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The map label for this gene is ppiA [H]

Identifier: 85060281

GI number: 85060281

Start: 3957161

End: 3957733

Strand: Reverse

Name: ppiA [H]

Synonym: SG2303

Alternate gene names: 85060281

Gene position: 3957733-3957161 (Counterclockwise)

Preceding gene: 85060282

Following gene: 85060280

Centisome position: 94.88

GC content: 55.67

Gene sequence:

>573_bases
ATGCTCAAACGCTCTCTGGCGACCGCTACTACCCTGCTTGCCCTGACATTTTGCTCTGCGGGTGCGTATGCCGCGGCACA
GGACTCTCATGTGCTGTTGACCACTTCGGCGGGTAATATCGAGCTGGAATTGGACAGCGCCAAAGCGCCGGTTTCGGTAA
ACAACTTTGTGCAATACGTGAACAGCGGGTTTTATAACAACACCATTTTCCACCGCGTGATCCCCGGTTTTATGATCCAG
GGTGGCGGTTTCAACCAGGACATGTCGCAAAAGCCCACCCAGGCGCCAATCAAAAATGAAGCCGACAATGGCCTGCGCAA
CACCCGCGGCACCATCGCCATGGCGCGAACCGCCGATAAAGATAGCGCGACCAGCCAATTCTTTATCAACGTGGCGGACA
ATGCTTTCCTCGATCACGGCCAGCGCGATTTCGGCTATGCCGTGTTCGGCAAGGTGGTGAAAGGGATCGAGGTGGCGGAT
AAAATTGCCCAGGTGCCCACCAAGAATGAGGGGCCATACCAGAACGTGCCGGTTGAGCCGATTGTCATTCTCTCTGCCAA
AGTGCTGCCCTAG

Upstream 100 bases:

>100_bases
TACTCCGTTACGTAAAAAAAGGTAAATGGCTGGCACTGCCGGAAACGGCTCTTTAGAATCTAATCGCTTCCCGTGGCCTT
ATCTCTTAAAAGGAATTCTT

Downstream 100 bases:

>100_bases
AGCTGAACCTAAAGTAAAGGTATCGACGCATAGCGGCCGGGCTTGCAGCAGGTCCCGCCGTGATGCTGCCTGGCGCGAGC
TGACGTCCTACACCCCGCGG

Product: peptidyl-prolyl cis-trans isomerase A (rotamase A)

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MLKRSLATATTLLALTFCSAGAYAAAQDSHVLLTTSAGNIELELDSAKAPVSVNNFVQYVNSGFYNNTIFHRVIPGFMIQ
GGGFNQDMSQKPTQAPIKNEADNGLRNTRGTIAMARTADKDSATSQFFINVADNAFLDHGQRDFGYAVFGKVVKGIEVAD
KIAQVPTKNEGPYQNVPVEPIVILSAKVLP

Sequences:

>Translated_190_residues
MLKRSLATATTLLALTFCSAGAYAAAQDSHVLLTTSAGNIELELDSAKAPVSVNNFVQYVNSGFYNNTIFHRVIPGFMIQ
GGGFNQDMSQKPTQAPIKNEADNGLRNTRGTIAMARTADKDSATSQFFINVADNAFLDHGQRDFGYAVFGKVVKGIEVAD
KIAQVPTKNEGPYQNVPVEPIVILSAKVLP
>Mature_190_residues
MLKRSLATATTLLALTFCSAGAYAAAQDSHVLLTTSAGNIELELDSAKAPVSVNNFVQYVNSGFYNNTIFHRVIPGFMIQ
GGGFNQDMSQKPTQAPIKNEADNGLRNTRGTIAMARTADKDSATSQFFINVADNAFLDHGQRDFGYAVFGKVVKGIEVAD
KIAQVPTKNEGPYQNVPVEPIVILSAKVLP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI64276486, Length=126, Percent_Identity=41.2698412698413, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=34.3949044585987, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI19557636, Length=163, Percent_Identity=33.1288343558282, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7706339, Length=166, Percent_Identity=34.9397590361446, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI22547212, Length=163, Percent_Identity=32.5153374233129, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI7657473, Length=163, Percent_Identity=32.5153374233129, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI22547215, Length=163, Percent_Identity=32.5153374233129, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1789763, Length=190, Percent_Identity=78.9473684210526, Blast_Score=307, Evalue=2e-85,
Organism=Escherichia coli, GI1786736, Length=161, Percent_Identity=55.2795031055901, Blast_Score=173, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17532641, Length=167, Percent_Identity=32.3353293413174, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=145, Percent_Identity=35.1724137931034, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=143, Percent_Identity=34.2657342657343, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=170, Percent_Identity=34.1176470588235, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=155, Percent_Identity=33.5483870967742, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=165, Percent_Identity=32.1212121212121, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=159, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17986117, Length=174, Percent_Identity=35.0574712643678, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21357249, Length=162, Percent_Identity=33.9506172839506, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19922376, Length=163, Percent_Identity=31.2883435582822, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922912, Length=153, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20397; Mature: 20397

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRSLATATTLLALTFCSAGAYAAAQDSHVLLTTSAGNIELELDSAKAPVSVNNFVQYV
CCCHHHHHHHHHHHHHHHCCCCCEECCCCEEEEEECCCEEEEEECCCCCCCCHHHHHHHH
NSGFYNNTIFHRVIPGFMIQGGGFNQDMSQKPTQAPIKNEADNGLRNTRGTIAMARTADK
HCCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
DSATSQFFINVADNAFLDHGQRDFGYAVFGKVVKGIEVADKIAQVPTKNEGPYQNVPVEP
CCCCCEEEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
IVILSAKVLP
EEEEEEECCC
>Mature Secondary Structure
MLKRSLATATTLLALTFCSAGAYAAAQDSHVLLTTSAGNIELELDSAKAPVSVNNFVQYV
CCCHHHHHHHHHHHHHHHCCCCCEECCCCEEEEEECCCEEEEEECCCCCCCCHHHHHHHH
NSGFYNNTIFHRVIPGFMIQGGGFNQDMSQKPTQAPIKNEADNGLRNTRGTIAMARTADK
HCCCCCCCHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCC
DSATSQFFINVADNAFLDHGQRDFGYAVFGKVVKGIEVADKIAQVPTKNEGPYQNVPVEP
CCCCCEEEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
IVILSAKVLP
EEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]