRVREQVAAARRALGMEE

Sequences:

>Translated_445_residues
MREINASIPFDKALWRQDIAGSRAHVAMLAKQGIVSAEDAKAIDDGLQQVAAEYERDGVPEDWDLEDIHMTVEARLTELI
GPVAGRLHTARSRNDQVATDFKLWVREATNCALDGIAALQRALVVRAGEHADSVMPGFTHLQTAQPVTLGHHLLAYYEML
RRDASRFGDNLARADECPLGAAALAGTGFDLDRTMTADALGFARPTANSLDTVSDRDFALDYLQAASQCALHLSRLAEEL
ILWASQPFGFVRLPDSLSTGSSIMPQKKNPDAAELVRGHAGRIVGATTALIVTMKGLPLAYSKDMQDDKPPVFEAAGLLD
LCLAAMEGMIAGADFNAERMRHAAGLGHATATDLADWLVREADIPFREAHHITGAAVKLADRKECTLEDLSLDDLKGIDA
RLDERVRAVLTLDASVAARASYGGTAPDRVREQVAAARRALGMEE
>Mature_445_residues
MREINASIPFDKALWRQDIAGSRAHVAMLAKQGIVSAEDAKAIDDGLQQVAAEYERDGVPEDWDLEDIHMTVEARLTELI
GPVAGRLHTARSRNDQVATDFKLWVREATNCALDGIAALQRALVVRAGEHADSVMPGFTHLQTAQPVTLGHHLLAYYEML
RRDASRFGDNLARADECPLGAAALAGTGFDLDRTMTADALGFARPTANSLDTVSDRDFALDYLQAASQCALHLSRLAEEL
ILWASQPFGFVRLPDSLSTGSSIMPQKKNPDAAELVRGHAGRIVGATTALIVTMKGLPLAYSKDMQDDKPPVFEAAGLLD
LCLAAMEGMIAGADFNAERMRHAAGLGHATATDLADWLVREADIPFREAHHITGAAVKLADRKECTLEDLSLDDLKGIDA
RLDERVRAVLTLDASVAARASYGGTAPDRVREQVAAARRALGMEE

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=445, Percent_Identity=41.3483146067416, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI68303542, Length=445, Percent_Identity=41.3483146067416, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI68303549, Length=441, Percent_Identity=39.9092970521542, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI68303547, Length=445, Percent_Identity=39.1011235955056, Blast_Score=298, Evalue=9e-81,
Organism=Escherichia coli, GI1790398, Length=443, Percent_Identity=46.5011286681716, Blast_Score=370, Evalue=1e-104,
Organism=Escherichia coli, GI87082375, Length=264, Percent_Identity=26.5151515151515, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17553882, Length=306, Percent_Identity=25.4901960784314, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32565146, Length=274, Percent_Identity=26.2773722627737, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321806, Length=444, Percent_Identity=39.4144144144144, Blast_Score=330, Evalue=3e-91,
Organism=Drosophila melanogaster, GI221473854, Length=443, Percent_Identity=37.6975169300226, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI78706858, Length=443, Percent_Identity=37.6975169300226, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI78710009, Length=225, Percent_Identity=27.1111111111111, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 48065; Mature: 48065

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00163 FUMARATE_LYASES ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREINASIPFDKALWRQDIAGSRAHVAMLAKQGIVSAEDAKAIDDGLQQVAAEYERDGVP
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
EDWDLEDIHMTVEARLTELIGPVAGRLHTARSRNDQVATDFKLWVREATNCALDGIAALQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RALVVRAGEHADSVMPGFTHLQTAQPVTLGHHLLAYYEMLRRDASRFGDNLARADECPLG
HHHHHHCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCC
AAALAGTGFDLDRTMTADALGFARPTANSLDTVSDRDFALDYLQAASQCALHLSRLAEEL
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ILWASQPFGFVRLPDSLSTGSSIMPQKKNPDAAELVRGHAGRIVGATTALIVTMKGLPLA
HHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHEEHEEECCCCCC
YSKDMQDDKPPVFEAAGLLDLCLAAMEGMIAGADFNAERMRHAAGLGHATATDLADWLVR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
EADIPFREAHHITGAAVKLADRKECTLEDLSLDDLKGIDARLDERVRAVLTLDASVAARA
HCCCCHHHHHCCCCHHEEECCCCCCCHHCCCHHHHCCCHHHHHHHHHHHHEECHHHHHHC
SYGGTAPDRVREQVAAARRALGMEE
CCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MREINASIPFDKALWRQDIAGSRAHVAMLAKQGIVSAEDAKAIDDGLQQVAAEYERDGVP
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
EDWDLEDIHMTVEARLTELIGPVAGRLHTARSRNDQVATDFKLWVREATNCALDGIAALQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RALVVRAGEHADSVMPGFTHLQTAQPVTLGHHLLAYYEMLRRDASRFGDNLARADECPLG
HHHHHHCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCC
AAALAGTGFDLDRTMTADALGFARPTANSLDTVSDRDFALDYLQAASQCALHLSRLAEEL
HHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ILWASQPFGFVRLPDSLSTGSSIMPQKKNPDAAELVRGHAGRIVGATTALIVTMKGLPLA
HHHCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHEEHEEECCCCCC
YSKDMQDDKPPVFEAAGLLDLCLAAMEGMIAGADFNAERMRHAAGLGHATATDLADWLVR
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
EADIPFREAHHITGAAVKLADRKECTLEDLSLDDLKGIDARLDERVRAVLTLDASVAARA
HCCCCHHHHHCCCCHHEEECCCCCCCHHCCCHHHHCCCHHHHHHHHHHHHEECHHHHHHC
SYGGTAPDRVREQVAAARRALGMEE
CCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA