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The map label for this gene is modE [H]

Identifier: 85058876

GI number: 85058876

Start: 1459451

End: 1459963

Strand: Reverse

Name: modE [H]

Synonym: SG0898

Alternate gene names: 85058876

Gene position: 1459963-1459451 (Counterclockwise)

Preceding gene: 85058879

Following gene: 85058875

Centisome position: 35.0

GC content: 54.97

Gene sequence:

>513_bases
ATGCAGGCAGAAATTCTGTTAACCCTGAAACTCCGGCAGCACTTGTTTGCCGACCCACGCCGCATTGAGTTGCTTAAACA
GATTCGCGCAACCGGCTCCATCACACAAGGAGCAAAACTGGCGGGCGTTAGCTACAAAAGTGCCTGGGATGCGATTAACG
CCATGAATACGCTGGCGGAACAGTCGCTAGTTGAGCGCGCAACCGGCAGCAAGGGCAGCGGCGGCACCCTGACCCGATAC
TCTGAAAGGTTGTTTCAGCTCTATGACCTCTTGGGCCAGATCCAACAAAAAGCGTTCGATGTCCTGCAGGACGATACGCT
GCCGTTAGACAGTCTGCTTGCAGCGATCTCGCGTTTCTCGCTGCAAACCAGCGCACGCAATCAGTTTTTTGGCACTATCG
TCAGCCGCAGTTGTCAAGCTGTACAGCAGCAGGTGACGGTCGCGCTGGCCTATGGCCATACCCGATTGCATGTCGCATTG
ACTGAAAAGAGCTCATGCGCCACGCTGTGCTAA

Upstream 100 bases:

>100_bases
CTGTAGCGATTAGGCCTTTTATGTTATCGCGACCGGCATGATTCGCCGCTGCCGGTAAGATAAGCGAAAATTTCCCTTTT
AAAAGCCACGAGGTTCCCTC

Downstream 100 bases:

>100_bases
AGGCGGACGGCCGCCATTGACATCCCCACACAAATTTCCCATGCTGACCGTACTATTGCATTAAAAGGAACAATTAATGC
TTTCATTGCAAATTTTGCAA

Product: putative molybdenum uptake operon transcriptional repressor ModE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MQAEILLTLKLRQHLFADPRRIELLKQIRATGSITQGAKLAGVSYKSAWDAINAMNTLAEQSLVERATGSKGSGGTLTRY
SERLFQLYDLLGQIQQKAFDVLQDDTLPLDSLLAAISRFSLQTSARNQFFGTIVSRSCQAVQQQVTVALAYGHTRLHVAL
TEKSSCATLC

Sequences:

>Translated_170_residues
MQAEILLTLKLRQHLFADPRRIELLKQIRATGSITQGAKLAGVSYKSAWDAINAMNTLAEQSLVERATGSKGSGGTLTRY
SERLFQLYDLLGQIQQKAFDVLQDDTLPLDSLLAAISRFSLQTSARNQFFGTIVSRSCQAVQQQVTVALAYGHTRLHVAL
TEKSSCATLC
>Mature_170_residues
MQAEILLTLKLRQHLFADPRRIELLKQIRATGSITQGAKLAGVSYKSAWDAINAMNTLAEQSLVERATGSKGSGGTLTRY
SERLFQLYDLLGQIQQKAFDVLQDDTLPLDSLLAAISRFSLQTSARNQFFGTIVSRSCQAVQQQVTVALAYGHTRLHVAL
TEKSSCATLC

Specific function: The modE-Mo complex acts as a repressor of the modABC operon, involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA reg

COG id: COG2005

COG function: function code R; N-terminal domain of molybdenum-binding protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the modE family [H]

Homologues:

Organism=Escherichia coli, GI1786976, Length=166, Percent_Identity=72.8915662650602, Blast_Score=202, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR004606
- InterPro:   IPR008995
- InterPro:   IPR003725
- InterPro:   IPR016462
- InterPro:   IPR005116
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03459 TOBE [H]

EC number: NA

Molecular weight: Translated: 18676; Mature: 18676

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEILLTLKLRQHLFADPRRIELLKQIRATGSITQGAKLAGVSYKSAWDAINAMNTLAE
CCCEEEEHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHH
QSLVERATGSKGSGGTLTRYSERLFQLYDLLGQIQQKAFDVLQDDTLPLDSLLAAISRFS
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LQTSARNQFFGTIVSRSCQAVQQQVTVALAYGHTRLHVALTEKSSCATLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MQAEILLTLKLRQHLFADPRRIELLKQIRATGSITQGAKLAGVSYKSAWDAINAMNTLAE
CCCEEEEHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHHHHHHHHH
QSLVERATGSKGSGGTLTRYSERLFQLYDLLGQIQQKAFDVLQDDTLPLDSLLAAISRFS
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LQTSARNQFFGTIVSRSCQAVQQQVTVALAYGHTRLHVALTEKSSCATLC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]