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The map label for this gene is tyrR [H]

Identifier: 85059477

GI number: 85059477

Start: 2513603

End: 2515174

Strand: Reverse

Name: tyrR [H]

Synonym: SG1499

Alternate gene names: 85059477

Gene position: 2515174-2513603 (Counterclockwise)

Preceding gene: 85059478

Following gene: 85059475

Centisome position: 60.3

GC content: 56.74

Gene sequence:

>1572_bases
ATGCGTTTGGAAGTAGTTTGTCAGGACCGTTTGGGTCTGGTGCGGGAGTTATTGGATTTGTTGGTCTCCCGCTCAATCGA
CTTACGCGGCATCGAAATTACCCCCACCGGCCGTGTTTATCTTAATTGTACGCCGCTGGAATTTGATCTTTTTCGTTCGC
TTATGGCGGAAATTCGCCGCATAGAGGGCGTTACCGATGTGCGGACCGTGGCTTTTATGCCCACCGAACGCGACTCCCGC
GCCATGCAGGCAATACTGTCCGCCATGCCGGAAGCCGTGTTGTCCATCGACCTGAAAGGCCGGATCGCGTTATCCAATCC
GGCGGCCGCTCTGCTGTTTAATGCCAGCGGGGAGAAATTACTCGGCCAATCTTTGTCGGCGCTGGTCGGCGGGTTTGATT
TCAATCGCTGGCTGGAAGATGCCCTGCCGCAGCCGGCCGCTGAACGGGTGGTGATTCAAGGCCAGGATTTCCTGCTGGAT
ATCACGCCCGTACAACTGCCCGGGGACGATGGTCATACCGCCACCGTCGGAGGGGTCGTGATGTTGAAATCGGCATTGTG
CATGGACCGGCAATTGAAAGACCATTCGGTCAACGACGACAACGCGTTCAGCCATCTGCTGGCGAGCAGCGAGCGTATGC
GCCAGGTCATCAACAATGCCCGCAAGTTGGCGATGCTCGACGCACCGCTGCTGATTATCGGCGAGACCGGTACCGGTAAA
GATCTTCTGTCGCACGCCTGCCATCTGCGCAGCGCCCGTGGACGTCAGCCCTTTTTGGCGCTCAATTGCGCCGCCTTGCC
CGACGAAGTGGCCGAAAGCGAACTGTTTGGCCACGCCGCGGGCGCTTATCCCAACGCGCTTGAGAGTAAAAAAGGCTTTT
TTGAACAGGCGGACGGCGGGTCGGTGTTGCTGGACGAAATCGCGGAAATGTCCCCGCGTATGCAAAATAAATTACTCCGC
TTTCTCAATGACGGCACGTTCCGGCGGGTTGGGGAAGACAAAGAGATGCACGTCGACGTACGGGTCATCTGCGCCACACA
GAAGAATTTGCTGGAACTGGTGCGGGACGGCCATTTTCGCGAGGATCTGTATTATCGTCTGAACGTACTTACCCTGGCAA
TCCCGCCGTTGCGCGATCGCCCCGAAGATATCATGCCGTTAACGTCGCTGTTTGTTGCCCGCTTCTGCGACGAGCAAGGC
GTTACCCGACCACAATTGGCGCCGGATCTGGCCGCCAAATTAACGCGTTACCCCTGGCCGGGTAACGTACGGCAGCTGAA
AAATGCTCTGTACCGGGCAATGGCCCAGCGTGAAGGGCCGGCATTGAGCGCTGTGGACATCGATTTACCCGACTTTGGCC
AGGCGCTGCCGCTGACGGATGACTTGCTTGACGGCTCGCTTGATGACATCAGCAAACGGTTCGAGCGTTCGGTGCTAACG
CGCCTTTACCGTGCCTATCCCAGTACCCGTAAATTGGCGAAACGGCTGGGGGTTTCCCATACCGCCATTGCCAATAAATT
ACGTGAATACGGTTTAAACGGTAAAAAAACGGATGATGACACCACGGTCTAA

Upstream 100 bases:

>100_bases
TGTCCATACTGTCAACTTTTTGTGACAGACAGCTTCAACCGCGGTGCAATGGCCAGTATGATATGCCCCAGATACCCTGA
TCGCTTGAGCGAGGCAATAC

Downstream 100 bases:

>100_bases
CCTGCTGGCGTCGCCGTTCAGCCGGCAGCGCCGCCGCCGGCCAGCTTACTTTGACGAAAGCGGCGTTTTGGGCTCAGGCC
TGCAGCGCGGCGAGCGCGGC

Product: DNA-binding transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MRLEVVCQDRLGLVRELLDLLVSRSIDLRGIEITPTGRVYLNCTPLEFDLFRSLMAEIRRIEGVTDVRTVAFMPTERDSR
AMQAILSAMPEAVLSIDLKGRIALSNPAAALLFNASGEKLLGQSLSALVGGFDFNRWLEDALPQPAAERVVIQGQDFLLD
ITPVQLPGDDGHTATVGGVVMLKSALCMDRQLKDHSVNDDNAFSHLLASSERMRQVINNARKLAMLDAPLLIIGETGTGK
DLLSHACHLRSARGRQPFLALNCAALPDEVAESELFGHAAGAYPNALESKKGFFEQADGGSVLLDEIAEMSPRMQNKLLR
FLNDGTFRRVGEDKEMHVDVRVICATQKNLLELVRDGHFREDLYYRLNVLTLAIPPLRDRPEDIMPLTSLFVARFCDEQG
VTRPQLAPDLAAKLTRYPWPGNVRQLKNALYRAMAQREGPALSAVDIDLPDFGQALPLTDDLLDGSLDDISKRFERSVLT
RLYRAYPSTRKLAKRLGVSHTAIANKLREYGLNGKKTDDDTTV

Sequences:

>Translated_523_residues
MRLEVVCQDRLGLVRELLDLLVSRSIDLRGIEITPTGRVYLNCTPLEFDLFRSLMAEIRRIEGVTDVRTVAFMPTERDSR
AMQAILSAMPEAVLSIDLKGRIALSNPAAALLFNASGEKLLGQSLSALVGGFDFNRWLEDALPQPAAERVVIQGQDFLLD
ITPVQLPGDDGHTATVGGVVMLKSALCMDRQLKDHSVNDDNAFSHLLASSERMRQVINNARKLAMLDAPLLIIGETGTGK
DLLSHACHLRSARGRQPFLALNCAALPDEVAESELFGHAAGAYPNALESKKGFFEQADGGSVLLDEIAEMSPRMQNKLLR
FLNDGTFRRVGEDKEMHVDVRVICATQKNLLELVRDGHFREDLYYRLNVLTLAIPPLRDRPEDIMPLTSLFVARFCDEQG
VTRPQLAPDLAAKLTRYPWPGNVRQLKNALYRAMAQREGPALSAVDIDLPDFGQALPLTDDLLDGSLDDISKRFERSVLT
RLYRAYPSTRKLAKRLGVSHTAIANKLREYGLNGKKTDDDTTV
>Mature_523_residues
MRLEVVCQDRLGLVRELLDLLVSRSIDLRGIEITPTGRVYLNCTPLEFDLFRSLMAEIRRIEGVTDVRTVAFMPTERDSR
AMQAILSAMPEAVLSIDLKGRIALSNPAAALLFNASGEKLLGQSLSALVGGFDFNRWLEDALPQPAAERVVIQGQDFLLD
ITPVQLPGDDGHTATVGGVVMLKSALCMDRQLKDHSVNDDNAFSHLLASSERMRQVINNARKLAMLDAPLLIIGETGTGK
DLLSHACHLRSARGRQPFLALNCAALPDEVAESELFGHAAGAYPNALESKKGFFEQADGGSVLLDEIAEMSPRMQNKLLR
FLNDGTFRRVGEDKEMHVDVRVICATQKNLLELVRDGHFREDLYYRLNVLTLAIPPLRDRPEDIMPLTSLFVARFCDEQG
VTRPQLAPDLAAKLTRYPWPGNVRQLKNALYRAMAQREGPALSAVDIDLPDFGQALPLTDDLLDGSLDDISKRFERSVLT
RLYRAYPSTRKLAKRLGVSHTAIANKLREYGLNGKKTDDDTTV

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=520, Percent_Identity=63.8461538461538, Blast_Score=658, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=316, Percent_Identity=39.5569620253165, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1790299, Length=252, Percent_Identity=44.047619047619, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1790437, Length=305, Percent_Identity=37.3770491803279, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789087, Length=318, Percent_Identity=37.4213836477987, Blast_Score=201, Evalue=9e-53,
Organism=Escherichia coli, GI87082152, Length=319, Percent_Identity=37.9310344827586, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1789233, Length=329, Percent_Identity=32.8267477203647, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082117, Length=238, Percent_Identity=40.7563025210084, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1788905, Length=238, Percent_Identity=39.9159663865546, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI87081872, Length=231, Percent_Identity=41.991341991342, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1786524, Length=276, Percent_Identity=37.3188405797101, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1789828, Length=230, Percent_Identity=36.5217391304348, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI87081858, Length=454, Percent_Identity=25.1101321585903, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57982; Mature: 57982

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVVCQDRLGLVRELLDLLVSRSIDLRGIEITPTGRVYLNCTPLEFDLFRSLMAEIRR
CCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHH
IEGVTDVRTVAFMPTERDSRAMQAILSAMPEAVLSIDLKGRIALSNPAAALLFNASGEKL
HCCCCHHEEEEECCCCCHHHHHHHHHHHCCHHHEEEECCCEEEECCCCEEEEECCCCHHH
LGQSLSALVGGFDFNRWLEDALPQPAAERVVIQGQDFLLDITPVQLPGDDGHTATVGGVV
HHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCEEEEEEEEEECCCCCCEEHHHHHH
MLKSALCMDRQLKDHSVNDDNAFSHLLASSERMRQVINNARKLAMLDAPLLIIGETGTGK
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCCCCH
DLLSHACHLRSARGRQPFLALNCAALPDEVAESELFGHAAGAYPNALESKKGFFEQADGG
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCC
SVLLDEIAEMSPRMQNKLLRFLNDGTFRRVGEDKEMHVDVRVICATQKNLLELVRDGHFR
CHHHHHHHHHCHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEEEECCHHHHHHHHHCCCCH
EDLYYRLNVLTLAIPPLRDRPEDIMPLTSLFVARFCDEQGVTRPQLAPDLAAKLTRYPWP
HHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCC
GNVRQLKNALYRAMAQREGPALSAVDIDLPDFGQALPLTDDLLDGSLDDISKRFERSVLT
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHH
RLYRAYPSTRKLAKRLGVSHTAIANKLREYGLNGKKTDDDTTV
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRLEVVCQDRLGLVRELLDLLVSRSIDLRGIEITPTGRVYLNCTPLEFDLFRSLMAEIRR
CCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHH
IEGVTDVRTVAFMPTERDSRAMQAILSAMPEAVLSIDLKGRIALSNPAAALLFNASGEKL
HCCCCHHEEEEECCCCCHHHHHHHHHHHCCHHHEEEECCCEEEECCCCEEEEECCCCHHH
LGQSLSALVGGFDFNRWLEDALPQPAAERVVIQGQDFLLDITPVQLPGDDGHTATVGGVV
HHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEECCCEEEEEEEEEECCCCCCEEHHHHHH
MLKSALCMDRQLKDHSVNDDNAFSHLLASSERMRQVINNARKLAMLDAPLLIIGETGTGK
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEEEEECCCCCH
DLLSHACHLRSARGRQPFLALNCAALPDEVAESELFGHAAGAYPNALESKKGFFEQADGG
HHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCC
SVLLDEIAEMSPRMQNKLLRFLNDGTFRRVGEDKEMHVDVRVICATQKNLLELVRDGHFR
CHHHHHHHHHCHHHHHHHHHHHCCCCHHHCCCCCCEEEEEEEEECCHHHHHHHHHCCCCH
EDLYYRLNVLTLAIPPLRDRPEDIMPLTSLFVARFCDEQGVTRPQLAPDLAAKLTRYPWP
HHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCC
GNVRQLKNALYRAMAQREGPALSAVDIDLPDFGQALPLTDDLLDGSLDDISKRFERSVLT
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHH
RLYRAYPSTRKLAKRLGVSHTAIANKLREYGLNGKKTDDDTTV
HHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]