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The map label for this gene is gyrA [H]

Identifier: 85059560

GI number: 85059560

Start: 2714862

End: 2717522

Strand: Reverse

Name: gyrA [H]

Synonym: SG1582

Alternate gene names: 85059560

Gene position: 2717522-2714862 (Counterclockwise)

Preceding gene: 85059566

Following gene: 85059559

Centisome position: 65.15

GC content: 58.44

Gene sequence:

>2661_bases
ATGAGCGACCTTGCCAGAGAAATTACACCGGTCAATATCGAAGAAGAGCTGAAACGTTCTTATCTGGATTACGCCATGTC
CGTCATCGTCGGACGTGCGTTGCCGGATGTGCGTGACGGGCTCAAGCCCGTGCACCGTCGTGTGCTGTTCGCAATGAGCG
TGCTCGGTAATGACTGGAATAAACCTTATAAAAAATCGGCGCGCGTTGTCGGCGACGTCATCGGTAAGTATCACCCCCAC
GGGGATACCGCCGTCTACGACACCATCGTGCGTATGGCACAGCCGTTCTCGCTGCGTTACATGCTGGTGGATGGCCAGGG
CAACTTCGGTTCGGTTGACGGCGACTCCGCCGCGGCGATGCGTTATACCGAAGTGCGCATGGCCAAAATCGCCCACGAAT
TACTAGCGGATCTGGAAAAAGAGACCGTCGATTACGTGCCCAACTATGACGGCACCGAGCAAATCCCCGATGTCATGCCC
ACCAGGATCCCGAATCTGTTGGTCAACGGCTCTTCCGGCATCGCGGTGGGAATGGCCACCAATATACCGCCCCACAACCT
CGCAGAAATCATTGACGGCTGTTTGGCCTATATCGACGATGAGAACATCAGCGTCGAAGGCTTAATGGAACACATCCCCG
GGCCCGATTTCCCGACCGCCGCCATCATTAATGGCCGGCGCGGCATAGAAGAGGCCTACCGCACCGGGCGCGGCAAAATC
TACATCCGTGCGCGCGCCGAGGTGGAAACGGACGGCAAGTCCGGCCGGGAAACCATCATCGTGCATGAAATTCCCTATCA
GGTGAATAAAGCGCGTCTGATTGAGAAAATCGCCGAGCTGGTAAAGGAAAAGCGCGTCGAAGGTATCAGCGGTCTGCGCG
ATGAGTCCGACAAGGACGGCATGCGGATCGTCATTGAAATCAAACGCGACGCGGTGGGAGAGGTGGTGCTCAACAACCTC
TACTCCCTGACCCAGCTGCAGGTGTCGTTTGGTATCAATATGGTGGCGCTGCATCAGGGGCAGCCGAAGATCCTGCCGCT
GAAGGATATTTTATCCGCTTTCGTGCGCCACCGCCGTGAAGTGGTGACCCGCCGCACGATTTTTGAATTACGCAAAGCCC
GCGAGCGCGCGCATATTCTGGAAGCGCTTGCGGTGGCGCTGGCGAATATCGACCCGATCATTGAGCTGATTCGCCAGGAG
CCGACGCCGGCGGAAGCGAAGGCCGCCCTGGTTGCGCGCTCATGGGCGCTGGGCACCGTCTCCGCTATGTTGGACCGCGC
CGGCGACGACGCTGCACGTCCGGAATGGCTGGAGCCGGAATACGGCATTCGCGACGGGCAATATTACCTGACCGAGCAGC
AGGCCCAGGCGATTCTGGATTTGCGCCTGCAAAAACTGACCGGCCTGGAGCATGAAAAACTGCTGGATGAATATAAGGAG
CTGCTGACCCAGATAGCTGAACTTATCCGTATCCTGCAGAACCCTGACTGCTTGATGGAGGTGATCCGCGAAGAGCTGGT
GGCCATCAAAGAGCAGTATAACGACCCGCGCCGCACCGAGATTACCGCCAATACGTCGGATATCAATATCGAAGACCTGA
TCAATCAGGAAGATGTTGTCGTCACACTGTCCCATCAGGGTTACGTGAAGTATCAGCCGTTGACGGACTATGAGGCGCAG
CGCCGCGGCGGTAAAGGGAAGTCGGCGGCCAGCATCAAGGAAGAGGACTTTATCGACCGGCTGCTGGTGGCGAATACCCA
CGACACTATTTTGCTGTTCTCCAGCCGGGGACGGATGTACTGGATGAAGGTTTATCAACTGCCGGAAGCCAGCCGCGGCG
CCCGTGGGCGGCCGATAGTCAATCTGTTGCCGCTGGAGTCCAACGAACGTATCACCGCTATCTTGCCGGTGCGTGAGTAT
GAAGAAGGACGACACGTCTTCATGGCGACTGCCAGCGGCACCGTGAAGAAGACCTCCCTCATCGAGTTCAGCCGTCCGCG
CAGCGCCGGTATCATTGCCGTCAATCTTAACGATGGCGATGAGCTGATTGGCGTGGATCTGACCGACGGAAGCAACGAAG
TCATGTTGTTCTCCGCCTACGGTAAGGTGGTGCGCTTCCCGGAAAACCAGGTGCGCAGCATGGGGCGGACCGCGACCGGC
GTGCGCGGTATCAATCTGGCCGAAGGCGACCGGGTGGTGTCTCTCATCGTGCCGCGCGGCGAGGGGCCGATATTGACGGT
GACGCAGCATGGCTACGGCAAGCGTACCGCGCAGGCGGAATATCCGACCAAGTCCCGCGCCACCCAGGGCGTTATCTCCA
TCAAGGTGAGCGAACGCAATGGTGAAGTGGTCGGCGCGGTACAGGTGGATGATTGCGATCAGATCATGATGATAACGGAC
GCTGGTACGCTGGTGCGTACGCGGGTCTCCGAGGTAAGCATCGTGGGCCGCAACACCCAGGGCGTGACGCTCATTCGCAC
CGCTCAGGACGAACACGTGGTGGGTCTGCAGTGTGTCGCCGAACAGGTCGATGACGACGATCTGGATTCGGTGGTGAGCC
CTGACGCGCTCGCGGATGACAGCCTTGTGGATGCTGATGACGCCGATGAGGCGGATAATGGCGTCGAGGGTGACGATGAT
GTCGACGGTGAACGTGAATAA

Upstream 100 bases:

>100_bases
CCTTTCAACGGTGACGGTGCCCTTTTACAGAAAAAAGATGGTATACTTTGACACCTTTAAATCCGGGTAGAAGCTTCATT
AGTAGAGGGATAGCGGCTCC

Downstream 100 bases:

>100_bases
TCGCCACGGTTGGCGTCGCGCCGGCGAGTAACAACGGTAACCAAAAAGAGCCAGCGCGGTTGCGCTGGCTCTTTTTAATT
TCGGCTGATTTTCTCTTATC

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 886; Mature: 885

Protein sequence:

>886_residues
MSDLAREITPVNIEEELKRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSVLGNDWNKPYKKSARVVGDVIGKYHPH
GDTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEVRMAKIAHELLADLEKETVDYVPNYDGTEQIPDVMP
TRIPNLLVNGSSGIAVGMATNIPPHNLAEIIDGCLAYIDDENISVEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKI
YIRARAEVETDGKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISGLRDESDKDGMRIVIEIKRDAVGEVVLNNL
YSLTQLQVSFGINMVALHQGQPKILPLKDILSAFVRHRREVVTRRTIFELRKARERAHILEALAVALANIDPIIELIRQE
PTPAEAKAALVARSWALGTVSAMLDRAGDDAARPEWLEPEYGIRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLTQIAELIRILQNPDCLMEVIREELVAIKEQYNDPRRTEITANTSDINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQ
RRGGKGKSAASIKEEDFIDRLLVANTHDTILLFSSRGRMYWMKVYQLPEASRGARGRPIVNLLPLESNERITAILPVREY
EEGRHVFMATASGTVKKTSLIEFSRPRSAGIIAVNLNDGDELIGVDLTDGSNEVMLFSAYGKVVRFPENQVRSMGRTATG
VRGINLAEGDRVVSLIVPRGEGPILTVTQHGYGKRTAQAEYPTKSRATQGVISIKVSERNGEVVGAVQVDDCDQIMMITD
AGTLVRTRVSEVSIVGRNTQGVTLIRTAQDEHVVGLQCVAEQVDDDDLDSVVSPDALADDSLVDADDADEADNGVEGDDD
VDGERE

Sequences:

>Translated_886_residues
MSDLAREITPVNIEEELKRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSVLGNDWNKPYKKSARVVGDVIGKYHPH
GDTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEVRMAKIAHELLADLEKETVDYVPNYDGTEQIPDVMP
TRIPNLLVNGSSGIAVGMATNIPPHNLAEIIDGCLAYIDDENISVEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKI
YIRARAEVETDGKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISGLRDESDKDGMRIVIEIKRDAVGEVVLNNL
YSLTQLQVSFGINMVALHQGQPKILPLKDILSAFVRHRREVVTRRTIFELRKARERAHILEALAVALANIDPIIELIRQE
PTPAEAKAALVARSWALGTVSAMLDRAGDDAARPEWLEPEYGIRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
LLTQIAELIRILQNPDCLMEVIREELVAIKEQYNDPRRTEITANTSDINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQ
RRGGKGKSAASIKEEDFIDRLLVANTHDTILLFSSRGRMYWMKVYQLPEASRGARGRPIVNLLPLESNERITAILPVREY
EEGRHVFMATASGTVKKTSLIEFSRPRSAGIIAVNLNDGDELIGVDLTDGSNEVMLFSAYGKVVRFPENQVRSMGRTATG
VRGINLAEGDRVVSLIVPRGEGPILTVTQHGYGKRTAQAEYPTKSRATQGVISIKVSERNGEVVGAVQVDDCDQIMMITD
AGTLVRTRVSEVSIVGRNTQGVTLIRTAQDEHVVGLQCVAEQVDDDDLDSVVSPDALADDSLVDADDADEADNGVEGDDD
VDGERE
>Mature_885_residues
SDLAREITPVNIEEELKRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSVLGNDWNKPYKKSARVVGDVIGKYHPHG
DTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAMRYTEVRMAKIAHELLADLEKETVDYVPNYDGTEQIPDVMPT
RIPNLLVNGSSGIAVGMATNIPPHNLAEIIDGCLAYIDDENISVEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKIY
IRARAEVETDGKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISGLRDESDKDGMRIVIEIKRDAVGEVVLNNLY
SLTQLQVSFGINMVALHQGQPKILPLKDILSAFVRHRREVVTRRTIFELRKARERAHILEALAVALANIDPIIELIRQEP
TPAEAKAALVARSWALGTVSAMLDRAGDDAARPEWLEPEYGIRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKEL
LTQIAELIRILQNPDCLMEVIREELVAIKEQYNDPRRTEITANTSDINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQR
RGGKGKSAASIKEEDFIDRLLVANTHDTILLFSSRGRMYWMKVYQLPEASRGARGRPIVNLLPLESNERITAILPVREYE
EGRHVFMATASGTVKKTSLIEFSRPRSAGIIAVNLNDGDELIGVDLTDGSNEVMLFSAYGKVVRFPENQVRSMGRTATGV
RGINLAEGDRVVSLIVPRGEGPILTVTQHGYGKRTAQAEYPTKSRATQGVISIKVSERNGEVVGAVQVDDCDQIMMITDA
GTLVRTRVSEVSIVGRNTQGVTLIRTAQDEHVVGLQCVAEQVDDDDLDSVVSPDALADDSLVDADDADEADNGVEGDDDV
DGERE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=319, Percent_Identity=25.705329153605, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=26.1627906976744, Blast_Score=80, Evalue=1e-14,
Organism=Escherichia coli, GI1788562, Length=873, Percent_Identity=84.9942726231386, Blast_Score=1506, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=739, Percent_Identity=35.4533152909337, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=32.3353293413174, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212645845, Length=208, Percent_Identity=30.2884615384615, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=356, Percent_Identity=25.8426966292135, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136538, Length=362, Percent_Identity=27.9005524861878, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 98257; Mature: 98126

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLAREITPVNIEEELKRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSVLGNDWN
CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMAKIAHELLADLEKETVDYVPNYDGTEQIPDVMPTRIPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHCCCCCEEEECCCCEEEEEEC
NIPPHNLAEIIDGCLAYIDDENISVEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKI
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCCCEE
YIRARAEVETDGKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISGLRDESDKDG
EEEEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
MRIVIEIKRDAVGEVVLNNLYSLTQLQVSFGINMVALHQGQPKILPLKDILSAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH
VVTRRTIFELRKARERAHILEALAVALANIDPIIELIRQEPTPAEAKAALVARSWALGTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SAMLDRAGDDAARPEWLEPEYGIRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLTQIAELIRILQNPDCLMEVIREELVAIKEQYNDPRRTEITANTSDINIEDLINQEDVV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCCCCCEE
VTLSHQGYVKYQPLTDYEAQRRGGKGKSAASIKEEDFIDRLLVANTHDTILLFSSRGRMY
EEEECCCEEEECCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEE
WMKVYQLPEASRGARGRPIVNLLPLESNERITAILPVREYEEGRHVFMATASGTVKKTSL
EEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEECHHCCCCCEEEEEECCCCEEEEEE
IEFSRPRSAGIIAVNLNDGDELIGVDLTDGSNEVMLFSAYGKVVRFPENQVRSMGRTATG
EEECCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEECCCEEECCHHHHHHCCCCCCC
VRGINLAEGDRVVSLIVPRGEGPILTVTQHGYGKRTAQAEYPTKSRATQGVISIKVSERN
CCCCEECCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCEEEEEEECCC
GEVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVTLIRTAQDEHVVGLQCVA
CCEEEEEEECCCCCEEEEECCCHHHHHHHHEEEEEECCCCCEEEEEECCCCCCHHHHHHH
EQVDDDDLDSVVSPDALADDSLVDADDADEADNGVEGDDDVDGERE
HHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLAREITPVNIEEELKRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMSVLGNDWN
CCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDSAAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHH
RYTEVRMAKIAHELLADLEKETVDYVPNYDGTEQIPDVMPTRIPNLLVNGSSGIAVGMAT
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHCCCCCEEEECCCCEEEEEEC
NIPPHNLAEIIDGCLAYIDDENISVEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKI
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCCCEE
YIRARAEVETDGKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISGLRDESDKDG
EEEEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
MRIVIEIKRDAVGEVVLNNLYSLTQLQVSFGINMVALHQGQPKILPLKDILSAFVRHRRE
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEECHHHHHHHHHHHHHH
VVTRRTIFELRKARERAHILEALAVALANIDPIIELIRQEPTPAEAKAALVARSWALGTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SAMLDRAGDDAARPEWLEPEYGIRDGQYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE
HHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLTQIAELIRILQNPDCLMEVIREELVAIKEQYNDPRRTEITANTSDINIEDLINQEDVV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCCCCCEE
VTLSHQGYVKYQPLTDYEAQRRGGKGKSAASIKEEDFIDRLLVANTHDTILLFSSRGRMY
EEEECCCEEEECCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCEE
WMKVYQLPEASRGARGRPIVNLLPLESNERITAILPVREYEEGRHVFMATASGTVKKTSL
EEEEEECCCCCCCCCCCCEEEEEECCCCCCEEEEEECHHCCCCCEEEEEECCCCEEEEEE
IEFSRPRSAGIIAVNLNDGDELIGVDLTDGSNEVMLFSAYGKVVRFPENQVRSMGRTATG
EEECCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEECCCEEECCHHHHHHCCCCCCC
VRGINLAEGDRVVSLIVPRGEGPILTVTQHGYGKRTAQAEYPTKSRATQGVISIKVSERN
CCCCEECCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCEEEEEEECCC
GEVVGAVQVDDCDQIMMITDAGTLVRTRVSEVSIVGRNTQGVTLIRTAQDEHVVGLQCVA
CCEEEEEEECCCCCEEEEECCCHHHHHHHHEEEEEECCCCCEEEEEECCCCCCHHHHHHH
EQVDDDDLDSVVSPDALADDSLVDADDADEADNGVEGDDDVDGERE
HHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7642123 [H]