Click here to switch to the map view.

The map label for this gene is upp

Identifier: 85059709

GI number: 85059709

Start: 2946533

End: 2947159

Strand: Reverse

Name: upp

Synonym: SG1731

Alternate gene names: 85059709

Gene position: 2947159-2946533 (Counterclockwise)

Preceding gene: 85059712

Following gene: 85059708

Centisome position: 70.66

GC content: 53.43

Gene sequence:

>627_bases
ATGAAGATCGTTGAGGTTAAACACCCGCTGGTGAAACACAAGCTGGGGTTGATGCGCGCTCACGATATCAGTACCAAACG
CTTTCGCGAACTGGCGTCGGAAGTGGGTAGCCTGTTGACCTATGTCGCGACCGCCGATATGGAAACCGAAAAGGTCACTA
TCGAGGGCTGGTGCGGGCCGGTTGAAATCGATCAAATCAAAGGAAAAAAAATTACCGTTGTACCGATTTTGCGCGCCGGG
CTCGGCATGATGGACGGTGTTTTGGAAAATCTGCCCAGCGCGCGTATTAGCGTGGTCGGCGTTTACCGTGACGAAAACAC
TCTGACGCCGGTACCTTATTTTCATAAACTGGTGTCGAGTATCGATGAGCGCATGGCTCTGGTGGTGGATCCGATGCTGG
CGACCGGCGGCTCGATGATCGCCACTATCGATTTACTGAAAAAAGCCGGCTGCCCCTGTATTAAGGTATTGGTGCTGGTG
GCGGCGCCTGAAGGCATCGCGGCGCTGGAAAAGGCGCATCCCGACGTGGAACTTTATACCGCGGCTATCGATAAGGGACT
TAACGAAAAAGGCTATATCATGCCGGGCCTGGGTGACGCGGGCGACAAAATCTTTGGTACCAAATAA

Upstream 100 bases:

>100_bases
GCCTTGATCAAGATCAGGCAAACTCATGTGGTGCGACGGGGAAAAGGGGTTATAATCTCGCGATTTTTTTGACCGTTCAG
TGCTCTAGGGGAGAGATAAT

Downstream 100 bases:

>100_bases
CCCTGAACCGGCCATTGAGTCGGTTTTTTTTGACCCTGAATTCTGAGGAAAGTCACCATGACCCGTCGCGCCATCGGGGT
GTCGGAACGCCCGCCGCCGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKIVEVKHPLVKHKLGLMRAHDISTKRFRELASEVGSLLTYVATADMETEKVTIEGWCGPVEIDQIKGKKITVVPILRAG
LGMMDGVLENLPSARISVVGVYRDENTLTPVPYFHKLVSSIDERMALVVDPMLATGGSMIATIDLLKKAGCPCIKVLVLV
AAPEGIAALEKAHPDVELYTAAIDKGLNEKGYIMPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MKIVEVKHPLVKHKLGLMRAHDISTKRFRELASEVGSLLTYVATADMETEKVTIEGWCGPVEIDQIKGKKITVVPILRAG
LGMMDGVLENLPSARISVVGVYRDENTLTPVPYFHKLVSSIDERMALVVDPMLATGGSMIATIDLLKKAGCPCIKVLVLV
AAPEGIAALEKAHPDVELYTAAIDKGLNEKGYIMPGLGDAGDKIFGTK
>Mature_208_residues
MKIVEVKHPLVKHKLGLMRAHDISTKRFRELASEVGSLLTYVATADMETEKVTIEGWCGPVEIDQIKGKKITVVPILRAG
LGMMDGVLENLPSARISVVGVYRDENTLTPVPYFHKLVSSIDERMALVVDPMLATGGSMIATIDLLKKAGCPCIKVLVLV
AAPEGIAALEKAHPDVELYTAAIDKGLNEKGYIMPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI57863312, Length=142, Percent_Identity=30.9859154929577, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI301129207, Length=142, Percent_Identity=30.9859154929577, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=90.3846153846154, Blast_Score=380, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.8706467661692, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.8706467661692, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=42.0289855072464, Blast_Score=104, Evalue=8e-24,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=27.5862068965517, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=27.5862068965517, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=27.5862068965517, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=27.5862068965517, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_SODGM (Q2NS69)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455411.1
- HSSP:   Q9WZI0
- ProteinModelPortal:   Q2NS69
- SMR:   Q2NS69
- STRING:   Q2NS69
- GeneID:   3866870
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1731
- NMPDR:   fig|343509.6.peg.3666
- eggNOG:   COG0035
- HOGENOM:   HBG326432
- OMA:   HDISTKR
- PhylomeDB:   Q2NS69
- ProtClustDB:   PRK00129
- BioCyc:   SGLO343509:SG1731-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 22421; Mature: 22421

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 103-103 BINDING 193-193 BINDING 199-199

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVEVKHPLVKHKLGLMRAHDISTKRFRELASEVGSLLTYVATADMETEKVTIEGWCGP
CCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
VEIDQIKGKKITVVPILRAGLGMMDGVLENLPSARISVVGVYRDENTLTPVPYFHKLVSS
CCHHCCCCCEEEEEHHHHHCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHH
IDERMALVVDPMLATGGSMIATIDLLKKAGCPCIKVLVLVAAPEGIAALEKAHPDVELYT
HHHHHHHHHCHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHCCCCHHHHH
AAIDKGLNEKGYIMPGLGDAGDKIFGTK
HHHHCCCCCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKIVEVKHPLVKHKLGLMRAHDISTKRFRELASEVGSLLTYVATADMETEKVTIEGWCGP
CCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
VEIDQIKGKKITVVPILRAGLGMMDGVLENLPSARISVVGVYRDENTLTPVPYFHKLVSS
CCHHCCCCCEEEEEHHHHHCHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHH
IDERMALVVDPMLATGGSMIATIDLLKKAGCPCIKVLVLVAAPEGIAALEKAHPDVELYT
HHHHHHHHHCHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHCCCCHHHHH
AAIDKGLNEKGYIMPGLGDAGDKIFGTK
HHHHCCCCCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA