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The map label for this gene is hutC [H]

Identifier: 85059117

GI number: 85059117

Start: 1890190

End: 1890942

Strand: Reverse

Name: hutC [H]

Synonym: SG1139

Alternate gene names: 85059117

Gene position: 1890942-1890190 (Counterclockwise)

Preceding gene: 85059119

Following gene: 85059116

Centisome position: 45.33

GC content: 57.77

Gene sequence:

>753_bases
ATGACTAATGACCAACCGATGTATGAGCAAATCAAAATGTCTATTGACCGACGTATCGAGGCGGAAGAATGGCCGAGTGA
TTTTCAAATACCCTCAGAAGACCAGTTGGCCGAGGAGTTTGGCGTCTCCAGTCTCACCGTCAGGCGGGCGCTGCGCGAGC
TGCAGGCGGAAGGCGTGCTGATCCGTATACAGGGACGCGGCACCTTTGTGGTCGGCCCGCGCATGCAGTGCGCAGTGTTT
ACCTTGTCCAATATTTCGGAAGACATCGCCCAGAGTGGCGGCGTGCATTCTTGCCAGGTGCTCGCCCATCTGACGCTGCC
GCCAGACAGCCCGTTGCGCAGTATGCTGCCTTTGCCGGCCGGGCAAGACATCTACCATTCCCGCCTGTTGCATATCGAAG
ACGGCACGCCGATTCAACTGGAAGACCGGTTTGTCAACGCCGCGGAAGCGCCGGGCTATATGGCGCAGGATTTTACCACC
CAGCCCTCCCACAGTTTTTTGGTGCGTAACACGACGGTGACGACGGTCGACAATATGATCCGCGCCGTACGGGCAAATGA
GGAGGCCCAATCGCTGCTGCACATCGATGCCGGGCAGCCCTGCCTGCTGCTCGACCGTGCCACCTGGCGTGACGGCGTTC
CCGTCACCCGCAGCCGTTTTCTTTATCCGGGAGACCTTTATAGTCTGCGCAGTTCCCATGAAGCGCGGCCCAGCCGTATT
ACTTCTTCTTTGTTCAACGTCAAAAACAGATAA

Upstream 100 bases:

>100_bases
CTCGCTGAAGCAATATCTGGGCAATATGCCGGCGGGTTATCATTTTGTCACCACGCCACCGATGGTAGTCAACGATAGAC
AGATTCTGAGAAGAAAATCC

Downstream 100 bases:

>100_bases
GGTCTAGCCATGAGGGAGTTTATTCGTCGTCTTGAACAACGCGGTTGTCTGTTGGTGGTTGAAAAAGAGATTGACCCGTT
TCACGAATTGGCCACCGTCA

Product: putative transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MTNDQPMYEQIKMSIDRRIEAEEWPSDFQIPSEDQLAEEFGVSSLTVRRALRELQAEGVLIRIQGRGTFVVGPRMQCAVF
TLSNISEDIAQSGGVHSCQVLAHLTLPPDSPLRSMLPLPAGQDIYHSRLLHIEDGTPIQLEDRFVNAAEAPGYMAQDFTT
QPSHSFLVRNTTVTTVDNMIRAVRANEEAQSLLHIDAGQPCLLLDRATWRDGVPVTRSRFLYPGDLYSLRSSHEARPSRI
TSSLFNVKNR

Sequences:

>Translated_250_residues
MTNDQPMYEQIKMSIDRRIEAEEWPSDFQIPSEDQLAEEFGVSSLTVRRALRELQAEGVLIRIQGRGTFVVGPRMQCAVF
TLSNISEDIAQSGGVHSCQVLAHLTLPPDSPLRSMLPLPAGQDIYHSRLLHIEDGTPIQLEDRFVNAAEAPGYMAQDFTT
QPSHSFLVRNTTVTTVDNMIRAVRANEEAQSLLHIDAGQPCLLLDRATWRDGVPVTRSRFLYPGDLYSLRSSHEARPSRI
TSSLFNVKNR
>Mature_249_residues
TNDQPMYEQIKMSIDRRIEAEEWPSDFQIPSEDQLAEEFGVSSLTVRRALRELQAEGVLIRIQGRGTFVVGPRMQCAVFT
LSNISEDIAQSGGVHSCQVLAHLTLPPDSPLRSMLPLPAGQDIYHSRLLHIEDGTPIQLEDRFVNAAEAPGYMAQDFTTQ
PSHSFLVRNTTVTTVDNMIRAVRANEEAQSLLHIDAGQPCLLLDRATWRDGVPVTRSRFLYPGDLYSLRSSHEARPSRIT
SSLFNVKNR

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=238, Percent_Identity=27.7310924369748, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790118, Length=139, Percent_Identity=29.4964028776978, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082252, Length=150, Percent_Identity=26.6666666666667, Blast_Score=71, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28045; Mature: 27914

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS51000 HTH_DEOR_2 ; PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDQPMYEQIKMSIDRRIEAEEWPSDFQIPSEDQLAEEFGVSSLTVRRALRELQAEGVL
CCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCEE
IRIQGRGTFVVGPRMQCAVFTLSNISEDIAQSGGVHSCQVLAHLTLPPDSPLRSMLPLPA
EEEECCEEEEECCCCEEEEEEHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHCCCCC
GQDIYHSRLLHIEDGTPIQLEDRFVNAAEAPGYMAQDFTTQPSHSFLVRNTTVTTVDNMI
CCCHHHHEEEEECCCCCEEEHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHH
RAVRANEEAQSLLHIDAGQPCLLLDRATWRDGVPVTRSRFLYPGDLYSLRSSHEARPSRI
HHHHCCHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCEECCCHHHHHHCCCCCCHHHH
TSSLFNVKNR
HHHHHHCCCC
>Mature Secondary Structure 
TNDQPMYEQIKMSIDRRIEAEEWPSDFQIPSEDQLAEEFGVSSLTVRRALRELQAEGVL
CCCCHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCEE
IRIQGRGTFVVGPRMQCAVFTLSNISEDIAQSGGVHSCQVLAHLTLPPDSPLRSMLPLPA
EEEECCEEEEECCCCEEEEEEHHHHHHHHHHCCCCCEEEEEEEEECCCCCHHHHHCCCCC
GQDIYHSRLLHIEDGTPIQLEDRFVNAAEAPGYMAQDFTTQPSHSFLVRNTTVTTVDNMI
CCCHHHHEEEEECCCCCEEEHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHH
RAVRANEEAQSLLHIDAGQPCLLLDRATWRDGVPVTRSRFLYPGDLYSLRSSHEARPSRI
HHHHCCHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCCEECCCHHHHHHCCCCCCHHHH
TSSLFNVKNR
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]