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The map label for this gene is arnA

Identifier: 85059821

GI number: 85059821

Start: 3127604

End: 3129586

Strand: Reverse

Name: arnA

Synonym: SG1843

Alternate gene names: 85059821

Gene position: 3129586-3127604 (Counterclockwise)

Preceding gene: 85059822

Following gene: 85059820

Centisome position: 75.03

GC content: 56.83

Gene sequence:

>1983_bases
ATGAAAGCTGTCATTTTTGCTTATCATGATATGGGCTGCGTGGGCGTCACCGCCCTTATCAACGCAGGCTATACTATCGA
GGCCATCATTACCCATCCTGATGCGCCGTCAGAGAAAACGTTTTTTGGTTCAGTGGCGCGCATCGCCGCGGAACACAATA
TTCCGGTTTTCGTGCCGGATGACGTTAACCATCCGCTATGGATAGCGCGCATCAAAGCGCTGGCGCCGGACGTGATTTTC
TCGTTCTACTATCGCCAGCTGCTTTGCCAGGACATCCTGAGCCTGCCGACGGTCGGCGCGTTCAACCTGCATGGTTCGCT
GTTGCCGCGCTACCGTGGCCGCTCGCCGCTGAATTGGGTGCTGGTTAACGGAGAACAGGAAACCGGTGTCACCCTGCATC
GTATGACGGCGCGCGCTGATGCGGGCGCCATTCTGGCGCAGCGCAGCGTGGCGATTACGCTGCAGGATGACGCGCTGACG
CTGCACCGCAAGCTGTGCGAAGCGGCGGCCGGGGTGCTGGAGAAGGTATTGCCGGCGATTCGCGAGCAGCGGTGCACTGA
AACGCCGCAGGACGAGAGCATCGCCAGCTATGTGGGCCACCGCACACCGGAAGATGGCCGCATCGACTGGGGGCAGCCGG
CCGCGACCCTGGCCAATCTGGTACGTGCCGTGACCGATCCCTGGCCGGGCGCCTTCAGCTATGCCGGCGGCGAGAAATTT
ATCATTTGGAAGGCGCAGGTACGGCCGAATAGCGCCGACGCGCAGCCCGGTACGGTACTCTCCATCGATCCGCTGGTTAT
CGCCTGCGGCAGCGATGCGCTGGAGGTTCAGACCGGCCAAAGTCAGCAGGGCGTGTATATGCAGGGCGGCCAGCTGGCAC
ATGCGCTGGGACTGGTGAAGGGTGCCTTGCTGAATCCGCGTCCGCTGGTCAGCCATAAGCGTCGCACCCGCGTACTTATC
CTGGGCGTCAACGGCTTTATCGGCAACCATTTGACCGAACGCCTGCTGCGCGACGGCAATTACGAGATTTACGGTCTGGA
TATTGGTACCGATGCGATAAGCCGCTTTATGGTGAACCCGCTATTCCATTTTGTCGAGGGCGATATTAGCATCCATTCGG
AGTGGATCGAATATCACATCAAGAAATGCGATATTGTCTTGCCGCTGGTGGCGATTGCCACGCCCATTGAATATACGCGT
AATCCGCTGCGGGTGTTTGAACTCGATTTTGAAGAGAACCTGAAAATTATCCGTCACTGCGTTAAATACCAAAAACGCAT
TATTTTCCCGTCGACGTCGGAAGTCTATGGGATGTGTACCGACCCGGTATTTGACGAAGATGACTCCAGCTTGATAGTGG
GGCCCATCAATAAGCAGCGCTGGATTTACTCGGTGTCCAAACAGCTTCTGGACCGCGTCTTGTGGGCCTATGGCGAAAAA
GAAGGGCTGCGCTTCACGCTATTCCGTCCCTTTAACTGGATGGGGCCGCGGCTGGATAACCTGAACGCGGCGCGTATCGG
CAGTTCGCGCGCCATTACGCAGCTGATTTTGAATCTGGTGGAGGGTTCGCACATCAAACTGGTGGACGGCGGTGCGCAGA
AACGGTGTTTTACCGATATCAGCGATGGCATTGAGGCACTGTTCCGCATCATTGAGAACAAGGACAATAATTGCGATGGT
CAGATAATCAATATCGGTAACCCGGACAATGAAGCCAGTATCCGGCAGTTGGCGGAATTGCTGCTGGCAAGCTTTGAGCG
TCATCCGTTGCGTCAGCATTTCCCACCGTTTGCCGGCTTCCGGGATGTGGAAAGCAGCAGTTACTACGGTAAAGGCTATC
AGGATGTGGAGCACCGTAAGCCGAGCATTCGTAATGCCAAACGCTTGCTGGGCTGGGCTCCTTCGGTGCCCATGGCTCAG
ACCATTGACGAAACGCTGGACTTTTTCCTGCAAACCGTCGATTTGCCGGACGCGGCGCAATGA

Upstream 100 bases:

>100_bases
AATATATCGGCCGTATCTACAACGATGTGCGTGCCCGTCCCCGTTATTTCGTCCAGTGTGTGGTCAGTCAAAATCCACTC
TCGTCTCAACAGGAAACACA

Downstream 100 bases:

>100_bases
AAAACGTCGGCCTGCGTATAGATGTCGATACCTGGCGCGGTACGCGCGACGGTATGCCGCGCCTGCTGGAATTGCTGGCG
GCGCAGCAGATCCAGGCGAC

Product: bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase

Number of amino acids: Translated: 660; Mature: 660

Protein sequence:

>660_residues
MKAVIFAYHDMGCVGVTALINAGYTIEAIITHPDAPSEKTFFGSVARIAAEHNIPVFVPDDVNHPLWIARIKALAPDVIF
SFYYRQLLCQDILSLPTVGAFNLHGSLLPRYRGRSPLNWVLVNGEQETGVTLHRMTARADAGAILAQRSVAITLQDDALT
LHRKLCEAAAGVLEKVLPAIREQRCTETPQDESIASYVGHRTPEDGRIDWGQPAATLANLVRAVTDPWPGAFSYAGGEKF
IIWKAQVRPNSADAQPGTVLSIDPLVIACGSDALEVQTGQSQQGVYMQGGQLAHALGLVKGALLNPRPLVSHKRRTRVLI
LGVNGFIGNHLTERLLRDGNYEIYGLDIGTDAISRFMVNPLFHFVEGDISIHSEWIEYHIKKCDIVLPLVAIATPIEYTR
NPLRVFELDFEENLKIIRHCVKYQKRIIFPSTSEVYGMCTDPVFDEDDSSLIVGPINKQRWIYSVSKQLLDRVLWAYGEK
EGLRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSHIKLVDGGAQKRCFTDISDGIEALFRIIENKDNNCDG
QIINIGNPDNEASIRQLAELLLASFERHPLRQHFPPFAGFRDVESSSYYGKGYQDVEHRKPSIRNAKRLLGWAPSVPMAQ
TIDETLDFFLQTVDLPDAAQ

Sequences:

>Translated_660_residues
MKAVIFAYHDMGCVGVTALINAGYTIEAIITHPDAPSEKTFFGSVARIAAEHNIPVFVPDDVNHPLWIARIKALAPDVIF
SFYYRQLLCQDILSLPTVGAFNLHGSLLPRYRGRSPLNWVLVNGEQETGVTLHRMTARADAGAILAQRSVAITLQDDALT
LHRKLCEAAAGVLEKVLPAIREQRCTETPQDESIASYVGHRTPEDGRIDWGQPAATLANLVRAVTDPWPGAFSYAGGEKF
IIWKAQVRPNSADAQPGTVLSIDPLVIACGSDALEVQTGQSQQGVYMQGGQLAHALGLVKGALLNPRPLVSHKRRTRVLI
LGVNGFIGNHLTERLLRDGNYEIYGLDIGTDAISRFMVNPLFHFVEGDISIHSEWIEYHIKKCDIVLPLVAIATPIEYTR
NPLRVFELDFEENLKIIRHCVKYQKRIIFPSTSEVYGMCTDPVFDEDDSSLIVGPINKQRWIYSVSKQLLDRVLWAYGEK
EGLRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSHIKLVDGGAQKRCFTDISDGIEALFRIIENKDNNCDG
QIINIGNPDNEASIRQLAELLLASFERHPLRQHFPPFAGFRDVESSSYYGKGYQDVEHRKPSIRNAKRLLGWAPSVPMAQ
TIDETLDFFLQTVDLPDAAQ
>Mature_660_residues
MKAVIFAYHDMGCVGVTALINAGYTIEAIITHPDAPSEKTFFGSVARIAAEHNIPVFVPDDVNHPLWIARIKALAPDVIF
SFYYRQLLCQDILSLPTVGAFNLHGSLLPRYRGRSPLNWVLVNGEQETGVTLHRMTARADAGAILAQRSVAITLQDDALT
LHRKLCEAAAGVLEKVLPAIREQRCTETPQDESIASYVGHRTPEDGRIDWGQPAATLANLVRAVTDPWPGAFSYAGGEKF
IIWKAQVRPNSADAQPGTVLSIDPLVIACGSDALEVQTGQSQQGVYMQGGQLAHALGLVKGALLNPRPLVSHKRRTRVLI
LGVNGFIGNHLTERLLRDGNYEIYGLDIGTDAISRFMVNPLFHFVEGDISIHSEWIEYHIKKCDIVLPLVAIATPIEYTR
NPLRVFELDFEENLKIIRHCVKYQKRIIFPSTSEVYGMCTDPVFDEDDSSLIVGPINKQRWIYSVSKQLLDRVLWAYGEK
EGLRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSHIKLVDGGAQKRCFTDISDGIEALFRIIENKDNNCDG
QIINIGNPDNEASIRQLAELLLASFERHPLRQHFPPFAGFRDVESSSYYGKGYQDVEHRKPSIRNAKRLLGWAPSVPMAQ
TIDETLDFFLQTVDLPDAAQ

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily

Homologues:

Organism=Homo sapiens, GI42516563, Length=355, Percent_Identity=26.4788732394366, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI21614513, Length=260, Percent_Identity=27.3076923076923, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI238814322, Length=221, Percent_Identity=27.1493212669683, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788589, Length=657, Percent_Identity=73.5159817351598, Blast_Score=1030, Evalue=0.0,
Organism=Escherichia coli, GI1789683, Length=261, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17539532, Length=354, Percent_Identity=24.8587570621469, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI133930964, Length=298, Percent_Identity=25.8389261744966, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21356223, Length=353, Percent_Identity=25.4957507082153, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARNA_SODGM (Q2NRV7)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455523.1
- ProteinModelPortal:   Q2NRV7
- SMR:   Q2NRV7
- STRING:   Q2NRV7
- GeneID:   3868636
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1843
- NMPDR:   fig|343509.6.peg.3897
- eggNOG:   COG0451
- HOGENOM:   HBG298638
- OMA:   KAVVFAY
- PhylomeDB:   Q2NRV7
- ProtClustDB:   PRK08125
- BioCyc:   SGLO343509:SG1843-MONOMER
- HAMAP:   MF_01166
- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF036506

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.13; =1.1.1.305

Molecular weight: Translated: 73536; Mature: 73536

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: ACT_SITE 104-104 ACT_SITE 434-434 ACT_SITE 619-619 BINDING 114-114 BINDING 347-347 BINDING 393-393 BINDING 398-398 BINDING 460-460 BINDING 492-492 BINDING 613-613

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVIFAYHDMGCVGVTALINAGYTIEAIITHPDAPSEKTFFGSVARIAAEHNIPVFVPD
CCEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCC
DVNHPLWIARIKALAPDVIFSFYYRQLLCQDILSLPTVGAFNLHGSLLPRYRGRSPLNWV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCEEE
LVNGEQETGVTLHRMTARADAGAILAQRSVAITLQDDALTLHRKLCEAAAGVLEKVLPAI
EECCCCCCCCEEEEEHHHCCCCHHEEECEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
REQRCTETPQDESIASYVGHRTPEDGRIDWGQPAATLANLVRAVTDPWPGAFSYAGGEKF
HHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IIWKAQVRPNSADAQPGTVLSIDPLVIACGSDALEVQTGQSQQGVYMQGGQLAHALGLVK
EEEEEEECCCCCCCCCCEEEEECCEEEEECCCCEEEECCCCCCCEEEECCHHHHHHHHHH
GALLNPRPLVSHKRRTRVLILGVNGFIGNHLTERLLRDGNYEIYGLDIGTDAISRFMVNP
HHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHH
LFHFVEGDISIHSEWIEYHIKKCDIVLPLVAIATPIEYTRNPLRVFELDFEENLKIIRHC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHHHHHHHHH
VKYQKRIIFPSTSEVYGMCTDPVFDEDDSSLIVGPINKQRWIYSVSKQLLDRVLWAYGEK
HHHHHEEECCCCCCCCEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
EGLRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSHIKLVDGGAQKRCFTDI
CCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHH
SDGIEALFRIIENKDNNCDGQIINIGNPDNEASIRQLAELLLASFERHPLRQHFPPFAGF
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
RDVESSSYYGKGYQDVEHRKPSIRNAKRLLGWAPSVPMAQTIDETLDFFLQTVDLPDAAQ
CCCCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKAVIFAYHDMGCVGVTALINAGYTIEAIITHPDAPSEKTFFGSVARIAAEHNIPVFVPD
CCEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEECCC
DVNHPLWIARIKALAPDVIFSFYYRQLLCQDILSLPTVGAFNLHGSLLPRYRGRSPLNWV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCEEE
LVNGEQETGVTLHRMTARADAGAILAQRSVAITLQDDALTLHRKLCEAAAGVLEKVLPAI
EECCCCCCCCEEEEEHHHCCCCHHEEECEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
REQRCTETPQDESIASYVGHRTPEDGRIDWGQPAATLANLVRAVTDPWPGAFSYAGGEKF
HHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IIWKAQVRPNSADAQPGTVLSIDPLVIACGSDALEVQTGQSQQGVYMQGGQLAHALGLVK
EEEEEEECCCCCCCCCCEEEEECCEEEEECCCCEEEECCCCCCCEEEECCHHHHHHHHHH
GALLNPRPLVSHKRRTRVLILGVNGFIGNHLTERLLRDGNYEIYGLDIGTDAISRFMVNP
HHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHH
LFHFVEGDISIHSEWIEYHIKKCDIVLPLVAIATPIEYTRNPLRVFELDFEENLKIIRHC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHHHHHHHHH
VKYQKRIIFPSTSEVYGMCTDPVFDEDDSSLIVGPINKQRWIYSVSKQLLDRVLWAYGEK
HHHHHEEECCCCCCCCEEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
EGLRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSHIKLVDGGAQKRCFTDI
CCCEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHH
SDGIEALFRIIENKDNNCDGQIINIGNPDNEASIRQLAELLLASFERHPLRQHFPPFAGF
HHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCCCCCC
RDVESSSYYGKGYQDVEHRKPSIRNAKRLLGWAPSVPMAQTIDETLDFFLQTVDLPDAAQ
CCCCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA