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The map label for this gene is kdsA

Identifier: 85059851

GI number: 85059851

Start: 3208948

End: 3209802

Strand: Reverse

Name: kdsA

Synonym: SG1873

Alternate gene names: 85059851

Gene position: 3209802-3208948 (Counterclockwise)

Preceding gene: 85059852

Following gene: 85059850

Centisome position: 76.95

GC content: 57.43

Gene sequence:

>855_bases
ATGAAACATTTGGTGGTCAATATTGGCGACATCCAGGCAGCGAACGATCTGCCCTTCGTGCTGTTTGGCGGCATGAACGT
GCTGGAGTCGCGCGATCTGGCGATGCGCATCTGCGAACACTATGTCACCGTGACGGAGAAACTGGGCATTCCCTATGTGT
TCAAGGCCTCGTTTGATAAAGCCAACCGCTCCTCCATCCATTCCTATCGTGGACCGGGTCTGGATGAGGGGATGAAGATC
TTCTCCGAGCTGAAAGCGCAGTTTGGCGTGAAGGTGATAACCGATGTGCACGAAGCCGGCCAGGCGCAAAGCGTGGCGGA
CGTAGTAGATGTGATTCAATTACCCGCATTCCTTGCCCGCCAGACCGATCTGGTGGAGGCCATGGCCCGCACCGGCGCGG
TGATAAACGTAAAAAAACCGCAGTTCATCAGCCCGGGGCAGGTCGGTAATATCGTCGATAAGTTCCGGGAAGCCGGCAAC
CACCAGGTGATCTTATGCGATCGCGGCAGCAATTTCGGCTATGACAATCTGGTCGTTGACATGCTCGGCTTTAATGTGAT
GAAACAGGTTTCCGGCGGCTGTCCGGTGATTTTCGATGTGACTCATGCCCTGCAGACCCGTGACCCGTTTGGCGCCGCCT
CCGGCGGGCGCCGCGCACAGGTGAGCGAATTGGCCCGCGCCGGTATGGCGGTCGGTATCGCCGGCCTGTTCATCGAAGCG
CATCCGGACCCGGCGAATGCCAAATGCGATGGCCCTTCGGCCTTGCCGATTGCCAAGCTGGAGCCGTTCTTGCGCCAGAT
GAAAGCGATTGATGAATTGGTCAAATCCTTCCCCGAACTCGATACCGGCCACTAA

Upstream 100 bases:

>100_bases
GTTCAGATTCACTCCATCGAGCAAAAATCGGTTACCCTACATTGATCGGCGGCGGTGTTTGCCACCGGTTGCCGGACAAT
TTTAATCAAAAAGGTGAAGC

Downstream 100 bases:

>100_bases
CGCCGGCAGAACGCATTGGCAGGGAGAGTTCCCCTGCCAGTCATCGCGCCAGTAAAACCTCCGCGCCCGGCCACCCGGCA
ATGTAGTTCCCGCGCCCGAT

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKHLVVNIGDIQAANDLPFVLFGGMNVLESRDLAMRICEHYVTVTEKLGIPYVFKASFDKANRSSIHSYRGPGLDEGMKI
FSELKAQFGVKVITDVHEAGQAQSVADVVDVIQLPAFLARQTDLVEAMARTGAVINVKKPQFISPGQVGNIVDKFREAGN
HQVILCDRGSNFGYDNLVVDMLGFNVMKQVSGGCPVIFDVTHALQTRDPFGAASGGRRAQVSELARAGMAVGIAGLFIEA
HPDPANAKCDGPSALPIAKLEPFLRQMKAIDELVKSFPELDTGH

Sequences:

>Translated_284_residues
MKHLVVNIGDIQAANDLPFVLFGGMNVLESRDLAMRICEHYVTVTEKLGIPYVFKASFDKANRSSIHSYRGPGLDEGMKI
FSELKAQFGVKVITDVHEAGQAQSVADVVDVIQLPAFLARQTDLVEAMARTGAVINVKKPQFISPGQVGNIVDKFREAGN
HQVILCDRGSNFGYDNLVVDMLGFNVMKQVSGGCPVIFDVTHALQTRDPFGAASGGRRAQVSELARAGMAVGIAGLFIEA
HPDPANAKCDGPSALPIAKLEPFLRQMKAIDELVKSFPELDTGH
>Mature_284_residues
MKHLVVNIGDIQAANDLPFVLFGGMNVLESRDLAMRICEHYVTVTEKLGIPYVFKASFDKANRSSIHSYRGPGLDEGMKI
FSELKAQFGVKVITDVHEAGQAQSVADVVDVIQLPAFLARQTDLVEAMARTGAVINVKKPQFISPGQVGNIVDKFREAGN
HQVILCDRGSNFGYDNLVVDMLGFNVMKQVSGGCPVIFDVTHALQTRDPFGAASGGRRAQVSELARAGMAVGIAGLFIEA
HPDPANAKCDGPSALPIAKLEPFLRQMKAIDELVKSFPELDTGH

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=282, Percent_Identity=86.8794326241135, Blast_Score=511, Evalue=1e-146,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_SODGM (Q2NRS7)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455553.1
- HSSP:   O66496
- ProteinModelPortal:   Q2NRS7
- SMR:   Q2NRS7
- STRING:   Q2NRS7
- GeneID:   3866347
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1873
- NMPDR:   fig|343509.6.peg.4011
- eggNOG:   COG2877
- HOGENOM:   HBG575990
- OMA:   EITFAND
- PhylomeDB:   Q2NRS7
- ProtClustDB:   PRK05198
- BioCyc:   SGLO343509:SG1873-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 30676; Mature: 30676

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLVVNIGDIQAANDLPFVLFGGMNVLESRDLAMRICEHYVTVTEKLGIPYVFKASFDK
CCEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRSSIHSYRGPGLDEGMKIFSELKAQFGVKVITDVHEAGQAQSVADVVDVIQLPAFLAR
CCHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
QTDLVEAMARTGAVINVKKPQFISPGQVGNIVDKFREAGNHQVILCDRGSNFGYDNLVVD
HHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
MLGFNVMKQVSGGCPVIFDVTHALQTRDPFGAASGGRRAQVSELARAGMAVGIAGLFIEA
HHHHHHHHHHCCCCCEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHEEEEEEE
HPDPANAKCDGPSALPIAKLEPFLRQMKAIDELVKSFPELDTGH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKHLVVNIGDIQAANDLPFVLFGGMNVLESRDLAMRICEHYVTVTEKLGIPYVFKASFDK
CCEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCC
ANRSSIHSYRGPGLDEGMKIFSELKAQFGVKVITDVHEAGQAQSVADVVDVIQLPAFLAR
CCHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
QTDLVEAMARTGAVINVKKPQFISPGQVGNIVDKFREAGNHQVILCDRGSNFGYDNLVVD
HHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHH
MLGFNVMKQVSGGCPVIFDVTHALQTRDPFGAASGGRRAQVSELARAGMAVGIAGLFIEA
HHHHHHHHHHCCCCCEEEEHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHEEEEEEE
HPDPANAKCDGPSALPIAKLEPFLRQMKAIDELVKSFPELDTGH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA