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The map label for this gene is mscS [H]

Identifier: 85059991

GI number: 85059991

Start: 3470764

End: 3471741

Strand: Reverse

Name: mscS [H]

Synonym: SG2013

Alternate gene names: 85059991

Gene position: 3471741-3470764 (Counterclockwise)

Preceding gene: 85059992

Following gene: 85059990

Centisome position: 83.23

GC content: 54.81

Gene sequence:

>978_bases
ATGGAAGATATAGACGTTGTTGATAAAATCAATCATGCCGGCAACTGGCTGGTTAATAATCAAGAGTTACTGATCCATTA
CGCGGTCAATATCGTCGCTGCGATCATTATCCTGTTTATCGGTTTGCTGATCTCGCGGATTGTCGCCCGTACACTGAACC
GGATGATGAAGGCGCGTCACATCGACGCCACGGTAGCCGATTTCGTCTCGGCGGTTTTGCGCTACGGCATCGTGATTTTC
ACCCTTATCGCCGCCCTAAACCGGATAGGCGTACAGACCGCTTCGATCATCGCCGTTATCGGTGCCGCCGGTTTGGCTAT
CGGCCTGGCCCTGCAGGGGTCCCTGTCCAACTTTGCGGCAGGGGTGCTGCTGGTGACCTTCCGCCATTTCCACGCCGGCG
ACTATGTGGATTTTTCTGGCACTTCGGGTACAGTGTTGGTAGTGCAGATCTTCTCCACCACGCTGAAAACCTATGACGGC
AAAATTGTGGTGGTGCCCAATAGCAAAATTCTTTCCGGCAATATTACCAACTTCTCCCAAGAGCCGAACCGGTTAATCGA
TACCATCATCAGCGTCAGCTATGATGCCGATATCGATGTCGTGAAGAAGCTGATTACCGATATTCTGGTCGCCGATAGCC
GCGTGATTCAGGATATGGGCCTGACCGTGCGGTTAAATGCGCTGGGCCCGTCCTCGATGGATTTCATGGTGCGGGCCTGG
GTTCCGCGCAGCGATCAGAAAAACGCGACTTTCGACCTGCTGGAAAAAGCCAAGGTTGCTCTGGATGAGCATCAGATCGG
TATTCCCTATCCGCAAATGGATGTGCATCTCTACCGCGCGCCGAAAGCGCGGTCTGAGCAGGATCAGCAAATGGCTAACG
CCGCGACCTCATTAGACGCCGCCCGTGCCGAGGAAGAGAGCCAGCAGGTGCAATCGCAGCCCGACGCCGATACCGGCAAG
CCGGAGCCGGTCGCCTAA

Upstream 100 bases:

>100_bases
GCTATTGGCAAAATGGGGCGTTGCGGTATAGGCTTAATACTGTTTTGTCATCGGCGCCAGGCCGAGAGACCTTTGAAATA
CACCAGAGCGGAAAACCTAA

Downstream 100 bases:

>100_bases
GCCGGCGCTATATAGTGCTGCGCGCCGCCAAGGCAGGTTAAAAGTAGAGTCGCACCTTGCCGCCGGGCAACGATAAATGC
CCGGCGGCGCGGTATTTCCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MEDIDVVDKINHAGNWLVNNQELLIHYAVNIVAAIIILFIGLLISRIVARTLNRMMKARHIDATVADFVSAVLRYGIVIF
TLIAALNRIGVQTASIIAVIGAAGLAIGLALQGSLSNFAAGVLLVTFRHFHAGDYVDFSGTSGTVLVVQIFSTTLKTYDG
KIVVVPNSKILSGNITNFSQEPNRLIDTIISVSYDADIDVVKKLITDILVADSRVIQDMGLTVRLNALGPSSMDFMVRAW
VPRSDQKNATFDLLEKAKVALDEHQIGIPYPQMDVHLYRAPKARSEQDQQMANAATSLDAARAEEESQQVQSQPDADTGK
PEPVA

Sequences:

>Translated_325_residues
MEDIDVVDKINHAGNWLVNNQELLIHYAVNIVAAIIILFIGLLISRIVARTLNRMMKARHIDATVADFVSAVLRYGIVIF
TLIAALNRIGVQTASIIAVIGAAGLAIGLALQGSLSNFAAGVLLVTFRHFHAGDYVDFSGTSGTVLVVQIFSTTLKTYDG
KIVVVPNSKILSGNITNFSQEPNRLIDTIISVSYDADIDVVKKLITDILVADSRVIQDMGLTVRLNALGPSSMDFMVRAW
VPRSDQKNATFDLLEKAKVALDEHQIGIPYPQMDVHLYRAPKARSEQDQQMANAATSLDAARAEEESQQVQSQPDADTGK
PEPVA
>Mature_325_residues
MEDIDVVDKINHAGNWLVNNQELLIHYAVNIVAAIIILFIGLLISRIVARTLNRMMKARHIDATVADFVSAVLRYGIVIF
TLIAALNRIGVQTASIIAVIGAAGLAIGLALQGSLSNFAAGVLLVTFRHFHAGDYVDFSGTSGTVLVVQIFSTTLKTYDG
KIVVVPNSKILSGNITNFSQEPNRLIDTIISVSYDADIDVVKKLITDILVADSRVIQDMGLTVRLNALGPSSMDFMVRAW
VPRSDQKNATFDLLEKAKVALDEHQIGIPYPQMDVHLYRAPKARSEQDQQMANAATSLDAARAEEESQQVQSQPDADTGK
PEPVA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=285, Percent_Identity=59.6491228070175, Blast_Score=355, Evalue=2e-99,
Organism=Escherichia coli, GI1786670, Length=217, Percent_Identity=26.7281105990783, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787591, Length=217, Percent_Identity=26.7281105990783, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI2367355, Length=190, Percent_Identity=22.1052631578947, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 35320; Mature: 35320

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS01246 UPF0003

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDIDVVDKINHAGNWLVNNQELLIHYAVNIVAAIIILFIGLLISRIVARTLNRMMKARH
CCCHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDATVADFVSAVLRYGIVIFTLIAALNRIGVQTASIIAVIGAAGLAIGLALQGSLSNFAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GVLLVTFRHFHAGDYVDFSGTSGTVLVVQIFSTTLKTYDGKIVVVPNSKILSGNITNFSQ
HHHHHHHHHHCCCCEEEECCCCCCEEEHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCC
EPNRLIDTIISVSYDADIDVVKKLITDILVADSRVIQDMGLTVRLNALGPSSMDFMVRAW
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHEEC
VPRSDQKNATFDLLEKAKVALDEHQIGIPYPQMDVHLYRAPKARSEQDQQMANAATSLDA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
ARAEEESQQVQSQPDADTGKPEPVA
HHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MEDIDVVDKINHAGNWLVNNQELLIHYAVNIVAAIIILFIGLLISRIVARTLNRMMKARH
CCCHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDATVADFVSAVLRYGIVIFTLIAALNRIGVQTASIIAVIGAAGLAIGLALQGSLSNFAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GVLLVTFRHFHAGDYVDFSGTSGTVLVVQIFSTTLKTYDGKIVVVPNSKILSGNITNFSQ
HHHHHHHHHHCCCCEEEECCCCCCEEEHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCC
EPNRLIDTIISVSYDADIDVVKKLITDILVADSRVIQDMGLTVRLNALGPSSMDFMVRAW
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHEEC
VPRSDQKNATFDLLEKAKVALDEHQIGIPYPQMDVHLYRAPKARSEQDQQMANAATSLDA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
ARAEEESQQVQSQPDADTGKPEPVA
HHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]