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The map label for this gene is dxs

Identifier: 85058634

GI number: 85058634

Start: 1117958

End: 1119820

Strand: Reverse

Name: dxs

Synonym: SG0656

Alternate gene names: 85058634

Gene position: 1119820-1117958 (Counterclockwise)

Preceding gene: 85058635

Following gene: 85058622

Centisome position: 26.85

GC content: 58.83

Gene sequence:

>1863_bases
ATGAGCCTTGATATCAAAAAGTATCCGACGCTGGTCCTAGCCGACAATCCTATGGAACTGCGTCAGTTGCCCAAAGAGAG
TTTGGTGGCGCTGTGCGACGAGCTGCGGCAATTTCTGCTCGACAGCGTAAGCCGCTCAAGCGGCCATTTCGCCTCGGGGC
TGGGCACGGTGGAACTGACGGTGGCGCTGCATTATGTGTACAACACGCCGTTCGACCGGCTGATTTGGGATGTCGGCCAT
CAGGCTTATCCCCATAAAATCCTGACCGGGCGACGGGACCGTATTGCTACTATTCGCCAGCGTAACGGCCTGCATCCGTT
TCCCTGGCGTGGCGAAAGTGAATACGACCAGCTCTCGGTAGGTCATTCCTCCACCTCCATCAGCGCCGGTCTCGGTATGG
CGGTGGCGGCGGAACATGAGGGATTGGGCCGCCGCACGGTTTGCGTTATCGGCGATGGCGCCATTACCGCCGGCATGGCC
TTCGAGGCCATGAACCATGCCGGCGATATCAAATCTGATTTGCTGGTGGTGCTGAACGACAATGAAATGTCCATTTCGGA
AAATGTCGGGGCGCTGAATAACCATTTGGCGCAGATCCTGTCCGGCAAGCTCTACTCGACCCTGCGCGAAGGCGGCAAAA
AGGTGCTGTCTGGTATCCCGCCGATTAAAGAGCTGGTGAAGCGCACCGAAGAGCACATTAAAGGCATGGTGGTGCCGGGC
ACACTGTTCGAGGAGCTGGGGTTTAACTATATCGGCCCGGTGGACGGCCATGATGTCCAGGGACTGGTGCAGACGCTGAA
GAATATGCGGGCCAAAAAAGGACCGCAGCTGCTGCATATCATGACGAAAAAAGGCCGTGGCTATGCGCCAGCCGAGAAAG
ACCCTATCAGTTGGCATGCGGTGCCGAAATTCGATCCCCACATGGGAACCCTGCCGAAAAGCGGCGACGGATGCCCCACT
TACTCAGCCATTTTCGGCGACTGGCTGTGCGCCACCGCCGCGGATGATGACAAATTGATGGCGATTACGCCCGCCATGCG
CGAAGGCTCCGGCATGGTGGCGTTTTCGCGCCAATATCCGCGCCAGTATTTTGATGTAGCCATCGCCGAGCAGCATGCGG
TCACCTTTGCCGCCGGGCTAGCCATCGGCGGGTATCACCCCGTGGTGGCCATCTATTCTACCTTTTTACAGCGCGCCTAC
GATCAGGTGATCCATGACGTCGCGATACAGAATTTGCCGGTACTGTTTGCCATCGATCGCGGCGGCGTTGTCGGCGCCGA
CGGGCAGACTCACCAAGGCGCGTTTGATCTCTCCTACCTGCGCTGCATCCCCAATATGGTCATCATGACGCCAAGCGATG
AAAACGAATGCCGACTGATGCTGCACACGGGTTATCACTACCAGGCTGGGCCAAGCACAGTGCGCTACCCGCGCGGTAAC
AGCACCGGCGCCCCGCTCACCGATTTGCATGAACTACCGCTGGGTAAAGGGGTGGTACACCGCCAGGGCGCCGGCGTGGC
AATTCTCAATTTCGGTACGTTGCTGCCCCAAGCCGAACACGCGGCGCAAGCGATAAATGCAACCCTGGTGGATATGCGCT
TCGTTAAGCCCCTCGACGACACGCTGATAAGCGAGCTGGCCGCCAGCCATCAGGCGCTGGTGACGGTCGAGGAGAATGCC
ATCATGGGCGGCGCCGGCAGCGGCGTAAACGAGTATGTGATGCAGCAGCGGCTGCAGGTGCCGGTATTGAATATCGGCCT
GCCGGACCATTTCATTCCTCAAGGCAGCCAGGAGGAGATCCGCGCGGATCTGGGCCTCGACGGCGCAGGGATACAGCGGC
AAATCAAGGATTGGCTGGCTTAA

Upstream 100 bases:

>100_bases
CTCGGTTATGATACCGCCACGCTGATGGCGCTGGCGCGCTATATTATTGAACGTGACAAATAAGTGATGCGGTTTTTTAC
ACCTCAGATATGAGTACCCC

Downstream 100 bases:

>100_bases
GCCCGCGGCACAGGAGCGCAACCGCGCTCCTTTTTTTGCCGGTGCCCCTCCTTCCCGGGCCGTGCCGCGCGCATCGTGCT
TAACCCCCTGTGCCGGCCCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MSLDIKKYPTLVLADNPMELRQLPKESLVALCDELRQFLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGH
QAYPHKILTGRRDRIATIRQRNGLHPFPWRGESEYDQLSVGHSSTSISAGLGMAVAAEHEGLGRRTVCVIGDGAITAGMA
FEAMNHAGDIKSDLLVVLNDNEMSISENVGALNNHLAQILSGKLYSTLREGGKKVLSGIPPIKELVKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVQGLVQTLKNMRAKKGPQLLHIMTKKGRGYAPAEKDPISWHAVPKFDPHMGTLPKSGDGCPT
YSAIFGDWLCATAADDDKLMAITPAMREGSGMVAFSRQYPRQYFDVAIAEQHAVTFAAGLAIGGYHPVVAIYSTFLQRAY
DQVIHDVAIQNLPVLFAIDRGGVVGADGQTHQGAFDLSYLRCIPNMVIMTPSDENECRLMLHTGYHYQAGPSTVRYPRGN
STGAPLTDLHELPLGKGVVHRQGAGVAILNFGTLLPQAEHAAQAINATLVDMRFVKPLDDTLISELAASHQALVTVEENA
IMGGAGSGVNEYVMQQRLQVPVLNIGLPDHFIPQGSQEEIRADLGLDGAGIQRQIKDWLA

Sequences:

>Translated_620_residues
MSLDIKKYPTLVLADNPMELRQLPKESLVALCDELRQFLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGH
QAYPHKILTGRRDRIATIRQRNGLHPFPWRGESEYDQLSVGHSSTSISAGLGMAVAAEHEGLGRRTVCVIGDGAITAGMA
FEAMNHAGDIKSDLLVVLNDNEMSISENVGALNNHLAQILSGKLYSTLREGGKKVLSGIPPIKELVKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVQGLVQTLKNMRAKKGPQLLHIMTKKGRGYAPAEKDPISWHAVPKFDPHMGTLPKSGDGCPT
YSAIFGDWLCATAADDDKLMAITPAMREGSGMVAFSRQYPRQYFDVAIAEQHAVTFAAGLAIGGYHPVVAIYSTFLQRAY
DQVIHDVAIQNLPVLFAIDRGGVVGADGQTHQGAFDLSYLRCIPNMVIMTPSDENECRLMLHTGYHYQAGPSTVRYPRGN
STGAPLTDLHELPLGKGVVHRQGAGVAILNFGTLLPQAEHAAQAINATLVDMRFVKPLDDTLISELAASHQALVTVEENA
IMGGAGSGVNEYVMQQRLQVPVLNIGLPDHFIPQGSQEEIRADLGLDGAGIQRQIKDWLA
>Mature_619_residues
SLDIKKYPTLVLADNPMELRQLPKESLVALCDELRQFLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQ
AYPHKILTGRRDRIATIRQRNGLHPFPWRGESEYDQLSVGHSSTSISAGLGMAVAAEHEGLGRRTVCVIGDGAITAGMAF
EAMNHAGDIKSDLLVVLNDNEMSISENVGALNNHLAQILSGKLYSTLREGGKKVLSGIPPIKELVKRTEEHIKGMVVPGT
LFEELGFNYIGPVDGHDVQGLVQTLKNMRAKKGPQLLHIMTKKGRGYAPAEKDPISWHAVPKFDPHMGTLPKSGDGCPTY
SAIFGDWLCATAADDDKLMAITPAMREGSGMVAFSRQYPRQYFDVAIAEQHAVTFAAGLAIGGYHPVVAIYSTFLQRAYD
QVIHDVAIQNLPVLFAIDRGGVVGADGQTHQGAFDLSYLRCIPNMVIMTPSDENECRLMLHTGYHYQAGPSTVRYPRGNS
TGAPLTDLHELPLGKGVVHRQGAGVAILNFGTLLPQAEHAAQAINATLVDMRFVKPLDDTLISELAASHQALVTVEENAI
MGGAGSGVNEYVMQQRLQVPVLNIGLPDHFIPQGSQEEIRADLGLDGAGIQRQIKDWLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=522, Percent_Identity=24.5210727969349, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4507521, Length=522, Percent_Identity=24.5210727969349, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI225637463, Length=549, Percent_Identity=24.5901639344262, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI225637461, Length=549, Percent_Identity=24.5901639344262, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI225637459, Length=549, Percent_Identity=24.5901639344262, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI133778974, Length=505, Percent_Identity=23.960396039604, Blast_Score=81, Evalue=4e-15,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=81.9354838709677, Blast_Score=1068, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=533, Percent_Identity=23.827392120075, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_SODGM (Q2NV94)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454336.1
- ProteinModelPortal:   Q2NV94
- SMR:   Q2NV94
- STRING:   Q2NV94
- GeneID:   3868002
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG0656
- NMPDR:   fig|343509.6.peg.1448
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q2NV94
- ProtClustDB:   PRK05444
- BioCyc:   SGLO343509:SG0656-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67365; Mature: 67234

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDIKKYPTLVLADNPMELRQLPKESLVALCDELRQFLLDSVSRSSGHFASGLGTVELT
CCCCCCCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEE
VALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDRIATIRQRNGLHPFPWRGESEYDQLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHEEC
GHSSTSISAGLGMAVAAEHEGLGRRTVCVIGDGAITAGMAFEAMNHAGDIKSDLLVVLND
CCCCCCHHCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQILSGKLYSTLREGGKKVLSGIPPIKELVKRTEEHIKGMVVPG
CCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVQGLVQTLKNMRAKKGPQLLHIMTKKGRGYAPAEKDPISWHA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEE
VPKFDPHMGTLPKSGDGCPTYSAIFGDWLCATAADDDKLMAITPAMREGSGMVAFSRQYP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCEEEEECCHHCCCCEEEECHHCC
RQYFDVAIAEQHAVTFAAGLAIGGYHPVVAIYSTFLQRAYDQVIHDVAIQNLPVLFAIDR
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
GGVVGADGQTHQGAFDLSYLRCIPNMVIMTPSDENECRLMLHTGYHYQAGPSTVRYPRGN
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCEEEEEEECCEEECCCCCEECCCCC
STGAPLTDLHELPLGKGVVHRQGAGVAILNFGTLLPQAEHAAQAINATLVDMRFVKPLDD
CCCCCHHHHHHCCCCCCCEEECCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHCCHHH
TLISELAASHQALVTVEENAIMGGAGSGVNEYVMQQRLQVPVLNIGLPDHFIPQGSQEEI
HHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHH
RADLGLDGAGIQRQIKDWLA
HHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SLDIKKYPTLVLADNPMELRQLPKESLVALCDELRQFLLDSVSRSSGHFASGLGTVELT
CCCCCCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEE
VALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDRIATIRQRNGLHPFPWRGESEYDQLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHEEC
GHSSTSISAGLGMAVAAEHEGLGRRTVCVIGDGAITAGMAFEAMNHAGDIKSDLLVVLND
CCCCCCHHCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQILSGKLYSTLREGGKKVLSGIPPIKELVKRTEEHIKGMVVPG
CCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVQGLVQTLKNMRAKKGPQLLHIMTKKGRGYAPAEKDPISWHA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCEEE
VPKFDPHMGTLPKSGDGCPTYSAIFGDWLCATAADDDKLMAITPAMREGSGMVAFSRQYP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCEEEEECCHHCCCCEEEECHHCC
RQYFDVAIAEQHAVTFAAGLAIGGYHPVVAIYSTFLQRAYDQVIHDVAIQNLPVLFAIDR
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
GGVVGADGQTHQGAFDLSYLRCIPNMVIMTPSDENECRLMLHTGYHYQAGPSTVRYPRGN
CCEECCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCEEEEEEECCEEECCCCCEECCCCC
STGAPLTDLHELPLGKGVVHRQGAGVAILNFGTLLPQAEHAAQAINATLVDMRFVKPLDD
CCCCCHHHHHHCCCCCCCEEECCCCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHCCHHH
TLISELAASHQALVTVEENAIMGGAGSGVNEYVMQQRLQVPVLNIGLPDHFIPQGSQEEI
HHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHH
RADLGLDGAGIQRQIKDWLA
HHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA