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The map label for this gene is tadA [H]

Identifier: 85059758

GI number: 85059758

Start: 3042979

End: 3043488

Strand: Reverse

Name: tadA [H]

Synonym: SG1780

Alternate gene names: 85059758

Gene position: 3043488-3042979 (Counterclockwise)

Preceding gene: 85059759

Following gene: 85059756

Centisome position: 72.97

GC content: 63.14

Gene sequence:

>510_bases
ATGAGCGAGCGCTGCAGCGATGAAGTTTGGATGCGTCACGCCCTGATGTTGGCCGGGCGCGCTGAAGCCGAAGGCGAGGT
GCCGGTCGGTGCGGTCCTGGTGCTAAATGGCGCGATTATCGGCGAAGGCTGGAACCGTTCCATCGGCCATCACGATCCCA
CCGCCCATGCCGAAATCATGGCGCTGCGCCAGGGGGGGCAGCAGGCGGGTAATTATCGTTTGCTGAAGGCGACCTTGTAC
GTGACCCTGGAACCGTGCGTGATGTGCGCGGGTGCGATGATCCACGCCCGTATCGGCCGCCTGGTGTTCGGCGCGCGGGA
CGAGAAAACCGGCGCAGCGGGATCTCTCATGGATGTACTCGGTCATCCGGGTATGAATCATCGGATTGAGCTTACCGGCG
ATATGTTGGCGCAGGCGTGTGCCGCCCAGCTCAGCGATTTTTTCCGCCGCCGCCGGGCGCAGCAAAAAGCGCAGCGGCAG
GCGCTGAAACTGCCAGATGGCCCCTGTTAA

Upstream 100 bases:

>100_bases
AACACATGACGGCCAACTCAAGCAGCTGGATTGATTCTGCCTTCCTTCTCTTTACCCGGGCCGGTATAATCCGCGGCGGT
TATCAGCGGAGAGGGCGGTC

Downstream 100 bases:

>100_bases
CGGCGTTAAACGATCCAAGCCGGACGAACCCCAGTAATGGCGCAGCAGCGCCGCCGCTCGTAACGGAATCGGTTTTGCTC
GGTGGCGTCCGTAGCGCCGT

Product: tRNA-specific adenosine deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSERCSDEVWMRHALMLAGRAEAEGEVPVGAVLVLNGAIIGEGWNRSIGHHDPTAHAEIMALRQGGQQAGNYRLLKATLY
VTLEPCVMCAGAMIHARIGRLVFGARDEKTGAAGSLMDVLGHPGMNHRIELTGDMLAQACAAQLSDFFRRRRAQQKAQRQ
ALKLPDGPC

Sequences:

>Translated_169_residues
MSERCSDEVWMRHALMLAGRAEAEGEVPVGAVLVLNGAIIGEGWNRSIGHHDPTAHAEIMALRQGGQQAGNYRLLKATLY
VTLEPCVMCAGAMIHARIGRLVFGARDEKTGAAGSLMDVLGHPGMNHRIELTGDMLAQACAAQLSDFFRRRRAQQKAQRQ
ALKLPDGPC
>Mature_168_residues
SERCSDEVWMRHALMLAGRAEAEGEVPVGAVLVLNGAIIGEGWNRSIGHHDPTAHAEIMALRQGGQQAGNYRLLKATLYV
TLEPCVMCAGAMIHARIGRLVFGARDEKTGAAGSLMDVLGHPGMNHRIELTGDMLAQACAAQLSDFFRRRRAQQKAQRQA
LKLPDGPC

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=153, Percent_Identity=30.0653594771242, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI145693172, Length=167, Percent_Identity=73.6526946107784, Blast_Score=241, Evalue=1e-65,
Organism=Escherichia coli, GI1786616, Length=153, Percent_Identity=34.640522875817, Blast_Score=62, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541138, Length=162, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17554608, Length=106, Percent_Identity=34.9056603773585, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322425, Length=115, Percent_Identity=35.6521739130435, Blast_Score=68, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21355527, Length=146, Percent_Identity=32.8767123287671, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 18298; Mature: 18167

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS00639 THIOL_PROTEASE_HIS ; PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERCSDEVWMRHALMLAGRAEAEGEVPVGAVLVLNGAIIGEGWNRSIGHHDPTAHAEIM
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCEEECCCCCCCCCCCCCCHHHHHH
ALRQGGQQAGNYRLLKATLYVTLEPCVMCAGAMIHARIGRLVFGARDEKTGAAGSLMDVL
HHHHCCCCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
GHPGMNHRIELTGDMLAQACAAQLSDFFRRRRAQQKAQRQALKLPDGPC
CCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SERCSDEVWMRHALMLAGRAEAEGEVPVGAVLVLNGAIIGEGWNRSIGHHDPTAHAEIM
CCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCEEECCCCCCCCCCCCCCHHHHHH
ALRQGGQQAGNYRLLKATLYVTLEPCVMCAGAMIHARIGRLVFGARDEKTGAAGSLMDVL
HHHHCCCCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
GHPGMNHRIELTGDMLAQACAAQLSDFFRRRRAQQKAQRQALKLPDGPC
CCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]