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The map label for this gene is cyoB [H]

Identifier: 85058644

GI number: 85058644

Start: 1128587

End: 1130581

Strand: Reverse

Name: cyoB [H]

Synonym: SG0666

Alternate gene names: 85058644

Gene position: 1130581-1128587 (Counterclockwise)

Preceding gene: 85058645

Following gene: 85058643

Centisome position: 27.1

GC content: 56.39

Gene sequence:

>1995_bases
ATGTTCGGAAAATTAACGCTTGATTCGGTTCCGTACCATGAACCGATCATTATGATAACCGTCGCCGCCATCATTGTGAT
TGGTCTGGGGCTGGTGGCCGCCATTACCTATTTTGGTAAGTGGCAATATCTTTGGCATGAGTGGTTCACCTCGGTAGACC
ATAAGAAAATCGGCATCATGTACATAATCGTGGCGTTCGTGATGCTGCTGCGCGGCTTTGCCGACGCCATCATGATGCGT
TCGCAGCAGGCGCTGGCCTCGGCGGGCGAAGCGGGCTTTCTGCCGCCGCATCACTATGACCAGGTGGTAACCGCCCACGG
CGTTATCATGATCATCTTCATGGCGACGCCATTCGTGGTCGGCCTGATGAACCTGGCCGTGCCGCTGCAAATCGGCGCCC
GCGACGTTGCTTTCCCTTTCCTGAACTCCCTGAGTTTCTGGTTCTTCGTCGTCGGTGTTATCCTGATAAACGTCTCCCTC
GGCGTGGGTGAATTCGCCCAAACCGGTTGGGTAGCCTATCCGCCGCTGGCGGGCAAGGAGTACAGTCCCGGCGTCGGGGT
CGATTACTGGATCTGGAGTATTCAGATAGCCGGTATCGGGACCACCCTGACCGGCGTGAACTTCTTCGCCACCATTTTGC
GGATGCGCGCGCCCGGCATGCCGATGATGAAAATGCCGGTCTTTACCTGGGCCGCGCTGTGCACCAACGTGCTTATCATC
GCCGCGTTCCCGATTTTGACCGTGACCATCGTACTGCTGACCCTGGATCGCTATCTGGGCACCCATTTCTTCACCAATGA
CATGGGTGGCAATATGATGATGTACATCAACCTGTTCTGGGCATGGGGCCATCCGGAAGTGTACATACTGGTGCTGCCGG
TATTCGGCGTGTTCTCGGAGTTGGTCGCCACCTTCTCGAAAAAGCGCCTGTTTGGCTATACCTCGCTGGTGTGGGCAACC
ATCGCCATTACCGTGCTGTCGTTCTGCGTCTGGCTGCATCACTTCTTTACCATGGGGTCCGGCGCCAACGTCAACGCCTT
CTTCGGCATCATGACGATGATCATCGCCATCCCGACCGGGGTGAAGATTTTCAACTGGCTGTTCACCATTTATCAGGGCC
GCGTGGTGCTTAACTCCCCGATGCTGTGGACCGTGGGCTTCGTCATCACCTTCTCCATCGGCGGGATGACCGGCGTGCTG
CTGGCGGTGCCCGGCGCCGACTTCGTGTTGCATAACAGCCTGTTTTTGATCGCCCACTTCCATAACGTCATTATCGGCGG
TGTAGTGTTCGGCTGCTTCGCCGGTATGACCTACTGGTTCCCGAAAGCGTTTGGCTATACCCTGAACGAAACCTGGGGCA
AGCGCGCTTTCTGGTTCTGGATTATTGGGTTCTACGTCGCCTTTATGCCGCTTTATGCGCTGGGCTTCATGGGGATGACC
CGCCGTCTGAGCCAGCAAATCGACCCCGTTTTCCATCCTCTGTTGATGGTGGCCGCCGCCGGCGCCGCGCTTATCGCGCT
GGGTATCCTGTGCCAGGTCATCCAGATTGTGGTCAGCGTGCGCGATCGGGAACAGAACCGCGACCTGACCGGCGATCCGT
GGGGTGGCCGCACCCTGGAATGGGCGACCTCCTCTCCCCCGCCGTTCTATAACTTTGCCATCGTGCCGGAAGTTAACAAT
CAGCGCGATGTGTTCTGGGAAATGAAGGAAGAAGGGTCCGCCTATCAGAAACCGCTGGCGTATGAACCGATTCATATGCC
GAAAAACACCGGCGCCGGCGTAGTTATTGCCGCCTTTAGCCTGGTGTTCAGCTTTGCTCTGATCTGGCATATCTGGTGGC
TAGCGATCGTCGGGTTTGCCGGCATGATCGTGACCTGGATAGTTCACAGCTTCAATGAAGACGTGGATTATTATGTGCCG
GTAGAGGAAGTCGAACGTATCGAGAACCGGCATTTTGACCAAATCAGTGAAGCGGGCGTGAAGAATGTCAACTAA

Upstream 100 bases:

>100_bases
TCGGCAAATTCATGGGCAAGGGGACGAGTATTGCCACCACCCAGGACGAAGGGATGTACATGGGTGAACACTCTCACACG
GGTACAGAGGAATAATAACG

Downstream 100 bases:

>100_bases
GATCCTATCCAATCATGAAGCCGCCCATACCGAGCATGGGCACCACGATGCGGGAGCCACCAAAGTATTCGGCTTCTGGA
TCTACCTGATGAGCGACTGT

Product: cytochrome o ubiquinol oxidase subunit I

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MFGKLTLDSVPYHEPIIMITVAAIIVIGLGLVAAITYFGKWQYLWHEWFTSVDHKKIGIMYIIVAFVMLLRGFADAIMMR
SQQALASAGEAGFLPPHHYDQVVTAHGVIMIIFMATPFVVGLMNLAVPLQIGARDVAFPFLNSLSFWFFVVGVILINVSL
GVGEFAQTGWVAYPPLAGKEYSPGVGVDYWIWSIQIAGIGTTLTGVNFFATILRMRAPGMPMMKMPVFTWAALCTNVLII
AAFPILTVTIVLLTLDRYLGTHFFTNDMGGNMMMYINLFWAWGHPEVYILVLPVFGVFSELVATFSKKRLFGYTSLVWAT
IAITVLSFCVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKIFNWLFTIYQGRVVLNSPMLWTVGFVITFSIGGMTGVL
LAVPGADFVLHNSLFLIAHFHNVIIGGVVFGCFAGMTYWFPKAFGYTLNETWGKRAFWFWIIGFYVAFMPLYALGFMGMT
RRLSQQIDPVFHPLLMVAAAGAALIALGILCQVIQIVVSVRDREQNRDLTGDPWGGRTLEWATSSPPPFYNFAIVPEVNN
QRDVFWEMKEEGSAYQKPLAYEPIHMPKNTGAGVVIAAFSLVFSFALIWHIWWLAIVGFAGMIVTWIVHSFNEDVDYYVP
VEEVERIENRHFDQISEAGVKNVN

Sequences:

>Translated_664_residues
MFGKLTLDSVPYHEPIIMITVAAIIVIGLGLVAAITYFGKWQYLWHEWFTSVDHKKIGIMYIIVAFVMLLRGFADAIMMR
SQQALASAGEAGFLPPHHYDQVVTAHGVIMIIFMATPFVVGLMNLAVPLQIGARDVAFPFLNSLSFWFFVVGVILINVSL
GVGEFAQTGWVAYPPLAGKEYSPGVGVDYWIWSIQIAGIGTTLTGVNFFATILRMRAPGMPMMKMPVFTWAALCTNVLII
AAFPILTVTIVLLTLDRYLGTHFFTNDMGGNMMMYINLFWAWGHPEVYILVLPVFGVFSELVATFSKKRLFGYTSLVWAT
IAITVLSFCVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKIFNWLFTIYQGRVVLNSPMLWTVGFVITFSIGGMTGVL
LAVPGADFVLHNSLFLIAHFHNVIIGGVVFGCFAGMTYWFPKAFGYTLNETWGKRAFWFWIIGFYVAFMPLYALGFMGMT
RRLSQQIDPVFHPLLMVAAAGAALIALGILCQVIQIVVSVRDREQNRDLTGDPWGGRTLEWATSSPPPFYNFAIVPEVNN
QRDVFWEMKEEGSAYQKPLAYEPIHMPKNTGAGVVIAAFSLVFSFALIWHIWWLAIVGFAGMIVTWIVHSFNEDVDYYVP
VEEVERIENRHFDQISEAGVKNVN
>Mature_664_residues
MFGKLTLDSVPYHEPIIMITVAAIIVIGLGLVAAITYFGKWQYLWHEWFTSVDHKKIGIMYIIVAFVMLLRGFADAIMMR
SQQALASAGEAGFLPPHHYDQVVTAHGVIMIIFMATPFVVGLMNLAVPLQIGARDVAFPFLNSLSFWFFVVGVILINVSL
GVGEFAQTGWVAYPPLAGKEYSPGVGVDYWIWSIQIAGIGTTLTGVNFFATILRMRAPGMPMMKMPVFTWAALCTNVLII
AAFPILTVTIVLLTLDRYLGTHFFTNDMGGNMMMYINLFWAWGHPEVYILVLPVFGVFSELVATFSKKRLFGYTSLVWAT
IAITVLSFCVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKIFNWLFTIYQGRVVLNSPMLWTVGFVITFSIGGMTGVL
LAVPGADFVLHNSLFLIAHFHNVIIGGVVFGCFAGMTYWFPKAFGYTLNETWGKRAFWFWIIGFYVAFMPLYALGFMGMT
RRLSQQIDPVFHPLLMVAAAGAALIALGILCQVIQIVVSVRDREQNRDLTGDPWGGRTLEWATSSPPPFYNFAIVPEVNN
QRDVFWEMKEEGSAYQKPLAYEPIHMPKNTGAGVVIAAFSLVFSFALIWHIWWLAIVGFAGMIVTWIVHSFNEDVDYYVP
VEEVERIENRHFDQISEAGVKNVN

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=510, Percent_Identity=39.2156862745098, Blast_Score=336, Evalue=5e-92,
Organism=Escherichia coli, GI1786634, Length=664, Percent_Identity=83.5843373493976, Blast_Score=1170, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=527, Percent_Identity=35.4838709677419, Blast_Score=320, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=39.3188854489164, Blast_Score=228, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6226523, Length=251, Percent_Identity=31.0756972111554, Blast_Score=124, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74257; Mature: 74257

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGKLTLDSVPYHEPIIMITVAAIIVIGLGLVAAITYFGKWQYLWHEWFTSVDHKKIGIM
CCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
YIIVAFVMLLRGFADAIMMRSQQALASAGEAGFLPPHHYDQVVTAHGVIMIIFMATPFVV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLMNLAVPLQIGARDVAFPFLNSLSFWFFVVGVILINVSLGVGEFAQTGWVAYPPLAGKE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEECCCCCCCC
YSPGVGVDYWIWSIQIAGIGTTLTGVNFFATILRMRAPGMPMMKMPVFTWAALCTNVLII
CCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AAFPILTVTIVLLTLDRYLGTHFFTNDMGGNMMMYINLFWAWGHPEVYILVLPVFGVFSE
HHHHHHHHHHHHHHHHHHHCCHHEECCCCCCEEEEEEEEEEECCCCEEEEHHHHHHHHHH
LVATFSKKRLFGYTSLVWATIAITVLSFCVWLHHFFTMGSGANVNAFFGIMTMIIAIPTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
VKIFNWLFTIYQGRVVLNSPMLWTVGFVITFSIGGMTGVLLAVPGADFVLHNSLFLIAHF
HHHHHHHHHHHCCCEEECCCHHHHHHHHHHEECCCCCEEEEECCCCCCHHHCCHHHHHHH
HNVIIGGVVFGCFAGMTYWFPKAFGYTLNETWGKRAFWFWIIGFYVAFMPLYALGFMGMT
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLSQQIDPVFHPLLMVAAAGAALIALGILCQVIQIVVSVRDREQNRDLTGDPWGGRTLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
WATSSPPPFYNFAIVPEVNNQRDVFWEMKEEGSAYQKPLAYEPIHMPKNTGAGVVIAAFS
ECCCCCCCCEEEEEEECCCCCCCHHEEEHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHH
LVFSFALIWHIWWLAIVGFAGMIVTWIVHSFNEDVDYYVPVEEVERIENRHFDQISEAGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHCCHHHHHHCCC
KNVN
CCCC
>Mature Secondary Structure
MFGKLTLDSVPYHEPIIMITVAAIIVIGLGLVAAITYFGKWQYLWHEWFTSVDHKKIGIM
CCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
YIIVAFVMLLRGFADAIMMRSQQALASAGEAGFLPPHHYDQVVTAHGVIMIIFMATPFVV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GLMNLAVPLQIGARDVAFPFLNSLSFWFFVVGVILINVSLGVGEFAQTGWVAYPPLAGKE
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCEECCCCCCCC
YSPGVGVDYWIWSIQIAGIGTTLTGVNFFATILRMRAPGMPMMKMPVFTWAALCTNVLII
CCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
AAFPILTVTIVLLTLDRYLGTHFFTNDMGGNMMMYINLFWAWGHPEVYILVLPVFGVFSE
HHHHHHHHHHHHHHHHHHHCCHHEECCCCCCEEEEEEEEEEECCCCEEEEHHHHHHHHHH
LVATFSKKRLFGYTSLVWATIAITVLSFCVWLHHFFTMGSGANVNAFFGIMTMIIAIPTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCC
VKIFNWLFTIYQGRVVLNSPMLWTVGFVITFSIGGMTGVLLAVPGADFVLHNSLFLIAHF
HHHHHHHHHHHCCCEEECCCHHHHHHHHHHEECCCCCEEEEECCCCCCHHHCCHHHHHHH
HNVIIGGVVFGCFAGMTYWFPKAFGYTLNETWGKRAFWFWIIGFYVAFMPLYALGFMGMT
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RRLSQQIDPVFHPLLMVAAAGAALIALGILCQVIQIVVSVRDREQNRDLTGDPWGGRTLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
WATSSPPPFYNFAIVPEVNNQRDVFWEMKEEGSAYQKPLAYEPIHMPKNTGAGVVIAAFS
ECCCCCCCCEEEEEEECCCCCCCHHEEEHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHH
LVFSFALIWHIWWLAIVGFAGMIVTWIVHSFNEDVDYYVPVEEVERIENRHFDQISEAGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHCCHHHHHHCCC
KNVN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]