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The map label for this gene is treA [H]

Identifier: 85059864

GI number: 85059864

Start: 3230176

End: 3231873

Strand: Reverse

Name: treA [H]

Synonym: SG1886

Alternate gene names: 85059864

Gene position: 3231873-3230176 (Counterclockwise)

Preceding gene: 85059865

Following gene: 85059863

Centisome position: 77.48

GC content: 53.89

Gene sequence:

>1698_bases
ATGATCACACGCTCTTTCCGGTGGACCTGGAAATCTTTTATCACACTAGGAGCTGTATTAAGCACAGCGTCCGGGCTGGT
AAAACCCCTGCCACCAGTAAAGCGCACGCCGCAGGATGAAACGCTGCAATCGCCCGATATCATGCTGGGACAGCTTTACA
TCGATGTACAAACCGCCAAACTGTATCCCGATCAGAAAACCTTTGCCGATGCGGTTCCGCGTCGCGCGCCGTCGGCTATC
ATTGCGGACTATCAAAACAAACGTTTGCGCAAAAATTTTAATCTGCGCCATTTCGTCGATAAAAACTTCATTTTCCCTAC
CGACCGGGTGAAATATGTGACGCCGACCGGCCAAAGTTTGCGTGAACATATCATCACGCTATGGCCGGTATTAACGCGCA
ATGACGCCAGGGTCCGCCCGCATGACTCGCTGTTGCAGATGCCCCATGACTATGTGGTGCCGGGTGGCCGTTTCCGCGAG
ATCTATTATTGGGACAGCTATTTTACCATGTTGGGGCTGGCGGAAAGCGGAAAATGGGACCTGGTGCGTGGCATGACTGA
AAATTTCGCCCATGAGATTAACGTATTTGGCCGAATTCCCAATGGTAATCGCAGTTACTATATCAGCCGCTCCCAGCCGC
CGTTTTTCTCGCTGATGGTGGATTTGGTTGCCAGCCAGGATGGCGCTGAGGTATATCAGCGCTATTTGCCGCAATTGAAG
AAAGAGTATGACTATTGGATGGAGGGCTATGAGACCCTCGATCCTGGTGTAGCGGCCGGACGTTTGGCCCGTATGCACGA
TGGTGCCTTTTTGAACCGCTATTGGGACGACGAGGATACGCCGCGTACCGAATCTTATCTGGATGATATTCTTACCGCCA
GCGAGGCAAAGGACCGTCCTGTGGCGGAAGTCTATCGCGATTTGCGTGCAGGTGCAGCCTCTGGCTGGGATTTCAGTTCG
CGCTGGTTCGATAATCCTTTGGAGCTCTCTTCAATTCGCACGACCTCCATCCTGCCGGTGGATTTGAATGCGTTGATGTA
TCACCTGGAGCACACGCTGGCCAATGCCAGCCATATGGCAGGCGACAATGAGGCGGCCGGCCGCTACAGCCTTGCCGCAC
AATCCCGTAAGGCGGCGATTAATCAGCATTTGTGGAATGAAGCCGAAGGCTACTATGCCGACTATGATTGGTTGCTGGGG
AGGCTGCGCGACCAATTGACCGCCGCAACGGTTTTTCCGCTTTACAACAAAATTGCGCCGCCGGACTACGCCCGCTGTAC
CGCGGTGGTGATACGACAGCAGTTGCTTAAGCAGGGCGGTATGATCACCACGACCAATGTTTCCGGCCAGCAATGGGATG
CACCCAATGGCTGGGCACCGCTGCAATGGGTAGCGGTTGAAGGCTTGCGTCACTACGGCGAAGAGGCCTTGGCAGAGCAG
ATAGCCACCCGTTTTCTCGGCAATGTGCAGCGACTTTACAATAACCAGCATAAACTGGTGGAAAAATATGTGGTGGAAGG
GAGTGGGCTTGGGGGCGGCGGCGGTGAATATCCGTTGCAGGATGGCTTCGGCTGGACCAACGGTGTGACCCTGAAGTTGA
TGGTGATGTATTGCGGTAAATCGCAAGACAATGTGGAAAATGTCGAGGCGCTATTGGCAGAAGCAGATACCAGCCAGCGT
GCCCTGGTGACATCTTGA

Upstream 100 bases:

>100_bases
CGCGCATTTCGTCCTGCCCGACCCGGAGCAGGCCAGTAGAGCTATAGTTATTAATCCGGTACCGTAGTTTGGGTAGCGTA
TAAAAAAGGAGAATTCACCT

Downstream 100 bases:

>100_bases
CGCTTGGGGCGGCGATATCGCGCTCTACGCCTGTCCGTCGCGGCGGGGGATTACCTCGTCGGTGCGAAAATACTGCCTGC
TATCGCGGCGGTAGTTCCCC

Product: periplasmic trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MITRSFRWTWKSFITLGAVLSTASGLVKPLPPVKRTPQDETLQSPDIMLGQLYIDVQTAKLYPDQKTFADAVPRRAPSAI
IADYQNKRLRKNFNLRHFVDKNFIFPTDRVKYVTPTGQSLREHIITLWPVLTRNDARVRPHDSLLQMPHDYVVPGGRFRE
IYYWDSYFTMLGLAESGKWDLVRGMTENFAHEINVFGRIPNGNRSYYISRSQPPFFSLMVDLVASQDGAEVYQRYLPQLK
KEYDYWMEGYETLDPGVAAGRLARMHDGAFLNRYWDDEDTPRTESYLDDILTASEAKDRPVAEVYRDLRAGAASGWDFSS
RWFDNPLELSSIRTTSILPVDLNALMYHLEHTLANASHMAGDNEAAGRYSLAAQSRKAAINQHLWNEAEGYYADYDWLLG
RLRDQLTAATVFPLYNKIAPPDYARCTAVVIRQQLLKQGGMITTTNVSGQQWDAPNGWAPLQWVAVEGLRHYGEEALAEQ
IATRFLGNVQRLYNNQHKLVEKYVVEGSGLGGGGGEYPLQDGFGWTNGVTLKLMVMYCGKSQDNVENVEALLAEADTSQR
ALVTS

Sequences:

>Translated_565_residues
MITRSFRWTWKSFITLGAVLSTASGLVKPLPPVKRTPQDETLQSPDIMLGQLYIDVQTAKLYPDQKTFADAVPRRAPSAI
IADYQNKRLRKNFNLRHFVDKNFIFPTDRVKYVTPTGQSLREHIITLWPVLTRNDARVRPHDSLLQMPHDYVVPGGRFRE
IYYWDSYFTMLGLAESGKWDLVRGMTENFAHEINVFGRIPNGNRSYYISRSQPPFFSLMVDLVASQDGAEVYQRYLPQLK
KEYDYWMEGYETLDPGVAAGRLARMHDGAFLNRYWDDEDTPRTESYLDDILTASEAKDRPVAEVYRDLRAGAASGWDFSS
RWFDNPLELSSIRTTSILPVDLNALMYHLEHTLANASHMAGDNEAAGRYSLAAQSRKAAINQHLWNEAEGYYADYDWLLG
RLRDQLTAATVFPLYNKIAPPDYARCTAVVIRQQLLKQGGMITTTNVSGQQWDAPNGWAPLQWVAVEGLRHYGEEALAEQ
IATRFLGNVQRLYNNQHKLVEKYVVEGSGLGGGGGEYPLQDGFGWTNGVTLKLMVMYCGKSQDNVENVEALLAEADTSQR
ALVTS
>Mature_565_residues
MITRSFRWTWKSFITLGAVLSTASGLVKPLPPVKRTPQDETLQSPDIMLGQLYIDVQTAKLYPDQKTFADAVPRRAPSAI
IADYQNKRLRKNFNLRHFVDKNFIFPTDRVKYVTPTGQSLREHIITLWPVLTRNDARVRPHDSLLQMPHDYVVPGGRFRE
IYYWDSYFTMLGLAESGKWDLVRGMTENFAHEINVFGRIPNGNRSYYISRSQPPFFSLMVDLVASQDGAEVYQRYLPQLK
KEYDYWMEGYETLDPGVAAGRLARMHDGAFLNRYWDDEDTPRTESYLDDILTASEAKDRPVAEVYRDLRAGAASGWDFSS
RWFDNPLELSSIRTTSILPVDLNALMYHLEHTLANASHMAGDNEAAGRYSLAAQSRKAAINQHLWNEAEGYYADYDWLLG
RLRDQLTAATVFPLYNKIAPPDYARCTAVVIRQQLLKQGGMITTTNVSGQQWDAPNGWAPLQWVAVEGLRHYGEEALAEQ
IATRFLGNVQRLYNNQHKLVEKYVVEGSGLGGGGGEYPLQDGFGWTNGVTLKLMVMYCGKSQDNVENVEALLAEADTSQR
ALVTS

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=523, Percent_Identity=33.8432122370937, Blast_Score=249, Evalue=7e-66,
Organism=Escherichia coli, GI1787447, Length=519, Percent_Identity=58.5741811175337, Blast_Score=621, Evalue=1e-179,
Organism=Escherichia coli, GI1789936, Length=510, Percent_Identity=49.4117647058824, Blast_Score=496, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI25148109, Length=559, Percent_Identity=31.1270125223614, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17542196, Length=535, Percent_Identity=33.0841121495327, Blast_Score=241, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25141398, Length=538, Percent_Identity=32.1561338289963, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17565078, Length=409, Percent_Identity=34.2298288508557, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI71987755, Length=403, Percent_Identity=28.5359801488834, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320204, Length=434, Percent_Identity=29.0322580645161, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319473, Length=436, Percent_Identity=31.1926605504587, Blast_Score=151, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24656680, Length=548, Percent_Identity=33.3941605839416, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24656675, Length=548, Percent_Identity=33.3941605839416, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24656661, Length=528, Percent_Identity=34.0909090909091, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI17933716, Length=528, Percent_Identity=34.0909090909091, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24656670, Length=528, Percent_Identity=34.0909090909091, Blast_Score=244, Evalue=8e-65,
Organism=Drosophila melanogaster, GI24656685, Length=500, Percent_Identity=33.6, Blast_Score=229, Evalue=6e-60,
Organism=Drosophila melanogaster, GI22024178, Length=532, Percent_Identity=28.3834586466165, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI45551104, Length=375, Percent_Identity=29.6, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI28573474, Length=297, Percent_Identity=26.9360269360269, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 64114; Mature: 64114

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITRSFRWTWKSFITLGAVLSTASGLVKPLPPVKRTPQDETLQSPDIMLGQLYIDVQTAK
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEHC
LYPDQKTFADAVPRRAPSAIIADYQNKRLRKNFNLRHFVDKNFIFPTDRVKYVTPTGQSL
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHEECCCCCCCCCCCEEEECCCCHHH
REHIITLWPVLTRNDARVRPHDSLLQMPHDYVVPGGRFREIYYWDSYFTMLGLAESGKWD
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEECCCCCEEEEEEECHHHHHHHCCCCCCHH
LVRGMTENFAHEINVFGRIPNGNRSYYISRSQPPFFSLMVDLVASQDGAEVYQRYLPQLK
HHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
KEYDYWMEGYETLDPGVAAGRLARMHDGAFLNRYWDDEDTPRTESYLDDILTASEAKDRP
HHHHHHHHCHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCC
VAEVYRDLRAGAASGWDFSSRWFDNPLELSSIRTTSILPVDLNALMYHLEHTLANASHMA
HHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCC
GDNEAAGRYSLAAQSRKAAINQHLWNEAEGYYADYDWLLGRLRDQLTAATVFPLYNKIAP
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PDYARCTAVVIRQQLLKQGGMITTTNVSGQQWDAPNGWAPLQWVAVEGLRHYGEEALAEQ
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IATRFLGNVQRLYNNQHKLVEKYVVEGSGLGGGGGEYPLQDGFGWTNGVTLKLMVMYCGK
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEHHCC
SQDNVENVEALLAEADTSQRALVTS
CCCCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MITRSFRWTWKSFITLGAVLSTASGLVKPLPPVKRTPQDETLQSPDIMLGQLYIDVQTAK
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEHC
LYPDQKTFADAVPRRAPSAIIADYQNKRLRKNFNLRHFVDKNFIFPTDRVKYVTPTGQSL
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHEECCCCCCCCCCCEEEECCCCHHH
REHIITLWPVLTRNDARVRPHDSLLQMPHDYVVPGGRFREIYYWDSYFTMLGLAESGKWD
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEECCCCCEEEEEEECHHHHHHHCCCCCCHH
LVRGMTENFAHEINVFGRIPNGNRSYYISRSQPPFFSLMVDLVASQDGAEVYQRYLPQLK
HHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
KEYDYWMEGYETLDPGVAAGRLARMHDGAFLNRYWDDEDTPRTESYLDDILTASEAKDRP
HHHHHHHHCHHHCCCCHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCC
VAEVYRDLRAGAASGWDFSSRWFDNPLELSSIRTTSILPVDLNALMYHLEHTLANASHMA
HHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCC
GDNEAAGRYSLAAQSRKAAINQHLWNEAEGYYADYDWLLGRLRDQLTAATVFPLYNKIAP
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
PDYARCTAVVIRQQLLKQGGMITTTNVSGQQWDAPNGWAPLQWVAVEGLRHYGEEALAEQ
CCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IATRFLGNVQRLYNNQHKLVEKYVVEGSGLGGGGGEYPLQDGFGWTNGVTLKLMVMYCGK
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHEEEEEEHHCC
SQDNVENVEALLAEADTSQRALVTS
CCCCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA