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The map label for this gene is cytR [H]

Identifier: 85058586

GI number: 85058586

Start: 1033632

End: 1034633

Strand: Reverse

Name: cytR [H]

Synonym: SG0608

Alternate gene names: 85058586

Gene position: 1034633-1033632 (Counterclockwise)

Preceding gene: 85058587

Following gene: 85058585

Centisome position: 24.8

GC content: 53.89

Gene sequence:

>1002_bases
TTGGCACCAGGCAGGAAGGTCAAGGCTACGCTTGCAAGCGTAGCCGCACAGTCCAACGTCAGCAAAATCACCGCATCGCG
CGCGTTCTCCCATCCGGAGAAGGTTCATCCGGATACGCTCAGGCGCGTGCTGGAAACGGCGCAGGAGATGGGCTACGTTG
TGAACACGGCGGCGAGAAATCTGCGCGCCAGAGCCAGTAAAACGATAGGCATCGTCAATCCCGATATGGGCAACCCTTTC
TTCGGCAATCTGACCAAGCTCATGACGCTTGAAGCGCAGAAGGCCGGTTATGACACGCTGGTCTTCGATTCATGGGAATC
ACAAGAGCAGGAAAACCGTATTATCGACAAGCTTATTGGCTACGGCGTCGATGCGATAGTGTTGTCGGTCATCTCTGCCG
ATCAAAACTATCGACCGGCGTACTTCGAGCGGCTGGCGTTATTGAATATTCCGATCATCCTGGTGGACCGCGAGCTGGAT
ATTGCCTCCTGCAGCGGCGTATATATCGACAATCTCGATTGCGGGCTACAGGCGGGCCGCTTTTTACAAGAGCAGCAGGC
GCAGCGGGTGGTTGTGGTGTCCGGTCCGGACGACTCGAACGTCGCCCGCGAAAGGGTTACCGGCGTTACCGCCGCACTGC
AGGGCAAAATAGCGCACCTGGATATTCTGTATGCCGATTTTTATATGGATGTGGCCTGGCAGGTCACCACGTATTATCTC
AATCACCAGCCGGCGCCAGATTATTTCGTAGGCTGTAATAACCAGATATCGCAAGGCATCATCAAATCCTGCATTGACCA
TCGGCTGCGACCGATGCAGGATGTTTCCGTTTTTAGCATCGATGAAATTCCCCATGCCGCCGTTTTCGGATTCAATTTCC
CCTGTATCGCCCATGATCTGTATGAGATGGCCTGGCAGGCGATTAATCTGGCGGTACGCCGCGCCTCGGATAGTCAAATC
AAACCGGGTAAAGTGATTATTCGCGGTAAAATGATGGTATGA

Upstream 100 bases:

>100_bases
GCGACGCGTGGCATAAAACGGGGAAGATCATTCGCTTCCGGCACAGGGATGTGTCATGATACTAAAATGATACAAAATGA
TAAAAACATAGGAGTGTAAA

Downstream 100 bases:

>100_bases
CGCGGGCTGGTTTGTCCCGGACATCCCCCGTTGTACCAAGCGCATACCGCTCACGCGGTGCCGCGTCCAACGCGTTCGCT
GAGCGCCCCCAGTCCCCCCT

Product: xylitol repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MAPGRKVKATLASVAAQSNVSKITASRAFSHPEKVHPDTLRRVLETAQEMGYVVNTAARNLRARASKTIGIVNPDMGNPF
FGNLTKLMTLEAQKAGYDTLVFDSWESQEQENRIIDKLIGYGVDAIVLSVISADQNYRPAYFERLALLNIPIILVDRELD
IASCSGVYIDNLDCGLQAGRFLQEQQAQRVVVVSGPDDSNVARERVTGVTAALQGKIAHLDILYADFYMDVAWQVTTYYL
NHQPAPDYFVGCNNQISQGIIKSCIDHRLRPMQDVSVFSIDEIPHAAVFGFNFPCIAHDLYEMAWQAINLAVRRASDSQI
KPGKVIIRGKMMV

Sequences:

>Translated_333_residues
MAPGRKVKATLASVAAQSNVSKITASRAFSHPEKVHPDTLRRVLETAQEMGYVVNTAARNLRARASKTIGIVNPDMGNPF
FGNLTKLMTLEAQKAGYDTLVFDSWESQEQENRIIDKLIGYGVDAIVLSVISADQNYRPAYFERLALLNIPIILVDRELD
IASCSGVYIDNLDCGLQAGRFLQEQQAQRVVVVSGPDDSNVARERVTGVTAALQGKIAHLDILYADFYMDVAWQVTTYYL
NHQPAPDYFVGCNNQISQGIIKSCIDHRLRPMQDVSVFSIDEIPHAAVFGFNFPCIAHDLYEMAWQAINLAVRRASDSQI
KPGKVIIRGKMMV
>Mature_332_residues
APGRKVKATLASVAAQSNVSKITASRAFSHPEKVHPDTLRRVLETAQEMGYVVNTAARNLRARASKTIGIVNPDMGNPFF
GNLTKLMTLEAQKAGYDTLVFDSWESQEQENRIIDKLIGYGVDAIVLSVISADQNYRPAYFERLALLNIPIILVDRELDI
ASCSGVYIDNLDCGLQAGRFLQEQQAQRVVVVSGPDDSNVARERVTGVTAALQGKIAHLDILYADFYMDVAWQVTTYYLN
HQPAPDYFVGCNNQISQGIIKSCIDHRLRPMQDVSVFSIDEIPHAAVFGFNFPCIAHDLYEMAWQAINLAVRRASDSQIK
PGKVIIRGKMMV

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=341, Percent_Identity=26.6862170087977, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787948, Length=336, Percent_Identity=22.0238095238095, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1786268, Length=255, Percent_Identity=25.8823529411765, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790194, Length=318, Percent_Identity=22.6415094339623, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789068, Length=297, Percent_Identity=26.9360269360269, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788474, Length=315, Percent_Identity=24.4444444444444, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787906, Length=270, Percent_Identity=27.4074074074074, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787580, Length=247, Percent_Identity=24.2914979757085, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790715, Length=281, Percent_Identity=23.4875444839858, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI48994940, Length=177, Percent_Identity=24.8587570621469, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36951; Mature: 36820

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPGRKVKATLASVAAQSNVSKITASRAFSHPEKVHPDTLRRVLETAQEMGYVVNTAARN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
LRARASKTIGIVNPDMGNPFFGNLTKLMTLEAQKAGYDTLVFDSWESQEQENRIIDKLIG
HHHHHHCEEEEECCCCCCCCCCCHHHHHEEEHHHCCCCEEEECCCCCHHHHHHHHHHHHH
YGVDAIVLSVISADQNYRPAYFERLALLNIPIILVDRELDIASCSGVYIDNLDCGLQAGR
CCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCHHHHH
FLQEQQAQRVVVVSGPDDSNVARERVTGVTAALQGKIAHLDILYADFYMDVAWQVTTYYL
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHEEEEEEEE
NHQPAPDYFVGCNNQISQGIIKSCIDHRLRPMQDVSVFSIDEIPHAAVFGFNFPCIAHDL
CCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCHHHHHHH
YEMAWQAINLAVRRASDSQIKPGKVIIRGKMMV
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
APGRKVKATLASVAAQSNVSKITASRAFSHPEKVHPDTLRRVLETAQEMGYVVNTAARN
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
LRARASKTIGIVNPDMGNPFFGNLTKLMTLEAQKAGYDTLVFDSWESQEQENRIIDKLIG
HHHHHHCEEEEECCCCCCCCCCCHHHHHEEEHHHCCCCEEEECCCCCHHHHHHHHHHHHH
YGVDAIVLSVISADQNYRPAYFERLALLNIPIILVDRELDIASCSGVYIDNLDCGLQAGR
CCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCHHHHH
FLQEQQAQRVVVVSGPDDSNVARERVTGVTAALQGKIAHLDILYADFYMDVAWQVTTYYL
HHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEEEHHHHHHHHEEEEEEEE
NHQPAPDYFVGCNNQISQGIIKSCIDHRLRPMQDVSVFSIDEIPHAAVFGFNFPCIAHDL
CCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCHHHHHHH
YEMAWQAINLAVRRASDSQIKPGKVIIRGKMMV
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]