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The map label for this gene is glyA

Identifier: 85059753

GI number: 85059753

Start: 3031185

End: 3032438

Strand: Reverse

Name: glyA

Synonym: SG1775

Alternate gene names: 85059753

Gene position: 3032438-3031185 (Counterclockwise)

Preceding gene: 85059754

Following gene: 85059752

Centisome position: 72.7

GC content: 55.42

Gene sequence:

>1254_bases
ATGTTAAAGCGTGATATGAACATTGCGGATTATGATGCCGAATTGTGGCATGCAATGGAGCAGGAAGTAGTGCGCCAGGA
AGAGCACATTGAACTGATTGCATCTGAAAACTACACCAGTCCGCGCGTTATGCAGGCGCAGGGCTCACAGCTGACCAATA
AGTACGCTGAAGGCTACCCCGGCAAGCGCTACTACGGCGGATGCGAATATGTCGATGTGGTAGAGCAACTGGCCATCGAT
CGTGCCAAAGCCCTGTTCGGCGCCGATTATGCCAACGTGCAGCCTCACTCGGGCTCTCAGGCCAACTTCGCCGTTTATAC
CACGTTGCTGCAGCCGGGCGATACGGTGCTGGGTATGAACCTGGCACACGGCGGCCATTTGACTCACGGCTCGCCGGTCA
ACTTCTCCGGCAAGCTGTATAATATCGTACCTTACGGCATCGATGAGAGCGGTCATATCGATTATGACCAATTGGCCGAG
CTGGCGAAAACTCATCAGCCGAAAATGATCATCGGTGGCTTCTCCGCCTACTCCGGGGTGGTTGACTGGGCCAGAATGCG
GCAGATTGCCGATAGCATCGGCGCCTATTTGTTTGTAGATATGGCACACGTGGCGGGTCTTATTGCCGCCGGCGTGTATC
CGAACCCGGTGCCCCACGCCCACGTTGTGACTACAACCACCCACAAAACTCTGGCCGGTCCGCGTGGTGGTTTGATCCTG
GCCAAGGGCGGTAGCGAAGAGCTGTATAAAAAGCTGAATTCTGCCGTATTCCCCGGCGCGCAAGGTGGCCCGTTGATGCA
TGTGATTGCCGCCAAGGCAGTTGCGCTGAAAGAGGCGATGGAGCCGGCGTTTAAAACCTACCAGCAGCAGGTGGCCAAAA
ACGCTAAAGCCATGGTAGAGGTTTTCTTGTCACGCGGTTTCAACGTTGTCTCCGGCGCTACGGATAATCACCTGTTCCTG
CTGGATCTGGTGGATAAGAATCTGACCGGCAAAGAAGCGGATGCGGCCTTGGGCCGTGCCAATATTACCGTTAATAAAAA
CAGCGTGCCCAATGATCCGAAAAGCCCGTTCGTCACCTCCGGGATGCGTATCGGTACGCCGGCGGTGACGCGTCGCGGTT
TTACCGAGGCCGACGTGCGCGATTTGGCGGGTTGGATGTGTGACGTGTTGGAAAATATCCATGACGACGCCGTAATCGAG
CGCACTAAGAATAAAGTGCTGGATATCTGCGACCGCCATCCTGTTTACGCGTGA

Upstream 100 bases:

>100_bases
CTGGCCCTATCGGAAGCCAGGCAAAAAAGATTACACTGACGGCCGGTCATTCCTCTATTTTAATCGCCGTAGTCAGTTAG
CTGAGAGTCAGGAGAAACAG

Downstream 100 bases:

>100_bases
TGATAAGGCGGGGCCGGTTTTTTTTGCCCTGGCGGAACCGAAGACTGCGTCGCTTTTGACGGCGGCTGGGGTATCTCATG
TCAATCGGCGCGGTGCCGGG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MLKRDMNIADYDAELWHAMEQEVVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAID
RAKALFGADYANVQPHSGSQANFAVYTTLLQPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDESGHIDYDQLAE
LAKTHQPKMIIGGFSAYSGVVDWARMRQIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLIL
AKGGSEELYKKLNSAVFPGAQGGPLMHVIAAKAVALKEAMEPAFKTYQQQVAKNAKAMVEVFLSRGFNVVSGATDNHLFL
LDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGMRIGTPAVTRRGFTEADVRDLAGWMCDVLENIHDDAVIE
RTKNKVLDICDRHPVYA

Sequences:

>Translated_417_residues
MLKRDMNIADYDAELWHAMEQEVVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAID
RAKALFGADYANVQPHSGSQANFAVYTTLLQPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDESGHIDYDQLAE
LAKTHQPKMIIGGFSAYSGVVDWARMRQIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLIL
AKGGSEELYKKLNSAVFPGAQGGPLMHVIAAKAVALKEAMEPAFKTYQQQVAKNAKAMVEVFLSRGFNVVSGATDNHLFL
LDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGMRIGTPAVTRRGFTEADVRDLAGWMCDVLENIHDDAVIE
RTKNKVLDICDRHPVYA
>Mature_417_residues
MLKRDMNIADYDAELWHAMEQEVVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAID
RAKALFGADYANVQPHSGSQANFAVYTTLLQPGDTVLGMNLAHGGHLTHGSPVNFSGKLYNIVPYGIDESGHIDYDQLAE
LAKTHQPKMIIGGFSAYSGVVDWARMRQIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLIL
AKGGSEELYKKLNSAVFPGAQGGPLMHVIAAKAVALKEAMEPAFKTYQQQVAKNAKAMVEVFLSRGFNVVSGATDNHLFL
LDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTSGMRIGTPAVTRRGFTEADVRDLAGWMCDVLENIHDDAVIE
RTKNKVLDICDRHPVYA

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=402, Percent_Identity=48.0099502487562, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI261862352, Length=402, Percent_Identity=48.0099502487562, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI261862350, Length=402, Percent_Identity=48.0099502487562, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI261862348, Length=402, Percent_Identity=48.0099502487562, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI261862346, Length=401, Percent_Identity=46.8827930174564, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=47.1321695760599, Blast_Score=336, Evalue=3e-92,
Organism=Homo sapiens, GI22547189, Length=389, Percent_Identity=43.9588688946015, Blast_Score=301, Evalue=7e-82,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=89.6882494004796, Blast_Score=766, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144732, Length=401, Percent_Identity=45.3865336658354, Blast_Score=338, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI25144729, Length=401, Percent_Identity=45.3865336658354, Blast_Score=337, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=417, Percent_Identity=44.6043165467626, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323087, Length=407, Percent_Identity=44.7174447174447, Blast_Score=332, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=47.75, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=47.75, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45340; Mature: 45340

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRDMNIADYDAELWHAMEQEVVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEHHCCHHHHHHHHCCCC
GKRYYGGCEYVDVVEQLAIDRAKALFGADYANVQPHSGSQANFAVYTTLLQPGDTVLGMN
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEE
LAHGGHLTHGSPVNFSGKLYNIVPYGIDESGHIDYDQLAELAKTHQPKMIIGGFSAYSGV
ECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHH
VDWARMRQIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHCCCCCCEEE
AKGGSEELYKKLNSAVFPGAQGGPLMHVIAAKAVALKEAMEPAFKTYQQQVAKNAKAMVE
ECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLSRGFNVVSGATDNHLFLLDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTS
HHHHCCCEEECCCCCCCEEEEEECCCCCCCCHHHHHHCCEEEEECCCCCCCCCCCCCCCC
GMRIGTPAVTRRGFTEADVRDLAGWMCDVLENIHDDAVIERTKNKVLDICDRHPVYA
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLKRDMNIADYDAELWHAMEQEVVRQEEHIELIASENYTSPRVMQAQGSQLTNKYAEGYP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEHHCCHHHHHHHHCCCC
GKRYYGGCEYVDVVEQLAIDRAKALFGADYANVQPHSGSQANFAVYTTLLQPGDTVLGMN
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEE
LAHGGHLTHGSPVNFSGKLYNIVPYGIDESGHIDYDQLAELAKTHQPKMIIGGFSAYSGV
ECCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHH
VDWARMRQIADSIGAYLFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHCCCCCCEEE
AKGGSEELYKKLNSAVFPGAQGGPLMHVIAAKAVALKEAMEPAFKTYQQQVAKNAKAMVE
ECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLSRGFNVVSGATDNHLFLLDLVDKNLTGKEADAALGRANITVNKNSVPNDPKSPFVTS
HHHHCCCEEECCCCCCCEEEEEECCCCCCCCHHHHHHCCEEEEECCCCCCCCCCCCCCCC
GMRIGTPAVTRRGFTEADVRDLAGWMCDVLENIHDDAVIERTKNKVLDICDRHPVYA
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA