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The map label for this gene is folD

Identifier: 85058684

GI number: 85058684

Start: 1187789

End: 1188661

Strand: Reverse

Name: folD

Synonym: SG0706

Alternate gene names: 85058684

Gene position: 1188661-1187789 (Counterclockwise)

Preceding gene: 85058687

Following gene: 85058682

Centisome position: 28.5

GC content: 58.99

Gene sequence:

>873_bases
ATGGTAGCAAAAATAATTGATGGTAGGGCCGTTGCCCAGCAGGTCAGAAGTGAGGTGGCCGCGCGGATTCAGGCGCGTCT
GAAGGCGGGCAAGCGCGCGCCGGGACTGGCGGTAGTGCTGGTCGGCGGCGATCCCGCTTCGCAAATTTATGTTGCCAGTA
AACGCAAAGCCTGTGAAGACGTCGGTTTTATTTCCCTCTCCTATGATCTGCCCAACACGGTCACGGAAGCGGCATTGTTG
GCGTTGATTGATCAACTGAATGCCGATCATCGGGTGAACGGGATTTTGGTGCAGTTGCCGTTGCCGGCGGGGATAGACAA
TATCAGCGTGCTGGAGCGCATTGCGCCGGATAAAGATGTGGACGGTTTCCATCCGTACAATGTCGGCCGACTGTGCCAGC
GCGCGCCTCTGCTGCGTCCTTGCACCCCGCGCGGCATCGTGACGCTGCTGGAGCGTTATCATATCGACACCTTTGGCCTT
AACGCCGTTGTGGTCGGCGCGTCCAATATCGTTGGACGCCCCATGAGTCTCGAGCTGTTGCTGGCGGGCTGTACCGTGAC
CGTCACCCACCGTTTCACGCGCGATTTACGGCGCCATATTGAAAATGCCGATCTGTTGGTCGTGGCGGTAGGCAAAGCGA
GCTTCATCCCCGGCGAGTGGATTAAACCCGGCGCTGTGGTCATGGATGTGGGGATTAATCGTCTGGAGAGCGGTAAAGTG
GTGGGCGACGTGGATTATGCCAGCGCCGCCGAGCGCGCCGCCTACATTACGCCGGTGCCCGGCGGCGTGGGGCCGATGAC
GGTTGCCACCCTTATCCAGAATACCCTTCAGGCCTGTGAAGATTATCACGATACGACAATGCCGGAGGCCTGA

Upstream 100 bases:

>100_bases
GTTGGCAAAAGGCCAGGATGCATTCTGTGCCTGACAGCGGGACGCGCTTCTGCCAAAATAGCGCCCTCAGCCTGATTACA
TTGACGGATTTCCGATTCAG

Downstream 100 bases:

>100_bases
CCATGACGACATTTTCTCTTGAAGGGCATCCTTACATCGCGTTATGCGATCTCCTGAAAATCTCAGGCTGATGCGAGAGC
GGTGCGGCGGCCAAGCTGGC

Product: bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MVAKIIDGRAVAQQVRSEVAARIQARLKAGKRAPGLAVVLVGGDPASQIYVASKRKACEDVGFISLSYDLPNTVTEAALL
ALIDQLNADHRVNGILVQLPLPAGIDNISVLERIAPDKDVDGFHPYNVGRLCQRAPLLRPCTPRGIVTLLERYHIDTFGL
NAVVVGASNIVGRPMSLELLLAGCTVTVTHRFTRDLRRHIENADLLVVAVGKASFIPGEWIKPGAVVMDVGINRLESGKV
VGDVDYASAAERAAYITPVPGGVGPMTVATLIQNTLQACEDYHDTTMPEA

Sequences:

>Translated_290_residues
MVAKIIDGRAVAQQVRSEVAARIQARLKAGKRAPGLAVVLVGGDPASQIYVASKRKACEDVGFISLSYDLPNTVTEAALL
ALIDQLNADHRVNGILVQLPLPAGIDNISVLERIAPDKDVDGFHPYNVGRLCQRAPLLRPCTPRGIVTLLERYHIDTFGL
NAVVVGASNIVGRPMSLELLLAGCTVTVTHRFTRDLRRHIENADLLVVAVGKASFIPGEWIKPGAVVMDVGINRLESGKV
VGDVDYASAAERAAYITPVPGGVGPMTVATLIQNTLQACEDYHDTTMPEA
>Mature_290_residues
MVAKIIDGRAVAQQVRSEVAARIQARLKAGKRAPGLAVVLVGGDPASQIYVASKRKACEDVGFISLSYDLPNTVTEAALL
ALIDQLNADHRVNGILVQLPLPAGIDNISVLERIAPDKDVDGFHPYNVGRLCQRAPLLRPCTPRGIVTLLERYHIDTFGL
NAVVVGASNIVGRPMSLELLLAGCTVTVTHRFTRDLRRHIENADLLVVAVGKASFIPGEWIKPGAVVMDVGINRLESGKV
VGDVDYASAAERAAYITPVPGGVGPMTVATLIQNTLQACEDYHDTTMPEA

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222418558, Length=293, Percent_Identity=43.0034129692833, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI94721354, Length=293, Percent_Identity=43.6860068259386, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI222136639, Length=298, Percent_Identity=41.6107382550336, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI36796743, Length=234, Percent_Identity=28.2051282051282, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786741, Length=284, Percent_Identity=80.9859154929577, Blast_Score=484, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17568735, Length=289, Percent_Identity=41.522491349481, Blast_Score=189, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321643, Length=297, Percent_Identity=43.7710437710438, Blast_Score=236, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319558, Length=285, Percent_Identity=44.2105263157895, Blast_Score=230, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6322933, Length=319, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17136816, Length=298, Percent_Identity=46.6442953020134, Blast_Score=246, Evalue=1e-65,
Organism=Drosophila melanogaster, GI17136818, Length=298, Percent_Identity=46.6442953020134, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI62472483, Length=291, Percent_Identity=44.6735395189003, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI45551871, Length=291, Percent_Identity=44.6735395189003, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24645718, Length=291, Percent_Identity=44.6735395189003, Blast_Score=223, Evalue=8e-59,
Organism=Drosophila melanogaster, GI17137370, Length=291, Percent_Identity=44.6735395189003, Blast_Score=223, Evalue=8e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_SODGM (Q2NV44)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454386.1
- ProteinModelPortal:   Q2NV44
- SMR:   Q2NV44
- STRING:   Q2NV44
- GeneID:   3868726
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG0706
- NMPDR:   fig|343509.6.peg.1522
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   HELPAST
- PhylomeDB:   Q2NV44
- ProtClustDB:   PRK10792
- BioCyc:   SGLO343509:SG0706-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 30983; Mature: 30983

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAKIIDGRAVAQQVRSEVAARIQARLKAGKRAPGLAVVLVGGDPASQIYVASKRKACED
CCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHH
VGFISLSYDLPNTVTEAALLALIDQLNADHRVNGILVQLPLPAGIDNISVLERIAPDKDV
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCC
DGFHPYNVGRLCQRAPLLRPCTPRGIVTLLERYHIDTFGLNAVVVGASNIVGRPMSLELL
CCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHCCCCEEEEE
LAGCTVTVTHRFTRDLRRHIENADLLVVAVGKASFIPGEWIKPGAVVMDVGINRLESGKV
EECCEEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCE
VGDVDYASAAERAAYITPVPGGVGPMTVATLIQNTLQACEDYHDTTMPEA
EECCCHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVAKIIDGRAVAQQVRSEVAARIQARLKAGKRAPGLAVVLVGGDPASQIYVASKRKACED
CCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEHHHHHHHH
VGFISLSYDLPNTVTEAALLALIDQLNADHRVNGILVQLPLPAGIDNISVLERIAPDKDV
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCC
DGFHPYNVGRLCQRAPLLRPCTPRGIVTLLERYHIDTFGLNAVVVGASNIVGRPMSLELL
CCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECHHHHCCCCEEEEE
LAGCTVTVTHRFTRDLRRHIENADLLVVAVGKASFIPGEWIKPGAVVMDVGINRLESGKV
EECCEEEEHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCE
VGDVDYASAAERAAYITPVPGGVGPMTVATLIQNTLQACEDYHDTTMPEA
EECCCHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA