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The map label for this gene is purC

Identifier: 85059702

GI number: 85059702

Start: 2938771

End: 2939484

Strand: Reverse

Name: purC

Synonym: SG1724

Alternate gene names: 85059702

Gene position: 2939484-2938771 (Counterclockwise)

Preceding gene: 85059703

Following gene: 85059701

Centisome position: 70.47

GC content: 51.68

Gene sequence:

>714_bases
ATGCAAAAATTAGCTGAGTTGTATCGCGGAAAAGCGAAAACGGTTTATACCACAGAGGATCCGGATTTGCTGATCCTGAC
GTTCCGCAACGATACGTCAGCACTGGACGGTCAGCGTATTGAGCAATTCGATCGCAAGGGCATGATTAACAATAATTTTA
ATTACTTTATCATGACCAAGTTAGCCGAGGCCGGCATTCCAACCCAGATCGTGCGCCTGCTTTCCGATAATGAAATGCTG
GTGAAAAAACTGGCTATGGTGCCCGTGGAATGCGTGGTGCGCAACCGCGCGGCCGGCTCGCTGGTAAAACGTTTAGGCGT
AGAGGAAGGCCTGGTCCTGGATCCGCCCCTGTTCGATCTGTTTTTGAAAAACGACGCCATGCACGATCCGATGATCAACG
AATCCTACTGTACCACCTTCGGCTGGGTCAGTGAACCCCATCTGGCACGGATGAAGCAGTTGACCTATCAGGCTAATGAC
GTGCTCAGCAAGATTTTCGACGATGCCGGGCTGATTCTGGTGGACTTCAAGCTGGAATTTGGTCTGTTTAACGGCGAGAT
TGTGCTGGGGGATGAATTCTCCCCGGACGGAAGCCGTCTGTGGGATAAAACCACCCTCGACAAAATGGACAAAGACCGGT
TCCGCCAGAACCTGGGTGGCGTTATCGAGGCCTATGAAGAAGTCGCCAAGCGTATCGGCGTCACGTTGGACTAA

Upstream 100 bases:

>100_bases
GGCGGCATTCAGCCGGTCAACATCCCATTAAATCAACAGGGGGCTTCGGCCCCCTTTTTTACCTGTATCAAAGCGTTATT
TGCCACTGGAGTATGTAAAG

Downstream 100 bases:

>100_bases
CTGCGCAATCGTTTACCTGGGCGGCAGTACCGCTGCCTGTCCAGGGTTATATGTTATCCTCATCATTAAATGATTAACGT
TTAACTGGGGATGACGATGC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MQKLAELYRGKAKTVYTTEDPDLLILTFRNDTSALDGQRIEQFDRKGMINNNFNYFIMTKLAEAGIPTQIVRLLSDNEML
VKKLAMVPVECVVRNRAAGSLVKRLGVEEGLVLDPPLFDLFLKNDAMHDPMINESYCTTFGWVSEPHLARMKQLTYQAND
VLSKIFDDAGLILVDFKLEFGLFNGEIVLGDEFSPDGSRLWDKTTLDKMDKDRFRQNLGGVIEAYEEVAKRIGVTLD

Sequences:

>Translated_237_residues
MQKLAELYRGKAKTVYTTEDPDLLILTFRNDTSALDGQRIEQFDRKGMINNNFNYFIMTKLAEAGIPTQIVRLLSDNEML
VKKLAMVPVECVVRNRAAGSLVKRLGVEEGLVLDPPLFDLFLKNDAMHDPMINESYCTTFGWVSEPHLARMKQLTYQAND
VLSKIFDDAGLILVDFKLEFGLFNGEIVLGDEFSPDGSRLWDKTTLDKMDKDRFRQNLGGVIEAYEEVAKRIGVTLD
>Mature_237_residues
MQKLAELYRGKAKTVYTTEDPDLLILTFRNDTSALDGQRIEQFDRKGMINNNFNYFIMTKLAEAGIPTQIVRLLSDNEML
VKKLAMVPVECVVRNRAAGSLVKRLGVEEGLVLDPPLFDLFLKNDAMHDPMINESYCTTFGWVSEPHLARMKQLTYQAND
VLSKIFDDAGLILVDFKLEFGLFNGEIVLGDEFSPDGSRLWDKTTLDKMDKDRFRQNLGGVIEAYEEVAKRIGVTLD

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=249, Percent_Identity=31.3253012048193, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI5453539, Length=249, Percent_Identity=31.3253012048193, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI119220559, Length=256, Percent_Identity=30.078125, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=83.5443037974684, Blast_Score=419, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17531275, Length=224, Percent_Identity=26.7857142857143, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI18860083, Length=237, Percent_Identity=32.0675105485232, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24583917, Length=247, Percent_Identity=29.5546558704453, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_SODGM (Q2NS76)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455404.1
- HSSP:   P0A7D7
- ProteinModelPortal:   Q2NS76
- SMR:   Q2NS76
- STRING:   Q2NS76
- GeneID:   3866863
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1724
- NMPDR:   fig|343509.6.peg.3657
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   Q2NS76
- ProtClustDB:   PRK09362
- BioCyc:   SGLO343509:SG1724-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 26908; Mature: 26908

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLAELYRGKAKTVYTTEDPDLLILTFRNDTSALDGQRIEQFDRKGMINNNFNYFIMTK
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEE
LAEAGIPTQIVRLLSDNEMLVKKLAMVPVECVVRNRAAGSLVKRLGVEEGLVLDPPLFDL
HHHCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCCEECCCHHHH
FLKNDAMHDPMINESYCTTFGWVSEPHLARMKQLTYQANDVLSKIFDDAGLILVDFKLEF
HCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
GLFNGEIVLGDEFSPDGSRLWDKTTLDKMDKDRFRQNLGGVIEAYEEVAKRIGVTLD
EEECCEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQKLAELYRGKAKTVYTTEDPDLLILTFRNDTSALDGQRIEQFDRKGMINNNFNYFIMTK
CCHHHHHHCCCCCEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEE
LAEAGIPTQIVRLLSDNEMLVKKLAMVPVECVVRNRAAGSLVKRLGVEEGLVLDPPLFDL
HHHCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHCCCCCCEECCCHHHH
FLKNDAMHDPMINESYCTTFGWVSEPHLARMKQLTYQANDVLSKIFDDAGLILVDFKLEF
HCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEE
GLFNGEIVLGDEFSPDGSRLWDKTTLDKMDKDRFRQNLGGVIEAYEEVAKRIGVTLD
EEECCEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA