Click here to switch to the map view.

The map label for this gene is bioA [H]

Identifier: 85058880

GI number: 85058880

Start: 1465259

End: 1466548

Strand: Reverse

Name: bioA [H]

Synonym: SG0902

Alternate gene names: 85058880

Gene position: 1466548-1465259 (Counterclockwise)

Preceding gene: 85058886

Following gene: 85058879

Centisome position: 35.16

GC content: 64.03

Gene sequence:

>1290_bases
ATGCAGGCCAATGACCTCGCCTTCGACCGCCGCCATATCTGGCATCCTTACACCTCCATGACCCGGCCGCTACCGGCCTA
CCCGGTGGTCTCCGCCGACGGCTGTGAGCTGACCCTCAGCGATGGCCGCCGCCTGGTCGACGGTATGTCCTCCTGGTGGG
CGGCTATTCACGGCTACAATCATCCGGTTATCAATCAGGCGATGAAGGATCAAATCGGCCGCATGTCCCATGTGATGTTC
GGCGGCATTACCCATCCGCCAGCGGTGGCCCTGTGTCGTCGCCTGGTGGCGCTGACGCCGGCCGGTCTGGACTGCGTTTT
CCTGGCAGATTCCGGCTCGGTAGCCGTGGAGGTGGCGATAAAAATGGCGCTGCAATATTGGCAGGCCCGCGGCGAACCAC
GGCGCGAGTTACTTGCCCTGCGCCAGGGCTATCACGGCGATACCTTTGGCGCGATGTCGGTATGCGATCCCGATAACTCG
ATGCACAGCCTATATCAGGGCTACCTGCCCCCACATCGGTTCATCGAGGCCCCCCGACGGCGTTTCGACGACACCTGGCG
CGAGGGAGACGATGCGCCGCTGGCCGCCCTGTTGGCCGCCCACCACCGTACGCTGGCGGCGGTGATTCTGGAACCGATCG
TGCAGGGCGCCGGCGGGATGCGCTTTTACCATCCCGAATACCTGCGCCGGGCGCGGGCGCTGTGCGATCGCTATGGAATA
TTGCTGATTGCCGATGAAATCGCTACCGGTTTCGGCCGCACCGGCGAATGGTTCGCCTGCAACCTCGCCGGCATCTCGCC
GGATATCCTTTGTGTGGGAAAAGCCTTGACCGGCGGCGCCCTGACCCTCTCCGCCACGCTGACCCGTCGCCACGTAGCGG
ATACCCTCAGCGATGGCGACGCCGGCTGTTTCATGCACGGGCCGACATTTATGGCCAATCCGCTGGCCTGCGCCGCCGCC
AACGCCAGCCTGTCGCTGTTGGAAGACGAAAGCTGGCGCCCACGCGTAGCGGCGATTGCCGCAGGGCTTAGCGCCGGGTT
GTTACCGCTGGCCGACCATCCGCGGGTGCGCGATGTGCGGGTGCTCGGCGCCATAGGAGTAGTGGAAACGACACAGCCGG
TCAATATGGCGGCGCTGCAGCGATGGTTTGTCGATCGCGGCGTGTGGATCCGTCCTTTCGGCAAGCTAATTTACCTGATG
CCGCCCTACATCATCTCACCGCCGGCGCTTGCGTGGCTTATCGACGCCATTACCGACGCCCTGGACTCGCCGACGCATTT
TCTCTCGTGA

Upstream 100 bases:

>100_bases
GGTTATCCACAGCATCTTGAAGGAAATAGATGGCGTCAGTGTAGAGTTTGCCGCTACACTGTCAACAATATATTAAAAAT
TTAGTTTACAGGATAATCCG

Downstream 100 bases:

>100_bases
CGTCGTCGGCACAGGGTGCGCATGCGCGCCGGGCCACATACGCTATGCTTAACCTCTGACGTTTGCGGCCCGAGGCGATC
CGCCGCCGGCGAGCATGAAT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MQANDLAFDRRHIWHPYTSMTRPLPAYPVVSADGCELTLSDGRRLVDGMSSWWAAIHGYNHPVINQAMKDQIGRMSHVMF
GGITHPPAVALCRRLVALTPAGLDCVFLADSGSVAVEVAIKMALQYWQARGEPRRELLALRQGYHGDTFGAMSVCDPDNS
MHSLYQGYLPPHRFIEAPRRRFDDTWREGDDAPLAALLAAHHRTLAAVILEPIVQGAGGMRFYHPEYLRRARALCDRYGI
LLIADEIATGFGRTGEWFACNLAGISPDILCVGKALTGGALTLSATLTRRHVADTLSDGDAGCFMHGPTFMANPLACAAA
NASLSLLEDESWRPRVAAIAAGLSAGLLPLADHPRVRDVRVLGAIGVVETTQPVNMAALQRWFVDRGVWIRPFGKLIYLM
PPYIISPPALAWLIDAITDALDSPTHFLS

Sequences:

>Translated_429_residues
MQANDLAFDRRHIWHPYTSMTRPLPAYPVVSADGCELTLSDGRRLVDGMSSWWAAIHGYNHPVINQAMKDQIGRMSHVMF
GGITHPPAVALCRRLVALTPAGLDCVFLADSGSVAVEVAIKMALQYWQARGEPRRELLALRQGYHGDTFGAMSVCDPDNS
MHSLYQGYLPPHRFIEAPRRRFDDTWREGDDAPLAALLAAHHRTLAAVILEPIVQGAGGMRFYHPEYLRRARALCDRYGI
LLIADEIATGFGRTGEWFACNLAGISPDILCVGKALTGGALTLSATLTRRHVADTLSDGDAGCFMHGPTFMANPLACAAA
NASLSLLEDESWRPRVAAIAAGLSAGLLPLADHPRVRDVRVLGAIGVVETTQPVNMAALQRWFVDRGVWIRPFGKLIYLM
PPYIISPPALAWLIDAITDALDSPTHFLS
>Mature_429_residues
MQANDLAFDRRHIWHPYTSMTRPLPAYPVVSADGCELTLSDGRRLVDGMSSWWAAIHGYNHPVINQAMKDQIGRMSHVMF
GGITHPPAVALCRRLVALTPAGLDCVFLADSGSVAVEVAIKMALQYWQARGEPRRELLALRQGYHGDTFGAMSVCDPDNS
MHSLYQGYLPPHRFIEAPRRRFDDTWREGDDAPLAALLAAHHRTLAAVILEPIVQGAGGMRFYHPEYLRRARALCDRYGI
LLIADEIATGFGRTGEWFACNLAGISPDILCVGKALTGGALTLSATLTRRHVADTLSDGDAGCFMHGPTFMANPLACAAA
NASLSLLEDESWRPRVAAIAAGLSAGLLPLADHPRVRDVRVLGAIGVVETTQPVNMAALQRWFVDRGVWIRPFGKLIYLM
PPYIISPPALAWLIDAITDALDSPTHFLS

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=432, Percent_Identity=27.7777777777778, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI284507298, Length=228, Percent_Identity=34.2105263157895, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=25.858123569794, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI226442705, Length=333, Percent_Identity=26.1261261261261, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI226442709, Length=324, Percent_Identity=26.8518518518519, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI37574042, Length=326, Percent_Identity=26.9938650306748, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=71.6627634660422, Blast_Score=615, Evalue=1e-177,
Organism=Escherichia coli, GI145693181, Length=394, Percent_Identity=32.2335025380711, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789016, Length=417, Percent_Identity=28.7769784172662, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1789759, Length=301, Percent_Identity=33.2225913621262, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788044, Length=308, Percent_Identity=31.1688311688312, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787560, Length=408, Percent_Identity=27.2058823529412, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786349, Length=389, Percent_Identity=27.5064267352185, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=426, Percent_Identity=24.4131455399061, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=422, Percent_Identity=26.303317535545, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144274, Length=226, Percent_Identity=30.0884955752212, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71992977, Length=403, Percent_Identity=24.0694789081886, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324386, Length=458, Percent_Identity=44.9781659388646, Blast_Score=388, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6323470, Length=430, Percent_Identity=27.906976744186, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=26.3819095477387, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6321456, Length=330, Percent_Identity=24.2424242424242, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357415, Length=430, Percent_Identity=26.046511627907, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI28574759, Length=423, Percent_Identity=27.1867612293144, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161085790, Length=355, Percent_Identity=28.169014084507, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21356575, Length=435, Percent_Identity=25.0574712643678, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46892; Mature: 46892

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQANDLAFDRRHIWHPYTSMTRPLPAYPVVSADGCELTLSDGRRLVDGMSSWWAAIHGYN
CCCCCCCCCHHHCCCCHHHHCCCCCCCCEECCCCCEEECCCCHHHHHHHHHHHHHHCCCC
HPVINQAMKDQIGRMSHVMFGGITHPPAVALCRRLVALTPAGLDCVFLADSGSVAVEVAI
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
KMALQYWQARGEPRRELLALRQGYHGDTFGAMSVCDPDNSMHSLYQGYLPPHRFIEAPRR
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHCCCCHHHHHHHHHH
RFDDTWREGDDAPLAALLAAHHRTLAAVILEPIVQGAGGMRFYHPEYLRRARALCDRYGI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHCCE
LLIADEIATGFGRTGEWFACNLAGISPDILCVGKALTGGALTLSATLTRRHVADTLSDGD
EEEEHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCCEEEEEHHHHHHHHHHHHCCCC
AGCFMHGPTFMANPLACAAANASLSLLEDESWRPRVAAIAAGLSAGLLPLADHPRVRDVR
CCEEEECCCHHCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEE
VLGAIGVVETTQPVNMAALQRWFVDRGVWIRPFGKLIYLMPPYIISPPALAWLIDAITDA
EEEEECEEECCCCCHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHHHH
LDSPTHFLS
HCCCHHHCC
>Mature Secondary Structure
MQANDLAFDRRHIWHPYTSMTRPLPAYPVVSADGCELTLSDGRRLVDGMSSWWAAIHGYN
CCCCCCCCCHHHCCCCHHHHCCCCCCCCEECCCCCEEECCCCHHHHHHHHHHHHHHCCCC
HPVINQAMKDQIGRMSHVMFGGITHPPAVALCRRLVALTPAGLDCVFLADSGSVAVEVAI
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
KMALQYWQARGEPRRELLALRQGYHGDTFGAMSVCDPDNSMHSLYQGYLPPHRFIEAPRR
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEECCCCHHHHHHHHCCCCHHHHHHHHHH
RFDDTWREGDDAPLAALLAAHHRTLAAVILEPIVQGAGGMRFYHPEYLRRARALCDRYGI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHCCE
LLIADEIATGFGRTGEWFACNLAGISPDILCVGKALTGGALTLSATLTRRHVADTLSDGD
EEEEHHHHHCCCCCCCEEEEEECCCCCCEEEECCCCCCCEEEEEHHHHHHHHHHHHCCCC
AGCFMHGPTFMANPLACAAANASLSLLEDESWRPRVAAIAAGLSAGLLPLADHPRVRDVR
CCEEEECCCHHCCCHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEE
VLGAIGVVETTQPVNMAALQRWFVDRGVWIRPFGKLIYLMPPYIISPPALAWLIDAITDA
EEEEECEEECCCCCHHHHHHHHHHHCCCEEECCCCEEEECCCCCCCCHHHHHHHHHHHHH
LDSPTHFLS
HCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 2971595 [H]